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Items: 22


Dentate gyrus μ-opioid receptor-mediated neurogenic processes are associated with alterations in morphine self-administration.

Zhang H, Jia M, Wang XW, Ye C, Li Y, Wang N, Elefant F, Ma H, Cui C.

Sci Rep. 2019 Feb 6;9(1):1471. doi: 10.1038/s41598-018-37083-8.


Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition.

Panikker P, Xu SJ, Zhang H, Sarthi J, Beaver M, Sheth A, Akhter S, Elefant F.

J Neurosci. 2018 May 9;38(19):4569-4583. doi: 10.1523/JNEUROSCI.2840-17.2018. Epub 2018 Apr 13.


Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.

Gulchina Y, Xu SJ, Snyder MA, Elefant F, Gao WJ.

J Neurochem. 2017 Nov;143(3):320-333. doi: 10.1111/jnc.14101. Epub 2017 Sep 5.


Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.

Xu S, Panikker P, Iqbal S, Elefant F.

PLoS One. 2016 Jul 25;11(7):e0159623. doi: 10.1371/journal.pone.0159623. eCollection 2016.


Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60.

Xu S, Elefant F.

Fly (Austin). 2015;9(1):22-8. doi: 10.1080/19336934.2015.1080887.


Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.

Xu S, Wilf R, Menon T, Panikker P, Sarthi J, Elefant F.

Genetics. 2014 Dec;198(4):1571-86. doi: 10.1534/genetics.114.171660. Epub 2014 Oct 17.


Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.

Johnson AA, Sarthi J, Pirooznia SK, Reube W, Elefant F.

J Neurosci. 2013 Apr 24;33(17):7535-47. doi: 10.1523/JNEUROSCI.3739-12.2013.


A HAT for sleep?: epigenetic regulation of sleep by Tip60 in Drosophila.

Pirooznia SK, Elefant F.

Fly (Austin). 2013 Apr-Jun;7(2):99-104. doi: 10.4161/fly.24141. Epub 2013 Apr 1.


Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities.

Pirooznia SK, Elefant F.

Front Cell Neurosci. 2013 Mar 28;7:30. doi: 10.3389/fncel.2013.00030. eCollection 2013.


Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep.

Pirooznia SK, Chiu K, Chan MT, Zimmerman JE, Elefant F.

Genetics. 2012 Dec;192(4):1327-45. doi: 10.1534/genetics.112.144667. Epub 2012 Sep 14.


Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model.

Pirooznia SK, Sarthi J, Johnson AA, Toth MS, Chiu K, Koduri S, Elefant F.

PLoS One. 2012;7(7):e41776. doi: 10.1371/journal.pone.0041776. Epub 2012 Jul 26.


dTip60 HAT activity controls synaptic bouton expansion at the Drosophila neuromuscular junction.

Sarthi J, Elefant F.

PLoS One. 2011;6(10):e26202. doi: 10.1371/journal.pone.0026202. Epub 2011 Oct 27.


Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism.

Lorbeck M, Pirooznia K, Sarthi J, Zhu X, Elefant F.

PLoS One. 2011 Apr 11;6(4):e18412. doi: 10.1371/journal.pone.0018412.


The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila.

Singh N, Lorbeck MT, Zervos A, Zimmerman J, Elefant F.

J Neurochem. 2010 Oct;115(2):493-504. doi: 10.1111/j.1471-4159.2010.06892.x. Epub 2010 Aug 24.


The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila.

Lorbeck MT, Singh N, Zervos A, Dhatta M, Lapchenko M, Yang C, Elefant F.

Gene. 2010 Jan 15;450(1-2):8-17. doi: 10.1016/j.gene.2009.09.007.


Locus control region transcription plays an active role in long-range gene activation.

Ho Y, Elefant F, Liebhaber SA, Cooke NE.

Mol Cell. 2006 Aug 4;23(3):365-75. Erratum in: Mol Cell. 2006 Aug;23(4):619.


Targeted recruitment of histone acetyltransferase activity to a locus control region.

Elefant F, Cooke NE, Liebhaber SA.

J Biol Chem. 2000 May 5;275(18):13827-34.


GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila.

Manseau L, Baradaran A, Brower D, Budhu A, Elefant F, Phan H, Philp AV, Yang M, Glover D, Kaiser K, Palter K, Selleck S.

Dev Dyn. 1997 Jul;209(3):310-22.

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