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Items: 47

1.

Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.

Rozov A, Khusainov I, El Omari K, Duman R, Mykhaylyk V, Yusupov M, Westhof E, Wagner A, Yusupova G.

Nat Commun. 2019 Jun 7;10(1):2519. doi: 10.1038/s41467-019-10409-4.

2.

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus.

Ilca SL, Sun X, El Omari K, Kotecha A, de Haas F, DiMaio F, Grimes JM, Stuart DI, Poranen MM, Huiskonen JT.

Nature. 2019 Jun;570(7760):252-256. doi: 10.1038/s41586-019-1229-9. Epub 2019 May 29.

PMID:
31142835
3.

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.

El Omari K, Li S, Kotecha A, Walter TS, Bignon EA, Harlos K, Somerharju P, De Haas F, Clare DK, Molin M, Hurtado F, Li M, Grimes JM, Bamford DH, Tischler ND, Huiskonen JT, Stuart DI, Roine E.

Nat Commun. 2019 Feb 19;10(1):846. doi: 10.1038/s41467-019-08728-7.

4.

In-vitro evaluation of the antibacterial activity of the essential oils of Micromeria barbata, Eucalyptus globulus and Juniperus excelsa against strains of Mycobacterium tuberculosis (including MDR), Mycobacterium kansasii and Mycobacterium gordonae.

El Omari K, Hamze M, Alwan S, Osman M, Jama C, Chihib NE.

J Infect Public Health. 2019 Feb 6. pii: S1876-0341(19)30060-7. doi: 10.1016/j.jiph.2019.01.058. [Epub ahead of print]

5.

Anomalous X-ray diffraction studies of ion transport in K+ channels.

Langan PS, Vandavasi VG, Weiss KL, Afonine PV, El Omari K, Duman R, Wagner A, Coates L.

Nat Commun. 2018 Oct 31;9(1):4540. doi: 10.1038/s41467-018-06957-w.

6.

Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1.

Pryce R, Ng WM, Zeltina A, Watanabe Y, El Omari K, Wagner A, Bowden TA.

J Virol. 2018 Dec 10;93(1). pii: e01048-18. doi: 10.1128/JVI.01048-18. Print 2019 Jan 1.

7.

First Lebanese Antibiotic Awareness Week campaign: knowledge, attitudes and practices towards antibiotics.

Al Omari S, Al Mir H, Wrayde S, Merhabi S, Dhaybi I, Jamal S, Chahine M, Bayaa R, Tourba F, Tantawi H, Al Atrouni A, El Omari K, Ayash O, Zeidan NS, Mallat H, Dabboussi F, Hamze M, Osman M.

J Hosp Infect. 2019 Apr;101(4):475-479. doi: 10.1016/j.jhin.2018.07.009. Epub 2018 Sep 17.

PMID:
30012377
8.

Characterization and engineering of a plastic-degrading aromatic polyesterase.

Austin HP, Allen MD, Donohoe BS, Rorrer NA, Kearns FL, Silveira RL, Pollard BC, Dominick G, Duman R, El Omari K, Mykhaylyk V, Wagner A, Michener WE, Amore A, Skaf MS, Crowley MF, Thorne AW, Johnson CW, Woodcock HL, McGeehan JE, Beckham GT.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4350-E4357. doi: 10.1073/pnas.1718804115. Epub 2018 Apr 17.

9.

Timescales of water accumulation in magmas and implications for short warning times of explosive eruptions.

Petrelli M, El Omari K, Spina L, Le Guer Y, La Spina G, Perugini D.

Nat Commun. 2018 Feb 22;9(1):770. doi: 10.1038/s41467-018-02987-6.

10.

Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.

Esposito D, Günster RA, Martino L, El Omari K, Wagner A, Thurston TLM, Rittinger K.

J Biol Chem. 2018 Apr 6;293(14):5064-5078. doi: 10.1074/jbc.RA118.001796. Epub 2018 Feb 15.

11.

Long-wavelength macromolecular crystallography - First successful native SAD experiment close to the sulfur edge.

Aurelius O, Duman R, El Omari K, Mykhaylyk V, Wagner A.

Nucl Instrum Methods Phys Res B. 2017 Nov 15;411:12-16. doi: 10.1016/j.nimb.2016.12.005.

12.

Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.

Bountra K, Hagelueken G, Choudhury HG, Corradi V, El Omari K, Wagner A, Mathavan I, Zirah S, Yuan Wahlgren W, Tieleman DP, Schiemann O, Rebuffat S, Beis K.

EMBO J. 2017 Oct 16;36(20):3062-3079. doi: 10.15252/embj.201797278. Epub 2017 Sep 1.

13.

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Wittmann S, Renner M, Watts BR, Adams O, Huseyin M, Baejen C, El Omari K, Kilchert C, Heo DH, Kecman T, Cramer P, Grimes JM, Vasiljeva L.

Nat Commun. 2017 Apr 3;8:14861. doi: 10.1038/ncomms14861.

14.

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping.

Sun Z, El Omari K, Sun X, Ilca SL, Kotecha A, Stuart DI, Poranen MM, Huiskonen JT.

Nat Commun. 2017 Mar 13;8:14814. doi: 10.1038/ncomms14814.

15.

The crystal structure of human dopamine β-hydroxylase at 2.9 Å resolution.

Vendelboe TV, Harris P, Zhao Y, Walter TS, Harlos K, El Omari K, Christensen HE.

Sci Adv. 2016 Apr 8;2(4):e1500980. doi: 10.1126/sciadv.1500980. eCollection 2016 Apr.

16.

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling.

Zeev-Ben-Mordehai T, Weberruß M, Lorenz M, Cheleski J, Hellberg T, Whittle C, El Omari K, Vasishtan D, Dent KC, Harlos K, Franzke K, Hagen C, Klupp BG, Antonin W, Mettenleiter TC, Grünewald K.

Cell Rep. 2015 Dec 29;13(12):2645-52. doi: 10.1016/j.celrep.2015.11.008. Epub 2015 Dec 17.

17.

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.

Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S.

Mol Cell. 2016 Jan 7;61(1):125-37. doi: 10.1016/j.molcel.2015.11.016. Epub 2015 Dec 17.

18.

Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.

Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM.

EMBO J. 2015 Dec 2;34(23):2937-52. doi: 10.15252/embj.201592651. Epub 2015 Oct 28.

19.

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E.

Nature. 2015 Nov 5;527(7576):114-7. doi: 10.1038/nature15525. Epub 2015 Oct 26.

20.

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1.

El Omari K, Iourin O, Kadlec J, Sutton G, Harlos K, Grimes JM, Stuart DI.

Nat Commun. 2014 Sep 16;5:4874. doi: 10.1038/ncomms5874.

21.

Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1.

El Omari K, Iourin O, Kadlec J, Fearn R, Hall DR, Harlos K, Grimes JM, Stuart DI.

Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2197-203. doi: 10.1107/S139900471401339X. Epub 2014 Jul 25.

22.

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.

Sewell H, Tanaka T, El Omari K, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH.

Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643.

23.

Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution.

El Omari K, Meier C, Kainov D, Sutton G, Grimes JM, Poranen MM, Bamford DH, Tuma R, Stuart DI, Mancini EJ.

Nucleic Acids Res. 2013 Nov;41(20):9396-410. doi: 10.1093/nar/gkt713. Epub 2013 Aug 11.

24.

Plate tectonics of virus shell assembly and reorganization in phage φ8, a distant relative of mammalian reoviruses.

El Omari K, Sutton G, Ravantti JJ, Zhang H, Walter TS, Grimes JM, Bamford DH, Stuart DI, Mancini EJ.

Structure. 2013 Aug 6;21(8):1384-95. doi: 10.1016/j.str.2013.06.017. Epub 2013 Jul 25.

25.

Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets.

El Omari K, Hoosdally SJ, Tuladhar K, Karia D, Hall-Ponselé E, Platonova O, Vyas P, Patient R, Porcher C, Mancini EJ.

Cell Rep. 2013 Jul 11;4(1):135-47. doi: 10.1016/j.celrep.2013.06.008. Epub 2013 Jul 3.

26.

Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.

Nichols CE, Lamb HK, Thompson P, El Omari K, Lockyer M, Charles I, Hawkins AR, Stammers DK.

Protein Sci. 2013 May;22(5):628-40. doi: 10.1002/pro.2247. Epub 2013 Mar 26.

27.

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus.

Iourin O, Harlos K, El Omari K, Lu W, Kadlec J, Iqbal M, Meier C, Palmer A, Jones I, Thomas C, Brownlie J, Grimes JM, Stuart DI.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):35-8. doi: 10.1107/S1744309112049184. Epub 2012 Dec 15.

28.

Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry.

El Omari K, Iourin O, Harlos K, Grimes JM, Stuart DI.

Cell Rep. 2013 Jan 31;3(1):30-5. doi: 10.1016/j.celrep.2012.12.001. Epub 2012 Dec 27.

29.

Production and crystallization of the C-propeptide trimer from human procollagen III.

Bourhis JM, Mariano N, Zhao Y, Walter TS, El Omari K, Delolme F, Moali C, Hulmes DJ, Aghajari N.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1209-13. doi: 10.1107/S1744309112035294. Epub 2012 Sep 26.

30.

Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form.

El Omari K, Dhaliwal B, Ren J, Abrescia NG, Lockyer M, Powell KL, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1179-83. doi: 10.1107/S1744309111029228. Epub 2011 Sep 24.

31.

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome.

El Omari K, De Mesmaeker J, Karia D, Ginn H, Bhattacharya S, Mancini EJ.

Proteins. 2012 Feb;80(2):655-60. doi: 10.1002/prot.23208. Epub 2011 Nov 17. No abstract available.

PMID:
22095455
32.

Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.

Stamp AL, Owen P, El Omari K, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Proteins. 2011 Jul;79(7):2352-7. doi: 10.1002/prot.23060. Epub 2011 May 10. No abstract available.

PMID:
21560168
33.

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.

El Omari K, Hoosdally SJ, Tuladhar K, Karia D, Vyas P, Patient R, Porcher C, Mancini EJ.

Blood. 2011 Feb 17;117(7):2146-56. doi: 10.1182/blood-2010-07-293357. Epub 2010 Nov 12.

34.

Purification, crystallization and preliminary X-ray analysis of a fusion of the LIM domains of LMO2 and the LID domain of Ldb1.

El Omari K, Porcher C, Mancini EJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1466-9. doi: 10.1107/S1744309110032872. Epub 2010 Oct 28.

35.

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

Stamp AL, Owen P, El Omari K, Nichols CE, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Protein Sci. 2010 Oct;19(10):1897-905. doi: 10.1002/pro.475.

36.

Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein.

El Omari K, Scott K, Dhaliwal B, Ren J, Abrescia NG, Budworth J, Lockyer M, Powell KL, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1019-23. doi: 10.1107/S1744309108031059. Epub 2008 Oct 28.

37.

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.

Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S.

Genes Dev. 2008 Jun 1;22(11):1465-77. doi: 10.1101/gad.479408.

38.

The design and development of drugs acting against the smallpox virus.

El Omari K, Stammers DK.

Expert Opin Drug Discov. 2007 Sep;2(9):1263-72. doi: 10.1517/17460441.2.9.1263.

PMID:
23496133
39.

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

El Omari K, Solaroli N, Karlsson A, Balzarini J, Stammers DK.

BMC Struct Biol. 2006 Oct 24;6:22.

40.

Structure of Staphylococcus aureus guanylate monophosphate kinase.

El Omari K, Dhaliwal B, Lockyer M, Charles I, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 1;62(Pt 10):949-53. Epub 2006 Sep 19.

41.

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.

El Omari K, Bronckaers A, Liekens S, Pérez-Pérez MJ, Balzarini J, Stammers DK.

Biochem J. 2006 Oct 15;399(2):199-204.

42.

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.

Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers DK, Karlsson A.

J Biol Chem. 2006 Jul 14;281(28):19273-9. Epub 2006 May 15.

43.

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.

El Omari K, Liekens S, Bird LE, Balzarini J, Stammers DK.

Mol Pharmacol. 2006 Jun;69(6):1891-6. Epub 2006 Mar 23.

PMID:
16556772
44.

Molecular architecture and ligand recognition determinants for T4 RNA ligase.

El Omari K, Ren J, Bird LE, Bona MK, Klarmann G, LeGrice SF, Stammers DK.

J Biol Chem. 2006 Jan 20;281(3):1573-9. Epub 2005 Nov 1.

45.

[Ocular manifestation of Behçet disease (study of 50 patients consulting in dermatology department)].

Janati K, EL Omari K, Benchiki H, Hamdani M, Lakhdar H.

Rev Med Interne. 2005 Oct;26(10):771-6. Epub 2005 Aug 18. French.

PMID:
16169129
46.

Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.

El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK.

J Biol Chem. 2005 May 6;280(18):18229-36. Epub 2005 Feb 22.

47.

[Vulvar pathology].

Zouhair K, El Ouazzani T, El Omari K, El Fajri S, Lakhdar H.

East Mediterr Health J. 2002 Nov;8(6):812-8. French.

PMID:
15568459

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