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Items: 1 to 50 of 144

1.

Targeting α1 inserted domain (I) of α1β1 integrin by Lebetin 2 from M. lebetina transmediterranea venom decreased tumorigenesis and angiogenesis.

Morjen M, Othman H, Abdelkafi-Koubaa Z, Messadi E, Jebali J, El Ayeb M, Abid NS, Luis J, Marrakchi N.

Int J Biol Macromol. 2018 Oct 1;117:790-799. doi: 10.1016/j.ijbiomac.2018.05.230. Epub 2018 Jun 2.

PMID:
29870815
2.

Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).

Bezine M, Maatoug S, Ben Khalifa R, Debbabi M, Zarrouk A, Wang Y, Griffiths WJ, Nury T, Samadi M, Vejux A, de Sèze J, Moreau T, Kharrat R, El Ayeb M, Lizard G.

Biochimie. 2018 Oct;153:56-69. doi: 10.1016/j.biochi.2018.02.008. Epub 2018 Feb 17.

PMID:
29462682
3.

Lipid Biomarkers in Alzheimer's Disease.

Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, Moreau T, Cherkaoui-Malki M, El Ayeb M, Nasser B, Hammami M, Lizard G.

Curr Alzheimer Res. 2018 Feb 22;15(4):303-312. doi: 10.2174/1567205014666170505101426. Review.

PMID:
28474568
4.

Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes.

Bezine M, Debbabi M, Nury T, Ben-Khalifa R, Samadi M, Cherkaoui-Malki M, Vejux A, Raas Q, de Sèze J, Moreau T, El-Ayeb M, Lizard G.

Chem Phys Lipids. 2017 Oct;207(Pt B):135-150. doi: 10.1016/j.chemphyslip.2017.03.006. Epub 2017 Mar 18.

PMID:
28322741
5.

The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein.

Jridi I, Catacchio I, Majdoub H, Shahbazzadeh D, El Ayeb M, Frassanito MA, Solimando AG, Ribatti D, Vacca A, Borchani L.

Toxicon. 2017 Feb;126:38-46. doi: 10.1016/j.toxicon.2016.12.001. Epub 2016 Dec 8.

PMID:
27940138
6.

Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.

Hassiki R, Labro AJ, Benlasfar Z, Vincke C, Somia M, El Ayeb M, Muyldermans S, Snyders DJ, Bouhaouala-Zahar B.

Int J Biol Macromol. 2016 Dec;93(Pt A):167-171. doi: 10.1016/j.ijbiomac.2016.06.031. Epub 2016 Jun 16.

PMID:
27320844
7.

Biochemical and monolayer characterization of Tunisian snake venom phospholipases.

Baîram D, Aissa I, Louati H, Othman H, Abdelkafi-Koubaa Z, Krayem N, El Ayeb M, Srairi-Abid N, Marrakchi N, Gargouri Y.

Int J Biol Macromol. 2016 Aug;89:640-6. doi: 10.1016/j.ijbiomac.2016.05.020. Epub 2016 May 7.

PMID:
27164498
8.

Interaction of a snake venom L-amino acid oxidase with different cell types membrane.

Abdelkafi-Koubaa Z, Aissa I, Morjen M, Kharrat N, El Ayeb M, Gargouri Y, Srairi-Abid N, Marrakchi N.

Int J Biol Macromol. 2016 Jan;82:757-64. doi: 10.1016/j.ijbiomac.2015.09.065. Epub 2015 Oct 9.

PMID:
26433175
9.

Hemilipin, a novel Hemiscorpius lepturus venom heterodimeric phospholipase A2, which inhibits angiogenesis in vitro and in vivo.

Jridi I, Catacchio I, Majdoub H, Shahbazeddah D, El Ayeb M, Frassanito MA, Ribatti D, Vacca A, Borchani L.

Toxicon. 2015 Oct;105:34-44. doi: 10.1016/j.toxicon.2015.08.022. Epub 2015 Sep 1.

PMID:
26335363
10.

AaTX1, from Androctonus australis scorpion venom: purification, synthesis and characterization in dopaminergic neurons.

Mlayah-Bellalouna S, Dufour M, Mabrouk K, Mejdoub H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N.

Toxicon. 2014 Dec 15;92:14-23. doi: 10.1016/j.toxicon.2014.09.005. Epub 2014 Sep 18.

PMID:
25240295
11.

PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis.

Morjen M, Honoré S, Bazaa A, Abdelkafi-Koubaa Z, Ellafi A, Mabrouk K, Kovacic H, El Ayeb M, Marrakchi N, Luis J.

Microvasc Res. 2014 Sep;95:149-56. doi: 10.1016/j.mvr.2014.08.006. Epub 2014 Aug 28.

PMID:
25173589
12.

A thermoactive L-amino acid oxidase from Cerastes cerastes snake venom: purification, biochemical and molecular characterization.

Abdelkafi-Koubaa Z, Jebali J, Othman H, Morjen M, Aissa I, Zouari-Kesentini R, Bazaa A, Ellefi AA, Majdoub H, Srairi-Abid N, Gargouri Y, El Ayeb M, Marrakchi N.

Toxicon. 2014 Oct;89:32-44. doi: 10.1016/j.toxicon.2014.06.020. Epub 2014 Jul 4.

PMID:
25009089
13.

Lebecin, a new C-type lectin like protein from Macrovipera lebetina venom with anti-tumor activity against the breast cancer cell line MDA-MB231.

Jebali J, Fakhfekh E, Morgen M, Srairi-Abid N, Majdoub H, Gargouri A, El Ayeb M, Luis J, Marrakchi N, Sarray S.

Toxicon. 2014 Aug;86:16-27. doi: 10.1016/j.toxicon.2014.04.010. Epub 2014 May 9.

PMID:
24814013
14.

[Snake Venom L-Amino Acid Oxidases potential biomedical applications].

Abdelkafi-Koubaa Z, Morjen M, Srairi-Abid N, El Ayeb M, Marrakchi N.

Arch Inst Pasteur Tunis. 2014;91(1-4):15-32. French.

PMID:
26402967
15.

[Snake venom Kunitz/BPTI family: Structure, classification and pharmacological potential].

Morjen M, Abdelkafi-Koubaa Z, Luis J, Othman H, Srairi-Abid N, El Ayeb M, Marrakchi N.

Arch Inst Pasteur Tunis. 2014;91(1-4):3-13. French.

PMID:
26402966
16.

Subtype-selective activation of K(v)7 channels by AaTXKβ₂₋₆₄, a novel toxin variant from the Androctonus australis scorpion venom.

Landoulsi Z, Miceli F, Palmese A, Amoresano A, Marino G, El Ayeb M, Taglialatela M, Benkhalifa R.

Mol Pharmacol. 2013 Nov;84(5):763-73. doi: 10.1124/mol.113.088971. Epub 2013 Sep 9.

PMID:
24019223
17.

The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.

Borchani L, Sassi A, Ben Gharsa H, Safra I, Shahbazzadeh D, Ben Lasfar Z, El Ayeb M.

Toxicon. 2013 Jun;68:30-9. doi: 10.1016/j.toxicon.2013.03.012. Epub 2013 Apr 2.

PMID:
23562369
18.

Antitumoral potential of Tunisian snake venoms secreted phospholipases A2.

Zouari-Kessentini R, Srairi-Abid N, Bazaa A, El Ayeb M, Luis J, Marrakchi N.

Biomed Res Int. 2013;2013:391389. doi: 10.1155/2013/391389. Epub 2013 Jan 31. Review.

19.

MMP inhibitors and cancer treatment trials, limitations and hopes for the future.

Tlatli R, El Ayeb M.

Arch Inst Pasteur Tunis. 2013;90(1-4):3-21. Review.

PMID:
26012207
20.

PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells.

Morjen M, Kallech-Ziri O, Bazaa A, Othman H, Mabrouk K, Zouari-Kessentini R, Sanz L, Calvete JJ, Srairi-Abid N, El Ayeb M, Luis J, Marrakchi N.

Matrix Biol. 2013 Jan;32(1):52-62. doi: 10.1016/j.matbio.2012.11.015. Epub 2012 Dec 20.

PMID:
23262217
21.

Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming.

Hmila I, Cosyns B, Tounsi H, Roosens B, Caveliers V, Abderrazek RB, Boubaker S, Muyldermans S, El Ayeb M, Bouhaouala-Zahar B, Lahoutte T.

Toxicol Appl Pharmacol. 2012 Oct 15;264(2):222-31. doi: 10.1016/j.taap.2012.07.033. Epub 2012 Aug 11.

PMID:
22968189
22.

Expression of a functional recombinant C-type lectin-like protein lebecetin in the human embryonic kidney cells.

Jebali J, Jeanneau C, Morjen M, Mathieu S, Bazaa A, El Ayeb M, Luis J, Gargouri A, Marrakchi N, el Battari A.

Biotechnol Prog. 2012 Nov-Dec;28(6):1560-5. doi: 10.1002/btpr.1632. Epub 2012 Oct 19.

PMID:
22961812
23.

Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice.

Heidarpour M, Ennaifer E, Ahari H, Srairi-Abid N, Borchani L, Khalili G, Amini H, Anvar AA, Boubaker S, El-Ayeb M, Shahbazzadeh D.

Toxicon. 2012 Mar 1;59(3):373-8. doi: 10.1016/j.toxicon.2011.12.011. Epub 2011 Dec 31.

PMID:
22230352
24.

Heminecrolysin, a potential immunogen for monospecific antivenom production against Hemiscorpius lepturus scorpion.

Borchani L, Sassi A, Ben Yekhlef R, Safra I, El Ayeb M.

Toxicon. 2011 Dec 1;58(8):681-8. doi: 10.1016/j.toxicon.2011.09.010. Epub 2011 Sep 28.

PMID:
21967811
25.

Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII scorpion toxin.

Ben Abderrazek R, Vincke C, Hmila I, Saerens D, Abidi N, El Ayeb M, Muyldermans S, Bouhaouala-Zahar B.

Protein Eng Des Sel. 2011 Sep;24(9):727-35. doi: 10.1093/protein/gzr037. Epub 2011 Jul 28.

PMID:
21798998
26.

Immunological aspects of scorpion toxins: current status and perspectives.

Bouhaouala-Zahar B, Ben Abderrazek R, Hmila I, Abidi N, Muyldermans S, El Ayeb M.

Inflamm Allergy Drug Targets. 2011 Oct;10(5):358-68. Review.

PMID:
21756244
27.

Heminecrolysin, the first hemolytic dermonecrotic toxin purified from scorpion venom.

Borchani L, Sassi A, Shahbazzadeh D, Strub JM, Tounsi-Guetteti H, Boubaker MS, Akbari A, Van Dorsselaer A, El Ayeb M.

Toxicon. 2011 Jul;58(1):130-9. doi: 10.1016/j.toxicon.2011.05.016. Epub 2011 May 31.

PMID:
21658401
28.

[Selectins as adhesion molecules and potential therapeutic target].

Jebali J, Jeanneau C, Bazaa A, Mathieu S, El Ayeb M, Luis J, El Battari A, Marrakchi N.

Arch Inst Pasteur Tunis. 2011;88(1-4):3-18. Review. French.

PMID:
23461138
29.

A bispecific nanobody to provide full protection against lethal scorpion envenoming.

Hmila I, Saerens D, Ben Abderrazek R, Vincke C, Abidi N, Benlasfar Z, Govaert J, El Ayeb M, Bouhaouala-Zahar B, Muyldermans S.

FASEB J. 2010 Sep;24(9):3479-89. doi: 10.1096/fj.09-148213. Epub 2010 Apr 21.

PMID:
20410443
30.

MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions.

Bazaa A, Pasquier E, Defilles C, Limam I, Kessentini-Zouari R, Kallech-Ziri O, El Battari A, Braguer D, El Ayeb M, Marrakchi N, Luis J.

PLoS One. 2010 Apr 12;5(4):e10124. doi: 10.1371/journal.pone.0010124.

31.

CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo.

Kessentini-Zouari R, Jebali J, Taboubi S, Srairi-Abid N, Morjen M, Kallech-Ziri O, Bezzine S, Marvaldi J, El Ayeb M, Marrakchi N, Luis J.

Lab Invest. 2010 Apr;90(4):510-9. doi: 10.1038/labinvest.2009.137. Epub 2010 Feb 8.

32.

[Snake venom metalloproteinases: structure, biosynthesis and function(s)].

Limam I, El Ayeb M, Marrakchi N.

Arch Inst Pasteur Tunis. 2010;87(1-2):3-15. Review. French.

PMID:
21604456
33.

Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion.

Limam I, Bazaa A, Srairi-Abid N, Taboubi S, Jebali J, Zouari-Kessentini R, Kallech-Ziri O, Mejdoub H, Hammami A, El Ayeb M, Luis J, Marrakchi N.

Matrix Biol. 2010 Mar;29(2):117-26. doi: 10.1016/j.matbio.2009.09.009. Epub 2009 Oct 4.

PMID:
19808093
34.

Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom.

Abderrazek RB, Hmila I, Vincke C, Benlasfar Z, Pellis M, Dabbek H, Saerens D, El Ayeb M, Muyldermans S, Bouhaouala-Zahar B.

Biochem J. 2009 Nov 11;424(2):263-72. doi: 10.1042/BJ20090697.

PMID:
19732033
35.

Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration.

Zouari-Kessentini R, Luis J, Karray A, Kallech-Ziri O, Srairi-Abid N, Bazaa A, Loret E, Bezzine S, El Ayeb M, Marrakchi N.

Toxicon. 2009 Mar 15;53(4):444-53. doi: 10.1016/j.toxicon.2009.01.003.

PMID:
19708222
36.

Lebectin increases N-cadherin-mediated adhesion through PI3K/AKT pathway.

Sarray S, Siret C, Lehmann M, Marrakchi N, Luis J, El Ayeb M, André F.

Cancer Lett. 2009 Nov 28;285(2):174-81. doi: 10.1016/j.canlet.2009.05.012. Epub 2009 Jun 5.

PMID:
19501458
37.

MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration.

Bazaa A, Luis J, Srairi-Abid N, Kallech-Ziri O, Kessentini-Zouari R, Defilles C, Lissitzky JC, El Ayeb M, Marrakchi N.

Matrix Biol. 2009 May;28(4):188-93. doi: 10.1016/j.matbio.2009.03.007. Epub 2009 Apr 5.

PMID:
19351557
38.

Bioinformatic characterizations and prediction of K+ and Na+ ion channels effector toxins.

Soli R, Kaabi B, Barhoumi M, El-Ayeb M, Srairi-Abid N.

BMC Pharmacol. 2009 Mar 10;9:4. doi: 10.1186/1471-2210-9-4.

39.

C-type lectin protein isoforms of Macrovipera lebetina: cDNA cloning and genetic diversity.

Jebali J, Bazaa A, Sarray S, Benhaj K, Karboul A, El Ayeb M, Marrakchi N, Gargouri A.

Toxicon. 2009 Feb;53(2):228-37. doi: 10.1016/j.toxicon.2008.11.006. Epub 2008 Nov 24.

PMID:
19059426
40.

Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus.

Srairi-Abid N, Shahbazzadeh D, Chatti I, Mlayah-Bellalouna S, Mejdoub H, Borchani L, Benkhalifa R, Akbari A, El Ayeb M.

FEBS J. 2008 Sep;275(18):4641-50. doi: 10.1111/j.1742-4658.2008.06607.x. Epub 2008 Aug 11.

41.

[Snake venoms C-type lectins and their receptors on platelets and cancerous cells].

Sarray S, Luis J, El Ayeb M, Marrakchi N.

Arch Inst Pasteur Tunis. 2008;85(1-4):69-80. French.

PMID:
19469418
42.

Immunological characterization of a non-toxic peptide conferring protection against the toxic fraction (AahG50) of the Androctonus australis hector venom.

Srairi-Abid N, Kaabi H, Mlayah-Bellalouna S, Mejri T, Sampieri F, El Ayeb M.

Toxicon. 2008 Mar 1;51(3):353-62. Epub 2007 Oct 24.

PMID:
18054371
43.

Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits angiogenesis both in vitro and in vivo.

Pilorget A, Conesa M, Sarray S, Michaud-Levesque J, Daoud S, Kim KS, Demeule M, Marvaldi J, El Ayeb M, Marrakchi N, Béliveau R, Luis J.

J Cell Physiol. 2007 May;211(2):307-15.

PMID:
17323383
44.

Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins.

Sarray S, Delamarre E, Marvaldi J, El Ayeb M, Marrakchi N, Luis J.

Matrix Biol. 2007 May;26(4):306-13. Epub 2007 Jan 13.

PMID:
17300927
45.

Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels.

Shahbazzadeh D, Srairi-Abid N, Feng W, Ram N, Borchani L, Ronjat M, Akbari A, Pessah IN, De Waard M, El Ayeb M.

Biochem J. 2007 May 15;404(1):89-96.

46.

[Use of medicinal plants against scorpionic and ophidian venoms].

Memmi A, Sansa G, Rjeibi I, El Ayeb M, Srairi-Abid N, Bellasfer Z, Fekhih A.

Arch Inst Pasteur Tunis. 2007;84(1-4):49-55. French.

PMID:
19388583
47.

[Modulation of skeletal muscle contraction by the non-toxic fraction of Buthus occitanus tunetanus venom via the cholinergic receptors].

Cheikh A, Cognard C, Potreau D, Bescond J, Raymond G, El Ayeb M, Benkhalifa R.

Arch Inst Pasteur Tunis. 2007;84(1-4):39-47. French.

PMID:
19388582
48.

[Snake venom disintegrins: classification and therapeutic potential].

Kallech-Ziri O, Luis J, El Ayeb M, Marrakchi N.

Arch Inst Pasteur Tunis. 2007;84(1-4):29-37. Review. French.

PMID:
19388581
49.

Loss of introns along the evolutionary diversification pathway of snake venom disintegrins evidenced by sequence analysis of genomic DNA from Macrovipera lebetina transmediterranea and Echis ocellatus.

Bazaa A, Juárez P, Marrakchi N, Bel Lasfer Z, El Ayeb M, Harrison RA, Calvete JJ, Sanz L.

J Mol Evol. 2007 Feb;64(2):261-71. Epub 2006 Dec 19.

PMID:
17177090
50.

A novel depolarizing activity of scorpion venom fraction M1 due to activation of skeletal muscle nicotinic receptors.

Cheikh A, Benkhalifa R, Potreau D, Raymond G, El Ayeb M, Cognard C.

Toxicon. 2007 Jan;49(1):117-22. Epub 2006 Sep 22.

PMID:
17069869

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