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Items: 7

1.

Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation.

Nomikos M, Theodoridou M, Elgmati K, Parthimos D, Calver BL, Buntwal L, Nounesis G, Swann K, Lai FA.

Mol Hum Reprod. 2014 Jun;20(6):489-98. doi: 10.1093/molehr/gau011. Epub 2014 Jan 29.

2.

Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.

Theodoridou M, Nomikos M, Parthimos D, Gonzalez-Garcia JR, Elgmati K, Calver BL, Sideratou Z, Nounesis G, Swann K, Lai FA.

Mol Hum Reprod. 2013 Dec;19(12):852-64. doi: 10.1093/molehr/gat070. Epub 2013 Oct 23.

3.

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.

Nomikos M, Yu Y, Elgmati K, Theodoridou M, Campbell K, Vassilakopoulou V, Zikos C, Livaniou E, Amso N, Nounesis G, Swann K, Lai FA.

Fertil Steril. 2013 Jan;99(1):76-85. doi: 10.1016/j.fertnstert.2012.08.035. Epub 2012 Sep 21.

4.

Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection.

Swann K, Windsor S, Campbell K, Elgmati K, Nomikos M, Zernicka-Goetz M, Amso N, Lai FA, Thomas A, Graham C.

Fertil Steril. 2012 Mar;97(3):742-7. doi: 10.1016/j.fertnstert.2011.12.013. Epub 2012 Jan 2.

5.

Novel regulation of PLCζ activity via its XY-linker.

Nomikos M, Elgmati K, Theodoridou M, Georgilis A, Gonzalez-Garcia JR, Nounesis G, Swann K, Lai FA.

Biochem J. 2011 Sep 15;438(3):427-32. doi: 10.1042/BJ20110953.

6.

Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region.

Nomikos M, Elgmati K, Theodoridou M, Calver BL, Nounesis G, Swann K, Lai FA.

J Cell Sci. 2011 Aug 1;124(Pt 15):2582-90. doi: 10.1242/jcs.083485. Epub 2011 Jul 5.

7.

Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ.

Nomikos M, Elgmati K, Theodoridou M, Calver BL, Cumbes B, Nounesis G, Swann K, Lai FA.

Biochem J. 2011 Mar 1;434(2):211-7. doi: 10.1042/BJ20101772. Erratum in: Biochem J. 2011 May 1;435(3):791. Nounesis, Georg [corrected to Nounesis, George].

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