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Items: 21


Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy.

Yosef HK, Frick T, Hammoud MK, Maghnouj A, Hahn S, Gerwert K, El-Mashtoly SF.

Analyst. 2018 Dec 3;143(24):6069-6078. doi: 10.1039/c8an02029a.


Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular level.

Hammoud MK, Yosef HK, Lechtonen T, Aljakouch K, Schuler M, Alsaidi W, Daho I, Maghnouj A, Hahn S, El-Mashtoly SF, Gerwert K.

Sci Rep. 2018 Oct 15;8(1):15278. doi: 10.1038/s41598-018-33682-7.


Hierarchical deep convolutional neural networks combine spectral and spatial information for highly accurate Raman-microscopy-based cytopathology.

Krauß SD, Roy R, Yosef HK, Lechtonen T, El-Mashtoly SF, Gerwert K, Mosig A.

J Biophotonics. 2018 Oct;11(10):e201800022. doi: 10.1002/jbio.201800022. Epub 2018 Jul 5.


Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells.

Aljakouch K, Lechtonen T, Yosef HK, Hammoud MK, Alsaidi W, Kötting C, Mügge C, Kourist R, El-Mashtoly SF, Gerwert K.

Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7250-7254. doi: 10.1002/anie.201803394. Epub 2018 May 16.


Noninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral Imaging.

Yosef HK, Krauß SD, Lechtonen T, Jütte H, Tannapfel A, Käfferlein HU, Brüning T, Roghmann F, Noldus J, Mosig A, El-Mashtoly SF, Gerwert K.

Anal Chem. 2017 Jun 20;89(12):6893-6899. doi: 10.1021/acs.analchem.7b01403. Epub 2017 Jun 5.


Raman fiber-optical method for colon cancer detection: Cross-validation and outlier identification approach.

Petersen D, Naveed P, Ragheb A, Niedieker D, El-Mashtoly SF, Brechmann T, Kötting C, Schmiegel WH, Freier E, Pox C, Gerwert K.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 15;181:270-275. doi: 10.1016/j.saa.2017.03.054. Epub 2017 Mar 25.


Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy.

Petersen D, Mavarani L, Niedieker D, Freier E, Tannapfel A, Kötting C, Gerwert K, El-Mashtoly SF.

Analyst. 2017 Apr 10;142(8):1207-1215. doi: 10.1039/c6an02072k.


In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging.

Yosef HK, Mavarani L, Maghnouj A, Hahn S, El-Mashtoly SF, Gerwert K.

Anal Bioanal Chem. 2015 Nov;407(27):8321-31. doi: 10.1007/s00216-015-8875-z. Epub 2015 Jul 14.


Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.

El-Mashtoly SF, Yosef HK, Petersen D, Mavarani L, Maghnouj A, Hahn S, Kötting C, Gerwert K.

Anal Chem. 2015 Jul 21;87(14):7297-304. doi: 10.1021/acs.analchem.5b01431. Epub 2015 Jun 26.


Colocalization of fluorescence and Raman microscopic images for the identification of subcellular compartments: a validation study.

Krauß SD, Petersen D, Niedieker D, Fricke I, Freier E, El-Mashtoly SF, Gerwert K, Mosig A.

Analyst. 2015 Apr 7;140(7):2360-8. doi: 10.1039/c4an02153c.


Automated identification of subcellular organelles by coherent anti-stokes Raman scattering.

El-Mashtoly SF, Niedieker D, Petersen D, Krauss SD, Freier E, Maghnouj A, Mosig A, Hahn S, Kötting C, Gerwert K.

Biophys J. 2014 May 6;106(9):1910-20. doi: 10.1016/j.bpj.2014.03.025.


Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy.

El-Mashtoly SF, Petersen D, Yosef HK, Mosig A, Reinacher-Schick A, Kötting C, Gerwert K.

Analyst. 2014 Mar 7;139(5):1155-61. doi: 10.1039/c3an01993d. Epub 2014 Jan 15.


Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells.

Mavarani L, Petersen D, El-Mashtoly SF, Mosig A, Tannapfel A, Kötting C, Gerwert K.

Analyst. 2013 Jul 21;138(14):4035-9. doi: 10.1039/c3an00370a. Epub 2013 Jun 4.


A heme-based redox sensor in the methanogenic archaeon Methanosarcina acetivorans.

Molitor B, Stassen M, Modi A, El-Mashtoly SF, Laurich C, Lubitz W, Dawson JH, Rother M, Frankenberg-Dinkel N.

J Biol Chem. 2013 Jun 21;288(25):18458-72. doi: 10.1074/jbc.M113.476267. Epub 2013 May 9.


Site-specific protein dynamics in communication pathway from sensor to signaling domain of oxygen sensor protein, HemAT-Bs: Time-resolved Ultraviolet Resonance Raman Study.

El-Mashtoly SF, Kubo M, Gu Y, Sawai H, Nakashima S, Ogura T, Aono S, Kitagawa T.

J Biol Chem. 2012 Jun 8;287(24):19973-84. doi: 10.1074/jbc.M112.357855. Epub 2012 Apr 23.


Roles of Arg-97 and Phe-113 in regulation of distal ligand binding to heme in the sensor domain of Ec DOS protein. Resonance Raman and mutation study.

El-Mashtoly SF, Nakashima S, Tanaka A, Shimizu T, Kitagawa T.

J Biol Chem. 2008 Jul 4;283(27):19000-10. doi: 10.1074/jbc.M801262200. Epub 2008 May 1.


Protein conformation changes of HemAT-Bs upon ligand binding probed by ultraviolet resonance Raman spectroscopy.

El-Mashtoly SF, Gu Y, Yoshimura H, Yoshioka S, Aono S, Kitagawa T.

J Biol Chem. 2008 Mar 14;283(11):6942-9. Epub 2007 Dec 27.


Ultraviolet resonance Raman evidence for utilization of the heme 6-propionate hydrogen-bond network in signal transmission from heme to protein in Ec DOS protein.

El-Mashtoly SF, Takahashi H, Shimizu T, Kitagawa T.

J Am Chem Soc. 2007 Mar 28;129(12):3556-63. Epub 2007 Mar 3.


Pathway of information transmission from heme to protein upon ligand binding/dissociation in myoglobin revealed by UV resonance raman spectroscopy.

Gao Y, El-Mashtoly SF, Pal B, Hayashi T, Harada K, Kitagawa T.

J Biol Chem. 2006 Aug 25;281(34):24637-46. Epub 2006 Jun 14.


Structural changes during the photocycle of photoactive yellow protein monitored by ultraviolet resonance raman spectra of tyrosine and tryptophan.

El-Mashtoly SF, Yamauchi S, Kumauchi M, Hamada N, Tokunaga F, Unno M.

J Phys Chem B. 2005 Dec 15;109(49):23666-73.


Resonance Raman spectroscopy reveals the origin of an intermediate wavelength form in photoactive yellow protein.

El-Mashtoly SF, Unno M, Kumauchi M, Hamada N, Fujiwara K, Sasaki J, Imamoto Y, Kataoka M, Tokunaga F, Yamauchi S.

Biochemistry. 2004 Mar 2;43(8):2279-87.


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