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Effects of the Tobacco Carcinogens N'-Nitrosonornicotine and Dibenzo[a,l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue.

Guttenplan JB, Chen KM, Sun YW, Shalaby NAE, Kosinska W, Desai D, Gowda K, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2019 Sep 16;32(9):1893-1899. doi: 10.1021/acs.chemrestox.9b00257. Epub 2019 Sep 3.


Customized Prevention Trials Could Resolve the Controversy of the Effects of Omega-3 Fatty Acids on Cancer.

El-Bayoumy K, Manni A.

Nutr Cancer. 2019 Aug 13:1-4. doi: 10.1080/01635581.2019.1651348. [Epub ahead of print]


Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women.

Sun YW, Xu H, Benitez G, Chen KM, Stanley A, Stanley B, Zhu J, Thompson H, Manni A, El-Bayoumy K.

J Proteome Res. 2019 Sep 6;18(9):3461-3469. doi: 10.1021/acs.jproteome.9b00356. Epub 2019 Aug 14.


Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary.

Chen KM, Sun YW, Cooper TK, Benitez G, Aliaga C, Zhu J, Gowda K, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2018 Nov 19;31(11):1111-1118. doi: 10.1021/acs.chemrestox.8b00152. Epub 2018 Oct 12.


Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer.

Manni A, El-Bayoumy K, Thompson H.

Int J Mol Sci. 2017 Dec 22;19(1). pii: E28. doi: 10.3390/ijms19010028. Review.


Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity.

Chen KM, Guttenplan JB, Sun YW, Cooper T, Shalaby NAE, Kosinska W, Benitez G, Aliaga C, Zhu J, Liao J, Gowda K, Amin S, Stoner G, El-Bayoumy K.

Cancer Prev Res (Phila). 2018 Mar;11(3):157-164. doi: 10.1158/1940-6207.CAPR-17-0278. Epub 2017 Nov 20.


Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice.

Chen KM, Schell TD, Richie JP Jr, Sun YW, Zhang SM, Calcagnotto A, Aliaga C, Gowda K, Amin S, El-Bayoumy K.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017 Oct 2;35(4):213-222. doi: 10.1080/10590501.2017.1391514. Epub 2017 Dec 4.


Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene.

Sun YW, Chen KM, Imamura Kawasawa Y, Salzberg AC, Cooper TK, Caruso C, Aliaga C, Zhu J, Gowda K, Amin S, El-Bayoumy K.

PLoS One. 2017 Oct 26;12(10):e0186873. doi: 10.1371/journal.pone.0186873. eCollection 2017.


Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts.

Guttenplan JB, Chen KM, Sun YW, Lajara B, Shalaby NAE, Kosinska W, Benitez G, Gowda K, Amin S, Stoner G, El-Bayoumy K.

Chem Res Toxicol. 2017 Dec 18;30(12):2159-2164. doi: 10.1021/acs.chemrestox.7b00242. Epub 2017 Nov 15.


Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women.

Manni A, Richie JP, Schetter SE, Calcagnotto A, Trushin N, Aliaga C, El-Bayoumy K.

Eur J Clin Nutr. 2017 Jun;71(6):762-765. doi: 10.1038/ejcn.2016.273. Epub 2017 Feb 1.


Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry.

El-Bayoumy K, Chen KM, Zhang SM, Sun YW, Amin S, Stoner G, Guttenplan JB.

Chem Res Toxicol. 2017 Jan 17;30(1):126-144. doi: 10.1021/acs.chemrestox.6b00306. Epub 2016 Dec 2.


Do omega-3 fatty acids reduce the risk of breast cancer in postmenopausal obese women?

Manni A, El-Bayoumy K.

Expert Rev Endocrinol Metab. 2016 Sep;11(5):365-367. doi: 10.1080/17446651.2016.1220296. Epub 2016 Aug 10. No abstract available.


Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells.

Guttenplan JB, Chen KM, Sun YW, Kosinska W, Zhou Y, Kim SA, Sung Y, Gowda K, Amin S, Stoner GD, El-Bayoumy K.

Cancer Prev Res (Phila). 2016 Aug;9(8):704-12. doi: 10.1158/1940-6207.CAPR-16-0003. Epub 2016 Jun 7.


A novel biologically active acid stable liposomal formulation of docosahexaenoic acid in human breast cancer cell lines.

Skibinski CG, Das A, Chen KM, Liao J, Manni A, Kester M, El-Bayoumy K.

Chem Biol Interact. 2016 May 25;252:1-8. doi: 10.1016/j.cbi.2016.03.035. Epub 2016 Apr 1.


Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial.

Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Calcagnotto A, Trushin N, Aliaga C, Demers LM, El-Bayoumy K, Manni A.

Cancer Prev Res (Phila). 2016 Apr;9(4):275-82. doi: 10.1158/1940-6207.CAPR-15-0235. Epub 2015 Dec 29.


Combination of Antiestrogens and Omega-3 Fatty Acids for Breast Cancer Prevention.

Manni A, El-Bayoumy K, Skibinski CG, Thompson HJ, Santucci-Pereira J, Bidinotto LT, Russo J.

Biomed Res Int. 2015;2015:638645. doi: 10.1155/2015/638645. Epub 2015 Aug 3. Review.


Fish Oil Enhances T Cell Function and Tumor Infiltration and Is Correlated With a Cancer Prevention Effect in HER-2/neu But Not PyMT Transgenic Mice.

Turbitt WJ, Black AJ, Collins SD, Meng H, Xu H, Washington S, Aliaga C, El-Bayoumy K, Manni A, Rogers CJ.

Nutr Cancer. 2015;67(6):965-75. doi: 10.1080/01635581.2015.1060351. Epub 2015 Jul 30.


Proteomic profiling of human plasma identifies apolipoprotein E as being associated with smoking and a marker for squamous metaplasia of the lung.

Rice SJ, Liu X, Miller B, Joshi M, Zhu J, Caruso C, Gilbert C, Toth J, Reed M, Rassaei N, Das A, Barochia A, El-Bayoumy K, Belani CP.

Proteomics. 2015 Sep;15(18):3267-77. doi: 10.1002/pmic.201500029. Epub 2015 Jul 3.


Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice.

Sun YW, El-Bayoumy K, Aliaga C, Awad AS, Gowda K, Amin S, Chen KM.

Chem Res Toxicol. 2015 Jul 20;28(7):1427-33. doi: 10.1021/acs.chemrestox.5b00097. Epub 2015 Jun 11.


Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells.

Pogash TJ, El-Bayoumy K, Amin S, Gowda K, de Cicco RL, Barton M, Su Y, Russo IH, Himmelberger JA, Slifker M, Manni A, Russo J.

In Vitro Cell Dev Biol Anim. 2015 Feb;51(2):121-7. doi: 10.1007/s11626-014-9822-6. Epub 2014 Nov 21.


Genetic and environmental influences on plasma vitamin D binding protein concentrations.

Wilson RT, Bortner JD Jr, Roff A, Das A, Battaglioli EJ, Richie JP Jr, Barnholtz-Sloan J, Chinchilli VM, Berg A, Liu G, Salzberg AC, El-Bayoumy K.

Transl Res. 2015 Jun;165(6):667-76. doi: 10.1016/j.trsl.2014.08.003. Epub 2014 Aug 27.


Differential impact of body mass index on absolute and percent breast density: implications regarding their use as breast cancer risk biomarkers.

Schetter SE, Hartman TJ, Liao J, Richie JP, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Demers LM, El-Bayoumy K, Manni A.

Breast Cancer Res Treat. 2014 Jul;146(2):355-63. doi: 10.1007/s10549-014-3031-6. Epub 2014 Jun 21.


Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial.

Richie JP Jr, Das A, Calcagnotto AM, Sinha R, Neidig W, Liao J, Lengerich EJ, Berg A, Hartman TJ, Ciccarella A, Baker A, Kaag MG, Goodin S, DiPaola RS, El-Bayoumy K.

Cancer Prev Res (Phila). 2014 Aug;7(8):796-804. doi: 10.1158/1940-6207.CAPR-14-0042. Epub 2014 Jun 17.


Simultaneous detection of deoxyadenosine and deoxyguanosine adducts in the tongue and other oral tissues of mice treated with Dibenzo[a,l]pyrene.

Zhang SM, Chen KM, Sun YW, Aliaga C, Lin JM, Sharma AK, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2014 Jul 21;27(7):1199-206. doi: 10.1021/tx5001078. Epub 2014 Jun 17.


RE: Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial.

El-Bayoumy K, Thompson H, Manni A.

J Natl Cancer Inst. 2014 Apr;106(4):dju017. doi: 10.1093/jnci/dju017. Epub 2014 Mar 31. No abstract available.


Influence of omega-3 fatty acids on Tamoxifen-induced suppression of rat mammary carcinogenesis.

Manni A, Richie JP Jr, Xu H, Washington S, Aliaga C, Bruggeman R, Cooper TK, Prokopczyk B, Trushin N, Calcagnotto A, Das A, Liao J, El-Bayoumy K.

Int J Cancer. 2014 Apr 1;134(7):1549-57. doi: 10.1002/ijc.28490. Epub 2013 Oct 12.


Adenine-DNA adduct derived from the nitroreduction of 6-nitrochrysene is more resistant to nucleotide excision repair than guanine-DNA adducts.

Krzeminski J, Kropachev K, Reeves D, Kolbanovskiy A, Kolbanovskiy M, Chen KM, Sharma AK, Geacintov N, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2013 Nov 18;26(11):1746-54. doi: 10.1021/tx400296x. Epub 2013 Oct 30.


Proteomic changes induced by effective chemopreventive ratios of n-3:n-6 fatty acids and tamoxifen against MNU-induced mammary cancer in the rat.

Skibinski CG, Thompson HJ, Das A, Manni A, Bortner JD, Stanley A, Stanley BA, El-Bayoumy K.

Cancer Prev Res (Phila). 2013 Sep;6(9):979-88. doi: 10.1158/1940-6207.CAPR-13-0152. Epub 2013 Jul 23.


Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent.

Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, DelTondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K.

Int J Cancer. 2013 Sep 15;133(6):1300-9. doi: 10.1002/ijc.28152. Epub 2013 Apr 22.


Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat.

Sun YW, Guttenplan JB, Cooper T, Krzeminski J, Aliaga C, Boyiri T, Kosinska W, Zhao ZL, Chen KM, Berg A, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2013 Apr 15;26(4):547-54. doi: 10.1021/tx300478z. Epub 2013 Mar 28.


Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors.

Bidinotto LT, de Cicco RL, Vanegas JE, Santucci-Pereira J, Vanden Heuvel JP, Washington S, Aliaga C, Xu H, Russo IH, Manni A, El-Bayoumy K, Russo J.

Nutr Cancer. 2012;64(7):991-9. doi: 10.1080/01635581.2012.712736.


Changes in proteomic profiles in different prostate lobes of male rats throughout growth and development and aging stages of the life span.

Das A, Bortner JD Jr, Aliaga CA, Baker A, Stanley A, Stanley BA, Kaag M, Richie JP Jr, El-Bayoumy K.

Prostate. 2013 Mar;73(4):363-75. doi: 10.1002/pros.22576. Epub 2012 Aug 21.


Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial.

Signori C, DuBrock C, Richie JP, Prokopczyk B, Demers LM, Hamilton C, Hartman TJ, Liao J, El-Bayoumy K, Manni A.

Eur J Clin Nutr. 2012 Aug;66(8):878-84. doi: 10.1038/ejcn.2012.60. Epub 2012 Jun 6.


Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids.

Jiang W, Zhu Z, McGinley JN, El Bayoumy K, Manni A, Thompson HJ.

Cancer Res. 2012 Aug 1;72(15):3795-806. doi: 10.1158/0008-5472.CAN-12-1047. Epub 2012 May 31.


Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2.

Emmert SW, El-Bayoumy K, Das A, Sun YW, Amin S, Desai D, Aliaga C, Richie JP Jr.

Free Radic Biol Med. 2012 May 15;52(10):2064-71. doi: 10.1016/j.freeradbiomed.2012.03.018. Epub 2012 Apr 17.


Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes.

Trushin N, Alam S, El-Bayoumy K, Krzeminski J, Amin SG, Gullett J, Meyers C, Prokopczyk B.

J Carcinog. 2012;11:1. doi: 10.4103/1477-3163.92309. Epub 2012 Jan 27.


Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells.

Facompre ND, Sinha I, El-Bayoumy K, Pinto JT, Sinha R.

Int J Cancer. 2012 Nov 1;131(9):2134-42. doi: 10.1002/ijc.27468. Epub 2012 Mar 20.


Age related changes in selenium and glutathione levels in different lobes of the rat prostate.

Richie JP Jr, Das A, Calcagnotto AM, Aliaga CA, El-Bayoumy K.

Exp Gerontol. 2012 Mar;47(3):223-8. doi: 10.1016/j.exger.2011.11.015. Epub 2011 Dec 24.


Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse.

Chen KM, Zhang SM, Aliaga C, Sun YW, Cooper T, Gowdahalli K, Zhu J, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2012 Feb 20;25(2):374-80. doi: 10.1021/tx2004322. Epub 2012 Jan 6.


The effect of selenium enrichment on baker's yeast proteome.

El-Bayoumy K, Das A, Russell S, Wolfe S, Jordan R, Renganathan K, Loughran TP, Somiari R.

J Proteomics. 2012 Jan 4;75(3):1018-30. doi: 10.1016/j.jprot.2011.10.013. Epub 2011 Oct 29.


Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations.

Signori C, El-Bayoumy K, Russo J, Thompson HJ, Richie JP, Hartman TJ, Manni A.

Cancer Res. 2011 Oct 1;71(19):6091-6. doi: 10.1158/0008-5472.CAN-11-0977. Epub 2011 Sep 20. Review.


Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.

Manni A, Richie JP Jr, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K.

Int J Oncol. 2011 Nov;39(5):1153-64. doi: 10.3892/ijo.2011.1133. Epub 2011 Jul 20.


Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer.

Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, DelTondo J, Cooper T, Sun YW, Zhang SM, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K.

Int J Cancer. 2012 Jun 15;130(12):2783-90. doi: 10.1002/ijc.26344. Epub 2011 Nov 19.


Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat.

Zhu Z, Jiang W, McGinley JN, Prokopczyk B, Richie JP Jr, El Bayoumy K, Manni A, Thompson HJ.

Cancer Prev Res (Phila). 2011 Oct;4(10):1675-85. doi: 10.1158/1940-6207.CAPR-11-0175. Epub 2011 Aug 2.


The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice.

Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP Jr, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K.

Horm Cancer. 2011 Aug;2(4):249-59. doi: 10.1007/s12672-011-0078-2.


Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS.

Zhang SM, Chen KM, Aliaga C, Sun YW, Lin JM, Sharma AK, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2011 Aug 15;24(8):1297-303. doi: 10.1021/tx200188j. Epub 2011 Jul 19.


Association of selenium status and blood glutathione concentrations in blacks and whites.

Richie JP Jr, Muscat JE, Ellison I, Calcagnotto A, Kleinman W, El-Bayoumy K.

Nutr Cancer. 2011;63(3):367-75. doi: 10.1080/01635581.2011.535967.


Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking.

Bortner JD Jr, Richie JP Jr, Das A, Liao J, Umstead TM, Stanley A, Stanley BA, Belani CP, El-Bayoumy K.

J Proteome Res. 2011 Mar 4;10(3):1151-9. doi: 10.1021/pr100925p. Epub 2011 Feb 7.


Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene.

Krzeminski J, Kropachev K, Kolbanovskiy M, Reeves D, Kolbanovskiy A, Yun BH, Geacintov NE, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2011 Jan 14;24(1):65-72. doi: 10.1021/tx100284h. Epub 2010 Nov 29.


Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib.

Desai D, Kaushal N, Gandhi UH, Arner RJ, D'Souza C, Chen G, Vunta H, El-Bayoumy K, Amin S, Prabhu KS.

Chem Biol Interact. 2010 Dec 5;188(3):446-56. doi: 10.1016/j.cbi.2010.09.021. Epub 2010 Sep 29.

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