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Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility.

Mondal AK, Sharma NK, Elbein SC, Das SK.

Physiol Genomics. 2013 Jul 2;45(13):509-20. doi: 10.1152/physiolgenomics.00048.2013. Epub 2013 May 14.


Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study.

Hasstedt SJ, Highland HM, Elbein SC, Hanis CL, Das SK; American Diabetes Association GENNID Study Group.

J Hum Genet. 2013 Jun;58(6):378-83. doi: 10.1038/jhg.2013.21. Epub 2013 Apr 4.


An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.

Ma L, Murea M, Snipes JA, Marinelarena A, Krüger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA, Shores NJ, Rudel LL, Blüher M, Stumvoll M, Bowden DW, Maeda S, Parks JS, Kovacs P, Hanson RL, Baier LJ, Elbein SC, Freedman BI.

PLoS One. 2013;8(2):e56193. doi: 10.1371/journal.pone.0056193. Epub 2013 Feb 27.


Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?

Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ.

Am J Hum Genet. 2012 Sep 7;91(3):466-77. doi: 10.1016/j.ajhg.2012.08.002.


Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes.

Mondal AK, Das SK, Varma V, Nolen GT, McGehee RE, Elbein SC, Wei JY, Ranganathan G.

Metab Syndr Relat Disord. 2012 Aug;10(4):297-306. doi: 10.1089/met.2012.0002. Epub 2012 Apr 30.


Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts.

Rasouli N, Kern PA, Elbein SC, Sharma NK, Das SK.

Pharmacogenet Genomics. 2012 Jul;22(7):484-97. doi: 10.1097/FPC.0b013e328352a72e.


Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study.

Langberg KA, Ma L, Sharma NK, Hanis CL, Elbein SC, Hasstedt SJ, Das SK; American Diabetes Association GENNID Study Group.

J Hum Genet. 2012 Jan;57(1):57-61. doi: 10.1038/jhg.2011.133. Epub 2011 Nov 24.


The effect of ACACB cis-variants on gene expression and metabolic traits.

Ma L, Mondal AK, Murea M, Sharma NK, Tönjes A, Langberg KA, Das SK, Franks PW, Kovacs P, Antinozzi PA, Stumvoll M, Parks JS, Elbein SC, Freedman BI.

PLoS One. 2011;6(8):e23860. doi: 10.1371/journal.pone.0023860. Epub 2011 Aug 26.


Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.

Below JE, Gamazon ER, Morrison JV, Konkashbaev A, Pluzhnikov A, McKeigue PM, Parra EJ, Elbein SC, Hallman DM, Nicolae DL, Bell GI, Cruz M, Cox NJ, Hanis CL.

Diabetologia. 2011 Aug;54(8):2047-55. doi: 10.1007/s00125-011-2188-3. Epub 2011 Jun 7.


An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects.

Das SK, Sharma NK, Hasstedt SJ, Mondal AK, Ma L, Langberg KA, Elbein SC.

J Clin Endocrinol Metab. 2011 Aug;96(8):E1308-13. doi: 10.1210/jc.2011-0101. Epub 2011 May 18.


Pleiotropy of type 2 diabetes with obesity.

Hasstedt SJ, Hanis CL, Das SK, Elbein SC.

J Hum Genet. 2011 Jul;56(7):491-5. doi: 10.1038/jhg.2011.46. Epub 2011 Apr 28.


Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI.

Elbein SC, Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK.

Diabetes. 2011 Mar;60(3):1019-29. doi: 10.2337/db10-1270. Epub 2011 Jan 24.


Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes.

Wagenknecht LE, Divers J, Bertoni AG, Langefeld CD, Carr JJ, Bowden DW, Elbein SC, Shea S, Lewis CE, Freedman BI.

Ann Epidemiol. 2011 Jan;21(1):34-41. doi: 10.1016/j.annepidem.2010.10.007.


Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.

Sharma NK, Langberg KA, Mondal AK, Elbein SC, Das SK.

J Clin Endocrinol Metab. 2011 Feb;96(2):E394-403. doi: 10.1210/jc.2010-1754. Epub 2010 Nov 17.


Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation.

Murea M, Freedman BI, Parks JS, Antinozzi PA, Elbein SC, Ma L.

Clin J Am Soc Nephrol. 2010 Dec;5(12):2373-9. doi: 10.2215/CJN.08160910. Epub 2010 Nov 4. Review.


Univariate and bivariate linkage analysis identifies pleiotropic loci underlying lipid levels and type 2 diabetes risk.

Hasstedt SJ, Hanis CL, Elbein SC; American Diabetes Association GENNID Study Group.

Ann Hum Genet. 2010 Jul;74(4):308-15. doi: 10.1111/j.1469-1809.2010.00589.x.


The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.

Tang SC, Leung VT, Chan LY, Wong SS, Chu DW, Leung JC, Ho YW, Lai KN, Ma L, Elbein SC, Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI.

Nephrol Dial Transplant. 2010 Dec;25(12):3931-4. doi: 10.1093/ndt/gfq303. Epub 2010 Jun 2.


Distinct gene expression profiles characterize cellular responses to palmitate and oleate.

Das SK, Mondal AK, Elbein SC.

J Lipid Res. 2010 Aug;51(8):2121-31. doi: 10.1194/jlr.M004275. Epub 2010 Apr 20.


Genetics factors contributing to type 2 diabetes across ethnicities.

Elbein SC.

J Diabetes Sci Technol. 2009 Jul 1;3(4):685-9. Review.


Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans.

Mondal AK, Das SK, Baldini G, Chu WS, Sharma NK, Hackney OG, Zhao J, Grant SF, Elbein SC.

J Clin Endocrinol Metab. 2010 Mar;95(3):1450-7. doi: 10.1210/jc.2009-2064. Epub 2010 Jan 22.


Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2009 Jul;58(7):1704-9. doi: 10.2337/db09-0081. Epub 2009 Apr 23.


Phenotypic and molecular evaluation of a chromosome 1q region with linkage and association to type 2 diabetes in humans.

Wang H, Hays NP, Das SK, Craig RL, Chu WS, Sharma N, Elbein SC.

J Clin Endocrinol Metab. 2009 Apr;94(4):1401-8. doi: 10.1210/jc.2008-2132. Epub 2009 Jan 13.


Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort.

Elbein SC, Das SK, Hallman DM, Hanis CL, Hasstedt SJ.

Diabetes. 2009 Jan;58(1):268-74. doi: 10.2337/db08-0931. Epub 2008 Oct 7.


Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects.

Sharma NK, Das SK, Mondal AK, Hackney OG, Chu WS, Kern PA, Rasouli N, Spencer HJ, Yao-Borengasser A, Elbein SC.

J Clin Endocrinol Metab. 2008 Nov;93(11):4532-41. doi: 10.1210/jc.2008-1001. Epub 2008 Aug 26.


Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.

Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, Elbein SC.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E393-400. doi: 10.1152/ajpendo.90355.2008. Epub 2008 Jun 10.


Intermuscular lipid: a marker of disordered fat partitioning or the consequence of obesity?

Elbein SC, Rasouli N.

Am J Clin Nutr. 2008 Jun;87(6):1585-6. No abstract available.


Type 2 diabetes susceptibility genes on chromosome 1q21-24.

Hasstedt SJ, Chu WS, Das SK, Wang H, Elbein SC.

Ann Hum Genet. 2008 Mar;72(Pt 2):163-9. doi: 10.1111/j.1469-1809.2007.00416.x.


Impact of family history of diabetes and ethnicity on -cell function in obese, glucose-tolerant individuals.

Rasouli N, Spencer HJ, Rashidi AA, Elbein SC.

J Clin Endocrinol Metab. 2007 Dec;92(12):4656-63. Epub 2007 Sep 18.


Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.

Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA.

Diabetologia. 2007 Aug;50(8):1621-30. Epub 2007 Jun 20.


Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations.

Elbein SC.

Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):415-9. Review.


The search for type 2 diabetes susceptibility loci: the chromosome 1q story.

Das SK, Elbein SC.

Curr Diab Rep. 2007 Apr;7(2):154-64. Review.


Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes.

Malhotra A, Elbein SC, Ng MC, Duggirala R, Arya R, Imperatore G, Adeyemo A, Pollin TI, Hsueh WC, Chan JC, Rotimi C, Hanson RL, Hasstedt SJ, Wolford JK.

Diabetes. 2007 Mar;56(3):890-6.


Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, McCarthy MI.

Diabetes. 2007 Mar;56(3):879-83.


Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.

Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, Elbein SC.

Diabetes. 2007 Mar;56(3):856-62.


Ectopic fat accumulation and metabolic syndrome.

Rasouli N, Molavi B, Elbein SC, Kern PA.

Diabetes Obes Metab. 2007 Jan;9(1):1-10. Review.


Detection of allelic imbalance in gene expression using pyrosequencing.

Wang H, Elbein SC.

Methods Mol Biol. 2007;373:157-76.


Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits.

Craig RL, Chu WS, Elbein SC.

Mol Genet Metab. 2007 Mar;90(3):338-44. Epub 2006 Dec 14.


Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes.

Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WH.

Diabetes. 2006 Oct;55(10):2909-14.


Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes.

Rasouli N, Kern PA, Reece EA, Elbein SC.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E359-65. Epub 2006 Sep 12.


Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.

Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI, Zeggini E, Hasstedt SJ, Elbein SC.

Diabetes. 2006 Sep;55(9):2631-9.


Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.

Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Xiang K, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2006 Sep;55(9):2541-8. Erratum in: Diabetes. 2006 Nov;55(11):3197. Kunsun, Xiang [corrected to Xiang, Kunsan].


The Genetic Basis of Type 2 Diabetes.

Das SK, Elbein SC.

Cellscience. 2006 Apr 30;2(4):100-131.


Analysis of FOXO1A as a candidate gene for type 2 diabetes.

Karim MA, Craig RL, Wang X, Hale TC, Elbein SC.

Mol Genet Metab. 2006 Jun;88(2):171-7. Epub 2006 Feb 23.


Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.

Karim MA, Wang X, Hale TC, Elbein SC.

BMC Med Genet. 2005 Oct 17;6:37.


Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression.

Rasouli N, Yao-Borengasser A, Miles LM, Elbein SC, Kern PA.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E42-E46. Epub 2005 Aug 23.


Effects of short-term experimental insulin resistance and family history of diabetes on pancreatic beta-cell function in nondiabetic individuals.

Rasouli N, Hale T, Kahn SE, Spencer HJ, Elbein SC.

J Clin Endocrinol Metab. 2005 Oct;90(10):5825-33. Epub 2005 Aug 9.


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