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Items: 1 to 50 of 55

1.

Blocking negative effects of senescence in human skin fibroblasts with a plant extract.

Lämmermann I, Terlecki-Zaniewicz L, Weinmüllner R, Schosserer M, Dellago H, de Matos Branco AD, Autheried D, Sevcnikar B, Kleissl L, Berlin I, Morizot F, Lejeune F, Fuzzati N, Forestier S, Toribio A, Tromeur A, Weinberg L, Higareda Almaraz JC, Scheideler M, Rietveld M, El Ghalbzouri A, Tschachler E, Gruber F, Grillari J.

NPJ Aging Mech Dis. 2018 Apr 11;4:4. doi: 10.1038/s41514-018-0023-5. eCollection 2018.

2.

A shift from papillary to reticular fibroblasts enables tumour-stroma interaction and invasion.

Hogervorst M, Rietveld M, de Gruijl F, El Ghalbzouri A.

Br J Cancer. 2018 Apr;118(8):1089-1097. doi: 10.1038/s41416-018-0024-y. Epub 2018 Mar 19.

PMID:
29551776
3.

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function.

Niehues H, Bouwstra JA, El Ghalbzouri A, Brandner JM, Zeeuwen PLJM, van den Bogaard EH.

Exp Dermatol. 2018 May;27(5):501-511. doi: 10.1111/exd.13531. Epub 2018 Apr 6. Review.

PMID:
29518287
4.

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.

de Breij A, Riool M, Cordfunke RA, Malanovic N, de Boer L, Koning RI, Ravensbergen E, Franken M, van der Heijde T, Boekema BK, Kwakman PHS, Kamp N, El Ghalbzouri A, Lohner K, Zaat SAJ, Drijfhout JW, Nibbering PH.

Sci Transl Med. 2018 Jan 10;10(423). pii: eaan4044. doi: 10.1126/scitranslmed.aan4044. Erratum in: Sci Transl Med. 2018 Mar 21;10 (433):.

PMID:
29321257
5.

Recapitulation of Native Dermal Tissue in a Full-Thickness Human Skin Model Using Human Collagens.

Mieremet A, Rietveld M, van Dijk R, Bouwstra JA, El Ghalbzouri A.

Tissue Eng Part A. 2018 Jun;24(11-12):873-881. doi: 10.1089/ten.TEA.2017.0326. Epub 2017 Dec 21.

PMID:
29130419
6.

Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition.

Danso M, Boiten W, van Drongelen V, Gmelig Meijling K, Gooris G, El Ghalbzouri A, Absalah S, Vreeken R, Kezic S, van Smeden J, Lavrijsen S, Bouwstra J.

J Dermatol Sci. 2017 Oct;88(1):57-66. doi: 10.1016/j.jdermsci.2017.05.005. Epub 2017 May 18.

PMID:
28571749
7.

Differential effect of extracellular matrix derived from papillary and reticular fibroblasts on epidermal development in vitro.

Janson D, Rietveld M, Mahé C, Saintigny G, El Ghalbzouri A.

Eur J Dermatol. 2017 Jun 1;27(3):237-246. doi: 10.1684/ejd.2017.2984.

PMID:
28524059
8.

Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices.

Mieremet A, Rietveld M, Absalah S, van Smeden J, Bouwstra JA, El Ghalbzouri A.

PLoS One. 2017 Mar 23;12(3):e0174478. doi: 10.1371/journal.pone.0174478. eCollection 2017.

9.

Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces.

Haisma EM, Göblyös A, Ravensbergen B, Adriaans AE, Cordfunke RA, Schrumpf J, Limpens RW, Schimmel KJ, den Hartigh J, Hiemstra PS, Drijfhout JW, El Ghalbzouri A, Nibbering PH.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4063-72. doi: 10.1128/AAC.03001-15. Print 2016 Jul.

10.

Correction: Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model.

den Reijer PM, Haisma EM, Lemmens-den Toom NA, Willemse J, Koning RI, Demmers JA, Dekkers DH, Rijkers E, El Ghalbzouri A, Nibbering PH, van Wamel W.

PLoS One. 2016 Mar 24;11(3):e0152544. doi: 10.1371/journal.pone.0152544. eCollection 2016. No abstract available.

11.

Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model.

den Reijer PM, Haisma EM, Lemmens-den Toom NA, Willemse J, Koning RI, Demmers JA, Dekkers DH, Rijkers E, El Ghalbzouri A, Nibbering PH, van Wamel W.

PLoS One. 2016 Jan 7;11(1):e0145722. doi: 10.1371/journal.pone.0145722. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0152544. Koning, R A [corrected to Koning, R I].

12.

Biocompatibility of a fish scale-derived artificial cornea: Cytotoxicity, cellular adhesion and phenotype, and in vivo immunogenicity.

van Essen TH, van Zijl L, Possemiers T, Mulder AA, Zwart SJ, Chou CH, Lin CC, Lai HJ, Luyten GPM, Tassignon MJ, Zakaria N, El Ghalbzouri A, Jager MJ.

Biomaterials. 2016 Mar;81:36-45. doi: 10.1016/j.biomaterials.2015.11.015. Epub 2015 Dec 1.

PMID:
26717247
13.

Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements.

Thakoersing VS, van Smeden J, Boiten WA, Gooris GS, Mulder AA, Vreeken RJ, El Ghalbzouri A, Bouwstra JA.

Exp Dermatol. 2015 Sep;24(9):669-74. doi: 10.1111/exd.12740. Epub 2015 Jul 14.

PMID:
25939986
14.

Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro.

van Drongelen V, Danso MO, Out JJ, Mulder A, Lavrijsen AP, Bouwstra JA, El Ghalbzouri A.

Cell Tissue Res. 2015 Sep;361(3):789-97. doi: 10.1007/s00441-015-2162-3. Epub 2015 Mar 18.

PMID:
25776938
15.

Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents.

Danso MO, van Drongelen V, Mulder A, Gooris G, van Smeden J, El Ghalbzouri A, Bouwstra JA.

J Dermatol Sci. 2015 Feb;77(2):102-9. doi: 10.1016/j.jdermsci.2014.12.002. Epub 2014 Dec 30.

PMID:
25600661
16.

Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models.

van Drongelen V, Haisma EM, Out-Luiting JJ, Nibbering PH, El Ghalbzouri A.

Clin Exp Allergy. 2014 Dec;44(12):1515-24. doi: 10.1111/cea.12443.

PMID:
25352374
17.

In-vitro melanoma models: invasive growth is determined by dermal matrix and basement membrane.

Commandeur S, Sparks SJ, Chan HL, Gao L, Out JJ, Gruis NA, van Doorn R, El Ghalbzouri A.

Melanoma Res. 2014 Aug;24(4):305-14. doi: 10.1097/CMR.0000000000000079.

PMID:
24892959
18.

LL-37-derived peptides eradicate multidrug-resistant Staphylococcus aureus from thermally wounded human skin equivalents.

Haisma EM, de Breij A, Chan H, van Dissel JT, Drijfhout JW, Hiemstra PS, El Ghalbzouri A, Nibbering PH.

Antimicrob Agents Chemother. 2014 Aug;58(8):4411-9. doi: 10.1128/AAC.02554-14. Epub 2014 May 19.

19.

Barrier properties of an N/TERT-based human skin equivalent.

van Drongelen V, Danso MO, Mulder A, Mieremet A, van Smeden J, Bouwstra JA, El Ghalbzouri A.

Tissue Eng Part A. 2014 Nov;20(21-22):3041-9. doi: 10.1089/ten.TEA.2014.0011. Epub 2014 Aug 4.

20.

Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation.

Alloul-Ramdhani M, Tensen CP, El Ghalbzouri A.

Toxicol In Vitro. 2014 Aug;28(5):982-9. doi: 10.1016/j.tiv.2014.04.007. Epub 2014 May 1.

PMID:
24794257
21.

TGF-β1 induces differentiation of papillary fibroblasts to reticular fibroblasts in monolayer culture but not in human skin equivalents.

Janson D, Saintigny G, Zeypveld J, Mahé C, El Ghalbzouri A.

Eur J Dermatol. 2014 May-Jun;24(3):342-8. doi: 10.1684/ejd.2014.2312.

PMID:
24721636
22.

TNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents.

Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA.

J Invest Dermatol. 2014 Jul;134(7):1941-1950. doi: 10.1038/jid.2014.83. Epub 2014 Feb 11.

23.

Inflammatory and antimicrobial responses to methicillin-resistant Staphylococcus aureus in an in vitro wound infection model.

Haisma EM, Rietveld MH, de Breij A, van Dissel JT, El Ghalbzouri A, Nibbering PH.

PLoS One. 2013 Dec 10;8(12):e82800. doi: 10.1371/journal.pone.0082800. eCollection 2013.

24.

Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents.

van Drongelen V, Alloul-Ramdhani M, Danso MO, Mieremet A, Mulder A, van Smeden J, Bouwstra JA, El Ghalbzouri A.

Exp Dermatol. 2013 Dec;22(12):807-12. doi: 10.1111/exd.12271.

PMID:
24164439
25.

Effects of serially passaged fibroblasts on dermal and epidermal morphogenesis in human skin equivalents.

Janson D, Rietveld M, Willemze R, El Ghalbzouri A.

Biogerontology. 2013 Apr;14(2):131-40. doi: 10.1007/s10522-013-9416-9. Epub 2013 Mar 16.

PMID:
23504375
26.

Needle-free injection into skin and soft matter with highly focused microjets.

Tagawa Y, Oudalov N, El Ghalbzouri A, Sun C, Lohse D.

Lab Chip. 2013 Apr 7;13(7):1357-63. doi: 10.1039/c2lc41204g.

PMID:
23386257
27.

Papillary fibroblasts differentiate into reticular fibroblasts after prolonged in vitro culture.

Janson D, Saintigny G, Mahé C, El Ghalbzouri A.

Exp Dermatol. 2013 Jan;22(1):48-53. doi: 10.1111/exd.12069.

PMID:
23278894
28.

Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas.

Voskamp P, Bodmann CA, Koehl GE, Rebel HG, Van Olderen MG, Gaumann A, El Ghalbzouri A, Tensen CP, Bavinck JN, Willemze R, Geissler EK, De Gruijl FR.

Cancer Prev Res (Phila). 2013 Feb;6(2):129-38. doi: 10.1158/1940-6207.CAPR-12-0361. Epub 2012 Dec 11.

29.

Nature versus nurture: does human skin maintain its stratum corneum lipid properties in vitro?

Thakoersing VS, Danso MO, Mulder A, Gooris G, El Ghalbzouri A, Bouwstra JA.

Exp Dermatol. 2012 Nov;21(11):865-70. doi: 10.1111/exd.12031.

PMID:
23163653
30.

Epidermal growth factor receptor activation and inhibition in 3D in vitro models of normal skin and human cutaneous squamous cell carcinoma.

Commandeur S, van Drongelen V, de Gruijl FR, El Ghalbzouri A.

Cancer Sci. 2012 Dec;103(12):2120-6. doi: 10.1111/cas.12026. Epub 2012 Oct 26.

31.

Marine-derived nutrient improves epidermal and dermal structure and prolongs the life span of reconstructed human skin equivalents.

Rietveld M, Janson D, Siamari R, Vicanova J, Andersen MT, El Ghalbzouri A.

J Cosmet Dermatol. 2012 Sep;11(3):213-22. doi: 10.1111/j.1473-2165.2012.00631.x.

PMID:
22938006
32.

Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents.

Thakoersing VS, van Smeden J, Mulder AA, Vreeken RJ, El Ghalbzouri A, Bouwstra JA.

J Invest Dermatol. 2013 Jan;133(1):59-67. doi: 10.1038/jid.2012.262. Epub 2012 Aug 16.

33.

Different gene expression patterns in human papillary and reticular fibroblasts.

Janson DG, Saintigny G, van Adrichem A, Mahé C, El Ghalbzouri A.

J Invest Dermatol. 2012 Nov;132(11):2565-72. doi: 10.1038/jid.2012.192. Epub 2012 Jun 14.

34.

Three-dimensional human skin equivalent as a tool to study Acinetobacter baumannii colonization.

de Breij A, Haisma EM, Rietveld M, El Ghalbzouri A, van den Broek PJ, Dijkshoorn L, Nibbering PH.

Antimicrob Agents Chemother. 2012 May;56(5):2459-64. doi: 10.1128/AAC.05975-11. Epub 2012 Jan 30.

35.

Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset.

Voskamp P, Bodmann CA, Rebel HG, Koehl GE, Tensen CP, Bouwes Bavinck JN, El Ghalbzouri A, Van Kranen HJ, Willemze R, Geissler EK, De Gruijl FR.

Int J Cancer. 2012 Sep 15;131(6):1267-76. doi: 10.1002/ijc.27391. Epub 2012 Jan 27.

36.

Unraveling barrier properties of three different in-house human skin equivalents.

Thakoersing VS, Gooris GS, Mulder A, Rietveld M, El Ghalbzouri A, Bouwstra JA.

Tissue Eng Part C Methods. 2012 Jan;18(1):1-11. doi: 10.1089/ten.TEC.2011.0175. Epub 2011 Oct 18.

PMID:
21902617
37.

Functional characterization of cancer-associated fibroblasts of human cutaneous squamous cell carcinoma.

Commandeur S, Ho SH, de Gruijl FR, Willemze R, Tensen CP, El Ghalbzouri A.

Exp Dermatol. 2011 Sep;20(9):737-42. doi: 10.1111/j.1600-0625.2011.01305.x. Epub 2011 May 25.

PMID:
21615509
38.

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin.

Merregaert J, Van Langen J, Hansen U, Ponsaerts P, El Ghalbzouri A, Steenackers E, Van Ostade X, Sercu S.

J Biol Chem. 2010 Nov 26;285(48):37823-37. doi: 10.1074/jbc.M110.136408. Epub 2010 Sep 24.

39.

An in vitro three-dimensional model of primary human cutaneous squamous cell carcinoma.

Commandeur S, de Gruijl FR, Willemze R, Tensen CP, El Ghalbzouri A.

Exp Dermatol. 2009 Oct;18(10):849-56. doi: 10.1111/j.1600-0625.2009.00856.x. Epub 2009 Mar 12.

PMID:
19469895
40.

ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.

Sercu S, Lambeir AM, Steenackers E, El Ghalbzouri A, Geentjens K, Sasaki T, Oyama N, Merregaert J.

Matrix Biol. 2009 Apr;28(3):160-9. doi: 10.1016/j.matbio.2009.02.003. Epub 2009 Mar 9.

PMID:
19275936
41.

Replacement of animal-derived collagen matrix by human fibroblast-derived dermal matrix for human skin equivalent products.

El Ghalbzouri A, Commandeur S, Rietveld MH, Mulder AA, Willemze R.

Biomaterials. 2009 Jan;30(1):71-8. doi: 10.1016/j.biomaterials.2008.09.002. Epub 2008 Oct 5.

PMID:
18838164
42.

Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines.

El Ghalbzouri A, Siamari R, Willemze R, Ponec M.

Toxicol In Vitro. 2008 Aug;22(5):1311-20. doi: 10.1016/j.tiv.2008.03.012. Epub 2008 Apr 7.

PMID:
18474418
43.

Fibroblasts accelerate culturing of mucosal substitutes.

Rakhorst HA, Posthumus-Van Sluijs SJ, Tra WM, Van Neck JW, Van Osch GJ, Hovius SE, El Ghalbzouri A, Hofer SO.

Tissue Eng. 2006 Aug;12(8):2321-31.

PMID:
16968172
44.

Endothelial network formed with human dermal microvascular endothelial cells in autologous multicellular skin substitutes.

Ponec M, El Ghalbzouri A, Dijkman R, Kempenaar J, van der Pluijm G, Koolwijk P.

Angiogenesis. 2004;7(4):295-305. Epub 2005 May 9.

PMID:
15886873
45.
46.
47.

Human adipose tissue-derived cells delay re-epithelialization in comparison with skin fibroblasts in organotypic skin culture.

El-Ghalbzouri A, Van Den Bogaerdt AJ, Kempenaar J, Ponec M.

Br J Dermatol. 2004 Mar;150(3):444-54.

PMID:
15030326
48.

The use of PEGT/PBT as a dermal scaffold for skin tissue engineering.

El-Ghalbzouri A, Lamme EN, van Blitterswijk C, Koopman J, Ponec M.

Biomaterials. 2004 Jul;25(15):2987-96.

PMID:
14967531
49.

Differential expression of CRABP-II in fibroblasts derived from dermis and subcutaneous fat.

Van den Bogaerdt AJ, El Ghalbzouri A, Hensbergen PJ, Reijnen L, Verkerk M, Kroon-Smits M, Middelkoop E, Ulrich MM.

Biochem Biophys Res Commun. 2004 Mar 5;315(2):428-33.

PMID:
14766225
50.

Fibroblasts facilitate re-epithelialization in wounded human skin equivalents.

El Ghalbzouri A, Hensbergen P, Gibbs S, Kempenaar J, van der Schors R, Ponec M.

Lab Invest. 2004 Jan;84(1):102-12.

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