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Items: 1 to 50 of 96

1.

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands.

Menegatti R, Cunha AC, Ferreira VF, Perreira EF, El-Nabawi A, Eldefrawi AT, Albuquerque EX, Neves G, Rates SM, Fraga CA, Barreiro EJ.

Bioorg Med Chem. 2003 Nov 3;11(22):4807-13.

PMID:
14556797
2.

Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor.

Takahata H, Takahashi S, Azer N, Eldefrawi AT, Eldefrawi ME.

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1293-5.

PMID:
10866403
3.

Cytotoxicity of organophosphate anticholinesterases.

Cao CJ, Mioduszewski RJ, Menking DE, Valdes JJ, Katz EJ, Eldefrawi ME, Eldefrawi AT.

In Vitro Cell Dev Biol Anim. 1999 Oct;35(9):493-500.

PMID:
10548430
4.

Toxicity of sea nettle toxin to human hepatocytes and the protective effects of phosphorylating and alkylating agents.

Cao CJ, Eldefrawi ME, Eldefrawi AT, Burnett JW, Mioduszewski RJ, Menking DE, Valdes JJ.

Toxicon. 1998 Feb;36(2):269-81.

PMID:
9620575
5.

Common mechanism of toxicity: a case study of organophosphorus pesticides.

Mileson BE, Chambers JE, Chen WL, Dettbarn W, Ehrich M, Eldefrawi AT, Gaylor DW, Hamernik K, Hodgson E, Karczmar AG, Padilla S, Pope CN, Richardson RJ, Saunders DR, Sheets LP, Sultatos LG, Wallace KB.

Toxicol Sci. 1998 Jan;41(1):8-20. Review.

PMID:
9520337
6.

Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities.

Katz EJ, Cortes VI, Eldefrawi ME, Eldefrawi AT.

Toxicol Appl Pharmacol. 1997 Oct;146(2):227-36.

PMID:
9344890
7.

Validation of the cytosensor for in vitro cytotoxicity studies.

Cao CJ, Mioduszewski RJ, Menking DE, Valdes JJ, Cortes VI, Eldefrawi ME, Eldefrawi AT.

Toxicol In Vitro. 1997 Jun;11(3):285-93.

PMID:
20654314
8.

Evaluation of a fiber optic immunosensor for quantitating cocaine in coca leaf extracts.

Toppozada AR, Wright J, Eldefrawi AT, Eldefrawi ME, Johnson EL, Emche SD, Helling CS.

Biosens Bioelectron. 1997;12(2):113-24.

PMID:
9011023
9.

A fiber-optic cocaine biosensor.

Devine PJ, Anis NA, Wright J, Kim S, Eldefrawi AT, Eldefrawi ME.

Anal Biochem. 1995 May 1;227(1):216-24.

PMID:
7668383
10.

Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon.

Dehlawi MS, Eldefrawi AT, Eldefrawi ME, Anis NA, Valdes JJ.

J Biochem Toxicol. 1994 Oct;9(5):261-8.

PMID:
7853361
11.

Differential regulation of muscarinic receptor subtypes in rat brain regions by repeated injections of parathion.

Jett DA, Fernando JC, Eldefrawi ME, Eldefrawi AT.

Toxicol Lett. 1994 Jul;73(1):33-41.

PMID:
8042201
12.

Down-regulation of muscarinic receptors and the m3 subtype in white-footed mice by dietary exposure to parathion.

Jett DA, Hill EF, Fernando JC, Eldefrawi ME, Eldefrawi AT.

J Toxicol Environ Health. 1993 Jul;39(3):395-415.

PMID:
8350385
13.

Glutamate receptor inhibitors as potential insecticides.

Eldefrawi ME, Anis NA, Eldefrawi AT.

Arch Insect Biochem Physiol. 1993;22(1-2):25-39. Review.

PMID:
8431599
14.

Differential effects of paraoxon on the M3 muscarinic receptor and its effector system in rat submaxillary gland cells.

Abdallah EA, Jett DA, Eldefrawi ME, Eldefrawi AT.

J Biochem Toxicol. 1992 Summer;7(2):125-32.

PMID:
1328639
15.

Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes.

Goodnow RA Jr, Bukownik R, Nakanishi K, Usherwood PN, Eldefrawi AT, Anis NA, Eldefrawi ME.

J Med Chem. 1991 Aug;34(8):2389-94.

PMID:
1652018
16.

Acetylcholinesterase fiber-optic biosensor for detection of anticholinesterases.

Rogers KR, Cao CJ, Valdes JJ, Eldefrawi AT, Eldefrawi ME.

Fundam Appl Toxicol. 1991 May;16(4):810-20.

PMID:
1909249
17.

Pharmacologic characterization of muscarinic receptors of insect brains.

Abdallah EA, Eldefrawi ME, Eldefrawi AT.

Arch Insect Biochem Physiol. 1991;17(2-3):107-18.

PMID:
1802028
18.

Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.

Silveira CL, Eldefrawi AT, Eldefrawi ME.

Toxicol Appl Pharmacol. 1990 May;103(3):474-81.

PMID:
2339420
19.

Structure-activity relationships of analogues of the wasp toxin philanthotoxin: non-competitive antagonists of quisqualate receptors.

Bruce M, Bukownik R, Eldefrawi AT, Eldefrawi ME, Goodnow R Jr, Kallimopoulos T, Konno K, Nakanishi K, Niwa M, Usherwood PN.

Toxicon. 1990;28(11):1333-46.

PMID:
1965063
20.

ATP-regulated neuronal catecholamine uptake: a new mechanism.

Cao CJ, Eldefrawi AT, Eldefrawi ME.

Life Sci. 1990;47(7):655-67.

PMID:
2402189
21.

Inhibition of rat brain glutamate receptors by philanthotoxin.

Ragsdale D, Gant DB, Anis NA, Eldefrawi AT, Eldefrawi ME, Konno K, Miledi R.

J Pharmacol Exp Ther. 1989 Oct;251(1):156-63.

PMID:
2571715
22.

Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors.

Sattelle DB, Buckingham SD, Wafford KA, Sherby SM, Bakry NM, Eldefrawi AT, Eldefrawi ME, May TE.

Proc R Soc Lond B Biol Sci. 1989 Sep 22;237(1289):501-14.

PMID:
2479949
23.

Allosteric inhibition of nicotinic acetylcholine receptors of vertebrates and insects by philanthotoxin.

Rozental R, Scoble GT, Albuquerque EX, Idriss M, Sherby S, Sattelle DB, Nakanishi K, Konno K, Eldefrawi AT, Eldefrawi ME.

J Pharmacol Exp Ther. 1989 Apr;249(1):123-30.

PMID:
2468760
25.

Structure and synthesis of a potent glutamate receptor antagonist in wasp venom.

Eldefrawi AT, Eldefrawi ME, Konno K, Mansour NA, Nakanishi K, Oltz E, Usherwood PN.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4910-3.

26.

Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors.

Bakry NM, el-Rashidy AH, Eldefrawi AT, Eldefrawi ME.

J Biochem Toxicol. 1988 Winter;3:235-59.

PMID:
3236334
27.

Action of tremorgenic mycotoxins on GABAA receptor.

Gant DB, Cole RJ, Valdes JJ, Eldefrawi ME, Eldefrawi AT.

Life Sci. 1987 Nov 9;41(19):2207-14.

PMID:
2444852
28.

Action of organophosphates on GABAA receptor and voltage-dependent chloride channels.

Gant DB, Eldefrawi ME, Eldefrawi AT.

Fundam Appl Toxicol. 1987 Nov;9(4):698-704.

PMID:
2446940
29.
30.

Cyclodiene insecticides inhibit GABAA receptor-regulated chloride transport.

Gant DB, Eldefrawi ME, Eldefrawi AT.

Toxicol Appl Pharmacol. 1987 May;88(3):313-21.

PMID:
3033845
31.

gamma-Aminobutyric acid-activated 36Cl- influx: a functional in vitro assay for CNS gamma-aminobutyric acid receptors of insects.

Wafford KA, Sattelle DB, Abalis I, Eldefrawi AT, Eldefrawi ME.

J Neurochem. 1987 Jan;48(1):177-80.

PMID:
3025362
32.

Pharmacology of putative glutamate receptors from insect skeletal muscles, insect central nervous system and rat brain.

Sherby SM, Eldefrawi ME, Wafford KA, Sattelle DB, Eldefrawi AT.

Comp Biochem Physiol C. 1987;87(1):99-106.

PMID:
2885148
33.

Actions of avermectin B1a on the gamma-aminobutyric acidA receptor and chloride channels in rat brain.

Abalis IM, Eldefrawi AT, Eldefrawi ME.

J Biochem Toxicol. 1986 Mar;1(1):69-82.

PMID:
2856070
34.

Oxadiazolidinones: irreversible inhibition of cholinesterases and effects on acetylcholine receptors.

Bakry NM, Sherby SM, Eldefrawi AT, Eldefrawi ME.

Neurotoxicology. 1986 Fall;7(3):1-10.

PMID:
3822252
35.

Effects of insecticides on GABA-induced chloride influx into rat brain microsacs.

Abalis IM, Eldefrawi ME, Eldefrawi AT.

J Toxicol Environ Health. 1986;18(1):13-23.

PMID:
3009836
36.

Binding of GABA receptor channel drugs to a putative voltage-dependent chloride channel in Torpedo electric organ.

Abalis IM, Eldefrawi ME, Eldefrawi AT.

Biochem Pharmacol. 1985 Jul 15;34(14):2579-82. No abstract available.

PMID:
2409983
37.

Biochemical identification of a putative glutamate receptor in housefly thoracic membranes.

Filbin MT, Eldefrawi ME, Eldefrawi AT.

Life Sci. 1985 Apr 22;36(16):1531-9.

PMID:
2858805
38.

Comparison of the actions of carbamate anticholinesterases on the nicotinic acetylcholine receptor.

Sherby SM, Eldefrawi AT, Albuquerque EX, Eldefrawi ME.

Mol Pharmacol. 1985 Mar;27(3):343-8.

PMID:
3974572
39.

Interactions of pyrethroid and cyclodiene insecticides with nicotinic acetylcholine and GABA receptors.

Eldefrawi ME, Sherby SM, Abalis IM, Eldefrawi AT.

Neurotoxicology. 1985 Summer;6(2):47-62. No abstract available.

PMID:
2410832
40.

Interactions of phencyclidine with crayfish muscle membranes. Sensitivity to calcium channel antagonists and other drugs.

El-Fakahany EE, Eldefrawi AT, Murphy DL, Aguayo LG, Triggle DJ, Albuquerque EX, Eldefrawi ME.

Mol Pharmacol. 1984 May;25(3):369-78.

PMID:
6328263
41.

Distinction between high-affinity [3H]phencyclidine binding sites and muscarinic receptors in guinea-pig ileum muscle.

El-Fakahany EE, Triggle DJ, Eldefrawi AT, Eldefrawi ME.

J Pharmacol Exp Ther. 1984 May;229(2):447-54.

PMID:
6325665
42.

Influence of the alcohol moiety of pyrethroids on their interactions with the nicotinic acetylcholine receptor.

Abbassy MA, Eldefrawi ME, Eldefrawi AT.

J Toxicol Environ Health. 1983 Oct-Dec;12(4-6):575-90.

PMID:
6321746
43.

Alcohol modulation of drug binding to the channel sites of the nicotinic acetylcholine receptor.

Ei-Fakahany EF, Miller ER, Abbassy MA, Eldefrawi AT, Eldefrawi ME.

J Pharmacol Exp Ther. 1983 Feb;224(2):289-96. No abstract available.

PMID:
6296354
44.

Neurotransmitter receptors as targets for pesticides.

Eldefrawi ME, Eldefrawi AT.

J Environ Sci Health B. 1983;18(1):65-88. Review.

PMID:
6339601
45.

Allethrin interactions with the nicotinic acetylcholine receptor channel.

Abbassy MA, Eldefrawi ME, Eldefrawi AT.

Life Sci. 1982 Oct 11;31(15):1547-52.

PMID:
6292640
46.

High affinity binding of phencyclidine (PCP) to crayfish muscle. Displacement by calcium antagonists.

Eldefrawi ME, El-Fakahany EF, Murphy DL, Eldefrawi AT, Triggle DJ.

Biochem Pharmacol. 1982 Aug 1;31(15):2549-52. No abstract available.

PMID:
7126268
47.

Interactions of quaternary ammonium drugs with acetylcholinesterase and acetylcholine receptor of Torpedo electric organ.

Bakry NM, Eldefrawi AT, Eldefrawi ME, Riker WF Jr.

Mol Pharmacol. 1982 Jul;22(1):63-71. No abstract available.

PMID:
7121452
50.

Nicotinic acetylcholine receptor desensitization studied by [3H]perhydrohistrionicotoxin binding.

El-Fakahany EF, Eldefrawi AT, Eldefrawi ME.

J Pharmacol Exp Ther. 1982 Jun;221(3):694-700.

PMID:
7086681

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