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Items: 1 to 50 of 80

1.

Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.

Dickstein DL, De Gasperi R, Gama Sosa MA, Perez-Garcia G, Short JA, Sosa H, Perez GM, Tschiffely AE, Dams-O'Connor K, Pullman MY, Knesaurek K, Knutsen A, Pham DL, Soleimani L, Jordan BD, Gordon WA, Delman BN, Shumyatsky G, Shahim PP, DeKosky ST, Stone JR, Peskind E, Blennow K, Zetterberg H, Chance SA, Torso M, Kostakoglu L, Sano M, Hof PR, Ahlers ST, Gandy S, Elder GA.

Mol Psychiatry. 2020 Feb 25. doi: 10.1038/s41380-020-0674-z. [Epub ahead of print]

PMID:
32094584
2.

Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans.

Elder GA, Ehrlich ME, Gandy S.

Neurosci Lett. 2019 Aug 10;707:134294. doi: 10.1016/j.neulet.2019.134294. Epub 2019 May 26. Review.

PMID:
31141716
3.

Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain.

Gama Sosa MA, De Gasperi R, Perez Garcia GS, Perez GM, Searcy C, Vargas D, Spencer A, Janssen PL, Tschiffely AE, McCarron RM, Ache B, Manoharan R, Janssen WG, Tappan SJ, Hanson RW, Gandy S, Hof PR, Ahlers ST, Elder GA.

Acta Neuropathol Commun. 2019 Jan 9;7(1):6. doi: 10.1186/s40478-018-0647-5.

4.

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Abrams RMC, Elder GA.

Neurologist. 2018 Nov;23(6):185-187. doi: 10.1097/NRL.0000000000000197.

PMID:
30379740
5.

Blast-induced "PTSD": Evidence from an animal model.

Perez-Garcia G, Gama Sosa MA, De Gasperi R, Tschiffely AE, McCarron RM, Hof PR, Gandy S, Ahlers ST, Elder GA.

Neuropharmacology. 2019 Feb;145(Pt B):220-229. doi: 10.1016/j.neuropharm.2018.09.023. Epub 2018 Sep 15. Review.

PMID:
30227150
6.

PTSD-Related Behavioral Traits in a Rat Model of Blast-Induced mTBI Are Reversed by the mGluR2/3 Receptor Antagonist BCI-838.

Perez-Garcia G, De Gasperi R, Gama Sosa MA, Perez GM, Otero-Pagan A, Tschiffely A, McCarron RM, Ahlers ST, Elder GA, Gandy S.

eNeuro. 2018 Jan 30;5(1). pii: ENEURO.0357-17.2018. doi: 10.1523/ENEURO.0357-17.2018. eCollection 2018 Jan-Feb.

7.

Lack of chronic neuroinflammation in the absence of focal hemorrhage in a rat model of low-energy blast-induced TBI.

Gama Sosa MA, De Gasperi R, Perez Garcia GS, Sosa H, Searcy C, Vargas D, Janssen PL, Perez GM, Tschiffely AE, Janssen WG, McCarron RM, Hof PR, Haghighi FG, Ahlers ST, Elder GA.

Acta Neuropathol Commun. 2017 Nov 10;5(1):80. doi: 10.1186/s40478-017-0483-z.

8.

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions.

Cernak I, Stein DG, Elder GA, Ahlers S, Curley K, DePalma RG, Duda J, Ikonomovic M, Iverson GL, Kobeissy F, Koliatsos VE, Leggieri MJ Jr, Pacifico AM, Smith DH, Swanson R, Thompson FJ, Tortella FC.

Brain Inj. 2017;31(9):1168-1176. doi: 10.1080/02699052.2016.1274779. Review.

PMID:
28981339
9.

Blast Exposure, White Matter Integrity, and Cognitive Function in Iraq and Afghanistan Combat Veterans.

Ivanov I, Fernandez C, Mitsis EM, Dickstein DL, Wong E, Tang CY, Simantov J, Bang C, Moshier E, Sano M, Elder GA, Hazlett EA.

Front Neurol. 2017 Apr 21;8:127. doi: 10.3389/fneur.2017.00127. eCollection 2017.

10.

Exposure to a Predator Scent Induces Chronic Behavioral Changes in Rats Previously Exposed to Low-level Blast: Implications for the Relationship of Blast-Related TBI to PTSD.

Perez-Garcia G, Gama Sosa MA, De Gasperi R, Lashof-Sullivan M, Maudlin-Jeronimo E, Stone JR, Haghighi F, Ahlers ST, Elder GA.

Front Neurol. 2016 Oct 18;7:176. eCollection 2016.

11.

Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure.

Perez-Garcia G, Gama Sosa MA, De Gasperi R, Lashof-Sullivan M, Maudlin-Jeronimo E, Stone JR, Haghighi F, Ahlers ST, Elder GA.

Behav Brain Res. 2018 Mar 15;340:117-125. doi: 10.1016/j.bbr.2016.09.061. Epub 2016 Sep 28.

PMID:
27693852
12.

Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.

Gama Sosa MA, De Gasperi R, Hof PR, Elder GA.

Sci Rep. 2016 Jul 22;6:30267. doi: 10.1038/srep30267.

13.

In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy.

Zhao W, Ho L, Wang J, Bi W, Yemul S, Ward L, Freire D, Mazzola P, Brathwaite J, Mezei M, Sanchez R, Elder GA, Pasinetti GM.

J Cell Biochem. 2016 Oct;117(10):2241-8. doi: 10.1002/jcb.25521. Epub 2016 Jul 12.

14.

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11965-70. doi: 10.1073/pnas.1510011112. Epub 2015 Sep 8.

15.

Update on TBI and Cognitive Impairment in Military Veterans.

Elder GA.

Curr Neurol Neurosci Rep. 2015 Oct;15(10):68. doi: 10.1007/s11910-015-0591-8. Review.

PMID:
26299275
16.

Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury.

Elder GA, Gama Sosa MA, De Gasperi R, Stone JR, Dickstein DL, Haghighi F, Hof PR, Ahlers ST.

Front Neurol. 2015 Mar 16;6:48. doi: 10.3389/fneur.2015.00048. eCollection 2015. Review.

17.

Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury.

Haghighi F, Ge Y, Chen S, Xin Y, Umali MU, De Gasperi R, Gama Sosa MA, Ahlers ST, Elder GA.

J Neurotrauma. 2015 Aug 15;32(16):1200-9. doi: 10.1089/neu.2014.3640. Epub 2015 May 7.

18.

Effects of low-level blast exposure on the nervous system: is there really a controversy?

Elder GA, Stone JR, Ahlers ST.

Front Neurol. 2014 Dec 19;5:269. doi: 10.3389/fneur.2014.00269. eCollection 2014. Review.

19.

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.

Mitsis EM, Riggio S, Kostakoglu L, Dickstein DL, Machac J, Delman B, Goldstein M, Jennings D, D'Antonio E, Martin J, Naidich TP, Aloysi A, Fernandez C, Seibyl J, DeKosky ST, Elder GA, Marek K, Gordon W, Hof PR, Sano M, Gandy S.

Transl Psychiatry. 2014 Sep 16;4:e441. doi: 10.1038/tp.2014.91.

20.

Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury.

Gama Sosa MA, De Gasperi R, Janssen PL, Yuk FJ, Anazodo PC, Pricop PE, Paulino AJ, Wicinski B, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dickstein DL, McCarron RM, Chavko M, Hof PR, Ahlers ST, Elder GA.

Acta Neuropathol Commun. 2014 Jun 17;2:67. doi: 10.1186/2051-5960-2-67.

21.

Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice.

Charles R, Sakurai T, Takahashi N, Elder GA, Gama Sosa MA, Young LJ, Buxbaum JD.

Dis Model Mech. 2014 Aug;7(8):1013-22. doi: 10.1242/dmm.017053. Epub 2014 Jun 12.

22.

Absence of strong strain effects in behavioral analyses of Shank3-deficient mice.

Drapeau E, Dorr NP, Elder GA, Buxbaum JD.

Dis Model Mech. 2014 Jun;7(6):667-81. doi: 10.1242/dmm.013821. Epub 2014 Mar 20.

23.

Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury.

Sosa MA, De Gasperi R, Paulino AJ, Pricop PE, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Janssen WG, Yuk FJ, Dorr NP, Dickstein DL, McCarron RM, Chavko M, Hof PR, Ahlers ST, Elder GA.

Acta Neuropathol Commun. 2013 Aug 14;1:51. doi: 10.1186/2051-5960-1-51.

24.

Acute blast injury reduces brain abeta in two rodent species.

De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA.

Front Neurol. 2012 Dec 21;3:177. doi: 10.3389/fneur.2012.00177. eCollection 2012.

25.

Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells.

De Gasperi R, Gama Sosa MA, Elder GA.

BMC Biochem. 2012 Dec 21;13:28. doi: 10.1186/1471-2091-13-28.

26.

Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury.

Elder GA, Dorr NP, De Gasperi R, Gama Sosa MA, Shaughness MC, Maudlin-Jeronimo E, Hall AA, McCarron RM, Ahlers ST.

J Neurotrauma. 2012 Nov 1;29(16):2564-75. doi: 10.1089/neu.2012.2510. Epub 2012 Aug 27.

28.

Modeling human neurodegenerative diseases in transgenic systems.

Gama Sosa MA, De Gasperi R, Elder GA.

Hum Genet. 2012 Apr;131(4):535-63. doi: 10.1007/s00439-011-1119-1. Epub 2011 Dec 14. Review.

PMID:
22167414
29.

PERIPHERAL MYELIN PROTEIN-22 IS EXPRESSED IN CNS MYELIN.

De Gasperi R, Gama Sosa MA, Naumowicz Z, Hof PR, Notterpek L, Davis KL, Buxbaum JD, Elder GA.

Transl Neurosci. 2010 Dec 1;1(4):282-285.

30.

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

Sakurai T, Dorr NP, Takahashi N, McInnes LA, Elder GA, Buxbaum JD.

Autism Res. 2011 Feb;4(1):28-39. doi: 10.1002/aur.169. Epub 2010 Dec 3.

PMID:
21328569
31.

Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes.

Takahashi N, Sakurai T, Bozdagi-Gunal O, Dorr NP, Moy J, Krug L, Gama-Sosa M, Elder GA, Koch RJ, Walker RH, Hof PR, Davis KL, Buxbaum JD.

Transl Psychiatry. 2011 May 10;1:e8. doi: 10.1038/tp.2011.8.

32.

Blast-induced mild traumatic brain injury.

Elder GA, Mitsis EM, Ahlers ST, Cristian A.

Psychiatr Clin North Am. 2010 Dec;33(4):757-81. doi: 10.1016/j.psc.2010.08.001. Epub 2010 Oct 15. Review.

PMID:
21093677
33.

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease.

De Gasperi R, Sosa MA, Dracheva S, Elder GA.

Mol Neurodegener. 2010 Sep 23;5:38. doi: 10.1186/1750-1326-5-38.

34.

Introduction to the special issue of brain structure and function on transgenic modeling of neurodegenerative disorders.

Hof PR, Elder GA.

Brain Struct Funct. 2010 Mar;214(2-3):89-90. doi: 10.1007/s00429-010-0243-3. No abstract available.

PMID:
20169361
35.

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.

Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z.

J Neurosci. 2010 Feb 3;30(5):1788-97. doi: 10.1523/JNEUROSCI.5604-09.2010.

36.

Transgenic mouse models of Alzheimer's disease.

Elder GA, Gama Sosa MA, De Gasperi R.

Mt Sinai J Med. 2010 Jan-Feb;77(1):69-81. doi: 10.1002/msj.20159. Review.

37.

Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders.

Sakurai T, Ramoz N, Barreto M, Gazdoiu M, Takahashi N, Gertner M, Dorr N, Gama Sosa MA, De Gasperi R, Perez G, Schmeidler J, Mitropoulou V, Le HC, Lupu M, Hof PR, Elder GA, Buxbaum JD.

Biol Psychiatry. 2010 May 1;67(9):887-94. doi: 10.1016/j.biopsych.2009.08.042. Epub 2009 Dec 16.

38.

Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.

Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC, Janssen WG, Flores T, Perez GM, Schmeidler J, Dickstein DL, Hof PR, Elder GA.

Am J Pathol. 2010 Jan;176(1):353-68. doi: 10.2353/ajpath.2010.090482. Epub 2009 Dec 11.

39.

Animal transgenesis: an overview.

Gama Sosa MA, De Gasperi R, Elder GA.

Brain Struct Funct. 2010 Mar;214(2-3):91-109. doi: 10.1007/s00429-009-0230-8. Epub 2009 Nov 25. Review.

PMID:
19937345
40.

Presenilin transgenic mice as models of Alzheimer's disease.

Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR.

Brain Struct Funct. 2010 Mar;214(2-3):127-43. doi: 10.1007/s00429-009-0227-3. Epub 2009 Nov 18. Review.

41.

Novel cerebrovascular pathology in mice fed a high cholesterol diet.

Franciosi S, Gama Sosa MA, English DF, Oler E, Oung T, Janssen WG, De Gasperi R, Schmeidler J, Dickstein DL, Schmitz C, Gandy S, Hof PR, Buxbaum JD, Elder GA.

Mol Neurodegener. 2009 Oct 24;4:42. doi: 10.1186/1750-1326-4-42.

42.

The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells.

Eder-Colli L, Abad-Estarlich N, Pannetier C, Vallet PG, Walzer C, Elder GA, Robakis NK, Bouras C, Savioz A.

Brain Res Bull. 2009 Oct 28;80(4-5):296-301. doi: 10.1016/j.brainresbull.2009.06.007. Epub 2009 Jun 23.

43.

Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care.

Elder GA, Cristian A.

Mt Sinai J Med. 2009 Apr;76(2):111-8. doi: 10.1002/msj.20098. Review.

PMID:
19306373
44.

C-reactive protein and memory function suggest antagonistic pleiotropy in very old nondemented subjects.

Silverman JM, Beeri MS, Schmeidler J, Rosendorff C, Angelo G, Mavris RS, Grossman HT, Elder GA, Carrion-Baralt J, West R.

Age Ageing. 2009 Mar;38(2):237-41. doi: 10.1093/ageing/afn278. Epub 2009 Jan 15. No abstract available.

45.

Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.

De Gasperi R, Gama Sosa MA, Wen PH, Li J, Perez GM, Curran T, Elder GA.

Dev Dyn. 2008 Sep;237(9):2405-14. doi: 10.1002/dvdy.21661.

46.

The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ.

De Gasperi R, Rocher AB, Sosa MA, Wearne SL, Perez GM, Friedrich VL Jr, Hof PR, Elder GA.

Genesis. 2008 Jun;46(6):308-17. doi: 10.1002/dvg.20400.

47.

Increased locomotor activity in mice lacking the low-density lipoprotein receptor.

Elder GA, Ragnauth A, Dorr N, Franciosi S, Schmeidler J, Haroutunian V, Buxbaum JD.

Behav Brain Res. 2008 Aug 22;191(2):256-65. doi: 10.1016/j.bbr.2008.03.036. Epub 2008 Apr 8.

48.
49.

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor.

Elder GA, Cho JY, English DF, Franciosi S, Schmeidler J, Sosa MA, Gasperi RD, Fisher EA, Mathews PM, Haroutunian V, Buxbaum JD.

J Neurochem. 2007 Aug;102(4):1220-31. Epub 2007 Apr 30.

50.

Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain.

Franciosi S, De Gasperi R, Dickstein DL, English DF, Rocher AB, Janssen WG, Christoffel D, Sosa MA, Hof PR, Buxbaum JD, Elder GA.

J Neurosci Methods. 2007 Jun 15;163(1):76-82. Epub 2007 Feb 25.

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