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Items: 37


Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.

LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, McClintick J, Witzmann FA, Winfree S, Phillips CL, Hato T, Dagher PC, Wu XR, El-Achkar TM, Micanovic R.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaaw3639. doi: 10.1126/scitranslmed.aaw3639.


Development and Validation of a Model to Predict Acute Kidney Injury in Hospitalized Patients With Cirrhosis.

Patidar KR, Xu C, Shamseddeen H, Cheng YW, Ghabril MS, Mukthinuthalapati VVPK, Fricker ZP, Akinyeye S, Nephew LD, Desai AP, Anderson M, El-Achkar TM, Chalasani NP, Orman ES.

Clin Transl Gastroenterol. 2019 Sep;10(9):e00075. doi: 10.14309/ctg.0000000000000075.


Admission plasma uromodulin and the risk of acute kidney injury in hospitalized patients with cirrhosis: a pilot study.

Patidar KR, Garimella PS, Macedo E, Slaven JE, Ghabril MS, Weber RE, Anderson M, Orman ES, Nephew LD, Desai AP, Chalasani NP, El-Achkar TM.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G447-G452. doi: 10.1152/ajpgi.00158.2019. Epub 2019 Aug 14.


Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis.

Micanovic R, LaFavers K, Garimella PS, Wu XR, El-Achkar TM.

Nephrol Dial Transplant. 2019 Jan 14. doi: 10.1093/ndt/gfy394. [Epub ahead of print]


Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.

Winfree S, Dagher PC, Dunn KW, Eadon MT, Ferkowicz M, Barwinska D, Kelly KJ, Sutton TA, El-Achkar TM.

Nephron. 2018;140(2):134-139. doi: 10.1159/000490006. Epub 2018 Jun 5. Review.


In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice.

Eadon MT, Cheng YH, Hato T, Benson EA, Ipe J, Collins KS, De Luca T, El-Achkar TM, Bacallao RL, Skaar TC, Dagher PC.

J Drug Deliv. 2017;2017:4070793. doi: 10.1155/2017/4070793. Epub 2017 Dec 20.


Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia.

Liu Y, Goldfarb DS, El-Achkar TM, Lieske JC, Wu XR.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1062-F1076. doi: 10.1152/ajprenal.00233.2017. Epub 2018 Jan 10.


Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Micanovic R, Khan S, Janosevic D, Lee ME, Hato T, Srour EF, Winfree S, Ghosh J, Tong Y, Rice SE, Dagher PC, Wu XR, El-Achkar TM.

J Am Soc Nephrol. 2018 Mar;29(3):841-856. doi: 10.1681/ASN.2017040409. Epub 2017 Nov 27.


Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

Ma L, Liu Y, Landry NK, El-Achkar TM, Lieske JC, Wu XR.

PLoS One. 2017 Nov 16;12(11):e0186769. doi: 10.1371/journal.pone.0186769. eCollection 2017.


Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney.

Hato T, Zollman A, Plotkin Z, El-Achkar TM, Maier BF, Pay SL, Dube S, Cabral P, Yoshimoto M, McClintick J, Dagher PC.

J Am Soc Nephrol. 2018 Jan;29(1):104-117. doi: 10.1681/ASN.2017060624. Epub 2017 Oct 10.


Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications.

Winfree S, Ferkowicz MJ, Dagher PC, Kelly KJ, Eadon MT, Sutton TA, Markel TA, Yoder MC, Dunn KW, El-Achkar TM.

Transl Res. 2017 Nov;189:1-12. doi: 10.1016/j.trsl.2017.07.006. Epub 2017 Jul 22. Review.


Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells.

Winfree S, Khan S, Micanovic R, Eadon MT, Kelly KJ, Sutton TA, Phillips CL, Dunn KW, El-Achkar TM.

J Am Soc Nephrol. 2017 Jul;28(7):2108-2118. doi: 10.1681/ASN.2016091027. Epub 2017 Feb 2.


Association of Preoperative Urinary Uromodulin with AKI after Cardiac Surgery.

Garimella PS, Jaber BL, Tighiouart H, Liangos O, Bennett MR, Devarajan P, El-Achkar TM, Sarnak MJ.

Clin J Am Soc Nephrol. 2017 Jan 6;12(1):10-18. doi: 10.2215/CJN.02520316. Epub 2016 Oct 26.


Tubular cross talk in acute kidney injury: a story of sense and sensibility.

El-Achkar TM, Dagher PC.

Am J Physiol Renal Physiol. 2015 Jun 15;308(12):F1317-23. doi: 10.1152/ajprenal.00030.2015. Epub 2015 Apr 15. Review.


Immunofluorescence laser micro-dissection of specific nephron segments in the mouse kidney allows targeted downstream proteomic analysis.

Micanovic R, Khan S, El-Achkar TM.

Physiol Rep. 2015 Feb 12;3(2). pii: e12306. doi: 10.14814/phy2.12306. Print 2015 Feb 1.


Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Micanovic R, Chitteti BR, Dagher PC, Srour EF, Khan S, Hato T, Lyle A, Tong Y, Wu XR, El-Achkar TM.

J Am Soc Nephrol. 2015 Sep;26(9):2172-82. doi: 10.1681/ASN.2014070664. Epub 2015 Jan 2.


The role of tumor necrosis factor alpha in regulating the expression of Tamm-Horsfall Protein (uromodulin) in thick ascending limbs during kidney injury.

Heitmeier M, McCracken R, Micanovic R, Khan S, El-Achkar TM.

Am J Nephrol. 2014;40(5):458-67. doi: 10.1159/000369836. Epub 2014 Dec 6.


Acute kidney injury after cardiac surgery: is minocycline protective?

Golestaneh L, Lindsey K, Malhotra P, Kargoli F, Farkas E, Barner H, Qazi R, Schmidt A, Rauchman M, Al-Aly Z, Johnson R, Martin K, Dagher P, Friedman A, El-Achkar TM.

J Nephrol. 2015 Apr;28(2):193-9. doi: 10.1007/s40620-014-0152-2. Epub 2014 Oct 28.


An intricate network of conserved DNA upstream motifs and associated transcription factors regulate the expression of uromodulin gene.

Srivastava R, Micanovic R, El-Achkar TM, Janga SC.

J Urol. 2014 Sep;192(3):981-9. doi: 10.1016/j.juro.2014.02.095. Epub 2014 Mar 1.


Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.

Hato T, El-Achkar TM, Dagher PC.

Am J Physiol Renal Physiol. 2013 May 15;304(10):F1243-51. doi: 10.1152/ajprenal.00101.2013. Epub 2013 Mar 20. Review.


Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury.

El-Achkar TM, McCracken R, Liu Y, Heitmeier MR, Bourgeois S, Ryerse J, Wu XR.

Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1066-75. doi: 10.1152/ajprenal.00543.2012. Epub 2013 Feb 6.


Modulation of apoptosis by ischemic preconditioning: an emerging role for miR-21.

El-Achkar TM.

Kidney Int. 2012 Dec;82(11):1149-51. doi: 10.1038/ki.2012.305.


Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap.

Liu Y, El-Achkar TM, Wu XR.

J Biol Chem. 2012 May 11;287(20):16365-78. doi: 10.1074/jbc.M112.348243. Epub 2012 Mar 27.


Uromodulin in kidney injury: an instigator, bystander, or protector?

El-Achkar TM, Wu XR.

Am J Kidney Dis. 2012 Mar;59(3):452-61. doi: 10.1053/j.ajkd.2011.10.054. Epub 2012 Jan 23. Review.


Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones.

Ma L, Liu Y, El-Achkar TM, Wu XR.

J Biol Chem. 2012 Jan 6;287(2):1290-305. doi: 10.1074/jbc.M111.283036. Epub 2011 Nov 22.


Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment.

Kalakeche R, Hato T, Rhodes G, Dunn KW, El-Achkar TM, Plotkin Z, Sandoval RM, Dagher PC.

J Am Soc Nephrol. 2011 Aug;22(8):1505-16. doi: 10.1681/ASN.2011020203. Epub 2011 Jul 22.


Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.

El-Achkar TM, McCracken R, Rauchman M, Heitmeier MR, Al-Aly Z, Dagher PC, Wu XR.

Am J Physiol Renal Physiol. 2011 Apr;300(4):F999-1007. doi: 10.1152/ajprenal.00621.2010. Epub 2011 Jan 12.


Early nephrologist involvement in hospital-acquired acute kidney injury: a pilot study.

Balasubramanian G, Al-Aly Z, Moiz A, Rauchman M, Zhang Z, Gopalakrishnan R, Balasubramanian S, El-Achkar TM.

Am J Kidney Dis. 2011 Feb;57(2):228-34. doi: 10.1053/j.ajkd.2010.08.026. Epub 2010 Dec 31.


Tumor necrosis factor-α blockade, cardiovascular outcomes, and survival in rheumatoid arthritis.

Al-Aly Z, Pan H, Zeringue A, Xian H, McDonald JR, El-Achkar TM, Eisen S.

Transl Res. 2011 Jan;157(1):10-8. doi: 10.1016/j.trsl.2010.09.005. Epub 2010 Oct 21.


Rate of kidney function decline associates with mortality.

Al-Aly Z, Zeringue A, Fu J, Rauchman MI, McDonald JR, El-Achkar TM, Balasubramanian S, Nurutdinova D, Xian H, Stroupe K, Abbott KC, Eisen S.

J Am Soc Nephrol. 2010 Nov;21(11):1961-9. doi: 10.1681/ASN.2009121210. Epub 2010 Oct 14.


Pathways of renal injury in systemic gram-negative sepsis.

El-Achkar TM, Hosein M, Dagher PC.

Eur J Clin Invest. 2008 Oct;38 Suppl 2:39-44. doi: 10.1111/j.1365-2362.2008.02007.x. Review.


Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression.

El-Achkar TM, Wu XR, Rauchman M, McCracken R, Kiefer S, Dagher PC.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F534-44. doi: 10.1152/ajprenal.00083.2008. Epub 2008 May 21.


Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent.

El-Achkar TM, Plotkin Z, Marcic B, Dagher PC.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1187-96. Epub 2007 Jul 18.


Renal Toll-like receptors: recent advances and implications for disease.

El-Achkar TM, Dagher PC.

Nat Clin Pract Nephrol. 2006 Oct;2(10):568-81. Review.


Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney.

El-Achkar TM, Huang X, Plotkin Z, Sandoval RM, Rhodes GJ, Dagher PC.

Am J Physiol Renal Physiol. 2006 May;290(5):F1034-43. Epub 2005 Dec 6.


Approach to acute renal failure with multiple myeloma: role of plasmapheresis.

El-Achkar TM, Sharfuddin AA, Dominguez J.

Ther Apher Dial. 2005 Oct;9(5):417-22.


Higher prevalence of anemia with diabetes mellitus in moderate kidney insufficiency: The Kidney Early Evaluation Program.

El-Achkar TM, Ohmit SE, McCullough PA, Crook ED, Brown WW, Grimm R, Bakris GL, Keane WF, Flack JM; Kidney Early Evaluation Program.

Kidney Int. 2005 Apr;67(4):1483-8.

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