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Items: 1 to 50 of 178

1.

PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.

Wang S, Chen Z, Zhu S, Lu H, Peng D, Soutto M, Naz H, Peek R Jr, Xu H, Zaika A, Xu Z, El-Rifai W.

Redox Biol. 2019 Sep 5;28:101319. doi: 10.1016/j.redox.2019.101319. [Epub ahead of print]

2.

APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma.

Lu H, Bhat AA, Peng D, Chen Z, Zhu S, Hong J, Maacha S, Yan J, Robbins DJ, Washington MK, Belkhiri A, El-Rifai W.

Cancer Res. 2019 Sep 1;79(17):4426-4438. doi: 10.1158/0008-5472.CAN-19-0237. Epub 2019 Jul 15.

PMID:
31308045
3.

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.

Soutto M, Chen Z, Bhat AA, Wang L, Zhu S, Gomaa A, Bates A, Bhat NS, Peng D, Belkhiri A, Piazuelo MB, Washington MK, Steven XC, Peek R Jr, El-Rifai W.

Nat Commun. 2019 Jul 10;10(1):3039. doi: 10.1038/s41467-019-11011-4.

4.

Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.

Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W.

Oncogene. 2019 Jul;38(29):5805-5816. doi: 10.1038/s41388-019-0843-1. Epub 2019 Jun 24.

PMID:
31235784
5.

NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, Zaika A, El-Rifai W.

Cancer Lett. 2019 Aug 28;458:46-55. doi: 10.1016/j.canlet.2019.05.031. Epub 2019 May 24.

PMID:
31132430
6.

Phase IB Study of Induction Chemotherapy With XELOX, Followed by Radiation Therapy, Carboplatin, and Everolimus in Patients With Locally Advanced Esophageal Cancer.

Saba NF, Force S, Staley C, Fernandez F, Willingham F, Pickens A, Cardona K, Chen Z, Goff L, Cardin D, Lambright E, Nesbitt J, Krasinskas A, Higgins K, Harvey RD, Owonikoko T, Ramalingam SS, Shin DM, Beitler JJ, El-Rayes BF, Salaria S, El-Rifai W, Landry J, Chakravarthy AB.

Am J Clin Oncol. 2019 Apr;42(4):331-336. doi: 10.1097/COC.0000000000000524.

PMID:
30789414
7.

Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage.

Zhou Z, Lu H, Zhu S, Gomaa A, Chen Z, Yan J, Washington K, El-Rifai W, Dang C, Peng D.

J Exp Clin Cancer Res. 2019 Jan 9;38(1):13. doi: 10.1186/s13046-018-1021-y.

8.

Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis.

Chen Z, Li Z, Soutto M, Wang W, Piazuelo MB, Zhu S, Guo Y, Maturana MJ, Corvalan AH, Chen X, Xu Z, El-Rifai WM.

Gastroenterology. 2019 Mar;156(4):1127-1139.e8. doi: 10.1053/j.gastro.2018.11.052. Epub 2018 Nov 28.

PMID:
30502323
9.

Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.

Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W.

Gastroenterology. 2019 Feb;156(3):662-675.e7. doi: 10.1053/j.gastro.2018.10.030. Epub 2018 Oct 17.

PMID:
30342037
10.

Correction to: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Goff LW, Azad NS, Stein S, Whisenant JG, Koyama T, Vaishampayan U, Hochster H, Connolly R, Weise A, LoRusso PM, Salaria SN, El-Rifai W, Berlin JD.

Invest New Drugs. 2018 Dec;36(6):1158. doi: 10.1007/s10637-018-0679-5.

PMID:
30334109
11.

Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Goff LW, Azad NS, Stein S, Whisenant JG, Koyama T, Vaishampayan U, Hochster H, Connolly R, Weise A, LoRusso PM, Salaria SN, El-Rifai W, Berlin JD.

Invest New Drugs. 2019 Apr;37(2):315-322. doi: 10.1007/s10637-018-0663-0. Epub 2018 Sep 6. Erratum in: Invest New Drugs. 2018 Oct 18;:.

PMID:
30191522
12.

TFF1 antagonizes TIMP-1 mediated proliferative functions in gastric cancer.

Omar OM, Soutto M, Bhat NS, Bhat AA, Lu H, Chen Z, El-Rifai W.

Mol Carcinog. 2018 Nov;57(11):1577-1587. doi: 10.1002/mc.22880. Epub 2018 Aug 14.

PMID:
30035371
13.

Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.

Bhat AA, Lu H, Soutto M, Capobianco A, Rai P, Zaika A, El-Rifai W.

Oncogene. 2018 Nov;37(46):6011-6024. doi: 10.1038/s41388-018-0388-8. Epub 2018 Jul 10.

14.

Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer.

Shao L, Chen Z, Soutto M, Zhu S, Lu H, Romero-Gallo J, Peek R, Zhang S, El-Rifai W.

FASEB J. 2019 Jan;33(1):264-274. doi: 10.1096/fj.201701456RR. Epub 2018 Jul 9.

PMID:
29985646
15.

Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells.

Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek RM Jr, Zaika AI.

Oncogene. 2018 Sep;37(37):5054-5065. doi: 10.1038/s41388-018-0343-8. Epub 2018 May 30.

16.

Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells.

Shao L, Chen Z, Peng D, Soutto M, Zhu S, Bates A, Zhang S, El-Rifai W.

Mol Cancer Res. 2018 Apr;16(4):696-706. doi: 10.1158/1541-7786.MCR-17-0655. Epub 2018 Feb 16.

17.

A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.

Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W.

Clin Cancer Res. 2018 Apr 15;24(8):1905-1916. doi: 10.1158/1078-0432.CCR-17-1716. Epub 2018 Jan 31.

18.

MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression.

Li B, Wang W, Li Z, Chen Z, Zhi X, Xu J, Li Q, Wang L, Huang X, Wang L, Wei S, Sun G, Zhang X, He Z, Zhang L, Zhang D, Xu H, El-Rifai W, Xu Z.

Cancer Lett. 2017 Dec 1;410:212-227. doi: 10.1016/j.canlet.2017.09.035. Epub 2017 Sep 28.

19.

Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer.

Chen Z, Hu T, Zhu S, Mukaisho K, El-Rifai W, Peng DF.

Oncotarget. 2017 Apr 29;8(33):54345-54356. doi: 10.18632/oncotarget.17527. eCollection 2017 Aug 15.

20.

Loss of Tff1 Promotes Pro-Inflammatory Phenotype with Increase in the Levels of RORγt+ T Lymphocytes and Il-17 in Mouse Gastric Neoplasia.

Soutto M, Saleh M, Arredouani MS, Piazuelo B, Belkhiri A, El-Rifai W.

J Cancer. 2017 Jul 22;8(13):2424-2435. doi: 10.7150/jca.19639. eCollection 2017.

21.

Activation of NADPH oxidases leads to DNA damage in esophageal cells.

Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI.

Sci Rep. 2017 Aug 30;7(1):9956. doi: 10.1038/s41598-017-09620-4.

22.

Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.

Wang L, Arras J, Katsha A, Hamdan S, Belkhiri A, Ecsedy J, El-Rifai W.

Mol Oncol. 2017 Aug;11(8):981-995. doi: 10.1002/1878-0261.12066. Epub 2017 May 30.

23.

Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia.

Chen Z, Soutto M, Rahman B, Fazili MW, Peng D, Blanca Piazuelo M, Chen H, Kay Washington M, Shyr Y, El-Rifai W.

Genes Chromosomes Cancer. 2017 Jul;56(7):535-547. doi: 10.1002/gcc.22456. Epub 2017 Apr 4.

24.

Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas.

Peng D, Guo Y, Chen H, Zhao S, Washington K, Hu T, Shyr Y, El-Rifai W.

Sci Rep. 2017 Jan 19;7:40729. doi: 10.1038/srep40729.

25.

Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells.

Katsha A, Wang L, Arras J, Omar OM, Ecsedy J, Belkhiri A, El-Rifai W.

Clin Cancer Res. 2017 Jul 15;23(14):3756-3768. doi: 10.1158/1078-0432.CCR-16-2141. Epub 2017 Jan 10.

26.

Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts.

Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI.

Carcinogenesis. 2016 Dec;37(12):1161-1169. Epub 2016 Sep 21.

27.

Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32.

Zhu S, Soutto M, Chen Z, Peng D, Romero-Gallo J, Krishna US, Belkhiri A, Washington MK, Peek R, El-Rifai W.

Gut. 2017 May;66(5):761-762. doi: 10.1136/gutjnl-2016-312141. Epub 2016 Sep 2.

28.

Erratum to: Epigenetic and genetic variation in GATA5 is associated with gastric disease risk.

Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG.

Hum Genet. 2016 Aug;135(8):907-908. doi: 10.1007/s00439-016-1708-0. No abstract available.

PMID:
27417435
29.

Epigenetic and genetic variation in GATA5 is associated with gastric disease risk.

Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG.

Hum Genet. 2016 Aug;135(8):895-906. doi: 10.1007/s00439-016-1687-1. Epub 2016 May 25. Erratum in: Hum Genet. 2016 Aug;135(8):907-8.

30.

APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts.

Hong J, Chen Z, Peng D, Zaika A, Revetta F, Washington MK, Belkhiri A, El-Rifai W.

Oncotarget. 2016 Mar 29;7(13):16688-702. doi: 10.18632/oncotarget.7696.

31.

DARPP-32: from neurotransmission to cancer.

Belkhiri A, Zhu S, El-Rifai W.

Oncotarget. 2016 Apr 5;7(14):17631-40. doi: 10.18632/oncotarget.7268. Review.

32.

Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma.

Taylor C, Loomans HA, Le Bras GF, Koumangoye RB, Romero-Morales AI, Quast LL, Zaika AI, El-Rifai W, Andl T, Andl CD.

Oncotarget. 2015 Oct 27;6(33):34228-44. doi: 10.18632/oncotarget.5349.

33.

Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis.

Soutto M, Chen Z, Katsha AM, Romero-Gallo J, Krishna US, Piazuelo MB, Washington MK, Peek RM Jr, Belkhiri A, El-Rifai WM.

Cancer. 2015 Dec 15;121(24):4348-58. doi: 10.1002/cncr.29644. Epub 2015 Sep 15.

34.

DNA Methylation Predicts Progression of Human Gastric Lesions.

Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM Jr, Correa P.

Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1607-13. doi: 10.1158/1055-9965.EPI-15-0388. Epub 2015 Aug 12.

35.

Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis.

Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, El-Rifai W.

Oncogene. 2016 Apr 7;35(14):1847-56. doi: 10.1038/onc.2015.250. Epub 2015 Jun 29.

36.

Aurora kinase A in gastrointestinal cancers: time to target.

Katsha A, Belkhiri A, Goff L, El-Rifai W.

Mol Cancer. 2015 May 20;14:106. doi: 10.1186/s12943-015-0375-4. Review.

37.

Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis.

Soutto M, Romero-Gallo J, Krishna U, Piazuelo MB, Washington MK, Belkhiri A, Peek RM Jr, El-Rifai W.

Oncotarget. 2015 Jul 20;6(20):17911-22.

38.

Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis.

Chen Z, Zhu S, Hong J, Soutto M, Peng D, Belkhiri A, Xu Z, El-Rifai W.

Gut. 2016 Jun;65(6):925-34. doi: 10.1136/gutjnl-2014-308416. Epub 2015 Mar 16.

39.

Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway.

Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI.

Oncotarget. 2015 Jan 30;6(3):1531-43.

40.

Advances in targeted therapies and new promising targets in esophageal cancer.

Belkhiri A, El-Rifai W.

Oncotarget. 2015 Jan 30;6(3):1348-58. Review.

41.

Translational research on Barrett's esophagus.

Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X.

Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531.

PMID:
25266024
42.

Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis.

Soutto M, Peng D, Katsha A, Chen Z, Piazuelo MB, Washington MK, Belkhiri A, Correa P, El-Rifai W.

Gut. 2015 Jul;64(7):1028-39. doi: 10.1136/gutjnl-2014-307191. Epub 2014 Aug 8.

43.

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner.

Wei J, Noto JM, Zaika E, Romero-Gallo J, Piazuelo MB, Schneider B, El-Rifai W, Correa P, Peek RM, Zaika AI.

Gut. 2015 Jul;64(7):1040-8. doi: 10.1136/gutjnl-2014-307295. Epub 2014 Jul 30.

44.

TFF1 activates p53 through down-regulation of miR-504 in gastric cancer.

Soutto M, Chen Z, Saleh MA, Katsha A, Zhu S, Zaika A, Belkhiri A, El-Rifai W.

Oncotarget. 2014 Jul 30;5(14):5663-73.

45.

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis.

Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W.

J Cancer. 2014 Jun 10;5(7):510-7. doi: 10.7150/jca.9215. eCollection 2014.

46.

AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers.

Katsha A, Arras J, Soutto M, Belkhiri A, El-Rifai W.

Mol Oncol. 2014 Dec;8(8):1419-28. doi: 10.1016/j.molonc.2014.05.012. Epub 2014 Jun 3.

47.

Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis.

Mohamed MM, Sabet S, Peng DF, Nouh MA, El-Shinawi M, El-Rifai W.

Oxid Med Cell Longev. 2014;2014:787195. doi: 10.1155/2014/787195. Epub 2014 Mar 20.

48.

Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesis.

Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W.

Carcinogenesis. 2014 Jul;35(7):1620-8. doi: 10.1093/carcin/bgu083. Epub 2014 Apr 1.

49.

HDM2 regulation by AURKA promotes cell survival in gastric cancer.

Sehdev V, Katsha A, Arras J, Peng D, Soutto M, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W.

Clin Cancer Res. 2014 Jan 1;20(1):76-86. doi: 10.1158/1078-0432.CCR-13-1187. Epub 2013 Nov 15. Erratum in: Clin Cancer Res. 2015 Feb 1;21(3):661. Clin Cancer Res. 2015 Feb 1;21(3):661.

50.

Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae.

Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM Jr, Correa P.

Epigenetics. 2013 Nov;8(11):1153-61. doi: 10.4161/epi.26072. Epub 2013 Aug 22.

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