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Items: 1 to 50 of 87

1.

Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion.

Coucha M, Shanab AY, Sayed M, Vazdarjanova A, El-Remessy AB.

Int J Mol Sci. 2019 Aug 15;20(16). pii: E3969. doi: 10.3390/ijms20163969.

2.

Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.

Elshaer SL, Alwhaibi A, Mohamed R, Lemtalsi T, Coucha M, Longo FM, El-Remessy AB.

Diabetologia. 2019 Aug;62(8):1488-1500. doi: 10.1007/s00125-019-4885-2. Epub 2019 May 9.

PMID:
31073629
3.
4.

High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells.

Elshaer SL, Lemtalsi T, El-Remessy AB.

Antioxidants (Basel). 2018 Mar 25;7(4). pii: E47. doi: 10.3390/antiox7040047.

5.

Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study.

Mohamed IN, Sarhan NR, Eladl MA, El-Remessy AB, El-Sherbiny M.

Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.

PMID:
29482933
6.

Inducible overexpression of endothelial proNGF as a mouse model to study microvascular dysfunction.

Mohamed R, Coucha M, Elshaer SL, Artham S, Lemtalsi T, El-Remessy AB.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):746-757. doi: 10.1016/j.bbadis.2017.12.023. Epub 2017 Dec 16.

7.

Correction: Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway.

El-Remessy AB, Franklin T, Ghaley N, Yang J, Brands MW, Caldwell RB, Behzadian MA.

PLoS One. 2017 Oct 16;12(10):e0186749. doi: 10.1371/journal.pone.0186749. eCollection 2017.

8.

Implication of the neurotrophin receptor p75NTR in vascular diseases: beyond the eye.

Elshaer SL, El-Remessy AB.

Expert Rev Ophthalmol. 2017;12(2):149-158. doi: 10.1080/17469899.2017.1269602. Epub 2016 Dec 21.

9.

Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia.

Mbata O, Abo El-Magd NF, El-Remessy AB.

World J Diabetes. 2017 Jul 15;8(7):317-329. doi: 10.4239/wjd.v8.i7.317. Review.

10.

Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia.

Elshaer SL, Mohamed IN, Coucha M, Altantawi S, Eldahshan W, Bartasi ML, Shanab AY, Lorys R, El-Remessy AB.

Antioxidants (Basel). 2017 Jun 29;6(3). pii: E47. doi: 10.3390/antiox6030047.

11.

High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.

Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB.

World J Diabetes. 2017 Feb 15;8(2):56-65. doi: 10.4239/wjd.v8.i2.56.

12.

Deletion of the Neurotrophin Receptor p75NTR Prevents Diabetes-Induced Retinal Acellular Capillaries in Streptozotocin-Induced Mouse Diabetic Model.

Mohamed R, Shanab AY, El Remessy AB.

J Diabetes Metab Disord Control. 2017;4(6). pii: 129. doi: 10.15406/jdmdc.2017.04.00129. Epub 2017 Dec 21.

13.

Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.

Coucha M, Abdelsaid M, Li W, Johnson MH, Orfi L, El-Remessy AB, Fagan SC, Ergul A.

Life Sci. 2016 Oct 15;163:46-54. doi: 10.1016/j.lfs.2016.08.018. Epub 2016 Aug 21.

14.

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.

El-Remessy AB, Bartoli M, Platt DH, Fulton D, Caldwell RB.

J Cell Sci. 2016 Aug 15;129(16):3203. doi: 10.1242/jcs.195966. No abstract available.

15.

Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.

Mohamed R, El-Remessy AB.

J Clin Exp Ophthalmol. 2015 Oct;6(5). pii: 483. Epub 2015 Oct 25.

16.

Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence.

Fouda AY, Artham S, El-Remessy AB, Fagan SC.

Clin Sci (Lond). 2016 Feb;130(4):221-38. doi: 10.1042/CS20150350. Review.

PMID:
26769658
17.

Cell Therapy and Critical Limb Ischemia: Evidence and Window of Opportunity in Obesity.

Elshaer SL, Lorys RE, El-Remessy AB.

Obes Control Ther. 2016;3(1). pii: 121. Epub 2016 Sep 15. No abstract available.

18.

Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure.

Artham S, Fouda AY, El-Remessy AB, Fagan SC.

Receptors Clin Investig. 2015;2(3). pii: e774. No abstract available.

19.

Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina.

Shanab AY, Mysona BA, Matragoon S, El-Remessy AB.

Mol Ther Methods Clin Dev. 2015 May 6;2:15013. doi: 10.1038/mtm.2015.13. eCollection 2015.

20.

Molecular mechanisms of diabetic retinopathy: potential therapeutic targets.

Coucha M, Elshaer SL, Eldahshan WS, Mysona BA, El-Remessy AB.

Middle East Afr J Ophthalmol. 2015 Apr-Jun;22(2):135-44. doi: 10.4103/0974-9233.154386. Review.

21.

Imbalance of the nerve growth factor and its precursor as a potential biomarker for diabetic retinopathy.

Mysona BA, Matragoon S, Stephens M, Mohamed IN, Farooq A, Bartasis ML, Fouda AY, Shanab AY, Espinosa-Heidmann DG, El-Remessy AB.

Biomed Res Int. 2015;2015:571456. doi: 10.1155/2015/571456. Epub 2015 Mar 17.

22.

Erratum to: Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.

Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB.

Diabetologia. 2015 Mar;58(3):644. doi: 10.1007/s00125-014-3476-5. No abstract available.

PMID:
25527000
23.

Erratum to: Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice.

Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC.

Mol Neurobiol. 2015 Apr;51(2):779-80. doi: 10.1007/s12035-014-9025-x. No abstract available.

PMID:
25502293
24.

Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1).

Shanab AY, Elshaer SL, El-Azab MF, Soliman S, Sabbineni H, Matragoon S, Fagan SC, El-Remessy AB.

Angiogenesis. 2015 Apr;18(2):137-50. doi: 10.1007/s10456-014-9451-4. Epub 2014 Nov 25.

25.

Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy.

Abdelsaid MA, Matragoon S, Ergul A, El-Remessy AB.

PLoS One. 2014 Oct 16;9(10):e110388. doi: 10.1371/journal.pone.0110388. eCollection 2014.

26.

Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit.

Mohamed IN, Ishrat T, Fagan SC, El-Remessy AB.

Antioxid Redox Signal. 2015 May 1;22(13):1188-206. doi: 10.1089/ars.2014.6126. Epub 2014 Nov 11. Review.

27.

Role of matrix metalloproteinase activity in the neurovascular protective effects of Angiotensin antagonism.

Ishrat T, Kozak A, Alhusban A, Pillai B, Johnson MH, El-Remessy AB, Ergul A, Fagan SC.

Stroke Res Treat. 2014;2014:560491. doi: 10.1155/2014/560491. Epub 2014 Jul 24.

28.

Nerve growth factor in diabetic retinopathy: beyond neurons.

Mysona BA, Shanab AY, Elshaer SL, El-Remessy AB.

Expert Rev Ophthalmol. 2014 Apr;9(2):99-107.

29.

Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice.

Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC.

Mol Neurobiol. 2015 Apr;51(2):766-78. doi: 10.1007/s12035-014-8766-x. Epub 2014 Jun 18. Erratum in: Mol Neurobiol. 2015 Apr;51(2):779-80.

30.

Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice.

Rozette NA, Matragoon S, Sethi S, Goei S, Manasco KB, El-Remessy AB.

Neonatology. 2014;106(1):37-41. doi: 10.1159/000358228. Epub 2014 Apr 25.

31.

Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B.

Soliman S, Ishrat T, Pillai A, Somanath PR, Ergul A, El-Remessy AB, Fagan SC.

J Pharmacol Exp Ther. 2014 Jun;349(3):444-57. doi: 10.1124/jpet.113.212613. Epub 2014 Mar 28.

32.

Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.

El-Azab MF, Baldowski BR, Mysona BA, Shanab AY, Mohamed IN, Abdelsaid MA, Matragoon S, Bollinger KE, Saul A, El-Remessy AB.

Br J Pharmacol. 2014 Mar;171(5):1299-313. doi: 10.1111/bph.12535.

33.

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet.

Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, El-Remessy AB.

Diabetologia. 2014 Feb;57(2):413-23. doi: 10.1007/s00125-013-3101-z. Epub 2013 Nov 8.

34.

Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy.

Elshaer SL, Abdelsaid MA, Al-Azayzih A, Kumar P, Matragoon S, Nussbaum JJ, El-Remessy AB.

J Diabetes Res. 2013;2013:432659. doi: 10.1155/2013/432659. Epub 2013 Aug 12.

35.

Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.

El-Kenawi AE, El-Remessy AB.

Br J Pharmacol. 2013 Oct;170(4):712-29. doi: 10.1111/bph.12344. Review.

36.

Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway.

El-Remessy AB, Franklin T, Ghaley N, Yang J, Brands MW, Caldwell RB, Behzadian MA.

PLoS One. 2013 Aug 7;8(8):e71868. doi: 10.1371/journal.pone.0071868. eCollection 2013. Erratum in: PLoS One. 2017 Oct 16;12 (10 ):e0186749.

37.

Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.

Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB.

Diabetologia. 2013 Oct;56(10):2329-39. doi: 10.1007/s00125-013-2998-6. Epub 2013 Aug 7. Erratum in: Diabetologia. 2014 Jun;57(6):1268. Diabetologia. 2015 Mar;58(3):644.

38.

Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.

Abdelsaid MA, Matragoon S, El-Remessy AB.

Antioxid Redox Signal. 2013 Dec 20;19(18):2199-212. doi: 10.1089/ars.2012.4761. Epub 2013 Jul 12.

39.

Potential roles of adenosine deaminase-2 in diabetic retinopathy.

Elsherbiny NM, Naime M, Ahmad S, Elsherbini AM, Mohammad S, Fulzele S, El-Remessy AB, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Han G, White R, Haroldo TF, Liou GI.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):355-61. doi: 10.1016/j.bbrc.2013.05.023. Epub 2013 May 16.

PMID:
23685153
40.

Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway.

Al-Gayyar MM, Mysona BA, Matragoon S, Abdelsaid MA, El-Azab MF, Shanab AY, Ha Y, Smith SB, Bollinger KE, El-Remessy AB.

PLoS One. 2013;8(1):e54692. doi: 10.1371/journal.pone.0054692. Epub 2013 Jan 24. Retraction in: PLoS One. 2017 Oct 16;12 (10 ):e0186748.

41.

Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels.

Puttabyatappa Y, Stallone JN, Ergul A, El-Remessy AB, Kumar S, Black S, Johnson M, Owen MP, White RE.

J Pharmacol Exp Ther. 2013 Apr;345(1):7-14. doi: 10.1124/jpet.112.201947. Epub 2013 Jan 14.

42.

Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration.

Matragoon S, Al-Gayyar MM, Mysona BA, Abdelsaid MA, Pillai BA, Neet KE, Fagan SC, El-Remessy AB.

Mol Vis. 2012;18:2993-3003. Epub 2012 Dec 14.

43.

S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.

Abdelsaid MA, El-Remessy AB.

J Cell Sci. 2012 Oct 15;125(Pt 20):4751-60. doi: 10.1242/jcs.103481. Epub 2012 Aug 1.

44.

Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats.

Mohamed IN, Soliman SA, Alhusban A, Matragoon S, Pillai BA, Elmarkaby AA, El-Remessy AB.

Mol Vis. 2012;18:1457-66. Epub 2012 Jun 2.

45.

Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis.

Lupachyk S, Stavniichuk R, Komissarenko JI, Drel VR, Obrosov AA, El-Remessy AB, Pacher P, Obrosova IG.

Int J Mol Med. 2012 Jun;29(6):989-98. doi: 10.3892/ijmm.2012.933. Epub 2012 Mar 7.

46.

Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling.

Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC, Ergul A.

Diabetes. 2012 Jun;61(6):1533-42. doi: 10.2337/db11-1528. Epub 2012 Mar 8.

47.

Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.

Bhatia K, Elmarakby AA, El-Remessy AB, Sullivan JC.

Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R274-82. doi: 10.1152/ajpregu.00546.2011. Epub 2011 Nov 2. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1233. El-Remessey, Azza [corrected to El-Remessy, Azza B].

48.

Statins for prevention of diabetic-related blindness: a new treatment option?

El-Azab MF, Mysona BA, El-Remessy AB.

Expert Rev Ophthalmol. 2011 Jun;6(3):269-272. No abstract available.

49.

Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke.

Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A, Johnson MH, Alhusban A, Soliman S, Fagan SC.

PLoS One. 2011;6(9):e24551. doi: 10.1371/journal.pone.0024551. Epub 2011 Sep 1.

50.

Acute treatment with candesartan reduces early injury after permanent middle cerebral artery occlusion.

Guan W, Kozak A, El-Remessy AB, Johnson MH, Pillai BA, Fagan SC.

Transl Stroke Res. 2011 Jun 1;2(2):179-85. doi: 10.1007/s12975-010-0061-1.

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