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Items: 30


The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice.

Nahomi RB, Sampathkumar S, Myers AM, Elghazi L, Smith DG, Tang J, Lee CA, Kern TS, Nagaraj RH, Fort PE.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2042-2053. doi: 10.1167/iovs.17-22702.


Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development.

Elghazi L, Blandino-Rosano M, Alejandro E, Cras-Méneur C, Bernal-Mizrachi E.

Mol Metab. 2017 Mar 28;6(6):560-573. doi: 10.1016/j.molmet.2017.03.010. eCollection 2017 Jun.


Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.

Alejandro EU, Bozadjieva N, Blandino-Rosano M, Wasan MA, Elghazi L, Vadrevu S, Satin L, Bernal-Mizrachi E.

Diabetes. 2017 Aug;66(8):2150-2162. doi: 10.2337/db16-1349. Epub 2017 May 25.


Noninvasive in vivo imaging of embryonic β-cell development in the anterior chamber of the eye.

Cras-Méneur C, Elghazi L, Fort P, Bernal-Mizrachi E.

Islets. 2016 Mar 3;8(2):35-47. doi: 10.1080/19382014.2016.1148236.


S6K1 controls pancreatic β cell size independently of intrauterine growth restriction.

Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC.

J Clin Invest. 2015 Jul 1;125(7):2736-47. doi: 10.1172/JCI77030. Epub 2015 Jun 15.


Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors.

Gregg B, Elghazi L, Alejandro EU, Smith MR, Blandino-Rosano M, El-Gabri D, Cras-Méneur C, Bernal-Mizrachi E.

Diabetologia. 2014 Dec;57(12):2566-75. doi: 10.1007/s00125-014-3379-5. Epub 2014 Sep 24.


Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis.

Sadagurski M, Landeryou T, Blandino-Rosano M, Cady G, Elghazi L, Meister D, See L, Bartke A, Bernal-Mizrachi E, Miller RA.

Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1305-14. doi: 10.1152/ajpendo.00031.2014. Epub 2014 Apr 15.


Importance of β-Catenin in glucose and energy homeostasis.

Elghazi L, Gould AP, Weiss AJ, Barker DJ, Callaghan J, Opland D, Myers M, Cras-Méneur C, Bernal-Mizrachi E.

Sci Rep. 2012;2:693. Epub 2012 Sep 25.


mTORC1 signaling and regulation of pancreatic β-cell mass.

Blandino-Rosano M, Chen AY, Scheys JO, Alejandro EU, Gould AP, Taranukha T, Elghazi L, Cras-Méneur C, Bernal-Mizrachi E.

Cell Cycle. 2012 May 15;11(10):1892-902. doi: 10.4161/cc.20036. Epub 2012 May 15. Review.


Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip.

Blandino-Rosano M, Alejandro EU, Sathyamurthy A, Scheys JO, Gregg B, Chen AY, Rachdi L, Weiss A, Barker DJ, Gould AP, Elghazi L, Bernal-Mizrachi E.

Diabetologia. 2012 May;55(5):1380-9. doi: 10.1007/s00125-012-2465-9. Epub 2012 Feb 12.


Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ.

Diabetes. 2010 Dec;59(12):3090-8. doi: 10.2337/db10-0624. Epub 2010 Aug 29.


Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.

Elghazi L, Balcazar N, Blandino-Rosano M, Cras-Méneur C, Fatrai S, Gould AP, Chi MM, Moley KH, Bernal-Mizrachi E.

Diabetes. 2010 Oct;59(10):2390-9. doi: 10.2337/db09-0851. Epub 2010 Jul 9.


Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.

Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R.

Mol Cell Biol. 2010 Sep;30(17):4234-44. doi: 10.1128/MCB.01396-09. Epub 2010 Jun 28.


Akt and PTEN: beta-cell mass and pancreas plasticity.

Elghazi L, Bernal-Mizrachi E.

Trends Endocrinol Metab. 2009 Jul;20(5):243-51. doi: 10.1016/j.tem.2009.03.002. Epub 2009 Jun 21. Review.


mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability.

Balcazar N, Sathyamurthy A, Elghazi L, Gould A, Weiss A, Shiojima I, Walsh K, Bernal-Mizrachi E.

J Biol Chem. 2009 Mar 20;284(12):7832-42. doi: 10.1074/jbc.M807458200. Epub 2009 Jan 14.


Regulation of pancreas plasticity and malignant transformation by Akt signaling.

Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E.

Gastroenterology. 2009 Mar;136(3):1091-103. doi: 10.1053/j.gastro.2008.11.043. Epub 2008 Nov 27.


Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, Chang-Chen KJ, Gambello MJ, Bernal-Mizrachi E.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9250-5. doi: 10.1073/pnas.0803047105. Epub 2008 Jun 27.


Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.

Elghazi L, Weiss AJ, Gould AP, Hegedus B, Gutmann DH, Bernal-Mizrachi E.

Genesis. 2008 May;46(5):256-64. doi: 10.1002/dvg.20388.


Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.

Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH.

Cell Stem Cell. 2007 Oct 11;1(4):443-57. doi: 10.1016/j.stem.2007.07.008.


Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.

Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B.

Dev Dyn. 2008 Jan;237(1):51-61.


Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway.

Elghazi L, Rachdi L, Weiss AJ, Cras-Méneur C, Bernal-Mizrachi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:147-57. Review.


Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life.

Rachdi L, Balcazar N, Elghazi L, Barker DJ, Krits I, Kiyokawa H, Bernal-Mizrachi E.

Diabetes. 2006 Dec;55(12):3520-8.


Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.

Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E.

Diabetes. 2006 Feb;55(2):318-25.


MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R.

Diabetes. 2006 Feb;55(2):297-304.


Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function.

Elghazi L, Balcazar N, Bernal-Mizrachi E.

Int J Biochem Cell Biol. 2006 Feb;38(2):157-63. Epub 2005 Sep 23. Review.


Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2924-9. Epub 2004 Feb 17.


The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.

Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B.

Dev Biol. 2004 Feb 1;266(1):178-89.


Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation.

Elghazi L, Cras-Méneur C, Czernichow P, Scharfmann R.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3884-9. Epub 2002 Mar 12.


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