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Items: 23

1.

Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord.

Bianchi BR, El Kouhen R, Chen J, Puttfarcken PS.

Eur J Pharmacol. 2010 May 10;633(1-3):15-23. doi: 10.1016/j.ejphar.2010.02.004. Epub 2010 Feb 11.

PMID:
20153316
2.

Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination.

Anderson DJ, Malysz J, Grønlien JH, El Kouhen R, Håkerud M, Wetterstrand C, Briggs CA, Gopalakrishnan M.

Biochem Pharmacol. 2009 Oct 1;78(7):844-51. doi: 10.1016/j.bcp.2009.06.024. Epub 2009 Jun 23.

PMID:
19555668
3.

Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.

Faghih R, Gopalakrishnan SM, Gronlien JH, Malysz J, Briggs CA, Wetterstrand C, Ween H, Curtis MP, Sarris KA, Gfesser GA, El-Kouhen R, Robb HM, Radek RJ, Marsh KC, Bunnelle WH, Gopalakrishnan M.

J Med Chem. 2009 May 28;52(10):3377-84. doi: 10.1021/jm9003818.

PMID:
19419141
4.

Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells.

El Kouhen R, Hu M, Anderson DJ, Li J, Gopalakrishnan M.

Br J Pharmacol. 2009 Feb;156(4):638-48. doi: 10.1111/j.1476-5381.2008.00069.x.

5.

(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.

Surowy CS, Neelands TR, Bianchi BR, McGaraughty S, El Kouhen R, Han P, Chu KL, McDonald HA, Vos M, Niforatos W, Bayburt EK, Gomtsyan A, Lee CH, Honore P, Sullivan JP, Jarvis MF, Faltynek CR.

J Pharmacol Exp Ther. 2008 Sep;326(3):879-88. doi: 10.1124/jpet.108.138511. Epub 2008 May 30.

PMID:
18515644
6.

[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.

Bianchi BR, El Kouhen R, Neelands TR, Lee CH, Gomtsyan A, Raja SN, Vaidyanathan SN, Surber B, McDonald HA, Surowy CS, Faltynek CR, Moreland RB, Jarvis MF, Puttfarcken PS.

J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. Epub 2007 Jul 27.

PMID:
17660385
7.
8.

Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.

Bianchi BR, Lee CH, Jarvis MF, El Kouhen R, Moreland RB, Faltynek CR, Puttfarcken PS.

Eur J Pharmacol. 2006 May 10;537(1-3):20-30. Epub 2006 Mar 10.

PMID:
16630609
9.

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.

El Kouhen R, Surowy CS, Bianchi BR, Neelands TR, McDonald HA, Niforatos W, Gomtsyan A, Lee CH, Honore P, Sullivan JP, Jarvis MF, Faltynek CR.

J Pharmacol Exp Ther. 2005 Jul;314(1):400-9. Epub 2005 Apr 18.

PMID:
15837819
10.

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.

Honore P, Wismer CT, Mikusa J, Zhu CZ, Zhong C, Gauvin DM, Gomtsyan A, El Kouhen R, Lee CH, Marsh K, Sullivan JP, Faltynek CR, Jarvis MF.

J Pharmacol Exp Ther. 2005 Jul;314(1):410-21. Epub 2005 Apr 18.

PMID:
15837818
11.

Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.

McGaraughty S, Chu KL, Bitner RS, Martino B, El Kouhen R, Han P, Nikkel AL, Burgard EC, Faltynek CR, Jarvis MF.

J Neurophysiol. 2003 Oct;90(4):2702-10. Epub 2003 Jun 18.

12.

Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties.

McCurdy CR, Le Bourdonnec B, Metzger TG, El Kouhen R, Zhang Y, Law PY, Portoghese PS.

J Med Chem. 2002 Jul 4;45(14):2887-90.

PMID:
12086475
13.

Affinity labels as tools for the identification of opioid receptor recognition sites.

Portoghese PS, el Kouhen R, Law PY, Loh HH, Le Bourdonnec B.

Farmaco. 2001 Mar;56(3):191-6. Review.

PMID:
11409326
14.

Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI).

Le Bourdonnec B, El Kouhen R, Poda G, Law PY, Loh HH, Ferguson DM, Portoghese PS.

J Med Chem. 2001 Mar 29;44(7):1017-20. No abstract available.

PMID:
11297446
15.

Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.

El Kouhen R, Burd AL, Erickson-Herbrandson LJ, Chang CY, Law PY, Loh HH.

J Biol Chem. 2001 Apr 20;276(16):12774-80. Epub 2001 Jan 25.

16.

Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor.

Law PY, Erickson LJ, El-Kouhen R, Dicker L, Solberg J, Wang W, Miller E, Burd AL, Loh HH.

Mol Pharmacol. 2000 Aug;58(2):388-98.

PMID:
10908307
17.

Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors.

Le Bourdonnec B, El Kouhen R, Lunzer MM, Law PY, Loh HH, Portoghese PS.

J Med Chem. 2000 Jun 29;43(13):2489-92. No abstract available.

PMID:
10891107
19.
20.

Colicin N interaction with sensitive Escherichia coli cells: in situ and kinetic approaches.

el Kouhen R, Bernadac A, Pagès JM.

Res Microbiol. 1998 Oct;149(9):645-51.

PMID:
9826920
21.
22.

In vitro approaches to investigation of the early steps of colicin-OmpF interaction.

el Kouhen R, Hoenger A, Engel A, Pagès JM.

Eur J Biochem. 1994 Sep 1;224(2):723-8.

23.

Characterization of the receptor and translocator domains of colicin N.

el Kouhen R, Fierobe HP, Scianimanico S, Steiert M, Pattus F, Pagès JM.

Eur J Biochem. 1993 Jun 15;214(3):635-9.

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