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Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion.

Coucha M, Shanab AY, Sayed M, Vazdarjanova A, El-Remessy AB.

Int J Mol Sci. 2019 Aug 15;20(16). pii: E3969. doi: 10.3390/ijms20163969.


Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.

Elshaer SL, Alwhaibi A, Mohamed R, Lemtalsi T, Coucha M, Longo FM, El-Remessy AB.

Diabetologia. 2019 Aug;62(8):1488-1500. doi: 10.1007/s00125-019-4885-2. Epub 2019 May 9.


High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells.

Elshaer SL, Lemtalsi T, El-Remessy AB.

Antioxidants (Basel). 2018 Mar 25;7(4). pii: E47. doi: 10.3390/antiox7040047.


Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study.

Mohamed IN, Sarhan NR, Eladl MA, El-Remessy AB, El-Sherbiny M.

Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.


Inducible overexpression of endothelial proNGF as a mouse model to study microvascular dysfunction.

Mohamed R, Coucha M, Elshaer SL, Artham S, Lemtalsi T, El-Remessy AB.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):746-757. doi: 10.1016/j.bbadis.2017.12.023. Epub 2017 Dec 16.


Correction: Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway.

El-Remessy AB, Franklin T, Ghaley N, Yang J, Brands MW, Caldwell RB, Behzadian MA.

PLoS One. 2017 Oct 16;12(10):e0186749. doi: 10.1371/journal.pone.0186749. eCollection 2017.


Implication of the neurotrophin receptor p75NTR in vascular diseases: beyond the eye.

Elshaer SL, El-Remessy AB.

Expert Rev Ophthalmol. 2017;12(2):149-158. doi: 10.1080/17469899.2017.1269602. Epub 2016 Dec 21.


Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia.

Mbata O, Abo El-Magd NF, El-Remessy AB.

World J Diabetes. 2017 Jul 15;8(7):317-329. doi: 10.4239/wjd.v8.i7.317. Review.


Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia.

Elshaer SL, Mohamed IN, Coucha M, Altantawi S, Eldahshan W, Bartasi ML, Shanab AY, Lorys R, El-Remessy AB.

Antioxidants (Basel). 2017 Jun 29;6(3). pii: E47. doi: 10.3390/antiox6030047.


High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.

Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB.

World J Diabetes. 2017 Feb 15;8(2):56-65. doi: 10.4239/wjd.v8.i2.56.


Deletion of the Neurotrophin Receptor p75NTR Prevents Diabetes-Induced Retinal Acellular Capillaries in Streptozotocin-Induced Mouse Diabetic Model.

Mohamed R, Shanab AY, El Remessy AB.

J Diabetes Metab Disord Control. 2017;4(6). pii: 129. doi: 10.15406/jdmdc.2017.04.00129. Epub 2017 Dec 21.


Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.

Coucha M, Abdelsaid M, Li W, Johnson MH, Orfi L, El-Remessy AB, Fagan SC, Ergul A.

Life Sci. 2016 Oct 15;163:46-54. doi: 10.1016/j.lfs.2016.08.018. Epub 2016 Aug 21.


Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.

El-Remessy AB, Bartoli M, Platt DH, Fulton D, Caldwell RB.

J Cell Sci. 2016 Aug 15;129(16):3203. doi: 10.1242/jcs.195966. No abstract available.


Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.

Mohamed R, El-Remessy AB.

J Clin Exp Ophthalmol. 2015 Oct;6(5). pii: 483. Epub 2015 Oct 25.


Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence.

Fouda AY, Artham S, El-Remessy AB, Fagan SC.

Clin Sci (Lond). 2016 Feb;130(4):221-38. doi: 10.1042/CS20150350. Review.


Cell Therapy and Critical Limb Ischemia: Evidence and Window of Opportunity in Obesity.

Elshaer SL, Lorys RE, El-Remessy AB.

Obes Control Ther. 2016;3(1). pii: 121. Epub 2016 Sep 15. No abstract available.


Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure.

Artham S, Fouda AY, El-Remessy AB, Fagan SC.

Receptors Clin Investig. 2015;2(3). pii: e774. No abstract available.


Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina.

Shanab AY, Mysona BA, Matragoon S, El-Remessy AB.

Mol Ther Methods Clin Dev. 2015 May 6;2:15013. doi: 10.1038/mtm.2015.13. eCollection 2015.


Molecular mechanisms of diabetic retinopathy: potential therapeutic targets.

Coucha M, Elshaer SL, Eldahshan WS, Mysona BA, El-Remessy AB.

Middle East Afr J Ophthalmol. 2015 Apr-Jun;22(2):135-44. doi: 10.4103/0974-9233.154386. Review.


Imbalance of the nerve growth factor and its precursor as a potential biomarker for diabetic retinopathy.

Mysona BA, Matragoon S, Stephens M, Mohamed IN, Farooq A, Bartasis ML, Fouda AY, Shanab AY, Espinosa-Heidmann DG, El-Remessy AB.

Biomed Res Int. 2015;2015:571456. doi: 10.1155/2015/571456. Epub 2015 Mar 17.


Erratum to: Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.

Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB.

Diabetologia. 2015 Mar;58(3):644. doi: 10.1007/s00125-014-3476-5. No abstract available.


Erratum to: Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice.

Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC.

Mol Neurobiol. 2015 Apr;51(2):779-80. doi: 10.1007/s12035-014-9025-x. No abstract available.


Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1).

Shanab AY, Elshaer SL, El-Azab MF, Soliman S, Sabbineni H, Matragoon S, Fagan SC, El-Remessy AB.

Angiogenesis. 2015 Apr;18(2):137-50. doi: 10.1007/s10456-014-9451-4. Epub 2014 Nov 25.


Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy.

Abdelsaid MA, Matragoon S, Ergul A, El-Remessy AB.

PLoS One. 2014 Oct 16;9(10):e110388. doi: 10.1371/journal.pone.0110388. eCollection 2014.


Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit.

Mohamed IN, Ishrat T, Fagan SC, El-Remessy AB.

Antioxid Redox Signal. 2015 May 1;22(13):1188-206. doi: 10.1089/ars.2014.6126. Epub 2014 Nov 11. Review.


Role of matrix metalloproteinase activity in the neurovascular protective effects of Angiotensin antagonism.

Ishrat T, Kozak A, Alhusban A, Pillai B, Johnson MH, El-Remessy AB, Ergul A, Fagan SC.

Stroke Res Treat. 2014;2014:560491. doi: 10.1155/2014/560491. Epub 2014 Jul 24.


Nerve growth factor in diabetic retinopathy: beyond neurons.

Mysona BA, Shanab AY, Elshaer SL, El-Remessy AB.

Expert Rev Ophthalmol. 2014 Apr;9(2):99-107.


Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice.

Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC.

Mol Neurobiol. 2015 Apr;51(2):766-78. doi: 10.1007/s12035-014-8766-x. Epub 2014 Jun 18. Erratum in: Mol Neurobiol. 2015 Apr;51(2):779-80.


Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice.

Rozette NA, Matragoon S, Sethi S, Goei S, Manasco KB, El-Remessy AB.

Neonatology. 2014;106(1):37-41. doi: 10.1159/000358228. Epub 2014 Apr 25.


Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B.

Soliman S, Ishrat T, Pillai A, Somanath PR, Ergul A, El-Remessy AB, Fagan SC.

J Pharmacol Exp Ther. 2014 Jun;349(3):444-57. doi: 10.1124/jpet.113.212613. Epub 2014 Mar 28.


Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.

El-Azab MF, Baldowski BR, Mysona BA, Shanab AY, Mohamed IN, Abdelsaid MA, Matragoon S, Bollinger KE, Saul A, El-Remessy AB.

Br J Pharmacol. 2014 Mar;171(5):1299-313. doi: 10.1111/bph.12535.


Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet.

Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, El-Remessy AB.

Diabetologia. 2014 Feb;57(2):413-23. doi: 10.1007/s00125-013-3101-z. Epub 2013 Nov 8.


Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy.

Elshaer SL, Abdelsaid MA, Al-Azayzih A, Kumar P, Matragoon S, Nussbaum JJ, El-Remessy AB.

J Diabetes Res. 2013;2013:432659. doi: 10.1155/2013/432659. Epub 2013 Aug 12.


Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.

El-Kenawi AE, El-Remessy AB.

Br J Pharmacol. 2013 Oct;170(4):712-29. doi: 10.1111/bph.12344. Review.


Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway.

El-Remessy AB, Franklin T, Ghaley N, Yang J, Brands MW, Caldwell RB, Behzadian MA.

PLoS One. 2013 Aug 7;8(8):e71868. doi: 10.1371/journal.pone.0071868. eCollection 2013. Erratum in: PLoS One. 2017 Oct 16;12 (10 ):e0186749.


Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.

Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB.

Diabetologia. 2013 Oct;56(10):2329-39. doi: 10.1007/s00125-013-2998-6. Epub 2013 Aug 7. Erratum in: Diabetologia. 2014 Jun;57(6):1268. Diabetologia. 2015 Mar;58(3):644.


Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.

Abdelsaid MA, Matragoon S, El-Remessy AB.

Antioxid Redox Signal. 2013 Dec 20;19(18):2199-212. doi: 10.1089/ars.2012.4761. Epub 2013 Jul 12.


Potential roles of adenosine deaminase-2 in diabetic retinopathy.

Elsherbiny NM, Naime M, Ahmad S, Elsherbini AM, Mohammad S, Fulzele S, El-Remessy AB, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Han G, White R, Haroldo TF, Liou GI.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):355-61. doi: 10.1016/j.bbrc.2013.05.023. Epub 2013 May 16.


Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway.

Al-Gayyar MM, Mysona BA, Matragoon S, Abdelsaid MA, El-Azab MF, Shanab AY, Ha Y, Smith SB, Bollinger KE, El-Remessy AB.

PLoS One. 2013;8(1):e54692. doi: 10.1371/journal.pone.0054692. Epub 2013 Jan 24. Retraction in: PLoS One. 2017 Oct 16;12 (10 ):e0186748.


Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels.

Puttabyatappa Y, Stallone JN, Ergul A, El-Remessy AB, Kumar S, Black S, Johnson M, Owen MP, White RE.

J Pharmacol Exp Ther. 2013 Apr;345(1):7-14. doi: 10.1124/jpet.112.201947. Epub 2013 Jan 14.


Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration.

Matragoon S, Al-Gayyar MM, Mysona BA, Abdelsaid MA, Pillai BA, Neet KE, Fagan SC, El-Remessy AB.

Mol Vis. 2012;18:2993-3003. Epub 2012 Dec 14.


S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.

Abdelsaid MA, El-Remessy AB.

J Cell Sci. 2012 Oct 15;125(Pt 20):4751-60. doi: 10.1242/jcs.103481. Epub 2012 Aug 1.


Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats.

Mohamed IN, Soliman SA, Alhusban A, Matragoon S, Pillai BA, Elmarkaby AA, El-Remessy AB.

Mol Vis. 2012;18:1457-66. Epub 2012 Jun 2.


Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis.

Lupachyk S, Stavniichuk R, Komissarenko JI, Drel VR, Obrosov AA, El-Remessy AB, Pacher P, Obrosova IG.

Int J Mol Med. 2012 Jun;29(6):989-98. doi: 10.3892/ijmm.2012.933. Epub 2012 Mar 7.


Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling.

Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC, Ergul A.

Diabetes. 2012 Jun;61(6):1533-42. doi: 10.2337/db11-1528. Epub 2012 Mar 8.


Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.

Bhatia K, Elmarakby AA, El-Remessy AB, Sullivan JC.

Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R274-82. doi: 10.1152/ajpregu.00546.2011. Epub 2011 Nov 2. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1233. El-Remessey, Azza [corrected to El-Remessy, Azza B].


Statins for prevention of diabetic-related blindness: a new treatment option?

El-Azab MF, Mysona BA, El-Remessy AB.

Expert Rev Ophthalmol. 2011 Jun;6(3):269-272. No abstract available.


Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke.

Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A, Johnson MH, Alhusban A, Soliman S, Fagan SC.

PLoS One. 2011;6(9):e24551. doi: 10.1371/journal.pone.0024551. Epub 2011 Sep 1.


Acute treatment with candesartan reduces early injury after permanent middle cerebral artery occlusion.

Guan W, Kozak A, El-Remessy AB, Johnson MH, Pillai BA, Fagan SC.

Transl Stroke Res. 2011 Jun 1;2(2):179-85. doi: 10.1007/s12975-010-0061-1.

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