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Items: 25

1.

Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.

Johansson Å, Rask-Andersen M, Karlsson T, Ek WE.

Hum Mol Genet. 2019 Jul 30. pii: ddz175. doi: 10.1093/hmg/ddz175. [Epub ahead of print]

PMID:
31361310
2.

Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

Rask-Andersen M, Karlsson T, Ek WE, Johansson Å.

Nat Commun. 2019 Jan 21;10(1):339. doi: 10.1038/s41467-018-08000-4.

3.

Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci.

Drobin K, Assadi G, Hong MG, Andersson E, Fredolini C, Forsström B, Reznichenko A, Akhter T, Ek WE, Bonfiglio F, Hansen MB, Sandberg K, Greco D, Repsilber D, Schwenk JM, D'Amato M, Halfvarson J.

Inflamm Bowel Dis. 2019 Jan 10;25(2):306-316. doi: 10.1093/ibd/izy326.

4.

A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome.

Bonfiglio F, Henström M, Nag A, Hadizadeh F, Zheng T, Cenit MC, Tigchelaar E, Williams F, Reznichenko A, Ek WE, Rivera NV, Homuth G, Aghdassi AA, Kacprowski T, Männikkö M, Karhunen V, Bujanda L, Rafter J, Wijmenga C, Ronkainen J, Hysi P, Zhernakova A, D'Amato M.

Neurogastroenterol Motil. 2018 Sep;30(9):e13358. doi: 10.1111/nmo.13358. Epub 2018 Apr 19.

PMID:
29673008
5.

A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood.

Jiang J, Thalamuthu A, Ho JE, Mahajan A, Ek WE, Brown DA, Breit SN, Wang TJ, Gyllensten U, Chen MH, Enroth S, Januzzi JL Jr, Lind L, Armstrong NJ, Kwok JB, Schofield PR, Wen W, Trollor JN, Johansson Å, Morris AP, Vasan RS, Sachdev PS, Mather KA.

Front Genet. 2018 Mar 23;9:97. doi: 10.3389/fgene.2018.00097. eCollection 2018.

6.

Genetic variants influencing phenotypic variance heterogeneity.

Ek WE, Rask-Andersen M, Karlsson T, Enroth S, Gyllensten U, Johansson Å.

Hum Mol Genet. 2018 Mar 1;27(5):799-810. doi: 10.1093/hmg/ddx441.

PMID:
29325024
7.

Breast-feeding and risk of asthma, hay fever, and eczema.

Ek WE, Karlsson T, Hernándes CA, Rask-Andersen M, Johansson Å.

J Allergy Clin Immunol. 2018 Mar;141(3):1157-1159.e9. doi: 10.1016/j.jaci.2017.10.022. Epub 2017 Nov 10. No abstract available.

PMID:
29132959
8.

The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases.

Ahsan M, Ek WE, Rask-Andersen M, Karlsson T, Lind-Thomsen A, Enroth S, Gyllensten U, Johansson Å.

PLoS Genet. 2017 Sep 15;13(9):e1007005. doi: 10.1371/journal.pgen.1007005. eCollection 2017 Sep.

9.

Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status.

Rask-Andersen M, Karlsson T, Ek WE, Johansson Å.

PLoS Genet. 2017 Sep 5;13(9):e1006977. doi: 10.1371/journal.pgen.1006977. eCollection 2017 Sep.

10.

Tea and coffee consumption in relation to DNA methylation in four European cohorts.

Ek WE, Tobi EW, Ahsan M, Lampa E, Ponzi E, Kyrtopoulos SA, Georgiadis P, Lumey LH, Heijmans BT, Botsivali M, Bergdahl IA, Karlsson T, Rask-Andersen M, Palli D, Ingelsson E, Hedman ÅK, Nilsson LM, Vineis P, Lind L, Flanagan JM, Johansson Å; Epigenome-Wide Association Study Consortium.

Hum Mol Genet. 2017 Aug 15;26(16):3221-3231. doi: 10.1093/hmg/ddx194.

11.

Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies.

Ek WE, Ahsan M, Rask-Andersen M, Liang L, Moffatt MF, Gyllensten U, Johansson Å.

Epigenomics. 2017 Apr;9(4):407-418. doi: 10.2217/epi-2016-0158. Epub 2017 Mar 21.

PMID:
28322575
12.

Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction.

Rask-Andersen M, Martinsson D, Ahsan M, Enroth S, Ek WE, Gyllensten U, Johansson Å.

Hum Mol Genet. 2016 Nov 1;25(21):4739-4748. doi: 10.1093/hmg/ddw302.

PMID:
28172975
13.

The role of DNA methylation in the pathogenesis of disease: what can epigenome-wide association studies tell?

Ek WE, Rask-Andersen M, Johansson Å.

Epigenomics. 2016 Jan;8(1):5-7. doi: 10.2217/epi.15.99. Epub 2015 Dec 23. No abstract available.

PMID:
26698830
14.

Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15.

Ek WE, Hedman ÅK, Enroth S, Morris AP, Lindgren CM, Mahajan A, Gustafsson S, Gyllensten U, Lind L, Johansson Å.

Hum Mol Genet. 2016 Feb 15;25(4):817-27. doi: 10.1093/hmg/ddv511. Epub 2015 Dec 17.

15.

Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma.

Ek WE, Lagergren K, Cook M, Wu AH, Abnet CC, Levine D, Chow WH, Bernstein L, Risch HA, Shaheen NJ, Bird NC, Corley DA, Hardie LJ, Fitzgerald RC, Gammon MD, Romero Y, Liu G, Ye W, Vaughan TL, MacGregor S, Whiteman DC, Westberg L, Lagergren J.

Int J Cancer. 2016 Mar 1;138(5):1146-52. doi: 10.1002/ijc.29863. Epub 2015 Oct 5.

16.

Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium.

Lagergren K, Ek WE, Levine D, Chow WH, Bernstein L, Casson AG, Risch HA, Shaheen NJ, Bird NC, Reid BJ, Corley DA, Hardie LJ, Wu AH, Fitzgerald RC, Pharoah P, Caldas C, Romero Y, Vaughan TL, MacGregor S, Whiteman D, Westberg L, Nyren O, Lagergren J.

PLoS One. 2015 Sep 25;10(9):e0138738. doi: 10.1371/journal.pone.0138738. eCollection 2015.

17.

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk.

Lee E, Stram DO, Ek WE, Onstad LE, MacGregor S, Gharahkhani P, Ye W, Lagergren J, Shaheen NJ, Murray LJ, Hardie LJ, Gammon MD, Chow WH, Risch HA, Corley DA, Levine DM, Whiteman DC, Bernstein L, Bird NC, Vaughan TL, Wu AH.

Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1801-3. doi: 10.1158/1055-9965.EPI-15-0596. Epub 2015 Sep 12.

18.

Analysis of the genetic architecture of susceptibility to cervical cancer indicates that common SNPs explain a large proportion of the heritability.

Chen D, Cui T, Ek WE, Liu H, Wang H, Gyllensten U.

Carcinogenesis. 2015 Sep;36(9):992-8. doi: 10.1093/carcin/bgv083. Epub 2015 Jun 4.

PMID:
26045304
19.

The history of genetics in inflammatory bowel disease.

Ek WE, D'Amato M, Halfvarson J.

Ann Gastroenterol. 2014;27(4):294-303. Review.

20.

Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study.

Thrift AP, Shaheen NJ, Gammon MD, Bernstein L, Reid BJ, Onstad L, Risch HA, Liu G, Bird NC, Wu AH, Corley DA, Romero Y, Chanock SJ, Chow WH, Casson AG, Levine DM, Zhang R, Ek WE, MacGregor S, Ye W, Hardie LJ, Vaughan TL, Whiteman DC.

J Natl Cancer Inst. 2014 Sep 30;106(11). pii: dju252. doi: 10.1093/jnci/dju252. Print 2014 Nov.

21.

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.

Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, Schmidt PT, Pedersen NL, Magnusson P, Talley NJ, Holliday EG, Houghton L, Gazouli M, Karamanolis G, Rappold G, Burwinkel B, Surowy H, Rafter J, Assadi G, Li L, Papadaki E, Gambaccini D, Marchi S, Colucci R, Blandizzi C, Barbaro R, Karling P, Walter S, Ohlsson B, Tornblom H, Bresso F, Andreasson A, Dlugosz A, Simren M, Agreus L, Lindberg G, Boeckxstaens G, Bellini M, Stanghellini V, Barbara G, Daly MJ, Camilleri M, Wouters MM, D'Amato M.

Gut. 2015 Nov;64(11):1774-82. doi: 10.1136/gutjnl-2014-307997. Epub 2014 Sep 23.

PMID:
25248455
22.

Most common 'sporadic' cancers have a significant germline genetic component.

Lu Y, Ek WE, Whiteman D, Vaughan TL, Spurdle AB, Easton DF, Pharoah PD, Thompson DJ, Dunning AM, Hayward NK, Chenevix-Trench G; Q-MEGA and AMFS Investigators; ANECS-SEARCH; UKOPS-SEARCH; BEACON Consortium, Macgregor S.

Hum Mol Genet. 2014 Nov 15;23(22):6112-8. doi: 10.1093/hmg/ddu312. Epub 2014 Jun 18.

23.

Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome.

Beyder A, Mazzone A, Strege PR, Tester DJ, Saito YA, Bernard CE, Enders FT, Ek WE, Schmidt PT, Dlugosz A, Lindberg G, Karling P, Ohlsson B, Gazouli M, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Camilleri M, Locke GR, Talley NJ, D'Amato M, Ackerman MJ, Farrugia G.

Gastroenterology. 2014 Jun;146(7):1659-1668. doi: 10.1053/j.gastro.2014.02.054. Epub 2014 Mar 5.

24.

Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux.

Ek WE, Levine DM, D'Amato M, Pedersen NL, Magnusson PK, Bresso F, Onstad LE, Schmidt PT, Törnblom H, Nordenstedt H, Romero Y; Mayo Clinic Esophageal Adenocarcinoma and Barrett’s Esophagus Registry Consortium, Chow WH, Murray LJ, Gammon MD, Liu G, Bernstein L, Casson AG, Risch HA, Shaheen NJ, Bird NC, Reid BJ, Corley DA, Hardie LJ, Ye W, Wu AH, Zucchelli M, Spector TD, Hysi P, Vaughan TL, Whiteman DC, MacGregor S; BEACON study investigators.

J Natl Cancer Inst. 2013 Nov 20;105(22):1711-8. doi: 10.1093/jnci/djt303. Epub 2013 Oct 29.

25.

A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL.

Nat Genet. 2013 Dec;45(12):1487-93. doi: 10.1038/ng.2796. Epub 2013 Oct 13.

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