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Items: 18

1.

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Evdokimova E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD.

ACS Infect Dis. 2018 Jun 8;4(6):980-987. doi: 10.1021/acsinfecdis.8b00001. Epub 2018 Apr 19.

2.

Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.

Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen D, Wright GD.

Cell Chem Biol. 2018 Apr 19;25(4):403-412.e5. doi: 10.1016/j.chembiol.2018.01.009. Epub 2018 Feb 1.

3.

Epoxynemanione A, nemanifuranones A-F, and nemanilactones A-C, from Nemania serpens, an endophytic fungus isolated from Riesling grapevines.

Ibrahim A, Sørensen D, Jenkins HA, Ejim L, Capretta A, Sumarah MW.

Phytochemistry. 2017 Aug;140:16-26. doi: 10.1016/j.phytochem.2017.04.009. Epub 2017 Apr 22.

PMID:
28441516
4.

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.

Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.

Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015. Epub 2016 Oct 13.

5.

The comprehensive antibiotic resistance database.

McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, O'Brien JS, Pawlowski AC, Piddock LJ, Spanogiannopoulos P, Sutherland AD, Tang I, Taylor PL, Thaker M, Wang W, Yan M, Yu T, Wright GD.

Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.

6.

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

Farha MA, Leung A, Sewell EW, D'Elia MA, Allison SE, Ejim L, Pereira PM, Pinho MG, Wright GD, Brown ED.

ACS Chem Biol. 2013 Jan 18;8(1):226-33. doi: 10.1021/cb300413m. Epub 2012 Oct 19.

7.

Diversity of integron- and culture-associated antibiotic resistance genes in freshwater floc.

Drudge CN, Elliott AV, Plach JM, Ejim LJ, Wright GD, Droppo IG, Warren LA.

Appl Environ Microbiol. 2012 Jun;78(12):4367-72. doi: 10.1128/AEM.00405-12. Epub 2012 Mar 30.

8.

A small molecule discrimination map of the antibiotic resistance kinome.

Shakya T, Stogios PJ, Waglechner N, Evdokimova E, Ejim L, Blanchard JE, McArthur AG, Savchenko A, Wright GD.

Chem Biol. 2011 Dec 23;18(12):1591-601. doi: 10.1016/j.chembiol.2011.10.018.

9.

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole.

Spitzer M, Griffiths E, Blakely KM, Wildenhain J, Ejim L, Rossi L, De Pascale G, Curak J, Brown E, Tyers M, Wright GD.

Mol Syst Biol. 2011 Jun 21;7:499. doi: 10.1038/msb.2011.31.

10.

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD.

Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24.

PMID:
21516114
11.

Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations.

McNulty J, Nair JJ, Bollareddy E, Keskar K, Thorat A, Crankshaw DJ, Holloway AC, Khan G, Wright GD, Ejim L.

Phytochemistry. 2009 Dec;70(17-18):2040-6. doi: 10.1016/j.phytochem.2009.08.018.

PMID:
19837443
12.

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.

Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. doi: 10.1073/pnas.0711939105. Epub 2008 Mar 18.

13.

Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.

Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD.

J Med Chem. 2007 Feb 22;50(4):755-64.

PMID:
17300162
14.

New phenolic inhibitors of yeast homoserine dehydrogenase.

Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD.

Bioorg Med Chem. 2004 Jul 15;12(14):3825-30.

PMID:
15210149
15.

Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium.

Ejim LJ, D'Costa VM, Elowe NH, Loredo-Osti JC, Malo D, Wright GD.

Infect Immun. 2004 Jun;72(6):3310-4.

16.

Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase.

Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD.

Chem Biol. 2003 Oct;10(10):989-95.

PMID:
14583265
17.

Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer.

Jacques SL, Ejim LJ, Wright GD.

Biochim Biophys Acta. 2001 Jan 12;1544(1-2):42-54.

PMID:
11341915
18.

Facilitated uptake of zinc into human erythrocytes. Relevance to the treatment of sickle-cell anaemia.

Hider RC, Ejim L, Taylor PD, Gale R, Huehns E, Porter JB.

Biochem Pharmacol. 1990 Mar 15;39(6):1005-12.

PMID:
2322289

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