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Items: 41


Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2.

Nguyen LT, Saibil SD, Sotov V, Le MX, Khoja L, Ghazarian D, Bonilla L, Majeed H, Hogg D, Joshua AM, Crump M, Franke N, Spreafico A, Hansen A, Al-Habeeb A, Leong W, Easson A, Reedijk M, Goldstein DP, McCready D, Yasufuku K, Waddell T, Cypel M, Pierre A, Zhang B, Boross-Harmer S, Cipollone J, Nelles M, Scheid E, Fyrsta M, Lo CS, Nie J, Yam JY, Yen PH, Gray D, Motta V, Elford AR, DeLuca S, Wang L, Effendi S, Ellenchery R, Hirano N, Ohashi PS, Butler MO.

Cancer Immunol Immunother. 2019 May;68(5):773-785. doi: 10.1007/s00262-019-02307-x. Epub 2019 Feb 11.


Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW.

Science. 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072.


Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy.

Saibil SD, St Paul M, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, Grimshaw N, Robert-Tissot C, Roy DG, Jones RG, Nguyen LT, Ohashi PS.

Cancer Res. 2019 Feb 1;79(3):445-451. doi: 10.1158/0008-5472.CAN-17-3053. Epub 2018 Dec 20.


Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS.

J Immunol. 2017 Dec 15;199(12):4056-4065. doi: 10.4049/jimmunol.1600396. Epub 2017 Nov 6.


Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.

Ono N, Murakami K, Chan O, Hall H, Elford AR, Yen P, Calzascia T, Spencer DM, Ohashi PS, Dhanji S.

PLoS One. 2017 Mar 3;12(3):e0173176. doi: 10.1371/journal.pone.0173176. eCollection 2017.


Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.

Cancer Cell. 2016 Aug 8;30(2):337-348. doi: 10.1016/j.ccell.2016.05.018. Epub 2016 Jul 14.


Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.

Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.


B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

Rahbar R, Lin A, Ghazarian M, Yau HL, Paramathas S, Lang PA, Schildknecht A, Elford AR, Garcia-Batres C, Martin B, Berman HK, Leong WL, McCready DR, Reedijk M, Done SJ, Miller N, Youngson B, Suh WK, Mak TW, Ohashi PS.

Cancer Immunol Res. 2015 Feb;3(2):184-95. doi: 10.1158/2326-6066.CIR-14-0113. Epub 2014 Dec 19.


Peptide-pulsed dendritic cells have superior ability to induce immune-mediated tissue destruction compared to peptide with adjuvant.

Dissanayake D, Murakami K, Tran MD, Elford AR, Millar DG, Ohashi PS.

PLoS One. 2014 Mar 19;9(3):e92380. doi: 10.1371/journal.pone.0092380. eCollection 2014.


IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.

Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Death Differ. 2014 Jul;21(7):1050-60. doi: 10.1038/cdd.2014.19. Epub 2014 Feb 14.


Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.

Dervovic DD, Liang HC, Cannons JL, Elford AR, Mohtashami M, Ohashi PS, Schwartzberg PL, Zúñiga-Pflücker JC.

J Immunol. 2013 Aug 15;191(4):1704-15. doi: 10.4049/jimmunol.1300417. Epub 2013 Jul 12.


Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges.

Lind EF, Elford AR, Ohashi PS.

J Immunol. 2013 Feb 1;190(3):1210-6. doi: 10.4049/jimmunol.1202700. Epub 2012 Dec 28.


Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.

Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH.

J Exp Med. 2012 Jan 16;209(1):77-91. doi: 10.1084/jem.20110675. Epub 2011 Dec 19.


Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.

Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5. doi: 10.1073/pnas.1118834109. Epub 2011 Dec 13.


Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells.

Dissanayake D, Hall H, Berg-Brown N, Elford AR, Hamilton SR, Murakami K, Deluca LS, Gommerman JL, Ohashi PS.

Nat Med. 2011 Nov 13;17(12):1663-7. doi: 10.1038/nm.2556.


Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity.

Lin AC, Dissanayake D, Dhanji S, Elford AR, Ohashi PS.

PLoS One. 2011;6(9):e23940. doi: 10.1371/journal.pone.0023940. Epub 2011 Sep 12.


Immunological perspective of self versus tumor antigens: insights from the RIP-gp model.

Dissanayake D, Gronski MA, Lin A, Elford AR, Ohashi PS.

Immunol Rev. 2011 May;241(1):164-79. doi: 10.1111/j.1600-065X.2011.01014.x. Review.


IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.

Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, DePinho RA, Basta S, Ohashi PS, Mak TW.

Cell. 2011 Feb 18;144(4):601-13. doi: 10.1016/j.cell.2011.01.011. Epub 2011 Feb 3.


Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death.

Murakami K, Liadis N, Sarmiento J, Elford AR, Woo M, Nguyen LT, Mak TW, Ohashi PS.

Eur J Immunol. 2010 Dec;40(12):3372-7. doi: 10.1002/eji.201040475.


c-Rel but not NF-kappaB1 is important for T regulatory cell development.

Deenick EK, Elford AR, Pellegrini M, Hall H, Mak TW, Ohashi PS.

Eur J Immunol. 2010 Mar;40(3):677-81. doi: 10.1002/eji.201040298.


c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Deenick EK, Po L, Chapatte L, Murakami K, Lu YC, Elford AR, Saibil SD, Ruland J, Gerondakis S, Mak TW, Ohashi PS.

Eur J Immunol. 2010 Mar;40(3):867-77. doi: 10.1002/eji.200939445.


Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage.

Alam MU, Harken JA, Knorn AM, Elford AR, Wigmore K, Ohashi PS, Millar DG.

J Immunol. 2009 Nov 1;183(9):5728-37. doi: 10.4049/jimmunol.0901288. Epub 2009 Oct 7.


DNA damage- and stress-induced apoptosis occurs independently of PIDD.

Kim IR, Murakami K, Chen NJ, Saibil SD, Matysiak-Zablocki E, Elford AR, Bonnard M, Benchimol S, Jurisicova A, Yeh WC, Ohashi PS.

Apoptosis. 2009 Sep;14(9):1039-49. doi: 10.1007/s10495-009-0375-1.


Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.

Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW.

Nat Med. 2009 May;15(5):528-36. doi: 10.1038/nm.1953. Epub 2009 Apr 26. Erratum in: Nat Med. 2009 Jul;15(7):819.


CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.

Calzascia T, Pellegrini M, Lin A, Garza KM, Elford AR, Shahinian A, Ohashi PS, Mak TW.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2999-3004. doi: 10.1073/pnas.0712135105. Epub 2008 Feb 14.


IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

Lye E, Dhanji S, Calzascia T, Elford AR, Ohashi PS.

Eur J Immunol. 2008 Mar;38(3):870-6. doi: 10.1002/eji.200737429.


Targeting of pancreatic glia in type 1 diabetes.

Tsui H, Chan Y, Tang L, Winer S, Cheung RK, Paltser G, Selvanantham T, Elford AR, Ellis JR, Becker DJ, Ohashi PS, Dosch HM.

Diabetes. 2008 Apr;57(4):918-28. doi: 10.2337/db07-0226. Epub 2008 Jan 15.


CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

Dufner A, Duncan GS, Wakeham A, Elford AR, Hall HT, Ohashi PS, Mak TW.

Mol Cell Biol. 2008 Mar;28(5):1541-52. Epub 2007 Dec 26.


TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.

Calzascia T, Pellegrini M, Hall H, Sabbagh L, Ono N, Elford AR, Mak TW, Ohashi PS.

J Clin Invest. 2007 Dec;117(12):3833-45.


Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development.

Ford MS, Chen W, Wong S, Li C, Vanama R, Elford AR, Asa SL, Ohashi PS, Zhang L.

Eur J Immunol. 2007 Aug;37(8):2234-41.


CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B.

Saibil SD, Jones RG, Deenick EK, Liadis N, Elford AR, Vainberg MG, Baerg H, Woodgett JR, Gerondakis S, Ohashi PS.

J Immunol. 2007 Mar 1;178(5):2932-9.


A critical role for the innate immune signaling molecule IRAK-4 in T cell activation.

Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, Yamasaki S, Yokosuka T, Chen NJ, Elford AR, Suzuki J, Takeuchi A, Mirtsos C, Bouchard D, Ohashi PS, Yeh WC, Saito T.

Science. 2006 Mar 31;311(5769):1927-32.


NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.

Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons ME, Krawczyk CM, Gerondakis S, Yeh WC, Woodgett JR, Boothby MR, Ohashi PS.

J Immunol. 2005 Sep 15;175(6):3790-9.


Cellular FLICE-inhibitory protein is required for T cell survival and cycling.

Chau H, Wong V, Chen NJ, Huang HL, Lin WJ, Mirtsos C, Elford AR, Bonnard M, Wakeham A, You-Ten AI, Lemmers B, Salmena L, Pellegrini M, Hakem R, Mak TW, Ohashi P, Yeh WC.

J Exp Med. 2005 Aug 1;202(3):405-13. Epub 2005 Jul 25.


Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

Liadis N, Murakami K, Eweida M, Elford AR, Sheu L, Gaisano HY, Hakem R, Ohashi PS, Woo M.

Mol Cell Biol. 2005 May;25(9):3620-9.


TCR affinity and negative regulation limit autoimmunity.

Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS.

Nat Med. 2004 Nov;10(11):1234-9. Epub 2004 Oct 3.


PKCtheta signals activation versus tolerance in vivo.

Berg-Brown NN, Gronski MA, Jones RG, Elford AR, Deenick EK, Odermatt B, Littman DR, Ohashi PS.

J Exp Med. 2004 Mar 15;199(6):743-52.


Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.

Millar DG, Garza KM, Odermatt B, Elford AR, Ono N, Li Z, Ohashi PS.

Nat Med. 2003 Dec;9(12):1469-76. Epub 2003 Nov 16.


CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS.

J Exp Med. 2002 Aug 5;196(3):335-48.


In vivo generation of cytotoxic T cells from epitopes displayed on peptide-based delivery vehicles.

Kawamura KS, Su RC, Nguyen LT, Elford AR, Ohashi PS, Gariépy J.

J Immunol. 2002 Jun 1;168(11):5709-15.


Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance.

Nguyen LT, Elford AR, Murakami K, Garza KM, Schoenberger SP, Odermatt B, Speiser DE, Ohashi PS.

J Exp Med. 2002 Feb 18;195(4):423-35.

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