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Items: 1 to 50 of 132

1.

Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells.

Ringh MV, Hagemann-Jensen M, Needhamsen M, Kular L, Breeze CE, Sjöholm LK, Slavec L, Kullberg S, Wahlström J, Grunewald J, Brynedal B, Liu Y, Almgren M, Jagodic M, Öckinger J, Ekström TJ.

EBioMedicine. 2019 Aug;46:290-304. doi: 10.1016/j.ebiom.2019.07.006. Epub 2019 Jul 12.

2.

5‑Azacytidine treatment results in nuclear exclusion of DNA methyltransferase‑1, as well as reduced proliferation and invasion in human cytomegalovirus‑infected glioblastoma cells.

Estekizadeh A, Landázuri N, Pantalone MR, Davoudi B, Hu LF, Nawaz I, Stragliotto G, Ekström TJ, Rahbar A.

Oncol Rep. 2019 May;41(5):2927-2936. doi: 10.3892/or.2019.7074. Epub 2019 Mar 18.

PMID:
30896862
3.

Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse.

Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G; IMAGEN Consortium.

Am J Psychiatry. 2019 Feb 1;176(2):146-155. doi: 10.1176/appi.ajp.2018.17121360. Epub 2018 Dec 11.

PMID:
30525907
4.

Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: Design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study.

Wiik A, Andersson DP, Brismar TB, Chanpen S, Dhejne C, Ekström TJ, Flanagan JN, Holmberg M, Kere J, Lilja M, Lindholm ME, Lundberg TR, Maret E, Melin M, Olsson SM, Rullman E, Wåhlén K, Arver S, Gustafsson T.

Contemp Clin Trials Commun. 2018 Apr 12;10:148-153. doi: 10.1016/j.conctc.2018.04.005. eCollection 2018 Jun.

5.

Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.

Yu J, Yuan X, Sjöholm L, Liu T, Kong F, Ekström TJ, Björkholm M, Xu D.

Cancer Lett. 2018 Oct 10;434:33-41. doi: 10.1016/j.canlet.2018.07.013. Epub 2018 Jul 11.

PMID:
30017965
6.

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.

Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I, Feinberg AP, Jagodic M.

Nat Commun. 2018 Jun 19;9(1):2397. doi: 10.1038/s41467-018-04732-5.

7.

NR3C1 hypermethylation in depressed and bullied adolescents.

Efstathopoulos P, Andersson F, Melas PA, Yang LL, Villaescusa JC, Rȕegg J, Ekström TJ, Forsell Y, Galanti MR, Lavebratt C.

Transl Psychiatry. 2018 Jun 19;8(1):121. doi: 10.1038/s41398-018-0169-8.

8.

Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women.

Checknita D, Ekström TJ, Comasco E, Nilsson KW, Tiihonen J, Hodgins S.

J Neural Transm (Vienna). 2018 Jul;125(7):1053-1064. doi: 10.1007/s00702-018-1875-3. Epub 2018 Mar 29.

9.

Author Correction: Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship.

Marabita F, Almgren M, Sjöholm LK, Kular L, Liu Y, James T, Kiss NB, Feinberg AP, Olsson T, Kockum I, Alfredsson L, Ekström TJ, Jagodic M.

Sci Rep. 2018 Mar 7;8(1):4340. doi: 10.1038/s41598-018-22686-y.

10.

Increased cytomegalovirus replication by 5-Azacytidine and viral-induced cytoplasmic expression of DNMT‑1 in medulloblastoma and endothelial cells.

Estekizadeh A, Landázur N, Bartek J Jr, Beltoft Brøchner C, Davoudi B, Broholm H, Karimi M, Ekström TJ, Rahbar A.

Int J Oncol. 2018 Apr;52(4):1317-1327. doi: 10.3892/ijo.2018.4286. Epub 2018 Feb 26.

PMID:
29484388
11.

Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats.

Feltmann K, Borroto-Escuela DO, Rüegg J, Pinton L, de Oliveira Sergio T, Narváez M, Jimenez-Beristain A, Ekström TJ, Fuxe K, Steensland P.

Alcohol Clin Exp Res. 2018 Feb;42(2):338-351. doi: 10.1111/acer.13568. Epub 2018 Jan 24.

12.

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship.

Marabita F, Almgren M, Sjöholm LK, Kular L, Liu Y, James T, Kiss NB, Feinberg AP, Olsson T, Kockum I, Alfredsson L, Ekström TJ, Jagodic M.

Sci Rep. 2017 Nov 6;7(1):14589. doi: 10.1038/s41598-017-14788-w. Erratum in: Sci Rep. 2018 Mar 7;8(1):4340.

13.

Evaluation of Post-Mortem Effects on Global Brain DNA Methylation and Hydroxymethylation.

Sjöholm LK, Ransome Y, Ekström TJ, Karlsson O.

Basic Clin Pharmacol Toxicol. 2018 Feb;122(2):208-213. doi: 10.1111/bcpt.12875. Epub 2017 Nov 13.

14.

Current epigenetic aspects the clinical kidney researcher should embrace.

Witasp A, Van Craenenbroeck AH, Shiels PG, Ekström TJ, Stenvinkel P, Nordfors L.

Clin Sci (Lond). 2017 Jun 30;131(14):1649-1667. doi: 10.1042/CS20160596. Print 2017 Jul 15. Review.

PMID:
28667065
15.

Comment on "Epigenetics in the pathogenesis of RA".

Gomez-Cabrero D, Tegnér J, Ekström TJ, Ospelt C.

Semin Immunopathol. 2017 Jun;39(4):421-422. doi: 10.1007/s00281-017-0638-9. Epub 2017 May 11. No abstract available.

PMID:
28497351
16.

Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.

Sandén E, Dyberg C, Krona C, Gallo-Oller G, Olsen TK, Enríquez Pérez J, Wickström M, Estekizadeh A, Kool M, Visse E, Ekström TJ, Siesjö P, Johnsen JI, Darabi A.

Sci Rep. 2017 Apr 18;7:46366. doi: 10.1038/srep46366.

17.

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.

Meng W, Zhu Z, Jiang X, Too CL, Uebe S, Jagodic M, Kockum I, Murad S, Ferrucci L, Alfredsson L, Zou H, Klareskog L, Feinberg AP, Ekström TJ, Padyukov L, Liu Y.

Arthritis Res Ther. 2017 Mar 29;19(1):71. doi: 10.1186/s13075-017-1276-2.

18.

Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration.

Engdahl E, Dunn N, Niehusmann P, Wideman S, Wipfler P, Becker AJ, Ekström TJ, Almgren M, Fogdell-Hahn A.

J Virol. 2017 May 12;91(11). pii: e02105-16. doi: 10.1128/JVI.02105-16. Print 2017 Jun 1.

19.

Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis ‬.

Zeitelhofer M, Adzemovic MZ, Gomez-Cabrero D, Bergman P, Hochmeister S, N'diaye M, Paulson A, Ruhrmann S, Almgren M, Tegnér JN, Ekström TJ, Guerreiro-Cacais AO, Jagodic M.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1678-E1687. doi: 10.1073/pnas.1615783114. Epub 2017 Feb 14.

20.

Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide.

Barde S, Rüegg J, Prud'homme J, Ekström TJ, Palkovits M, Turecki G, Bagdy G, Ihnatko R, Theodorsson E, Juhasz G, Diaz-Heijtz R, Mechawar N, Hökfelt TG.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8472-E8481. doi: 10.1073/pnas.1617824113. Epub 2016 Dec 9.

21.

High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis.

Gomez-Cabrero D, Almgren M, Sjöholm LK, Hensvold AH, Ringh MV, Tryggvadottir R, Kere J, Scheynius A, Acevedo N, Reinius L, Taub MA, Montano C, Aryee MJ, Feinberg JI, Feinberg AP, Tegnér J, Klareskog L, Catrina AI, Ekström TJ.

Genome Med. 2016 Nov 22;8(1):124.

22.

Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder.

Backlund L, Wei YB, Martinsson L, Melas PA, Liu JJ, Mu N, Östenson CG, Ekström TJ, Schalling M, Lavebratt C.

Mol Neuropsychiatry. 2015 Jul;1(2):76-81. doi: 10.1159/000430867. Epub 2015 Jun 4.

23.

Global Analysis of DNA 5-Methylcytosine Using the Luminometric Methylation Assay, LUMA.

Luttropp K, Sjöholm LK, Ekström TJ.

Methods Mol Biol. 2015;1315:209-19. doi: 10.1007/978-1-4939-2715-9_16.

PMID:
26103902
24.

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training.

Lindholm ME, Marabita F, Gomez-Cabrero D, Rundqvist H, Ekström TJ, Tegnér J, Sundberg CJ.

Epigenetics. 2014 Dec;9(12):1557-69. doi: 10.4161/15592294.2014.982445.

25.

Cesarean delivery and hematopoietic stem cell epigenetics in the newborn infant: implications for future health?

Almgren M, Schlinzig T, Gomez-Cabrero D, Gunnar A, Sundin M, Johansson S, Norman M, Ekström TJ.

Am J Obstet Gynecol. 2014 Nov;211(5):502.e1-8. doi: 10.1016/j.ajog.2014.05.014. Epub 2014 Jul 1.

PMID:
24996659
26.

GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease.

Liu Y, Li X, Aryee MJ, Ekström TJ, Padyukov L, Klareskog L, Vandiver A, Moore AZ, Tanaka T, Ferrucci L, Fallin MD, Feinberg AP.

Am J Hum Genet. 2014 Apr 3;94(4):485-95. doi: 10.1016/j.ajhg.2014.02.011. Epub 2014 Mar 20.

27.

How can genetics and epigenetics help the nephrologist improve the diagnosis and treatment of chronic kidney disease patients?

Witasp A, Ekström TJ, Schalling M, Lindholm B, Stenvinkel P, Nordfors L.

Nephrol Dial Transplant. 2014 May;29(5):972-80. doi: 10.1093/ndt/gfu021. Epub 2014 Feb 24. Review.

PMID:
24569498
28.

Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men.

Gu T, Gu HF, Hilding A, Sjöholm LK, Ostenson CG, Ekström TJ, Brismar K.

Clin Epigenetics. 2013 Nov 19;5(1):21. doi: 10.1186/1868-7083-5-21.

29.

Novel insights from genetic and epigenetic studies in understanding the complex uraemic phenotype.

Witasp A, Ekström TJ, Lindholm B, Stenvinkel P, Schalling M, Nordfors L.

Nephrol Dial Transplant. 2014 May;29(5):964-71. doi: 10.1093/ndt/gft428. Epub 2013 Nov 13. Review.

PMID:
24235077
30.

Dietary alleviation of maternal obesity and diabetes: increased resistance to diet-induced obesity transcriptional and epigenetic signatures.

Attig L, Vigé A, Gabory A, Karimi M, Beauger A, Gross MS, Athias A, Gallou-Kabani C, Gambert P, Ekstrom TJ, Jais JP, Junien C.

PLoS One. 2013 Jun 24;8(6):e66816. doi: 10.1371/journal.pone.0066816. Print 2013.

31.

An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform.

Marabita F, Almgren M, Lindholm ME, Ruhrmann S, Fagerström-Billai F, Jagodic M, Sundberg CJ, Ekström TJ, Teschendorff AE, Tegnér J, Gomez-Cabrero D.

Epigenetics. 2013 Mar;8(3):333-46. doi: 10.4161/epi.24008. Epub 2013 Feb 19.

32.

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.

Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, Reinius L, Acevedo N, Taub M, Ronninger M, Shchetynsky K, Scheynius A, Kere J, Alfredsson L, Klareskog L, Ekström TJ, Feinberg AP.

Nat Biotechnol. 2013 Feb;31(2):142-7. doi: 10.1038/nbt.2487. Epub 2013 Jan 20.

33.

Physical activity is associated with decreased global DNA methylation in Swedish older individuals.

Luttropp K, Nordfors L, Ekström TJ, Lind L.

Scand J Clin Lab Invest. 2013 Mar;73(2):184-5. doi: 10.3109/00365513.2012.743166. Epub 2012 Nov 22. No abstract available.

PMID:
23171428
34.

Cell type and context-specific function of PLAG1 for IGF2 P3 promoter activity.

Akhtar M, Holmgren C, Göndör A, Vesterlund M, Kanduri C, Larsson C, Ekström TJ.

Int J Oncol. 2012 Dec;41(6):1959-66. doi: 10.3892/ijo.2012.1641. Epub 2012 Sep 26.

35.

Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor.

Gray SG, Baird AM, O'Kelly F, Nikolaidis G, Almgren M, Meunier A, Dockry E, Hollywood D, Ekström TJ, Perry AS, O'Byrne KJ.

Int J Mol Med. 2012 Dec;30(6):1505-11. doi: 10.3892/ijmm.2012.1138. Epub 2012 Sep 21.

PMID:
23007409
36.

The importance of epigenomic studies in schizophrenia.

Ekström TJ, Lavebratt C, Schalling M.

Epigenomics. 2012 Aug;4(4):359-62. doi: 10.2217/epi.12.33. No abstract available.

PMID:
22920175
37.

DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients.

Kato S, Lindholm B, Stenvinkel P, Ekström TJ, Luttropp K, Yuzawa Y, Yasuda Y, Tsuruta Y, Maruyama S.

Nephron Extra. 2012 Jan;2(1):159-68. doi: 10.1159/000339437. Epub 2012 Jun 20.

38.

Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex.

D'Addario C, Caputi FF, Ekström TJ, Di Benedetto M, Maccarrone M, Romualdi P, Candeletti S.

J Mol Neurosci. 2013 Feb;49(2):312-9. doi: 10.1007/s12031-012-9829-y. Epub 2012 Jun 10.

PMID:
22684622
39.

Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.

Esteki-Zadeh A, Karimi M, Strååt K, Ammerpohl O, Zeitelhofer M, Jagodic M, Mehrab-Mohseni M, Sjöholm L, Rahbar A, Söderberg-Nauclér C, Ekström TJ.

Epigenetics. 2012 Jun 1;7(6):585-93. doi: 10.4161/epi.20075. Epub 2012 Jun 1.

PMID:
22595877
40.

Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset.

Melas PA, Rogdaki M, Ösby U, Schalling M, Lavebratt C, Ekström TJ.

FASEB J. 2012 Jun;26(6):2712-8. doi: 10.1096/fj.11-202069. Epub 2012 Mar 16.

PMID:
22426120
41.

Epigenetic mechanisms as targets and companions of viral assaults.

Ernberg I, Karimi M, Ekström TJ.

Ann N Y Acad Sci. 2011 Aug;1230:E29-36. doi: 10.1111/j.1749-6632.2011.06357.x. Review.

PMID:
22417105
42.

Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.

Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlén M, Ekström TJ, Davisson MT, Hökfelt TG, Schalling M, Johansen JE.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18108-13. doi: 10.1073/pnas.1114863108. Epub 2011 Oct 24.

43.

Epigenetic regulation of glucose transporter 4 by estrogen receptor β.

Rüegg J, Cai W, Karimi M, Kiss NB, Swedenborg E, Larsson C, Ekström TJ, Pongratz I.

Mol Endocrinol. 2011 Dec;25(12):2017-28. doi: 10.1210/me.2011-1054. Epub 2011 Oct 20.

44.

Global DNA methylation analysis using the Luminometric Methylation Assay.

Karimi M, Luttropp K, Ekström TJ.

Methods Mol Biol. 2011;791:135-44. doi: 10.1007/978-1-61779-316-5_11.

PMID:
21913077
45.

Epigenetic regulation in obesity.

Lavebratt C, Almgren M, Ekström TJ.

Int J Obes (Lond). 2012 Jun;36(6):757-65. doi: 10.1038/ijo.2011.178. Epub 2011 Sep 13. Review.

PMID:
21912396
46.

HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase.

Khan Z, Akhtar M, Ekström TJ.

Int J Mol Med. 2011 Dec;28(6):977-83. doi: 10.3892/ijmm.2011.791. Epub 2011 Sep 5.

PMID:
21894430
47.

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.

Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, Ballon G, Yang SN, Weinhold N, Reimers M, Clozel T, Luttrop K, Ekstrom TJ, Frank J, Vasanthakumar A, Godley LA, Michor F, Elemento O, Melnick A.

Blood. 2011 Sep 29;118(13):3559-69. doi: 10.1182/blood-2011-06-357996. Epub 2011 Aug 9.

48.

Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics.

Arzenani MK, Zade AE, Ming Y, Vijverberg SJ, Zhang Z, Khan Z, Sadique S, Kallenbach L, Hu L, Vukojević V, Ekström TJ.

Mol Cell Biol. 2011 Oct;31(19):4119-28. doi: 10.1128/MCB.01304-10. Epub 2011 Jul 26.

49.

Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models.

Marino AM, Sofiadis A, Baryawno N, Johnsen JI, Larsson C, Vukojević V, Ekström TJ.

Biochem Biophys Res Commun. 2011 Jul 22;411(1):208-12. doi: 10.1016/j.bbrc.2011.06.141. Epub 2011 Jun 25.

PMID:
21726539
50.

Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet.

Gallou-Kabani C, Gabory A, Tost J, Karimi M, Mayeur S, Lesage J, Boudadi E, Gross MS, Taurelle J, Vigé A, Breton C, Reusens B, Remacle C, Vieau D, Ekström TJ, Jais JP, Junien C.

PLoS One. 2010 Dec 21;5(12):e14398. doi: 10.1371/journal.pone.0014398.

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