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Items: 1 to 50 of 338

1.

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

Nakayasu ES, Qian WJ, Evans-Molina C, Mirmira RG, Eizirik DL, Metz TO.

Expert Rev Proteomics. 2019 Jul;16(7):569-582. doi: 10.1080/14789450.2019.1634548. Epub 2019 Jun 24.

PMID:
31232620
2.

Fostering improved human islet research: a European perspective.

Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M.

Diabetologia. 2019 Aug;62(8):1514-1516. doi: 10.1007/s00125-019-4911-4. Epub 2019 Jun 13. No abstract available.

3.

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.

Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, Overbergh L.

Cell Death Dis. 2019 Apr 5;10(4):309. doi: 10.1038/s41419-019-1518-0.

4.

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes.

Bugliani M, Mossuto S, Grano F, Suleiman M, Marselli L, Boggi U, De Simone P, Eizirik DL, Cnop M, Marchetti P, De Tata V.

Front Endocrinol (Lausanne). 2019 Feb 26;10:52. doi: 10.3389/fendo.2019.00052. eCollection 2019.

5.

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells.

Colli ML, Paula FM, Marselli L, Marchetti P, Roivainen M, Eizirik DL, Op de Beeck A.

J Innate Immun. 2019;11(4):375-390. doi: 10.1159/000496034. Epub 2019 Feb 20.

6.

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.

Tyka K, Jörns A, Turatsinze JV, Eizirik DL, Lenzen S, Gurgul-Convey E.

Cell Death Dis. 2019 Jan 10;10(1):29. doi: 10.1038/s41419-018-1268-4.

7.

DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway.

Dos Santos RS, Marroqui L, Velayos T, Olazagoitia-Garmendia A, Jauregi-Miguel A, Castellanos-Rubio A, Eizirik DL, Castaño L, Santin I.

Diabetologia. 2019 Mar;62(3):459-472. doi: 10.1007/s00125-018-4782-0. Epub 2018 Nov 26.

PMID:
30478640
8.

Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.

Gotthardt M, Eizirik DL, Aanstoot HJ, Korsgren O, Mul D, Martin F, Boss M, Jansen TJP, van Lith SAM, Buitinga M, Eriksson O, Cnop M, Brom M.

Diabetologia. 2018 Dec;61(12):2516-2519. doi: 10.1007/s00125-018-4745-5. Epub 2018 Oct 3.

9.

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL.

EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27.

10.

Can GABA turn pancreatic α-cells into β-cells?

Eizirik DL, Gurzov EN.

Nat Rev Endocrinol. 2018 Nov;14(11):629-630. doi: 10.1038/s41574-018-0101-6. No abstract available.

PMID:
30254299
11.

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Cosentino C, Toivonen S, Diaz Villamil E, Atta M, Ravanat JL, Demine S, Schiavo AA, Pachera N, Deglasse JP, Jonas JC, Balboa D, Otonkoski T, Pearson ER, Marchetti P, Eizirik DL, Cnop M, Igoillo-Esteve M.

Nucleic Acids Res. 2018 Nov 2;46(19):10302-10318. doi: 10.1093/nar/gky839.

12.

When one becomes many-Alternative splicing in β-cell function and failure.

Alvelos MI, Juan-Mateu J, Colli ML, Turatsinze JV, Eizirik DL.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:77-87. doi: 10.1111/dom.13388. Review. Erratum in: Diabetes Obes Metab. 2018 Dec;20(12):2926.

13.

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.

Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla SNM, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL.

Molecules. 2018 Aug 21;23(9). pii: E2100. doi: 10.3390/molecules23092100.

14.

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation.

Cereijo R, Gavaldà-Navarro A, Cairó M, Quesada-López T, Villarroya J, Morón-Ros S, Sánchez-Infantes D, Peyrou M, Iglesias R, Mampel T, Turatsinze JV, Eizirik DL, Giralt M, Villarroya F.

Cell Metab. 2018 Nov 6;28(5):750-763.e6. doi: 10.1016/j.cmet.2018.07.015. Epub 2018 Aug 16.

PMID:
30122557
15.

Biomarkers of islet beta cell stress and death in type 1 diabetes.

Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG.

Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15. Review.

PMID:
30112687
16.

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R.

Cell Metab. 2018 Dec 4;28(6):946-960.e6. doi: 10.1016/j.cmet.2018.07.007. Epub 2018 Aug 2.

17.

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells.

Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, Richardson SJ.

Diabetologia. 2018 Nov;61(11):2344-2355. doi: 10.1007/s00125-018-4704-1. Epub 2018 Aug 3.

18.

A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.

Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, Shen W.

Br J Pharmacol. 2018 Sep;175(17):3470-3485. doi: 10.1111/bph.14388. Epub 2018 Jul 14.

19.

Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition.

Nardelli TR, Vanzela EC, Benedicto KC, Brozzi F, Fujita A, Cardozo AK, Eizirik DL, Boschero AC, Ortis F.

J Mol Endocrinol. 2018 Jul;61(1):25-36. doi: 10.1530/JME-16-0257. Epub 2018 Apr 9.

PMID:
29632026
20.

Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes.

Mastracci TL, Turatsinze JV, Book BK, Restrepo IA, Pugia MJ, Wiebke EA, Pescovitz MD, Eizirik DL, Mirmira RG.

Diabetes Obes Metab. 2018 Aug;20(8):1859-1867. doi: 10.1111/dom.13298. Epub 2018 Apr 16.

PMID:
29569324
21.

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes.

Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P.

Mol Cell Endocrinol. 2018 Sep 15;473:186-193. doi: 10.1016/j.mce.2018.01.019. Epub 2018 Feb 1.

PMID:
29409957
22.

Coxsackievirus and Type 1 Diabetes Mellitus: The Wolf's Footprints.

Eizirik DL, Op de Beeck A.

Trends Endocrinol Metab. 2018 Mar;29(3):137-139. doi: 10.1016/j.tem.2017.12.002. Epub 2018 Jan 8.

PMID:
29326001
23.

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

Coomans de Brachène A, Dos Santos RS, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL.

Diabetologia. 2018 Mar;61(3):636-640. doi: 10.1007/s00125-017-4536-4. Epub 2018 Jan 5.

24.

Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function.

He X, Lai Q, Chen C, Li N, Sun F, Huang W, Zhang S, Yu Q, Yang P, Xiong F, Chen Z, Gong Q, Ren B, Weng J, Eizirik DL, Zhou Z, Wang CY.

Diabetologia. 2018 Apr;61(4):881-895. doi: 10.1007/s00125-017-4523-9. Epub 2018 Jan 3.

PMID:
29299635
25.

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival.

Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL.

Diabetes. 2018 Mar;67(3):423-436. doi: 10.2337/db17-0736. Epub 2017 Dec 15.

26.

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis.

Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DL.

FASEB J. 2018 Mar;32(3):1524-1536. doi: 10.1096/fj.201700710R. Epub 2018 Jan 3.

PMID:
29133342
27.

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.

Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.

Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2.

28.

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

Litwak SA, Pang L, Galic S, Igoillo-Esteve M, Stanley WJ, Turatsinze JV, Loh K, Thomas HE, Sharma A, Trepo E, Moreno C, Gough DJ, Eizirik DL, de Haan JB, Gurzov EN.

Diabetes. 2017 Dec;66(12):2973-2986. doi: 10.2337/db17-0348. Epub 2017 Sep 19.

29.

Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons.

Calderari S, Ria M, Gérard C, Nogueira TC, Villate O, Collins SC, Neil H, Gervasi N, Hue C, Suarez-Zamorano N, Prado C, Cnop M, Bihoreau MT, Kaisaki PJ, Cazier JB, Julier C, Lathrop M, Werner M, Eizirik DL, Gauguier D.

Genomics. 2018 Mar;110(2):98-111. doi: 10.1016/j.ygeno.2017.09.001. Epub 2017 Sep 11.

30.

Erratum. Loss of Mbd2 Protects Mice Against High-Fat Diet-Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65:3384-3395.

Cheng J, Song J, He X, Zhang M, Hu S, Zhang S, Yu Q, Yang P, Xiong F, Wang DW, Zhou J, Ning Q, Chen Z, Eizirik DL, Zhou Z, Zhao C, Wang CY.

Diabetes. 2017 Sep;66(9):2531. doi: 10.2337/db17-er09b. Epub 2017 Jul 26. No abstract available.

31.

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11.

32.

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK.

Diabetes. 2017 Sep;66(9):2446-2458. doi: 10.2337/db16-1252. Epub 2017 Jun 30.

33.

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.

Dos Santos RS, Marroqui L, Grieco FA, Marselli L, Suleiman M, Henz SR, Marchetti P, Wernersson R, Eizirik DL.

Endocrinology. 2017 Aug 1;158(8):2503-2521. doi: 10.1210/en.2017-00104.

34.

Tolerogenic insulin peptide therapy precipitates type 1 diabetes.

Bergman ML, Lopes-Carvalho T, Martins AC, Grieco FA, Eizirik DL, Demengeot J.

J Exp Med. 2017 Jul 3;214(7):2153-2156. doi: 10.1084/jem.20160471. Epub 2017 May 23.

35.

Checks and Balances-The Limits of β-Cell Endurance to ER Stress.

Eizirik DL, Coomans de Brachène A.

Diabetes. 2017 Jun;66(6):1467-1469. doi: 10.2337/dbi17-0018. No abstract available.

36.

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

Lee SH, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F.

Biochem Pharmacol. 2017 Aug 15;138:140-149. doi: 10.1016/j.bcp.2017.05.007. Epub 2017 May 15.

PMID:
28522407
37.

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.

Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, Størling J.

Mol Cell Endocrinol. 2017 Jun 15;448:108-121. doi: 10.1016/j.mce.2017.04.001. Epub 2017 Apr 5.

PMID:
28390953
38.

UCP2 Expression Is Increased in Pancreas From Brain-Dead Donors and Involved in Cytokine-Induced β Cells Apoptosis.

Brondani LA, Rech TH, Boelter G, Bauer AC, Leitão CB, Eizirik DL, Crispim D.

Transplantation. 2017 Mar;101(3):e59-e67. doi: 10.1097/TP.0000000000001292.

PMID:
28222054
39.

Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival.

Juan-Mateu J, Rech TH, Villate O, Lizarraga-Mollinedo E, Wendt A, Turatsinze JV, Brondani LA, Nardelli TR, Nogueira TC, Esguerra JL, Alvelos MI, Marchetti P, Eliasson L, Eizirik DL.

J Biol Chem. 2017 Feb 24;292(8):3466-3480. doi: 10.1074/jbc.M116.748335. Epub 2017 Jan 11.

40.

dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.

Dos Santos RS, Daures M, Philippi A, Romero S, Marselli L, Marchetti P, Senée V, Bacq D, Besse C, Baz B, Marroquí L, Ivanoff S, Masliah-Planchon J, Nicolino M, Soulier J, Socié G, Eizirik DL, Gautier JF, Julier C.

Diabetes. 2017 Apr;66(4):1086-1096. doi: 10.2337/db16-0839. Epub 2017 Jan 10.

41.

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

Marroqui L, Dos Santos RS, Op de Beeck A, Coomans de Brachène A, Marselli L, Marchetti P, Eizirik DL.

Diabetologia. 2017 Apr;60(4):656-667. doi: 10.1007/s00125-016-4201-3. Epub 2017 Jan 6.

PMID:
28062922
42.

Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.

Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P.

Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1.

43.

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.

Quesada-López T, Cereijo R, Turatsinze JV, Planavila A, Cairó M, Gavaldà-Navarro A, Peyrou M, Moure R, Iglesias R, Giralt M, Eizirik DL, Villarroya F.

Nat Commun. 2016 Nov 17;7:13479. doi: 10.1038/ncomms13479.

44.

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladrière L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL.

Diabetes. 2017 Jan;66(1):100-112. doi: 10.2337/db16-0592. Epub 2016 Oct 13.

45.

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

Cunha DA, Cito M, Carlsson PO, Vanderwinden JM, Molkentin JD, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

Cell Death Differ. 2016 Dec;23(12):1995-2006. doi: 10.1038/cdd.2016.89. Epub 2016 Sep 2.

46.

Loss of Mbd2 Protects Mice Against High-Fat Diet-Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure.

Cheng J, Song J, He X, Zhang M, Hu S, Zhang S, Yu Q, Yang P, Xiong F, Wang DW, Zhou J, Ning Q, Chen Z, Eizirik DL, Zhou Z, Zhao C, Wang CY.

Diabetes. 2016 Nov;65(11):3384-3395. Epub 2016 Aug 23. Erratum in: Diabetes. 2017 Sep;66(9):2531.

47.

Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells.

Brozzi F, Gerlo S, Grieco FA, Juusola M, Balhuizen A, Lievens S, Gysemans C, Bugliani M, Mathieu C, Marchetti P, Tavernier J, Eizirik DL.

J Biol Chem. 2016 Jun 3;291(23):12040-56. doi: 10.1074/jbc.M115.704619. Epub 2016 Apr 4.

48.

Viral infections in type 1 diabetes mellitus--why the β cells?

Op de Beeck A, Eizirik DL.

Nat Rev Endocrinol. 2016 May;12(5):263-273. doi: 10.1038/nrendo.2016.30. Epub 2016 Mar 29. Review.

49.

Pancreatic Beta Cell Survival and Signaling Pathways: Effects of Type 1 Diabetes-Associated Genetic Variants.

Santin I, Dos Santos RS, Eizirik DL.

Methods Mol Biol. 2016;1433:21-54. doi: 10.1007/7651_2015_291.

PMID:
26936771
50.

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes.

Brozzi F, Eizirik DL.

Ups J Med Sci. 2016 May;121(2):133-9. doi: 10.3109/03009734.2015.1135217. Epub 2016 Feb 22. Review.

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