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Items: 1 to 50 of 58

1.

Recent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's.

Fleifel D, Rahmoon MA, AlOkda A, Nasr M, Elserafy M, El-Khamisy SF.

J Genet Eng Biotechnol. 2018 Dec;16(2):427-432. doi: 10.1016/j.jgeb.2018.09.002. Epub 2018 Dec 10. Review.

2.

Gold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis.

Shawky SM, Awad AM, Abugable AA, El-Khamisy SF.

Int J Nanomedicine. 2018 Nov 29;13:8137-8151. doi: 10.2147/IJN.S181732. eCollection 2018.

3.

Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells.

Moradzadeh M, Ghorbani A, Erfanian S, Mohaddes ST, Rahimi H, Karimiani EG, Mashkani B, Chiang SC, El-Khamisy SF, Tabarraei A, Sadeghnia HR.

J Cell Biochem. 2018 Sep 11. doi: 10.1002/jcb.27489. [Epub ahead of print]

PMID:
30203596
4.

Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs.

Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF, Ragab G; Mediterranean Consortium for the study of Cryoglobulinemic Vasculitis.

EBioMedicine. 2018 Sep;35:106-113. doi: 10.1016/j.ebiom.2018.08.007. Epub 2018 Aug 20.

5.

UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy.

Kassouf N, Kay CWM, Volkov A, Chiang SC, Birch-Machin MA, El-Khamisy SF, Haywood RM.

Free Radic Biol Med. 2018 Oct;126:153-165. doi: 10.1016/j.freeradbiomed.2018.07.019. Epub 2018 Jul 25.

PMID:
30055236
6.

miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2.

Mohamed Z, Hassan MK, Okasha S, Mitamura T, Keshk S, Konno Y, Kato T, El-Khamisy SF, Ohba Y, Watari H.

Oncotarget. 2018 Jul 10;9(53):30053-30065. doi: 10.18632/oncotarget.25698. eCollection 2018 Jul 10.

7.

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M, Williamson MP, Henderson PJF, Poole RK.

Redox Biol. 2018 Sep;18:114-123. doi: 10.1016/j.redox.2018.06.008. Epub 2018 Jun 30.

8.

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.

Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang SC, Ray S, Ashour ME, Sudbery I, Dickman MJ, El-Khamisy SF.

Cell Rep. 2018 Jun 12;23(11):3352-3365. doi: 10.1016/j.celrep.2018.05.033.

9.

Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.

Elserafy M, Abugable AA, Atteya R, El-Khamisy SF.

Trends Genet. 2018 Aug;34(8):574-577. doi: 10.1016/j.tig.2018.04.006. Epub 2018 May 26. Review.

10.

Competing endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer.

Samir N, Matboli M, El-Tayeb H, El-Tawdi A, Hassan MK, Waly A, El-Akkad HAE, Ramadan MG, Al-Belkini TN, El-Khamisy S, El-Asmar F.

J Cell Biochem. 2018 Aug;119(8):6869-6881. doi: 10.1002/jcb.26884. Epub 2018 May 8.

PMID:
29737552
11.

Choose your yeast strain carefully: the RAD5 gene matters.

Elserafy M, El-Khamisy SF.

Nat Rev Mol Cell Biol. 2018 Jun;19(6):343-344. doi: 10.1038/s41580-018-0005-2. No abstract available.

PMID:
29615784
12.

Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia.

Walker C, El-Khamisy SF.

Brain. 2018 May 1;141(5):1247-1262. doi: 10.1093/brain/awy076.

13.

Studying TDP1 Function in DNA Repair.

Chiang SC, Liversidge K, El-Khamisy SF.

Methods Mol Biol. 2018;1703:173-181. doi: 10.1007/978-1-4939-7459-7_13.

PMID:
29177742
14.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

15.

Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.

Abugable AA, Awwad DA, Fleifel D, Ali MM, El-Khamisy S, Elserafy M.

Adv Exp Med Biol. 2017;1007:157-178. doi: 10.1007/978-3-319-60733-7_9. Review.

PMID:
28840557
16.

Role of Protein Linked DNA Breaks in Cancer.

Allam WR, Ashour ME, Waly AA, El-Khamisy S.

Adv Exp Med Biol. 2017;1007:41-58. doi: 10.1007/978-3-319-60733-7_3.

PMID:
28840551
17.

C9orf72 expansion disrupts ATM-mediated chromosomal break repair.

Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, Lukashchuk V, Chiang SC, Ray S, Mulcahy PJ, Jurga M, Tsagakis I, Iannitti T, Chandran J, Coldicott I, De Vos KJ, Hassan MK, Higginbottom A, Shaw PJ, Hautbergue GM, Azzouz M, El-Khamisy SF.

Nat Neurosci. 2017 Sep;20(9):1225-1235. doi: 10.1038/nn.4604. Epub 2017 Jul 17.

18.

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, Myszczynska MA, Alam SM, Garneret P, Chandran JS, Karyka E, Stopford MJ, Smith EF, Kirby J, Meyer K, Kaspar BK, Isaacs AM, El-Khamisy SF, De Vos KJ, Ning K, Azzouz M, Whitworth AJ, Shaw PJ.

Nat Commun. 2017 Jul 5;8:16063. doi: 10.1038/ncomms16063.

19.

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.

Herranz-Martin S, Chandran J, Lewis K, Mulcahy P, Higginbottom A, Walker C, Valenzuela IMY, Jones RA, Coldicott I, Iannitti T, Akaaboune M, El-Khamisy SF, Gillingwater TH, Shaw PJ, Azzouz M.

Dis Model Mech. 2017 Jul 1;10(7):859-868. doi: 10.1242/dmm.029892. Epub 2017 May 26.

20.

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.

Chiang SC, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R, El-Khamisy SF.

Sci Adv. 2017 Apr 28;3(4):e1602506. doi: 10.1126/sciadv.1602506. eCollection 2017 Apr.

21.

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.

Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF.

Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026.

22.

Gold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples.

Shawky SM, Awad AM, Allam W, Alkordi MH, El-Khamisy SF.

Biosens Bioelectron. 2017 Jun 15;92:349-356. doi: 10.1016/j.bios.2016.11.001. Epub 2016 Nov 4.

23.

Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin.

Atteya R, Ashour ME, Ibrahim EE, Farag MA, El-Khamisy SF.

Mech Ageing Dev. 2017 Jan;161(Pt A):141-148. doi: 10.1016/j.mad.2016.04.012. Epub 2016 Jun 6.

24.

Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1.

Elsayed W, El-Shafie L, Hassan MK, Farag MA, El-Khamisy SF.

Sci Rep. 2016 May 25;6:26626. doi: 10.1038/srep26626.

25.

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI.

Cell Rep. 2016 Apr 26;15(4):893-908. doi: 10.1016/j.celrep.2016.03.077. Epub 2016 Apr 14.

26.

P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane.

Hassan MK, Watari H, Mitamura T, Mohamed Z, El-Khamisy SF, Ohba Y, Sakuragi N.

Oncoscience. 2015 Mar 23;2(3):294-308. eCollection 2015.

27.

Topoisomerase-mediated chromosomal break repair: an emerging player in many games.

Ashour ME, Atteya R, El-Khamisy SF.

Nat Rev Cancer. 2015 Mar;15(3):137-51. doi: 10.1038/nrc3892. Epub 2015 Feb 19. Review.

PMID:
25693836
28.

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan.

Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE, El-Khamisy SF.

Mol Cancer Ther. 2015 Feb;14(2):575-85. doi: 10.1158/1535-7163.MCT-14-0762. Epub 2014 Dec 18.

29.

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.

Carroll J, Page TK, Chiang SC, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M, El-Khamisy SF.

Hum Mol Genet. 2015 Feb 1;24(3):828-40. doi: 10.1093/hmg/ddu500. Epub 2014 Sep 30.

30.

TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan.

Meisenberg C, Ward SE, Schmid P, El-Khamisy SF.

J Cancer Sci Ther. 2014 Jul 25;6(7):258-267.

31.

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW.

Nat Genet. 2014 May;46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23.

PMID:
24658003
32.

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S, Atack JR.

Anal Biochem. 2014 Jun 1;454:17-22. doi: 10.1016/j.ab.2014.03.004. Epub 2014 Mar 14.

33.

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.

Alagoz M, Wells OS, El-Khamisy SF.

Nucleic Acids Res. 2014 Mar;42(5):3089-103. doi: 10.1093/nar/gkt1260. Epub 2013 Dec 13.

34.

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.

Alagoz M, Chiang SC, Sharma A, El-Khamisy SF.

PLoS One. 2013 Apr 23;8(4):e58239. doi: 10.1371/journal.pone.0058239. Print 2013.

35.

DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets.

Alagoz M, Gilbert DC, El-Khamisy S, Chalmers AJ.

Curr Med Chem. 2012;19(23):3874-85. Review.

PMID:
22788763
36.

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.

37.

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites.

Lebedeva NA, Rechkunova NI, El-Khamisy SF, Lavrik OI.

Biochimie. 2012 Aug;94(8):1749-53. doi: 10.1016/j.biochi.2012.04.004. Epub 2012 Apr 12.

38.

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.

Hudson JJ, Chiang SC, Wells OS, Rookyard C, El-Khamisy SF.

Nat Commun. 2012 Mar 13;3:733. doi: 10.1038/ncomms1739.

39.

Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets.

Gilbert DC, Chalmers AJ, El-Khamisy SF.

Br J Cancer. 2012 Jan 3;106(1):18-24. doi: 10.1038/bjc.2011.498. Epub 2011 Nov 22. Review.

40.

To live or to die: a matter of processing damaged DNA termini in neurons.

El-Khamisy SF.

EMBO Mol Med. 2011 Feb;3(2):78-88. doi: 10.1002/emmm.201000114. Epub 2011 Jan 19. Review.

41.

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW.

J Biol Chem. 2011 Jan 7;286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28.

42.

Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.

Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang SC, Turner G, Schwartz C, El-Khamisy S, Raymond FL, O'Driscoll M.

Hum Mol Genet. 2010 Apr 1;19(7):1324-34. doi: 10.1093/hmg/ddq008. Epub 2010 Jan 11.

43.

TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage.

Chiang SC, Carroll J, El-Khamisy SF.

Cell Cycle. 2010 Feb 1;9(3):588-595.

PMID:
20009512
44.

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW.

Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444.

PMID:
19794497
45.

The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.

Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ.

Nat Neurosci. 2009 Aug;12(8):973-80. doi: 10.1038/nn.2375. Epub 2009 Jul 26.

46.

Short-patch single-strand break repair in ataxia oculomotor apraxia-1.

Reynolds JJ, El-Khamisy SF, Caldecott KW.

Biochem Soc Trans. 2009 Jun;37(Pt 3):577-81. doi: 10.1042/BST0370577. Review.

PMID:
19442253
47.

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.

El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW.

DNA Repair (Amst). 2009 Jun 4;8(6):760-6. doi: 10.1016/j.dnarep.2009.02.002. Epub 2009 Mar 19.

48.

Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1.

Reynolds JJ, El-Khamisy SF, Katyal S, Clements P, McKinnon PJ, Caldecott KW.

Mol Cell Biol. 2009 Mar;29(5):1354-62. doi: 10.1128/MCB.01471-08. Epub 2008 Dec 22.

49.

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.

Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ.

EMBO J. 2007 Nov 14;26(22):4720-31. Epub 2007 Oct 4.

50.

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.

El-Khamisy SF, Hartsuiker E, Caldecott KW.

DNA Repair (Amst). 2007 Oct 1;6(10):1485-95. Epub 2007 Jun 28.

PMID:
17600775

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