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Items: 1 to 50 of 162

1.

Subterminal hydroxyeicosatetraenoic acids: Crucial lipid mediators in normal physiology and disease states.

Shoieb SM, El-Sherbeni AA, El-Kadi AOS.

Chem Biol Interact. 2019 Feb 1;299:140-150. doi: 10.1016/j.cbi.2018.12.004. Epub 2018 Dec 10. Review.

PMID:
30543782
2.

Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Noncompetitive Inhibitor of Cytochrome P450 1B1 with Enantioselective Activity.

Shoieb SM, El-Sherbeni AA, El-Kadi AOS.

Drug Metab Dispos. 2019 Feb;47(2):67-70. doi: 10.1124/dmd.118.084657. Epub 2018 Nov 12.

PMID:
30420405
3.

Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites.

Matsumura N, Takahara S, Maayah ZH, Parajuli N, Byrne NJ, Shoieb SM, Soltys CM, Beker DL, Masson G, El-Kadi AOS, Dyck JRB.

J Mol Cell Cardiol. 2018 Dec;125:162-173. doi: 10.1016/j.yjmcc.2018.10.023. Epub 2018 Oct 28.

PMID:
30381233
4.

DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways.

Maayah ZH, Zhang T, Forrest ML, Alrushaid S, Doschak MR, Davies NM, El-Kadi AOS.

Pharmaceutics. 2018 Sep 4;10(3). pii: E144. doi: 10.3390/pharmaceutics10030144.

5.

Correction to: Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.

Alrushaid S, Zhao Y, Sayre CL, Maayah ZH, Forrest ML, Senadheera SN, Chaboyer K, Anderson HD, El-Kadi AOS, Davies NM.

Drug Deliv Transl Res. 2018 Oct;8(5):1592. doi: 10.1007/s13346-018-0569-6.

PMID:
30073575
6.

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy.

Shoieb SM, El-Kadi AOS.

Drug Metab Dispos. 2018 Aug;46(8):1157-1168. doi: 10.1124/dmd.118.082073. Epub 2018 Jun 7.

PMID:
29880629
7.

Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies.

Alrushaid S, Davies NM, Anderson JE, Le T, Yáñez JA, Maayah ZH, El-Kadi AOS, Rachid O, Sayre CL, Löbenberg R, Burczynski FJ.

J Pharm Pharm Sci. 2018;21(1s):29683. doi: 10.18433/J3MS8H.

PMID:
29702047
8.

2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy.

Maayah ZH, Levasseur J, Siva Piragasam R, Abdelhamid G, Dyck JRB, Fahlman RP, Siraki AG, El-Kadi AOS.

Sci Rep. 2018 Feb 9;8(1):2780. doi: 10.1038/s41598-018-20613-9.

9.

The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity.

Maayah ZH, Abdelhamid G, Elshenawy OH, El-Sherbeni AA, Althurwi HN, McGinn E, Dawood D, Alammari AH, El-Kadi AOS.

Cardiovasc Toxicol. 2018 Jun;18(3):268-283. doi: 10.1007/s12012-017-9437-8.

PMID:
29196978
10.

Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.

Alrushaid S, Zhao Y, Sayre CL, Maayah ZH, Forrest ML, Senadheera SN, Chaboyer K, Anderson HD, El-Kadi AOS, Davies NM.

Drug Deliv Transl Res. 2017 Aug;7(4):582-597. doi: 10.1007/s13346-017-0379-2. Erratum in: Drug Deliv Transl Res. 2018 Oct;8(5):1592.

11.

Inhibition of Mid-chain HETEs Protects Against Angiotensin II-induced Cardiac Hypertrophy.

Elkhatali S, Maayah ZH, El-Sherbeni AA, Elshenawy OH, Abdelhamid G, Shoieb SM, El-Kadi AOS.

J Cardiovasc Pharmacol. 2017 Jul;70(1):16-24. doi: 10.1097/FJC.0000000000000494.

PMID:
28437282
12.

The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol.

Maayah ZH, Althurwi HN, El-Sherbeni AA, Abdelhamid G, Siraki AG, El-Kadi AO.

Mol Cell Biochem. 2017 May;429(1-2):151-165. doi: 10.1007/s11010-017-2943-y. Epub 2017 Mar 1.

PMID:
28251434
13.

Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target.

Elshenawy OH, Shoieb SM, Mohamed A, El-Kadi AO.

Pharmaceutics. 2017 Feb 20;9(1). pii: E9. doi: 10.3390/pharmaceutics9010009. Review.

14.

Down-regulation of cytochrome P450 1A1 by monomethylarsonous acid in human HepG2 cells.

Elshenawy OH, Abdelhamid G, Soshilov AA, Denison MS, El-Kadi AO.

Toxicol Lett. 2017 Mar 15;270:34-50. doi: 10.1016/j.toxlet.2017.02.012. Epub 2017 Feb 9.

PMID:
28189647
15.

The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination.

Abdussalam A, Elshenawy OH, Bin Jardan YA, El-Kadi AOS, Brocks DR.

J Pharm Sci. 2017 Jun;106(6):1650-1658. doi: 10.1016/j.xphs.2017.02.002. Epub 2017 Feb 9.

PMID:
28189626
16.

Pharmacokinetics of metformin in the rat: assessment of the effect of hyperlipidemia and evidence for its metabolism to guanylurea.

Gabr RQ, El-Sherbeni AA, Ben-Eltriki M, El-Kadi AO, Brocks DR.

Can J Physiol Pharmacol. 2017 May;95(5):530-538. doi: 10.1139/cjpp-2016-0329. Epub 2016 Dec 15.

PMID:
28177686
17.

Dimethylarsinic acid modulates the aryl hydrocarbon receptor-regulated genes in C57BL/6 mice: in vivo study.

Elshenawy OH, Abdelhamid G, Althurwi HN, El-Kadi AOS.

Xenobiotica. 2018 Feb;48(2):124-134. doi: 10.1080/00498254.2017.1289423. Epub 2017 Feb 21.

PMID:
28134025
18.

Microsomal cytochrome P450 as a target for drug discovery and repurposing.

El-Sherbeni AA, El-Kadi AO.

Drug Metab Rev. 2017 Feb;49(1):1-17. doi: 10.1080/03602532.2016.1257021. Epub 2016 Nov 22. Review.

PMID:
27819488
19.

Repurposing Resveratrol and Fluconazole To Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism.

El-Sherbeni AA, El-Kadi AO.

Mol Pharm. 2016 Apr 4;13(4):1278-88. doi: 10.1021/acs.molpharmaceut.5b00873. Epub 2016 Mar 10.

PMID:
26918316
20.

Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.

Anwar-Mohamed A, El-Sherbeni AA, Hamdy DA, Korashy HM, Brocks DR, El-Kadi AO.

J Pharm Sci. 2016 Mar;105(3):1318-26. doi: 10.1016/j.xphs.2015.12.009. Epub 2016 Feb 6.

PMID:
26886340
21.

CYP1B1 inhibition attenuates doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism.

Maayah ZH, Althurwi HN, Abdelhamid G, Lesyk G, Jurasz P, El-Kadi AO.

Pharmacol Res. 2016 Mar;105:28-43. doi: 10.1016/j.phrs.2015.12.016. Epub 2016 Jan 6.

PMID:
26772815
22.

The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy.

Maayah ZH, El-Kadi AO.

Arch Toxicol. 2016 Jan;90(1):119-36. doi: 10.1007/s00204-015-1620-8. Epub 2015 Nov 2. Review.

PMID:
26525395
23.
24.

19-Hydroxyeicosatetraenoic acid and isoniazid protect against angiotensin II-induced cardiac hypertrophy.

Elkhatali S, El-Sherbeni AA, Elshenawy OH, Abdelhamid G, El-Kadi AO.

Toxicol Appl Pharmacol. 2015 Dec 15;289(3):550-9. doi: 10.1016/j.taap.2015.10.003. Epub 2015 Oct 8.

PMID:
26454030
25.

Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies.

Elshenawy OH, El-Kadi AO.

Toxicol Lett. 2015 Oct 1;238(1):17-31. doi: 10.1016/j.toxlet.2015.06.1646. Epub 2015 Jul 2.

PMID:
26144063
26.

Correction: the tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.

Gordon M, El-Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, Mohamed A, El-Kadi AO, Liu L, Odenbach J, Thiesen A, Onyskiw C, Ghazaleh HA, Park J, Lee SB, Yu VC, Fernandez-Patron C, Alexander RT, Wine E, Baksh S.

PLoS One. 2015 Jun 24;10(6):e0131150. doi: 10.1371/journal.pone.0131150. eCollection 2015. No abstract available.

27.

Modulation of aryl hydrocarbon receptor regulated genes by acute administration of trimethylarsine oxide in the lung, kidney and heart of C57BL/6 mice.

Elshenawy OH, El-Kadi AO.

Xenobiotica. 2015;45(10):930-43. doi: 10.3109/00498254.2015.1032385. Epub 2015 Jun 4.

PMID:
26042454
28.

Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.

Althurwi HN, Maayah ZH, Elshenawy OH, El-Kadi AO.

Drug Metab Dispos. 2015 Aug;43(8):1254-66. doi: 10.1124/dmd.115.063776. Epub 2015 Jun 1.

PMID:
26033621
29.

Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.

Maayah ZH, Ghebeh H, Alhaider AA, El-Kadi AO, Soshilov AA, Denison MS, Ansari MA, Korashy HM.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):217-26. doi: 10.1016/j.taap.2015.02.007. Epub 2015 Feb 17.

PMID:
25697376
31.
32.

Human fetal ventricular cardiomyocyte, RL-14 cell line, is a promising model to study drug metabolizing enzymes and their associated arachidonic acid metabolites.

Maayah ZH, Elshenawy OH, Althurwi HN, Abdelhamid G, El-Kadi AO.

J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:33-41. doi: 10.1016/j.vascn.2014.11.005. Epub 2014 Nov 29.

PMID:
25454080
33.

Design and synthesis of resveratrol-salicylate hybrid derivatives as CYP1A1 inhibitors.

Aldawsari FS, Elshenawy OH, El Gendy MA, Aguayo-Ortiz R, Baksh S, El-Kadi AO, Velázquez-Martínez CA.

J Enzyme Inhib Med Chem. 2015 Dec;30(6):884-95. doi: 10.3109/14756366.2014.979347. Epub 2014 Nov 19.

PMID:
25407017
34.

The role of epoxide hydrolases in health and disease.

El-Sherbeni AA, El-Kadi AO.

Arch Toxicol. 2014 Nov;88(11):2013-32. doi: 10.1007/s00204-014-1371-y. Epub 2014 Sep 24. Review.

PMID:
25248500
35.

Acute arsenic treatment alters arachidonic acid and its associated metabolite levels in the brain of C57Bl/6 mice.

Anwar-Mohamed A, Elshenawy OH, El-Sherbeni AA, Abdelrady M, El-Kadi AO.

Can J Physiol Pharmacol. 2014 Aug;92(8):693-702. doi: 10.1139/cjpp-2014-0136.

PMID:
25065748
36.

Characterization of arachidonic acid metabolism by rat cytochrome P450 enzymes: the involvement of CYP1As.

El-Sherbeni AA, El-Kadi AO.

Drug Metab Dispos. 2014 Sep;42(9):1498-507. doi: 10.1124/dmd.114.057836. Epub 2014 Jun 26.

PMID:
24969701
37.

Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling.

Hamann I, Petroll K, Hou X, Anwar-Mohamed A, El-Kadi AO, Klotz LO.

Biometals. 2014 Apr;27(2):317-32. doi: 10.1007/s10534-014-9714-y. Epub 2014 Feb 18.

PMID:
24535192
38.

Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro.

Brocks DR, Chaudhary HR, Ben-Eltriki M, Elsherbiny ME, El-Kadi AO.

Can J Physiol Pharmacol. 2014 Feb;92(2):140-8. doi: 10.1139/cjpp-2013-0250.

PMID:
24502637
39.

Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.

Amara IE, Elshenawy OH, Abdelrady M, El-Kadi AO.

Toxicol Lett. 2014 Apr 7;226(1):53-62. doi: 10.1016/j.toxlet.2014.01.025. Epub 2014 Jan 25.

PMID:
24472606
40.

Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy.

El-Sherbeni AA, El-Kadi AO.

Biochem Pharmacol. 2014 Feb 1;87(3):456-66. doi: 10.1016/j.bcp.2013.11.015. Epub 2013 Dec 1.

PMID:
24300133
41.

Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms.

Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison MS, Chris Le X, Klotz LO, El-Kadi AO.

Free Radic Biol Med. 2014 Feb;67:171-87. doi: 10.1016/j.freeradbiomed.2013.10.810. Epub 2013 Oct 24.

PMID:
24161444
42.

Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.

Althurwi HN, Elshenawy OH, El-Kadi AO.

J Cardiovasc Pharmacol. 2014 Feb;63(2):167-77. doi: 10.1097/FJC.0000000000000036.

PMID:
24157956
43.

The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.

Gordon M, El-Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, Anwar-Mohamed A, El-Kadi AO, Liu L, Odenbach J, Thiesen A, Onyskiw C, Ghazaleh HA, Park J, Lee SB, Yu VC, Fernandez-Patron C, Alexander RT, Wine E, Baksh S.

PLoS One. 2013 Oct 16;8(10):e75483. doi: 10.1371/journal.pone.0075483. eCollection 2013. Erratum in: PLoS One. 2015;10(2):e0118034. PLoS One. 2015;10(6):e0131150. PLoS One. 2014;9(1). doi:10.1371/annotation/0ed852a0-eb39-4a28-986f-81f28d870747. Mohamed, Anwar [corrected to Anwar-Mohamed, Anwar].

44.

A rapid and sensitive HPLC assay of some concomitant anti-migraine drugs.

Rezk MR, Michael AM, Lotfy HM, El-Kadi AO, Shehata MA.

J Chromatogr Sci. 2014 Aug;52(7):704-6. doi: 10.1093/chromsci/bmt103. Epub 2013 Jul 11.

PMID:
23845885
45.

20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases.

Elshenawy OH, Anwar-Mohamed A, El-Kadi AO.

Curr Drug Metab. 2013 Jul;14(6):706-19. Review.

PMID:
23701160
46.

Effects of growth hormone and ultrasound on mandibular growth in rats: MicroCT and toxicity analyses.

Khan I, El-Kadi AO, El-Bialy T.

Arch Oral Biol. 2013 Sep;58(9):1217-24. doi: 10.1016/j.archoralbio.2013.03.018. Epub 2013 Apr 29.

PMID:
23639226
47.

Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy.

Alsaad AM, Zordoky BN, Tse MM, El-Kadi AO.

Drug Metab Rev. 2013 May;45(2):173-95. doi: 10.3109/03602532.2012.754460. Review.

PMID:
23600686
48.

Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: a role of heme oxygenase-1.

Amara IE, Anwar-Mohamed A, El-Kadi AO.

Toxicol Lett. 2013 Jun 7;219(3):239-47. doi: 10.1016/j.toxlet.2013.03.018. Epub 2013 Mar 26.

PMID:
23541843
49.

Harmine and harmaline downregulate TCDD-induced Cyp1a1 in the livers and lungs of C57BL/6 mice.

El Gendy MA, El-Kadi AO.

Biomed Res Int. 2013;2013:258095. doi: 10.1155/2013/258095. Epub 2012 Dec 20.

50.

Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line.

Tse MM, Aboutabl ME, Althurwi HN, Elshenawy OH, Abdelhamid G, El-Kadi AO.

Vascul Pharmacol. 2013 May-Jun;58(5-6):363-73. doi: 10.1016/j.vph.2013.02.004. Epub 2013 Mar 1.

PMID:
23466634

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