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Items: 1 to 50 of 67


Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis.

Dhillon AK, Kremer AE, Kummen M, Boberg KM, Elferink RPO, Karlsen TH, Beuers U, Vesterhus M, Hov JR.

Sci Rep. 2019 Jun 11;9(1):8450. doi: 10.1038/s41598-019-44762-7.


Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice.

Gasparin FRS, Carreño FO, Mewes JM, Gilglioni EH, Pagadigorria CLS, Natali MRM, Utsunomiya KS, Constantin RP, Ouchida AT, Curti C, Gaemers IC, Elferink RPJO, Constantin J, Ishii-Iwamoto EL.

Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2495-2509. doi: 10.1016/j.bbadis.2018.04.004. Epub 2018 Apr 10.


Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial.

Bolier R, de Vries ES, Parés A, Helder J, Kemper EM, Zwinderman K, Elferink RPO, Beuers U; Netherlands Association for the Study of the Liver (NASL) Cholestatic Liver Diseases Study Group.

Trials. 2017 May 23;18(1):230. doi: 10.1186/s13063-017-1966-8.


Erratum to: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4.

van der Mark VA, Ghiboub M, Marsman C, Zhao J, van Dijk R, Hiralall JK, Ho-Mok KS, Castricum Z, de Jonge WJ, Elferink RP, Paulusma CC.

Cell Mol Life Sci. 2017 Apr;74(7):1365. doi: 10.1007/s00018-017-2475-3. No abstract available.


Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells.

van der Mark VA, Rudi de Waart D, Shevchenko V, Elferink RP, Chamuleau RA, Hoekstra R.

Drug Metab Dispos. 2017 Jan;45(1):56-67. Epub 2016 Oct 25.


MRP2 in cholestasis: Putting down the anchor.

Elferink RP, Paulusma CC.

J Hepatol. 2015 Dec;63(6):1309-10. doi: 10.1016/j.jhep.2015.09.020. Epub 2015 Oct 3. No abstract available.


Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.

Slijepcevic D, Kaufman C, Wichers CG, Gilglioni EH, Lempp FA, Duijst S, de Waart DR, Elferink RP, Mier W, Stieger B, Beuers U, Urban S, van de Graaf SF.

Hepatology. 2015 Jul;62(1):207-19. doi: 10.1002/hep.27694. Epub 2015 May 8.


Pruritus in cholestasis: facts and fiction.

Beuers U, Kremer AE, Bolier R, Elferink RP.

Hepatology. 2014 Jul;60(1):399-407. doi: 10.1002/hep.26909. Epub 2014 May 29. Review.


P4 ATPases: flippases in health and disease.

van der Mark VA, Elferink RP, Paulusma CC.

Int J Mol Sci. 2013 Apr 11;14(4):7897-922. doi: 10.3390/ijms14047897. Review.


Antimitochondrial antibodies may be insufficiently specific to define primary biliary cirrhosis-like disease in mouse models.

Hohenester S, Beuers U, Medina JF, Elferink RP.

Hepatology. 2013 Aug;58(2):828-30. doi: 10.1002/hep.26243. Epub 2013 Jun 26. No abstract available.


Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis.

Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Baas F, Elferink RP, Tak PP, de Vries N, Beuers U.

Hepatology. 2013 Jun;57(6):2390-8. doi: 10.1002/hep.26232. Epub 2013 May 8.


Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide.

Hoekstra R, Nibourg GA, van der Hoeven TV, Plomer G, Seppen J, Ackermans MT, Camus S, Kulik W, van Gulik TM, Elferink RP, Chamuleau RA.

Drug Metab Dispos. 2013 Mar;41(3):562-7. doi: 10.1124/dmd.112.049098. Epub 2012 Dec 13.


Publication bias in laboratory animal research: a survey on magnitude, drivers, consequences and potential solutions.

ter Riet G, Korevaar DA, Leenaars M, Sterk PJ, Van Noorden CJ, Bouter LM, Lutter R, Elferink RP, Hooft L.

PLoS One. 2012;7(9):e43404. doi: 10.1371/journal.pone.0043404. Epub 2012 Sep 5.


A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.

Hohenester S, Wenniger LM, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RP, Beuers U.

Hepatology. 2012 Jan;55(1):173-83. doi: 10.1002/hep.24691.


The HepaRG cell line is suitable for bioartificial liver application.

Hoekstra R, Nibourg GA, van der Hoeven TV, Ackermans MT, Hakvoort TB, van Gulik TM, Lamers WH, Elferink RP, Chamuleau RA.

Int J Biochem Cell Biol. 2011 Oct;43(10):1483-9. doi: 10.1016/j.biocel.2011.06.011. Epub 2011 Jun 24.


Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes.

Nur E, Verwijs M, de Waart DR, Schnog JJ, Otten HM, Brandjes DP, Biemond BJ, Elferink RP; CURAMA Study Group.

Biochim Biophys Acta. 2011 Nov;1812(11):1412-7. doi: 10.1016/j.bbadis.2011.04.011. Epub 2011 May 3.


The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies.

Beuers U, Hohenester S, de Buy Wenniger LJ, Kremer AE, Jansen PL, Elferink RP.

Hepatology. 2010 Oct;52(4):1489-96. doi: 10.1002/hep.23810. Review.


Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.

van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, Kenworthy KE, Schinkel AH.

J Clin Invest. 2010 Aug;120(8):2942-52. doi: 10.1172/JCI42168. Epub 2010 Jul 19.


P4 ATPases--the physiological relevance of lipid flipping transporters.

Paulusma CC, Elferink RP.

FEBS Lett. 2010 Jul 2;584(13):2708-16. doi: 10.1016/j.febslet.2010.04.071. Epub 2010 May 7. Review.


Progressive familial intrahepatic cholestasis type 1.

Paulusma CC, Elferink RP, Jansen PL.

Semin Liver Dis. 2010 May;30(2):117-24. doi: 10.1055/s-0030-1253221. Epub 2010 Apr 26. Review.


Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells.

Sokolović A, Sokolović M, Boers W, Elferink RP, Bosma PJ.

Fibrogenesis Tissue Repair. 2010 Feb 17;3:3. doi: 10.1186/1755-1536-3-3.


Strain background modifies phenotypes in the ATP8B1-deficient mouse.

Shah S, Sanford UR, Vargas JC, Xu H, Groen A, Paulusma CC, Grenert JP, Pawlikowska L, Sen S, Elferink RP, Bull LN.

PLoS One. 2010 Feb 1;5(2):e8984. doi: 10.1371/journal.pone.0008984.


Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.

Cruchten ST, de Waart DR, Kunne C, Hooiveld GJ, Boekschoten MV, Katan MB, Elferink RP, Witkamp RF.

Drug Metab Dispos. 2010 Apr;38(4):635-40. doi: 10.1124/dmd.109.030213. Epub 2010 Jan 4.


Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes.

Deurholt T, van Til NP, Chhatta AA, ten Bloemendaal L, Schwartlander R, Payne C, Plevris JN, Sauer IM, Chamuleau RA, Elferink RP, Seppen J, Hoekstra R.

BMC Biotechnol. 2009 Oct 21;9:89. doi: 10.1186/1472-6750-9-89.


Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain.

Markusic DM, van Til NP, Hiralall JK, Elferink RP, Seppen J.

BMC Biotechnol. 2009 Oct 7;9:85. doi: 10.1186/1472-6750-9-85.


P4 ATPases - lipid flippases and their role in disease.

Folmer DE, Elferink RP, Paulusma CC.

Biochim Biophys Acta. 2009 Jul;1791(7):628-35. doi: 10.1016/j.bbalip.2009.02.008. Epub 2009 Feb 27. Review.


Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP.

J Biol Chem. 2009 Apr 10;284(15):9947-54. doi: 10.1074/jbc.M808667200. Epub 2009 Feb 19.


Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma.

Kuhlmann KF, van Geer MA, Bakker CT, Dekker JE, Havenga MJ, Elferink RP, Gouma DJ, Bosma PJ, Wesseling JG.

Cancer Gene Ther. 2009 Jul;16(7):585-97. doi: 10.1038/cgt.2009.4. Epub 2009 Jan 30.


Activation of cyclic AMP Signaling in Ae2-deficient mouse fibroblasts.

Mardones P, Medina JF, Elferink RP.

J Biol Chem. 2008 May 2;283(18):12146-53. doi: 10.1074/jbc.M710590200. Epub 2008 Mar 4.


Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity.

van Til NP, Heutinck KM, van der Rijt R, Paulusma CC, van Wijland M, Markusic DM, Elferink RP, Seppen J.

Retrovirology. 2008 Feb 1;5:14. doi: 10.1186/1742-4690-5-14.


In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions.

Deurholt T, ten Bloemendaal L, Chhatta AA, van Wijk AC, Weijer K, Seppen J, Elferink RP, Chamuleau RA, Hoekstra R.

Cell Transplant. 2006;15(8-9):811-22.


Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice.

Recalde S, Muruzábal F, Looije N, Kunne C, Burrell MA, Sáez E, Martínez-Ansó E, Salas JT, Mardones P, Prieto J, Medina JF, Elferink RP.

Am J Pathol. 2006 Jul;169(1):165-76.


Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.

Vlaming ML, Mohrmann K, Wagenaar E, de Waart DR, Elferink RP, Lagas JS, van Tellingen O, Vainchtein LD, Rosing H, Beijnen JH, Schellens JH, Schinkel AH.

J Pharmacol Exp Ther. 2006 Jul;318(1):319-27. Epub 2006 Apr 12.


Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats.

Seppen J, van Til NP, van der Rijt R, Hiralall JK, Kunne C, Elferink RP.

Gene Ther. 2006 Apr;13(8):672-7.


Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen.

Dietrich CG, Geier A, Wasmuth HE, Matern S, Gartung C, de Waart DR, Elferink RP.

Gut. 2004 Dec;53(12):1850-5.


A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion.

Pawlikowska L, Groen A, Eppens EF, Kunne C, Ottenhoff R, Looije N, Knisely AS, Killeen NP, Bull LN, Elferink RP, Freimer NB.

Hum Mol Genet. 2004 Apr 15;13(8):881-92. Epub 2004 Feb 19.


Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters.

Elferink RP, Ottenhoff R, Fricker G, Seward DJ, Ballatori N, Boyer J.

Am J Physiol Gastrointest Liver Physiol. 2004 May;286(5):G762-8. Epub 2003 Dec 30.


Anion exchanger 2 is essential for spermiogenesis in mice.

Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15847-52. Epub 2003 Dec 12.


Understanding and controlling hepatobiliary function.

Elferink RP.

Best Pract Res Clin Gastroenterol. 2002 Dec;16(6):1025-34. Review.


The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

Jonker JW, Buitelaar M, Wagenaar E, Van Der Valk MA, Scheffer GL, Scheper RJ, Plosch T, Kuipers F, Elferink RP, Rosing H, Beijnen JH, Schinkel AH.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15649-54. Epub 2002 Nov 12.


Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan.

Fouassier L, Kinnman N, Lefèvre G, Lasnier E, Rey C, Poupon R, Elferink RP, Housset C.

J Hepatol. 2002 Aug;37(2):184-91.


Tissue distribution and induction of human multidrug resistant protein 3.

Scheffer GL, Kool M, de Haas M, de Vree JM, Pijnenborg AC, Bosman DK, Elferink RP, van der Valk P, Borst P, Scheper RJ.

Lab Invest. 2002 Feb;82(2):193-201.


Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo.

Dietrich CG, de Waart DR, Ottenhoff R, Bootsma AH, van Gennip AH, Elferink RP.

Carcinogenesis. 2001 May;22(5):805-11.


The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood.

Jacquemin E, De Vree JM, Cresteil D, Sokal EM, Sturm E, Dumont M, Scheffer GL, Paul M, Burdelski M, Bosma PJ, Bernard O, Hadchouel M, Elferink RP.

Gastroenterology. 2001 May;120(6):1448-58.


Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.

Dietrich CG, de Waart DR, Ottenhoff R, Schoots IG, Elferink RP.

Mol Pharmacol. 2001 May;59(5):974-80.


Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice.

Voshol PJ, Koopen NR, de Vree JM, Havinga R, Princen HM, Elferink RP, Groen AK, Kuipers F.

J Hepatol. 2001 Feb;34(2):202-9.


Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der Linden M, de Vree JM, van der Valk P, Elferink RP, Borst P, Scheper RJ.

Cancer Res. 2000 Sep 15;60(18):5269-77.


Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice.

Voshol PJ, Minich DM, Havinga R, Elferink RP, Verkade HJ, Groen AK, Kuipers F.

Gastroenterology. 2000 Jan;118(1):173-82.


The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids.

Frijters CM, Tuijn CJ, Ottenhoff R, Zegers BN, Groen AK, Elferink RP.

J Lipid Res. 1999 Nov;40(11):1950-8.


Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces.

van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der Poll T, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP, Borst P.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11501-6.

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