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Items: 1 to 50 of 126

1.

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes.

Joshi K, Elso C, Motazedian A, Labonne T, Schiesser JV, Cameron F, Mannering SI, Elefanty AG, Stanley EG.

Diabetologia. 2019 Sep 12. doi: 10.1007/s00125-019-04988-6. [Epub ahead of print]

PMID:
31511930
2.

The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line.

Howden S, Hosseini Far H, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF.

Stem Cell Res. 2019 Jul;38:101453. doi: 10.1016/j.scr.2019.101453. Epub 2019 May 4.

3.

Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing.

Hosseini Far H, Patria YN, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF.

Stem Cell Res. 2019 May;37:101449. doi: 10.1016/j.scr.2019.101449. Epub 2019 Apr 23.

4.

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.

Dong L, Reljic B, Cheung JG, Ng ES, Lindqvist LM, Elefanty AG, Vaux DL, Tran H.

Cell Death Differ. 2019 Oct;26(10):2074-2085. doi: 10.1038/s41418-019-0275-z. Epub 2019 Feb 15.

PMID:
30770875
5.

Generation of iPSC lines from peripheral blood mononuclear cells from 5 healthy adults.

Vlahos K, Sourris K, Mayberry R, McDonald P, Bruveris FF, Schiesser JV, Bozaoglu K, Lockhart PJ, Stanley EG, Elefanty AG.

Stem Cell Res. 2019 Jan;34:101380. doi: 10.1016/j.scr.2018.101380. Epub 2018 Dec 27.

6.

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA.

Nat Commun. 2018 Apr 10;9(1):1373. doi: 10.1038/s41467-018-03714-x.

7.

Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease.

Gao Y, Wilson GR, Bozaoglu K, Elefanty AG, Stanley EG, Dottori M, Lockhart PJ.

Stem Cell Res. 2018 Apr;28:161-164. doi: 10.1016/j.scr.2018.02.015. Epub 2018 Feb 21.

8.

WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development.

Richter J, Stanley EG, Ng ES, Elefanty AG, Traver D, Willert K.

Genes (Basel). 2018 Jan 29;9(2). pii: E66. doi: 10.3390/genes9020066.

9.

Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development.

Meganathan K, Lewis EMA, Gontarz P, Liu S, Stanley EG, Elefanty AG, Huettner JE, Zhang B, Kroll KL.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11180-E11189. doi: 10.1073/pnas.1712365115. Epub 2017 Dec 11.

10.

Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination.

Lee JY, Kim MJ, Deliyanti D, Azari MF, Rossello F, Costin A, Ramm G, Stanley EG, Elefanty AG, Wilkinson-Berka JL, Petratos S.

EBioMedicine. 2017 Nov;25:122-135. doi: 10.1016/j.ebiom.2017.10.016. Epub 2017 Oct 19.

11.

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells.

Bellmaine SF, Ovchinnikov DA, Manallack DT, Cuddy CE, Elefanty AG, Stanley EG, Wolvetang EJ, Williams SJ, Pera M.

Elife. 2017 Sep 8;6. pii: e24502. doi: 10.7554/eLife.24502.

12.

Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.

Xiang Y, Tanaka Y, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH.

Cell Stem Cell. 2017 Sep 7;21(3):383-398.e7. doi: 10.1016/j.stem.2017.07.007. Epub 2017 Jul 27.

13.

Human haematopoietic stem cell development: from the embryo to the dish.

Ivanovs A, Rybtsov S, Ng ES, Stanley EG, Elefanty AG, Medvinsky A.

Development. 2017 Jul 1;144(13):2323-2337. doi: 10.1242/dev.134866. Review.

14.

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

Niclis JC, Gantner CW, Alsanie WF, McDougall SJ, Bye CR, Elefanty AG, Stanley EG, Haynes JM, Pouton CW, Thompson LH, Parish CL.

Stem Cells Transl Med. 2017 Mar;6(3):937-948. doi: 10.5966/sctm.2016-0073. Epub 2016 Oct 14.

15.

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM.

Nat Med. 2017 Jan;23(1):49-59. doi: 10.1038/nm.4233. Epub 2016 Nov 21.

16.

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros.

Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Layland K, Oshlack A, Mikkola HK, Stanley EG, Elefanty AG.

Nat Biotechnol. 2016 Nov;34(11):1168-1179. doi: 10.1038/nbt.3702. Epub 2016 Oct 17.

PMID:
27748754
17.

GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives.

Kao T, Labonne T, Niclis JC, Chaurasia R, Lokmic Z, Qian E, Bruveris FF, Howden SE, Motazedian A, Schiesser JV, Costa M, Sourris K, Ng E, Anderson D, Giudice A, Farlie P, Cheung M, Lamande SR, Penington AJ, Parish CL, Thomson LH, Rafii A, Elliott DA, Elefanty AG, Stanley EG.

Stem Cell Reports. 2016 Sep 13;7(3):518-526. doi: 10.1016/j.stemcr.2016.07.015. Epub 2016 Sep 1.

18.

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells.

Howden SE, McColl B, Glaser A, Vadolas J, Petrou S, Little MH, Elefanty AG, Stanley EG.

Stem Cell Reports. 2016 Sep 13;7(3):508-517. doi: 10.1016/j.stemcr.2016.07.001. Epub 2016 Aug 4.

19.

Spatio-temporal re-organization of replication foci accompanies replication domain consolidation during human pluripotent stem cell lineage specification.

Wilson KA, Elefanty AG, Stanley EG, Gilbert DM.

Cell Cycle. 2016 Sep 16;15(18):2464-75. doi: 10.1080/15384101.2016.1203492. Epub 2016 Jul 19.

20.

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.

Jackson M, Ma R, Taylor AH, Axton RA, Easterbrook J, Kydonaki M, Olivier E, Marenah L, Stanley EG, Elefanty AG, Mountford JC, Forrester LM.

Stem Cells Transl Med. 2016 Aug;5(8):981-90. doi: 10.5966/sctm.2015-0324. Epub 2016 Jun 28.

21.

ALPK3-deficient cardiomyocytes generated from patient-derived induced pluripotent stem cells and mutant human embryonic stem cells display abnormal calcium handling and establish that ALPK3 deficiency underlies familial cardiomyopathy.

Phelan DG, Anderson DJ, Howden SE, Wong RC, Hickey PF, Pope K, Wilson GR, Pébay A, Davis AM, Petrou S, Elefanty AG, Stanley EG, James PA, Macciocca I, Bahlo M, Cheung MM, Amor DJ, Elliott DA, Lockhart PJ.

Eur Heart J. 2016 Sep 1;37(33):2586-90. doi: 10.1093/eurheartj/ehw160. Epub 2016 Apr 22.

PMID:
27106955
22.

CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells.

Skelton RJ, Brady B, Khoja S, Sahoo D, Engel J, Arasaratnam D, Saleh KK, Abilez OJ, Zhao P, Stanley EG, Elefanty AG, Kwon M, Elliott DA, Ardehali R.

Stem Cell Reports. 2016 Jan 12;6(1):95-108. doi: 10.1016/j.stemcr.2015.11.006.

23.

Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts.

Howden SE, Maufort JP, Duffin BM, Elefanty AG, Stanley EG, Thomson JA.

Stem Cell Reports. 2015 Dec 8;5(6):1109-1118. doi: 10.1016/j.stemcr.2015.10.009. Epub 2015 Nov 12.

24.

Magnetic Resonance Imaging of Iron Oxide-Labeled Human Embryonic Stem Cell-Derived Cardiac Progenitors.

Skelton RJ, Khoja S, Almeida S, Rapacchi S, Han F, Engel J, Zhao P, Hu P, Stanley EG, Elefanty AG, Kwon M, Elliott DA, Ardehali R.

Stem Cells Transl Med. 2016 Jan;5(1):67-74. doi: 10.5966/sctm.2015-0077. Epub 2015 Nov 18.

25.

Isolation of human lymphatic endothelial cells by multi-parameter fluorescence-activated cell sorting.

Lokmic Z, Ng ES, Burton M, Stanley EG, Penington AJ, Elefanty AG.

J Vis Exp. 2015 May 1;(99):e52691. doi: 10.3791/52691.

26.

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.

Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G.

Nat Cell Biol. 2015 May;17(5):580-91. doi: 10.1038/ncb3161. Epub 2015 Apr 27.

27.

Productive Infection of Human Embryonic Stem Cell-Derived NKX2.1+ Respiratory Progenitors with Human Rhinovirus.

Jenny RA, Hirst C, Lim SM, Goulburn AL, Micallef SJ, Labonne T, Kicic A, Ling KM, Stick SM, Ng ES, Trounson A, Giudice A, Elefanty AG, Stanley EG.

Stem Cells Transl Med. 2015 Jun;4(6):603-14. doi: 10.5966/sctm.2014-0274. Epub 2015 Apr 14.

28.

Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.

Nostro MC, Sarangi F, Yang C, Holland A, Elefanty AG, Stanley EG, Greiner DL, Keller G.

Stem Cell Reports. 2015 Apr 14;4(4):591-604. doi: 10.1016/j.stemcr.2015.02.017. Epub 2015 Apr 2.

29.

β-cell regeneration and differentiation: how close are we to the 'holy grail'?

Tan G, Elefanty AG, Stanley EG.

J Mol Endocrinol. 2014 Dec;53(3):R119-29. doi: 10.1530/JME-14-0188. Review.

PMID:
25385843
30.

Derivation of insulin-producing beta-cells from human pluripotent stem cells.

Schiesser JV, Micallef SJ, Hawes S, Elefanty AG, Stanley EG.

Rev Diabet Stud. 2014 Spring;11(1):6-18. doi: 10.1900/RDS.2014.11.6. Epub 2014 May 10. Review.

31.

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

Skelton RJ, Costa M, Anderson DJ, Bruveris F, Finnin BW, Koutsis K, Arasaratnam D, White AJ, Rafii A, Ng ES, Elefanty AG, Stanley EG, Pouton CW, Haynes JM, Ardehali R, Davis RP, Mummery CL, Elliott DA.

Stem Cell Res. 2014 Jul;13(1):172-9. doi: 10.1016/j.scr.2014.04.016. Epub 2014 May 4.

32.

FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors.

Soh CL, Giudice A, Jenny RA, Elliott DA, Hatzistavrou T, Micallef SJ, Kianizad K, Seach N, Zúñiga-Pflücker JC, Chidgey AP, Trounson A, Nilsson SK, Haylock DN, Boyd RL, Elefanty AG, Stanley EG.

Stem Cell Reports. 2014 May 22;2(6):925-37. doi: 10.1016/j.stemcr.2014.04.009. eCollection 2014 Jun 3.

33.

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations.

Loh KM, Ang LT, Zhang J, Kumar V, Ang J, Auyeong JQ, Lee KL, Choo SH, Lim CY, Nichane M, Tan J, Noghabi MS, Azzola L, Ng ES, Durruthy-Durruthy J, Sebastiano V, Poellinger L, Elefanty AG, Stanley EG, Chen Q, Prabhakar S, Weissman IL, Lim B.

Cell Stem Cell. 2014 Feb 6;14(2):237-52. doi: 10.1016/j.stem.2013.12.007. Epub 2014 Jan 9.

34.

PGC-1α and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function.

Birket MJ, Casini S, Kosmidis G, Elliott DA, Gerencser AA, Baartscheer A, Schumacher C, Mastroberardino PG, Elefanty AG, Stanley EG, Mummery CL.

Stem Cell Reports. 2013 Dec 12;1(6):560-74. doi: 10.1016/j.stemcr.2013.11.008. eCollection 2013.

35.

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.

Takasato M, Er PX, Becroft M, Vanslambrouck JM, Stanley EG, Elefanty AG, Little MH.

Nat Cell Biol. 2014 Jan;16(1):118-26. doi: 10.1038/ncb2894. Epub 2013 Dec 15.

PMID:
24335651
36.

The characterisation of pluripotent and multipotent stem cells using Fourier transform infrared microspectroscopy.

Cao J, Ng ES, McNaughton D, Stanley EG, Elefanty AG, Tobin MJ, Heraud P.

Int J Mol Sci. 2013 Aug 26;14(9):17453-76. doi: 10.3390/ijms140917453. Review.

37.

WNT3A promotes hematopoietic or mesenchymal differentiation from hESCs depending on the time of exposure.

Gertow K, Hirst CE, Yu QC, Ng ES, Pereira LA, Davis RP, Stanley EG, Elefanty AG.

Stem Cell Reports. 2013 Jun 4;1(1):53-65. doi: 10.1016/j.stemcr.2013.04.002. eCollection 2013.

38.

Fourier transform infrared microspectroscopy reveals that tissue culture conditions affect the macromolecular phenotype of human embryonic stem cells.

Cao J, Ng ES, McNaughton D, Stanley EG, Elefanty AG, Tobin MJ, Heraud P.

Analyst. 2013 Jul 21;138(14):4147-60. doi: 10.1039/c3an00321c. Epub 2013 Jun 7.

PMID:
23745179
39.

Pancreatic differentiation.

Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Jun 10.

40.

Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.

Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR.

Cell Stem Cell. 2013 May 2;12(5):573-86. doi: 10.1016/j.stem.2013.04.005.

41.

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.

Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L.

Cell Stem Cell. 2013 May 2;12(5):559-72. doi: 10.1016/j.stem.2013.04.008.

42.

Fourier transform infrared microspectroscopy reveals unique phenotypes for human embryonic and induced pluripotent stem cell lines and their progeny.

Cao J, Ng ES, McNaughton D, Stanley EG, Elefanty AG, Tobin MJ, Heraud P.

J Biophotonics. 2014 Oct;7(10):767-81. doi: 10.1002/jbio.201200217. Epub 2013 Apr 25.

PMID:
23616434
43.

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.

Pick M, Azzola L, Osborne E, Stanley EG, Elefanty AG.

PLoS One. 2013;8(2):e55530. doi: 10.1371/journal.pone.0055530. Epub 2013 Feb 12.

44.

Human embryonic stem cell derived mesenchymal progenitors express cardiac markers but do not form contractile cardiomyocytes.

Raynaud CM, Halabi N, Elliott DA, Pasquier J, Elefanty AG, Stanley EG, Rafii A.

PLoS One. 2013;8(1):e54524. doi: 10.1371/journal.pone.0054524. Epub 2013 Jan 16.

45.

Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation.

Titmarsh DM, Hudson JE, Hidalgo A, Elefanty AG, Stanley EG, Wolvetang EJ, Cooper-White JJ.

PLoS One. 2012;7(12):e52405. doi: 10.1371/journal.pone.0052405. Epub 2012 Dec 26.

46.

Analysis of mitochondrial function and localisation during human embryonic stem cell differentiation in vitro.

Prowse AB, Chong F, Elliott DA, Elefanty AG, Stanley EG, Gray PP, Munro TP, Osborne GW.

PLoS One. 2012;7(12):e52214. doi: 10.1371/journal.pone.0052214. Epub 2012 Dec 19.

47.

Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization.

Costa M, Sourris K, Lim SM, Yu QC, Hirst CE, Parkington HC, Jokubaitis VJ, Dear AE, Liu HB, Micallef SJ, Koutsis K, Elefanty AG, Stanley EG.

Stem Cell Res. 2013 Jan;10(1):103-17. doi: 10.1016/j.scr.2012.10.003. Epub 2012 Oct 22.

48.

Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview.

Mummery CL, Zhang J, Ng ES, Elliott DA, Elefanty AG, Kamp TJ.

Circ Res. 2012 Jul 20;111(3):344-58. doi: 10.1161/CIRCRESAHA.110.227512. Review.

49.

APELIN promotes hematopoiesis from human embryonic stem cells.

Yu QC, Hirst CE, Costa M, Ng ES, Schiesser JV, Gertow K, Stanley EG, Elefanty AG.

Blood. 2012 Jun 28;119(26):6243-54. doi: 10.1182/blood-2011-12-396093. Epub 2012 May 18.

50.

The Mix family of homeobox genes--key regulators of mesendoderm formation during vertebrate development.

Pereira LA, Wong MS, Mei Lim S, Stanley EG, Elefanty AG.

Dev Biol. 2012 Jul 15;367(2):163-77. doi: 10.1016/j.ydbio.2012.04.033. Epub 2012 May 8. Review.

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