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Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands.
Menegatti R, Cunha AC, Ferreira VF, Perreira EF, El-Nabawi A, Eldefrawi AT, Albuquerque EX, Neves G, Rates SM, Fraga CA, Barreiro EJ.
Bioorg Med Chem. 2003 Nov 3;11(22):4807-13.
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Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor.
Takahata H, Takahashi S, Azer N, Eldefrawi AT, Eldefrawi ME.
Bioorg Med Chem Lett. 2000 Jun 5;10(11):1293-5.
Cytotoxicity of organophosphate anticholinesterases.
Cao CJ, Mioduszewski RJ, Menking DE, Valdes JJ, Katz EJ, Eldefrawi ME, Eldefrawi AT.
In Vitro Cell Dev Biol Anim. 1999 Oct;35(9):493-500.
Toxicity of sea nettle toxin to human hepatocytes and the protective effects of phosphorylating and alkylating agents.
Cao CJ, Eldefrawi ME, Eldefrawi AT, Burnett JW, Mioduszewski RJ, Menking DE, Valdes JJ.
Toxicon. 1998 Feb;36(2):269-81.
Common mechanism of toxicity: a case study of organophosphorus pesticides.
Mileson BE, Chambers JE, Chen WL, Dettbarn W, Ehrich M, Eldefrawi AT, Gaylor DW, Hamernik K, Hodgson E, Karczmar AG, Padilla S, Pope CN, Richardson RJ, Saunders DR, Sheets LP, Sultatos LG, Wallace KB.
Toxicol Sci. 1998 Jan;41(1):8-20. Review.
Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities.
Katz EJ, Cortes VI, Eldefrawi ME, Eldefrawi AT.
Toxicol Appl Pharmacol. 1997 Oct;146(2):227-36.
Validation of the cytosensor for in vitro cytotoxicity studies.
Cao CJ, Mioduszewski RJ, Menking DE, Valdes JJ, Cortes VI, Eldefrawi ME, Eldefrawi AT.
Toxicol In Vitro. 1997 Jun;11(3):285-93.
Evaluation of a fiber optic immunosensor for quantitating cocaine in coca leaf extracts.
Toppozada AR, Wright J, Eldefrawi AT, Eldefrawi ME, Johnson EL, Emche SD, Helling CS.
Biosens Bioelectron. 1997;12(2):113-24.
A fiber-optic cocaine biosensor.
Devine PJ, Anis NA, Wright J, Kim S, Eldefrawi AT, Eldefrawi ME.
Anal Biochem. 1995 May 1;227(1):216-24.
Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon.
Dehlawi MS, Eldefrawi AT, Eldefrawi ME, Anis NA, Valdes JJ.
J Biochem Toxicol. 1994 Oct;9(5):261-8.
Differential regulation of muscarinic receptor subtypes in rat brain regions by repeated injections of parathion.
Jett DA, Fernando JC, Eldefrawi ME, Eldefrawi AT.
Toxicol Lett. 1994 Jul;73(1):33-41.
Down-regulation of muscarinic receptors and the m3 subtype in white-footed mice by dietary exposure to parathion.
Jett DA, Hill EF, Fernando JC, Eldefrawi ME, Eldefrawi AT.
J Toxicol Environ Health. 1993 Jul;39(3):395-415.
Glutamate receptor inhibitors as potential insecticides.
Eldefrawi ME, Anis NA, Eldefrawi AT.
Arch Insect Biochem Physiol. 1993;22(1-2):25-39. Review.
Differential effects of paraoxon on the M3 muscarinic receptor and its effector system in rat submaxillary gland cells.
Abdallah EA, Jett DA, Eldefrawi ME, Eldefrawi AT.
J Biochem Toxicol. 1992 Summer;7(2):125-32.
Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes.
Goodnow RA Jr, Bukownik R, Nakanishi K, Usherwood PN, Eldefrawi AT, Anis NA, Eldefrawi ME.
J Med Chem. 1991 Aug;34(8):2389-94.
Acetylcholinesterase fiber-optic biosensor for detection of anticholinesterases.
Rogers KR, Cao CJ, Valdes JJ, Eldefrawi AT, Eldefrawi ME.
Fundam Appl Toxicol. 1991 May;16(4):810-20.
Pharmacologic characterization of muscarinic receptors of insect brains.
Abdallah EA, Eldefrawi ME, Eldefrawi AT.
Arch Insect Biochem Physiol. 1991;17(2-3):107-18.
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
Silveira CL, Eldefrawi AT, Eldefrawi ME.
Toxicol Appl Pharmacol. 1990 May;103(3):474-81.
Structure-activity relationships of analogues of the wasp toxin philanthotoxin: non-competitive antagonists of quisqualate receptors.
Bruce M, Bukownik R, Eldefrawi AT, Eldefrawi ME, Goodnow R Jr, Kallimopoulos T, Konno K, Nakanishi K, Niwa M, Usherwood PN.
Toxicon. 1990;28(11):1333-46.
ATP-regulated neuronal catecholamine uptake: a new mechanism.
Cao CJ, Eldefrawi AT, Eldefrawi ME.
Life Sci. 1990;47(7):655-67.
Inhibition of rat brain glutamate receptors by philanthotoxin.
Ragsdale D, Gant DB, Anis NA, Eldefrawi AT, Eldefrawi ME, Konno K, Miledi R.
J Pharmacol Exp Ther. 1989 Oct;251(1):156-63.
Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors.
Sattelle DB, Buckingham SD, Wafford KA, Sherby SM, Bakry NM, Eldefrawi AT, Eldefrawi ME, May TE.
Proc R Soc Lond B Biol Sci. 1989 Sep 22;237(1289):501-14.
Allosteric inhibition of nicotinic acetylcholine receptors of vertebrates and insects by philanthotoxin.
Rozental R, Scoble GT, Albuquerque EX, Idriss M, Sherby S, Sattelle DB, Nakanishi K, Konno K, Eldefrawi AT, Eldefrawi ME.
J Pharmacol Exp Ther. 1989 Apr;249(1):123-30.
Action of polychlorocycloalkane insecticides on binding of [35S]t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site.
Matsumoto K, Eldefrawi ME, Eldefrawi AT.
Toxicol Appl Pharmacol. 1988 Sep 15;95(2):220-9.
Structure and synthesis of a potent glutamate receptor antagonist in wasp venom.
Eldefrawi AT, Eldefrawi ME, Konno K, Mansour NA, Nakanishi K, Oltz E, Usherwood PN.
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4910-3.
Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors.
Bakry NM, el-Rashidy AH, Eldefrawi AT, Eldefrawi ME.
J Biochem Toxicol. 1988 Winter;3:235-59.
Action of tremorgenic mycotoxins on GABAA receptor.
Gant DB, Cole RJ, Valdes JJ, Eldefrawi ME, Eldefrawi AT.
Life Sci. 1987 Nov 9;41(19):2207-14.
Action of organophosphates on GABAA receptor and voltage-dependent chloride channels.
Gant DB, Eldefrawi ME, Eldefrawi AT.
Fundam Appl Toxicol. 1987 Nov;9(4):698-704.
Receptors for gamma-aminobutyric acid and voltage-dependent chloride channels as targets for drugs and toxicants.
Eldefrawi AT, Eldefrawi ME.
FASEB J. 1987 Oct;1(4):262-71. Review.
Cyclodiene insecticides inhibit GABAA receptor-regulated chloride transport.
Toxicol Appl Pharmacol. 1987 May;88(3):313-21.
gamma-Aminobutyric acid-activated 36Cl- influx: a functional in vitro assay for CNS gamma-aminobutyric acid receptors of insects.
Wafford KA, Sattelle DB, Abalis I, Eldefrawi AT, Eldefrawi ME.
J Neurochem. 1987 Jan;48(1):177-80.
Pharmacology of putative glutamate receptors from insect skeletal muscles, insect central nervous system and rat brain.
Sherby SM, Eldefrawi ME, Wafford KA, Sattelle DB, Eldefrawi AT.
Comp Biochem Physiol C. 1987;87(1):99-106.
Actions of avermectin B1a on the gamma-aminobutyric acidA receptor and chloride channels in rat brain.
Abalis IM, Eldefrawi AT, Eldefrawi ME.
J Biochem Toxicol. 1986 Mar;1(1):69-82.
Oxadiazolidinones: irreversible inhibition of cholinesterases and effects on acetylcholine receptors.
Bakry NM, Sherby SM, Eldefrawi AT, Eldefrawi ME.
Neurotoxicology. 1986 Fall;7(3):1-10.
Effects of insecticides on GABA-induced chloride influx into rat brain microsacs.
Abalis IM, Eldefrawi ME, Eldefrawi AT.
J Toxicol Environ Health. 1986;18(1):13-23.
Binding of GABA receptor channel drugs to a putative voltage-dependent chloride channel in Torpedo electric organ.
Biochem Pharmacol. 1985 Jul 15;34(14):2579-82. No abstract available.
Biochemical identification of a putative glutamate receptor in housefly thoracic membranes.
Filbin MT, Eldefrawi ME, Eldefrawi AT.
Life Sci. 1985 Apr 22;36(16):1531-9.
Comparison of the actions of carbamate anticholinesterases on the nicotinic acetylcholine receptor.
Sherby SM, Eldefrawi AT, Albuquerque EX, Eldefrawi ME.
Mol Pharmacol. 1985 Mar;27(3):343-8.
Interactions of pyrethroid and cyclodiene insecticides with nicotinic acetylcholine and GABA receptors.
Eldefrawi ME, Sherby SM, Abalis IM, Eldefrawi AT.
Neurotoxicology. 1985 Summer;6(2):47-62. No abstract available.
Interactions of phencyclidine with crayfish muscle membranes. Sensitivity to calcium channel antagonists and other drugs.
El-Fakahany EE, Eldefrawi AT, Murphy DL, Aguayo LG, Triggle DJ, Albuquerque EX, Eldefrawi ME.
Mol Pharmacol. 1984 May;25(3):369-78.
Distinction between high-affinity [3H]phencyclidine binding sites and muscarinic receptors in guinea-pig ileum muscle.
El-Fakahany EE, Triggle DJ, Eldefrawi AT, Eldefrawi ME.
J Pharmacol Exp Ther. 1984 May;229(2):447-54.
Influence of the alcohol moiety of pyrethroids on their interactions with the nicotinic acetylcholine receptor.
Abbassy MA, Eldefrawi ME, Eldefrawi AT.
J Toxicol Environ Health. 1983 Oct-Dec;12(4-6):575-90.
Alcohol modulation of drug binding to the channel sites of the nicotinic acetylcholine receptor.
Ei-Fakahany EF, Miller ER, Abbassy MA, Eldefrawi AT, Eldefrawi ME.
J Pharmacol Exp Ther. 1983 Feb;224(2):289-96. No abstract available.
Neurotransmitter receptors as targets for pesticides.
Eldefrawi ME, Eldefrawi AT.
J Environ Sci Health B. 1983;18(1):65-88. Review.
Allethrin interactions with the nicotinic acetylcholine receptor channel.
Life Sci. 1982 Oct 11;31(15):1547-52.
High affinity binding of phencyclidine (PCP) to crayfish muscle. Displacement by calcium antagonists.
Eldefrawi ME, El-Fakahany EF, Murphy DL, Eldefrawi AT, Triggle DJ.
Biochem Pharmacol. 1982 Aug 1;31(15):2549-52. No abstract available.
Interactions of quaternary ammonium drugs with acetylcholinesterase and acetylcholine receptor of Torpedo electric organ.
Bakry NM, Eldefrawi AT, Eldefrawi ME, Riker WF Jr.
Mol Pharmacol. 1982 Jul;22(1):63-71. No abstract available.
Structure-activity relationships of amantadine. I. Interaction of the N-alkyl analogues with the ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.
Warnick JE, Maleque MA, Bakry N, Eldefrawi AT, Albuquerque EX.
Mol Pharmacol. 1982 Jul;22(1):82-93.
[3H]Phencyclidine interactions with the nicotinic acetylcholine receptor channel and its inhibition by psychotropic, antipsychotic, opiate, antidepressant, antibiotic, antiviral, and antiarrhythmic drugs.
Eldefrawi AT, Miller ER, Murphy DL, Eldefrawi ME.
Mol Pharmacol. 1982 Jul;22(1):72-81. No abstract available.
Nicotinic acetylcholine receptor desensitization studied by [3H]perhydrohistrionicotoxin binding.
El-Fakahany EF, Eldefrawi AT, Eldefrawi ME.
J Pharmacol Exp Ther. 1982 Jun;221(3):694-700.
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