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Items: 1 to 50 of 54

1.

A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.

Johnson NB, Deck KM, Nizzi CP, Eisenstein RS.

J Biol Chem. 2017 Sep 22;292(38):15976-15989. doi: 10.1074/jbc.M117.785741. Epub 2017 Aug 2.

2.

Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells.

Vasta JD, Andersen KA, Deck KM, Nizzi CP, Eisenstein RS, Raines RT.

ACS Chem Biol. 2016 Jan 15;11(1):193-9. doi: 10.1021/acschembio.5b00749. Epub 2015 Nov 19.

3.

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH.

Sci Signal. 2015 Apr 14;8(372):ra34. doi: 10.1126/scisignal.aaa5903.

4.

Low intracellular iron increases the stability of matriptase-2.

Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS.

J Biol Chem. 2015 Feb 13;290(7):4432-46. doi: 10.1074/jbc.M114.611913. Epub 2014 Dec 30.

5.

Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria.

Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH.

J Biol Chem. 2014 Mar 14;289(11):7835-43. doi: 10.1074/jbc.M114.547778. Epub 2014 Feb 7. Erratum in: J Biol Chem. 2014 May 16;289(20):13707.

6.

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function.

Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B.

J Mol Med (Berl). 2013 Jul;91(7):871-81. doi: 10.1007/s00109-013-1008-2. Epub 2013 Mar 1.

7.

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.

Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS.

Cell Metab. 2013 Feb 5;17(2):282-90. doi: 10.1016/j.cmet.2013.01.007.

8.

F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.

Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK.

J Biol Chem. 2013 Jan 4;288(1):552-60. doi: 10.1074/jbc.M112.426171. Epub 2012 Nov 7.

9.

Mammalian iron metabolism and its control by iron regulatory proteins.

Anderson CP, Shen M, Eisenstein RS, Leibold EA.

Biochim Biophys Acta. 2012 Sep;1823(9):1468-83. doi: 10.1016/j.bbamcr.2012.05.010. Epub 2012 May 17. Review.

10.

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein.

Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA.

Blood. 2011 Feb 3;117(5):1687-99. doi: 10.1182/blood-2010-06-287292. Epub 2010 Nov 29.

11.

Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy.

Goforth JB, Anderson SA, Nizzi CP, Eisenstein RS.

RNA. 2010 Jan;16(1):154-69. doi: 10.1261/rna.1857210. Epub 2009 Nov 25.

12.

Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling.

Deck KM, Vasanthakumar A, Anderson SA, Goforth JB, Kennedy MC, Antholine WE, Eisenstein RS.

J Biol Chem. 2009 May 8;284(19):12701-9. doi: 10.1074/jbc.M807717200. Epub 2009 Mar 6.

13.

An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.

dos Santos CO, Dore LC, Valentine E, Shelat SG, Hardison RC, Ghosh M, Wang W, Eisenstein RS, Costa FF, Weiss MJ.

J Biol Chem. 2008 Oct 3;283(40):26956-64. doi: 10.1074/jbc.M802421200. Epub 2008 Aug 2.

14.

Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.

Stehling O, Netz DJ, Niggemeyer B, Rösser R, Eisenstein RS, Puccio H, Pierik AJ, Lill R.

Mol Cell Biol. 2008 Sep;28(17):5517-28. doi: 10.1128/MCB.00545-08. Epub 2008 Jun 23.

15.

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.

Zhang AS, Anderson SA, Meyers KR, Hernandez C, Eisenstein RS, Enns CA.

J Biol Chem. 2007 Apr 27;282(17):12547-56. Epub 2007 Mar 1.

16.

Molecular control of vertebrate iron homeostasis by iron regulatory proteins.

Wallander ML, Leibold EA, Eisenstein RS.

Biochim Biophys Acta. 2006 Jul;1763(7):668-89. Epub 2006 May 17. Review.

17.

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

Pondarré C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, Deck KM, McDonald A, Han AP, Medlock A, Kutok JL, Anderson SA, Eisenstein RS, Fleming MD.

Hum Mol Genet. 2006 Mar 15;15(6):953-64. Epub 2006 Feb 8.

PMID:
16467350
18.

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.

Clarke SL, Vasanthakumar A, Anderson SA, Pondarré C, Koh CM, Deck KM, Pitula JS, Epstein CJ, Fleming MD, Eisenstein RS.

EMBO J. 2006 Feb 8;25(3):544-53. Epub 2006 Jan 19.

20.

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.

Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, Epstein CJ, Huang TT.

Oncogene. 2005 Jan 13;24(3):367-80.

PMID:
15531919
21.

Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711.

Pitula JS, Deck KM, Clarke SL, Anderson SA, Vasanthakumar A, Eisenstein RS.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10907-12. Epub 2004 Jul 19.

22.

Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta.

Bradley J, Leibold EA, Harris ZL, Wobken JD, Clarke S, Zumbrennen KB, Eisenstein RS, Georgieff MK.

Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R894-901. Epub 2004 Jun 3.

23.

Novel roles for iron regulatory proteins in the adaptive response to iron deficiency.

Eisenstein RS, Ross KL.

J Nutr. 2003 May;133(5 Suppl 1):1510S-6S. doi: 10.1093/jn/133.5.1510S. Review.

PMID:
12730455
25.

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.

Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR.

Hepatology. 2002 Apr;35(4):912-21.

PMID:
11915039
26.

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.

Roy CN, Blemings KP, Deck KM, Davies PS, Anderson EL, Eisenstein RS, Enns CA.

J Cell Physiol. 2002 Feb;190(2):218-26.

PMID:
11807826
27.

Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling.

Brown NM, Kennedy MC, Antholine WE, Eisenstein RS, Walden WE.

J Biol Chem. 2002 Mar 1;277(9):7246-54. Epub 2001 Dec 13.

28.

Combinatorial mRNA regulation: iron regulatory proteins and iso-iron-responsive elements (Iso-IREs).

Theil EC, Eisenstein RS.

J Biol Chem. 2000 Dec 29;275(52):40659-62. Review. No abstract available.

29.

Iron regulatory proteins and the molecular control of mammalian iron metabolism.

Eisenstein RS.

Annu Rev Nutr. 2000;20:627-62. Review.

PMID:
10940348
30.
31.
32.

Iron regulatory proteins, iron responsive elements and iron homeostasis.

Eisenstein RS, Blemings KP.

J Nutr. 1998 Dec;128(12):2295-8. Review.

PMID:
9868172
33.

Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1.

Brown NM, Anderson SA, Steffen DW, Carpenter TB, Kennedy MC, Walden WE, Eisenstein RS.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15235-40.

34.

Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver.

Chen OS, Blemings KP, Schalinske KL, Eisenstein RS.

J Nutr. 1998 Mar;128(3):525-35.

PMID:
9482759
36.

Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line.

Schalinske KL, Blemings KP, Steffen DW, Chen OS, Eisenstein RS.

Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10681-6.

37.

Isolation, characterization, and functional studies of rat liver iron regulatory protein 1.

Eisenstein RS, Barton HA, Pettingell WH Jr, Bomford AB.

Arch Biochem Biophys. 1997 Jul 1;343(1):81-91.

PMID:
9210649
38.

The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites.

Schalinske KL, Anderson SA, Tuazon PT, Chen OS, Kennedy MC, Eisenstein RS.

Biochemistry. 1997 Apr 1;36(13):3950-8.

PMID:
9092825
39.
40.

Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells.

Schalinske KL, Eisenstein RS.

J Biol Chem. 1996 Mar 22;271(12):7168-76.

41.

Role of RNA secondary structure of the iron-responsive element in translational regulation of ferritin synthesis.

Kikinis Z, Eisenstein RS, Bettany AJ, Munro HN.

Nucleic Acids Res. 1995 Oct 25;23(20):4190-5.

42.

Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

Eisenstein RS, Tuazon PT, Schalinske KL, Anderson SA, Traugh JA.

J Biol Chem. 1993 Dec 25;268(36):27363-70.

44.

Relationship between protein intake and hepatic protein synthesis in rats.

Eisenstein RS, Harper AE.

J Nutr. 1991 Oct;121(10):1581-90.

PMID:
1765822
45.

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

Eisenstein RS, Garcia-Mayol D, Pettingell W, Munro HN.

Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):688-92.

46.
47.
48.

Regulation of ferritin gene expression.

Eisenstein RS, Bettany AJ, Munro HN.

Adv Inorg Biochem. 1990;8:91-138. Review. No abstract available.

PMID:
2206029
49.

Translational regulation of ferritin synthesis by iron.

Eisenstein RS, Munro HN.

Enzyme. 1990;44(1-4):42-58. Review.

PMID:
2133657
50.

Phylogenetic comparisons of the branched-chain alpha-ketoacid dehydrogenase complex.

Eisenstein RS, Miller RH, Hoganson G, Harper AE.

Comp Biochem Physiol B. 1990;97(4):719-26.

PMID:
2085956

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