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Items: 4


Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.

El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P.

Dis Model Mech. 2018 Jul 30;11(7). pii: dmm033563. doi: 10.1242/dmm.033563.


Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA Jr, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR.

PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680. eCollection 2017 Jul.


Biogenic amines and the control of neuromuscular signaling in schistosomes.

Ribeiro P, Gupta V, El-Sakkary N.

Invert Neurosci. 2012 Jun;12(1):13-28. doi: 10.1007/s10158-012-0132-y. Epub 2012 Apr 18. Review.


A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system.

El-Shehabi F, Taman A, Moali LS, El-Sakkary N, Ribeiro P.

PLoS Negl Trop Dis. 2012;6(2):e1523. doi: 10.1371/journal.pntd.0001523. Epub 2012 Feb 28.

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