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GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice.

Zhao Y, Haney MJ, Jin YS, Uvarov O, Vinod N, Lee YZ, Langworthy B, Fine JP, Rodriguez M, El-Hage N, Kabanov AV, Batrakova EV.

J Control Release. 2019 Oct 31;315:139-149. doi: 10.1016/j.jconrel.2019.10.027. [Epub ahead of print]


Selective Disruption of the Blood-Brain Barrier by Zika Virus.

Leda AR, Bertrand L, Andras IE, El-Hage N, Nair M, Toborek M.

Front Microbiol. 2019 Sep 18;10:2158. doi: 10.3389/fmicb.2019.02158. eCollection 2019.


Purification of High Yield Extracellular Vesicle Preparations Away from Virus.

DeMarino C, Barclay RA, Pleet ML, Pinto DO, Branscome H, Paul S, Lepene B, El-Hage N, Kashanchi F.

J Vis Exp. 2019 Sep 12;(151). doi: 10.3791/59876.


Stem Cell Extracellular Vesicles and their Potential to Contribute to the Repair of Damaged CNS Cells.

Branscome H, Paul S, Khatkar P, Kim Y, Barclay RA, Pinto DO, Yin D, Zhou W, Liotta LA, El-Hage N, Kashanchi F.

J Neuroimmune Pharmacol. 2019 Jul 24. doi: 10.1007/s11481-019-09865-y. [Epub ahead of print]


Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes.

Rodriguez M, Lapierre J, Ojha CR, Pawitwar S, Karuppan MKM, Kashanchi F, El-Hage N.

J Neurovirol. 2019 Apr;25(2):263-274. doi: 10.1007/s13365-018-0715-4. Epub 2019 Feb 11.


Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes.

Ojha CR, Rodriguez M, Karuppan MKM, Lapierre J, Kashanchi F, El-Hage N.

PLoS One. 2019 Feb 8;14(2):e0208543. doi: 10.1371/journal.pone.0208543. eCollection 2019.


Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time.

Pleet ML, Branscome H, DeMarino C, Pinto DO, Zadeh MA, Rodriguez M, Sariyer IK, El-Hage N, Kashanchi F.

Front Cell Infect Microbiol. 2018 Oct 18;8:362. doi: 10.3389/fcimb.2018.00362. eCollection 2018. Review.


Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus.

Ojha CR, Rodriguez M, Lapierre J, Muthu Karuppan MK, Branscome H, Kashanchi F, El-Hage N.

Front Immunol. 2018 Oct 15;9:2340. doi: 10.3389/fimmu.2018.02340. eCollection 2018. Review.


Publisher Correction: Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells.

DeMarino C, Pleet ML, Cowen M, Barclay RA, Akpamagbo Y, Erickson J, Ndembi N, Charurat M, Jumare J, Bwala S, Alabi P, Hogan M, Gupta A, Noren Hooten N, Evans MK, Lepene B, Zhou W, Caputi M, Romerio F, Royal W 3rd, El-Hage N, Liotta LA, Kashanchi F.

Sci Rep. 2018 Sep 19;8(1):14303. doi: 10.1038/s41598-018-32120-y.


Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis.

Tiwari S, Lapierre J, Ojha CR, Martins K, Parira T, Dutta RK, Caobi A, Garbinski L, Ceyhan Y, Esteban-Lopez M, El-Hage N.

J Neurosci Res. 2018 Dec;96(12):1831-1846. doi: 10.1002/jnr.24322. Epub 2018 Sep 11. Review.


Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells.

DeMarino C, Pleet ML, Cowen M, Barclay RA, Akpamagbo Y, Erickson J, Ndembi N, Charurat M, Jumare J, Bwala S, Alabi P, Hogan M, Gupta A, Noren Hooten N, Evans MK, Lepene B, Zhou W, Caputi M, Romerio F, Royal W 3rd, El-Hage N, Liotta LA, Kashanchi F.

Sci Rep. 2018 May 16;8(1):7653. doi: 10.1038/s41598-018-25943-2. Erratum in: Sci Rep. 2018 Sep 19;8(1):14303.


Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse.

Lapierre J, Rodriguez M, Ojha CR, El-Hage N.

J Neuroimmune Pharmacol. 2018 Sep;13(3):355-370. doi: 10.1007/s11481-018-9788-3. Epub 2018 May 11.


Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation.

Rodriguez M, Lapierre J, Ojha CR, Kaushik A, Batrakova E, Kashanchi F, Dever SM, Nair M, El-Hage N.

Sci Rep. 2018 Mar 14;8(1):4778. doi: 10.1038/s41598-018-23078-y.


Frequency of arrhythmia symptoms and acceptability of implantable cardiac monitors in Hemodialysis patients.

El Hage N, Jaar BG, Cheng A, Knight C, Blasco-Colmenares E, Gimenez L, Guallar E, Shafi T.

BMC Nephrol. 2017 Oct 10;18(1):309. doi: 10.1186/s12882-017-0740-1.


Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes.

Rodriguez M, Lapierre J, Ojha CR, Estrada-Bueno H, Dever SM, Gewirtz DA, Kashanchi F, El-Hage N.

Viruses. 2017 Jul 28;9(8). pii: E201. doi: 10.3390/v9080201.


Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications.

Ojha CR, Lapierre J, Rodriguez M, Dever SM, Zadeh MA, DeMarino C, Pleet ML, Kashanchi F, El-Hage N.

Viruses. 2017 Jul 6;9(7). pii: E176. doi: 10.3390/v9070176. Review.


HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency.

Akpamagbo YA, DeMarino C, Pleet ML, Schwab A, Rodriguez M, Barclay RA, Sampey G, Iordanskiy S, El-Hage N, Kashanchi F.

Curr Pharm Des. 2017;23(28):4133-4144. doi: 10.2174/1381612823666170622101319. Review.


Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation.

Rodriguez M, Lapierre J, Ojha CR, Kaushik A, Batrakova E, Kashanchi F, Dever SM, Nair M, El-Hage N.

Sci Rep. 2017 May 12;7(1):1862. doi: 10.1038/s41598-017-01819-9. Erratum in: Sci Rep. 2018 Mar 14;8(1):4778.


Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research.

Pawitwar SS, Dhar S, Tiwari S, Ojha CR, Lapierre J, Martins K, Rodzinski A, Parira T, Paudel I, Li J, Dutta RK, Silva MR, Kaushik A, El-Hage N.

J Neuroimmune Pharmacol. 2017 Sep;12(3):371-388. doi: 10.1007/s11481-017-9743-8. Epub 2017 Apr 25. Review.


Electrochemical Biosensors for Early Stage Zika Diagnostics.

Kaushik A, Tiwari S, Jayant RD, Vashist A, Nikkhah-Moshaie R, El-Hage N, Nair M.

Trends Biotechnol. 2017 Apr;35(4):308-317. doi: 10.1016/j.tibtech.2016.10.001. Epub 2016 Oct 26. Review.


Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.

Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zhou JZ, El-Hage NG, Deng J, Lin J, Yao F, Dewar RS 3rd, Jassal JS, Sandberg ML, Dai J, Cols M, Shen C, Polin LA, Nichols RA, Jones TB, Bluth MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei WZ, Cerutti A, Colonna M, Chen K.

Nat Med. 2017 Jan;23(1):128-135. doi: 10.1038/nm.4244. Epub 2016 Dec 5.


Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections.

Ojha CR, Rodriguez M, Dever SM, Mukhopadhyay R, El-Hage N.

J Biomed Sci. 2016 Oct 26;23(1):74. Review.


Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization.

Arnatt CK, Falls BA, Yuan Y, Raborg TJ, Masvekar RR, El-Hage N, Selley DE, Nicola AV, Knapp PE, Hauser KF, Zhang Y.

Bioorg Med Chem. 2016 Nov 15;24(22):5969-5987. doi: 10.1016/j.bmc.2016.09.059. Epub 2016 Sep 26.


Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain.

Sagar V, Atluri VSR, Tomitaka A, Shah P, Nagasetti A, Pilakka-Kanthikeel S, El-Hage N, McGoron A, Takemura Y, Nair M.

Sci Rep. 2016 Jul 28;6:29792. doi: 10.1038/srep29792.


Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection.

DeMarino C, Schwab A, Pleet M, Mathiesen A, Friedman J, El-Hage N, Kashanchi F.

J Neuroimmune Pharmacol. 2017 Mar;12(1):31-50. doi: 10.1007/s11481-016-9692-7. Epub 2016 Jul 2. Review.


Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro.

Rodriguez M, Kaushik A, Lapierre J, Dever SM, El-Hage N, Nair M.

J Neuroimmune Pharmacol. 2017 Mar;12(1):120-132. doi: 10.1007/s11481-016-9688-3. Epub 2016 Jun 10.


Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers.

Kaushik A, Jayant RD, Nikkhah-Moshaie R, Bhardwaj V, Roy U, Huang Z, Ruiz A, Yndart A, Atluri V, El-Hage N, Khalili K, Nair M.

Sci Rep. 2016 May 4;6:25309. doi: 10.1038/srep25309.


Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA.

Sampey GC, Saifuddin M, Schwab A, Barclay R, Punya S, Chung MC, Hakami RM, Zadeh MA, Lepene B, Klase ZA, El-Hage N, Young M, Iordanskiy S, Kashanchi F.

J Biol Chem. 2016 Jan 15;291(3):1251-66. doi: 10.1074/jbc.M115.662171. Epub 2015 Nov 9.


Fluorescently-labeled RNA packaging into HIV-1 particles: Direct examination of infectivity across central nervous system cell types.

Xu R, El-Hage N, Dever SM.

J Virol Methods. 2015 Nov;224:20-9. doi: 10.1016/j.jviromet.2015.07.023. Epub 2015 Aug 10.


Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure.

Dever SM, Rodriguez M, Lapierre J, Costin BN, El-Hage N.

Front Microbiol. 2015 Jul 6;6:653. doi: 10.3389/fmicb.2015.00653. eCollection 2015.


HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation.

Samikkannu T, Ranjith D, Rao KV, Atluri VS, Pimentel E, El-Hage N, Nair MP.

Front Microbiol. 2015 Jun 23;6:614. doi: 10.3389/fmicb.2015.00614. eCollection 2015.


Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.

Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M.

Virology. 2015 Sep;483:185-202. doi: 10.1016/j.virol.2015.03.036. Epub 2015 May 15.


Opiate addiction therapies and HIV-1 Tat: interactive effects on glial [Ca²⁺]i, oxyradical and neuroinflammatory chemokine production and correlative neurotoxicity.

Fitting S, Zou S, El-Hage N, Suzuki M, Paris JJ, Schier CJ, Rodríguez JW, Rodriguez M, Knapp PE, Hauser KF.

Curr HIV Res. 2014;12(6):424-34.


GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity.

Masvekar RR, El-Hage N, Hauser KF, Knapp PE.

Mol Cell Neurosci. 2015 Mar;65:11-20. doi: 10.1016/j.mcn.2015.01.001. Epub 2015 Jan 20.


HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse.

El-Hage N, Rodriguez M, Dever SM, Masvekar RR, Gewirtz DA, Shacka JJ.

J Virol. 2015 Jan 15;89(2):1024-35. doi: 10.1128/JVI.02022-14. Epub 2014 Oct 29.


Effects of HIV-1 Tat on enteric neuropathogenesis.

Ngwainmbi J, De DD, Smith TH, El-Hage N, Fitting S, Kang M, Dewey WL, Hauser KF, Akbarali HI.

J Neurosci. 2014 Oct 22;34(43):14243-51. doi: 10.1523/JNEUROSCI.2283-14.2014.


Morphine enhances HIV-1SF162-mediated neuron death and delays recovery of injured neurites.

Masvekar RR, El-Hage N, Hauser KF, Knapp PE.

PLoS One. 2014 Jun 20;9(6):e100196. doi: 10.1371/journal.pone.0100196. eCollection 2014.


Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.

El-Hage N, Rodriguez M, Podhaizer EM, Zou S, Dever SM, Snider SE, Knapp PE, Beardsley PM, Hauser KF.

AIDS. 2014 Jun 19;28(10):1409-19. doi: 10.1097/QAD.0000000000000291.


Differential expression of the alternatively spliced OPRM1 isoform μ-opioid receptor-1K in HIV-infected individuals.

Dever SM, Costin BN, Xu R, El-Hage N, Balinang J, Samoshkin A, O'Brien MA, McRae M, Diatchenko L, Knapp PE, Hauser KF.

AIDS. 2014 Jan 2;28(1):19-30. doi: 10.1097/QAD.0000000000000113.


A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-μ-opioid receptor interactions between human astroglia and microglia.

El-Hage N, Dever SM, Podhaizer EM, Arnatt CK, Zhang Y, Hauser KF.

AIDS. 2013 Sep 10;27(14):2181-90. doi: 10.1097/QAD.0b013e3283639804.


A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.

Yuan Y, Arnatt CK, El-Hage N, Dever SM, Jacob JC, Selley DE, Hauser KF, Zhang Y.

Medchemcomm. 2013 May 1;4(5):847-851.


Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia.

Zou S, Fitting S, Hahn YK, Welch SP, El-Hage N, Hauser KF, Knapp PE.

Brain. 2011 Dec;134(Pt 12):3616-31. doi: 10.1093/brain/awr281. Epub 2011 Nov 18.


Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain.

Podhaizer EM, Zou S, Fitting S, Samano KL, El-Hage N, Knapp PE, Hauser KF.

J Neuroimmune Pharmacol. 2012 Dec;7(4):877-91. doi: 10.1007/s11481-011-9326-z. Epub 2011 Nov 19.


Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death.

Suzuki M, El-Hage N, Zou S, Hahn YK, Sorrell ME, Sturgill JL, Conrad DH, Knapp PE, Hauser KF.

Mol Neurodegener. 2011 Nov 17;6:78. doi: 10.1186/1750-1326-6-78.


Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine.

El-Hage N, Podhaizer EM, Sturgill J, Hauser KF.

Immunol Invest. 2011;40(5):498-522. doi: 10.3109/08820139.2011.561904. Epub 2011 Mar 22.


PTEN gene silencing prevents HIV-1 gp120(IIIB)-induced degeneration of striatal neurons.

Zou S, El-Hage N, Podhaizer EM, Knapp PE, Hauser KF.

J Neurovirol. 2011 Feb;17(1):41-9. doi: 10.1007/s13365-010-0016-z. Epub 2011 Jan 14.


Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons.

Fitting S, Xu R, Bull C, Buch SK, El-Hage N, Nath A, Knapp PE, Hauser KF.

Am J Pathol. 2010 Sep;177(3):1397-410. doi: 10.2353/ajpath.2010.090945. Epub 2010 Jul 22.


Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription.

El-Hage N, Bruce-Keller AJ, Yakovleva T, Bazov I, Bakalkin G, Knapp PE, Hauser KF.

PLoS One. 2008;3(12):e4093. doi: 10.1371/journal.pone.0004093. Epub 2008 Dec 31.

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