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Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD.

Cairns TM, Ditto NT, Atanasiu D, Lou H, Brooks BD, Saw WT, Eisenberg RJ, Cohen GH.

J Virol. 2019 Jul 17;93(15). pii: e00289-19. doi: 10.1128/JVI.00289-19. Print 2019 Aug 1.


Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD.

Atanasiu D, Saw WT, Lazear E, Whitbeck JC, Cairns TM, Lou H, Eisenberg RJ, Cohen GH.

J Virol. 2018 Nov 27;92(24). pii: e01694-18. doi: 10.1128/JVI.01694-18. Print 2018 Dec 15.


Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.

Hook LM, Cairns TM, Awasthi S, Brooks BD, Ditto NT, Eisenberg RJ, Cohen GH, Friedman HM.

PLoS Pathog. 2018 May 23;14(5):e1007095. doi: 10.1371/journal.ppat.1007095. eCollection 2018 May.


The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane.

Fontana J, Atanasiu D, Saw WT, Gallagher JR, Cox RG, Whitbeck JC, Brown LM, Eisenberg RJ, Cohen GH.

MBio. 2017 Aug 22;8(4). pii: e01268-17. doi: 10.1128/mBio.01268-17.


Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging.

Cairns TM, Ditto NT, Lou H, Brooks BD, Atanasiu D, Eisenberg RJ, Cohen GH.

PLoS Pathog. 2017 Jun 14;13(6):e1006430. doi: 10.1371/journal.ppat.1006430. eCollection 2017 Jun.


Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir.

Hensel MT, Marshall JD, Dorwart MR, Heeke DS, Rao E, Tummala P, Yu L, Cohen GH, Eisenberg RJ, Sloan DD.

J Virol. 2017 Apr 13;91(9). pii: e02257-16. doi: 10.1128/JVI.02257-16. Print 2017 May 1.


Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs.

Persson J, Zhang Y, Olafsdottir TA, Thörn K, Cairns TM, Wegmann F, Sattentau QJ, Eisenberg RJ, Cohen GH, Harandi AM.

Front Immunol. 2016 Dec 26;7:640. doi: 10.3389/fimmu.2016.00640. eCollection 2016.


Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections.

Gilchuk I, Gilchuk P, Sapparapu G, Lampley R, Singh V, Kose N, Blum DL, Hughes LJ, Satheshkumar PS, Townsend MB, Kondas AV, Reed Z, Weiner Z, Olson VA, Hammarlund E, Raue HP, Slifka MK, Slaughter JC, Graham BS, Edwards KM, Eisenberg RJ, Cohen GH, Joyce S, Crowe JE Jr.

Cell. 2016 Oct 20;167(3):684-694.e9. doi: 10.1016/j.cell.2016.09.049.


Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion.

Atanasiu D, Saw WT, Eisenberg RJ, Cohen GH.

J Virol. 2016 Nov 14;90(23):10535-10544. doi: 10.1128/JVI.01501-16. Print 2016 Dec 1.


Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific.

Cairns TM, Huang ZY, Gallagher JR, Lin Y, Lou H, Whitbeck JC, Wald A, Cohen GH, Eisenberg RJ.

J Virol. 2015 Sep;89(18):9213-31. doi: 10.1128/JVI.01213-15. Epub 2015 Jun 24.


Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins.

Saw WT, Matsuda Z, Eisenberg RJ, Cohen GH, Atanasiu D.

Methods. 2015 Nov 15;90:68-75. doi: 10.1016/j.ymeth.2015.05.021. Epub 2015 May 26. Review.


Functional fluorescent protein insertions in herpes simplex virus gB report on gB conformation before and after execution of membrane fusion.

Gallagher JR, Atanasiu D, Saw WT, Paradisgarten MJ, Whitbeck JC, Eisenberg RJ, Cohen GH.

PLoS Pathog. 2014 Sep 18;10(9):e1004373. doi: 10.1371/journal.ppat.1004373. eCollection 2014 Sep.


Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humans.

Cairns TM, Huang ZY, Whitbeck JC, Ponce de Leon M, Lou H, Wald A, Krummenacher C, Eisenberg RJ, Cohen GH.

J Virol. 2014 Nov;88(21):12612-22. doi: 10.1128/JVI.01930-14. Epub 2014 Aug 20.


Repertoire of epitopes recognized by serum IgG from humans vaccinated with herpes simplex virus 2 glycoprotein D.

Whitbeck JC, Huang ZY, Cairns TM, Gallagher JR, Lou H, Ponce-de-Leon M, Belshe RB, Eisenberg RJ, Cohen GH.

J Virol. 2014 Jul;88(14):7786-95. doi: 10.1128/JVI.00544-14. Epub 2014 Apr 30.


Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B.

Cairns TM, Fontana J, Huang ZY, Whitbeck JC, Atanasiu D, Rao S, Shelly SS, Lou H, Ponce de Leon M, Steven AC, Eisenberg RJ, Cohen GH.

J Virol. 2014 Mar;88(5):2677-89. doi: 10.1128/JVI.03200-13. Epub 2013 Dec 18.


Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1.

Lazear E, Whitbeck JC, Zuo Y, Carfí A, Cohen GH, Eisenberg RJ, Krummenacher C.

Virology. 2014 Jan 5;448:185-95. doi: 10.1016/j.virol.2013.10.019. Epub 2013 Oct 29.


Displacement of the C terminus of herpes simplex virus gD is sufficient to expose the fusion-activating interfaces on gD.

Gallagher JR, Saw WT, Atanasiu D, Lou H, Eisenberg RJ, Cohen GH.

J Virol. 2013 Dec;87(23):12656-66. doi: 10.1128/JVI.01727-13. Epub 2013 Sep 18.


Dual split protein-based fusion assay reveals that mutations to herpes simplex virus (HSV) glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteins.

Atanasiu D, Saw WT, Gallagher JR, Hannah BP, Matsuda Z, Whitbeck JC, Cohen GH, Eisenberg RJ.

J Virol. 2013 Nov;87(21):11332-45. doi: 10.1128/JVI.01700-13. Epub 2013 Aug 14.


Entry of herpesviruses into cells: the enigma variations.

Krummenacher C, Carfí A, Eisenberg RJ, Cohen GH.

Adv Exp Med Biol. 2013;790:178-95. doi: 10.1007/978-1-4614-7651-1_10. Review.


The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction.

Maurer UE, Zeev-Ben-Mordehai T, Pandurangan AP, Cairns TM, Hannah BP, Whitbeck JC, Eisenberg RJ, Cohen GH, Topf M, Huiskonen JT, Grünewald K.

Structure. 2013 Aug 6;21(8):1396-405. doi: 10.1016/j.str.2013.05.018. Epub 2013 Jul 11.


The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy.

Ma X, Xu RH, Roscoe F, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ.

J Virol. 2013 Jun;87(12):7046-53. doi: 10.1128/JVI.03158-12. Epub 2013 Apr 17.


Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors.

Atanasiu D, Cairns TM, Whitbeck JC, Saw WT, Rao S, Eisenberg RJ, Cohen GH.

MBio. 2013 Feb 26;4(2). pii: e00046-13. doi: 10.1128/mBio.00046-13.


The membrane-proximal region (MPR) of herpes simplex virus gB regulates association of the fusion loops with lipid membranes.

Shelly SS, Cairns TM, Whitbeck JC, Lou H, Krummenacher C, Cohen GH, Eisenberg RJ.

MBio. 2012 Nov 20;3(6). pii: e00429-12. doi: 10.1128/mBio.00429-12.


Herpes virus fusion and entry: a story with many characters.

Eisenberg RJ, Atanasiu D, Cairns TM, Gallagher JR, Krummenacher C, Cohen GH.

Viruses. 2012 May;4(5):800-32. doi: 10.3390/v4050800. Epub 2012 May 10. Review.


The myristate moiety and amino terminus of vaccinia virus l1 constitute a bipartite functional region needed for entry.

Foo CH, Whitbeck JC, Ponce-de-León M, Saw WT, Cohen GH, Eisenberg RJ.

J Virol. 2012 May;86(10):5437-51. doi: 10.1128/JVI.06703-11. Epub 2012 Mar 7.


Antibody-induced conformational changes in herpes simplex virus glycoprotein gD reveal new targets for virus neutralization.

Lazear E, Whitbeck JC, Ponce-de-Leon M, Cairns TM, Willis SH, Zuo Y, Krummenacher C, Cohen GH, Eisenberg RJ.

J Virol. 2012 Feb;86(3):1563-76. doi: 10.1128/JVI.06480-11. Epub 2011 Nov 30.


Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.

Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A.

PLoS Pathog. 2011 Sep;7(9):e1002277. doi: 10.1371/journal.ppat.1002277. Epub 2011 Sep 29.


HCMV grabs a mechanism to escape neutralization.

Eisenberg RJ, Cairns TM, Cohen GH.

Cell Host Microbe. 2011 Sep 15;10(3):177-8. doi: 10.1016/j.chom.2011.08.011.


Antibody against extracellular vaccinia virus (EV) protects mice through complement and Fc receptors.

Cohen ME, Xiao Y, Eisenberg RJ, Cohen GH, Isaacs SN.

PLoS One. 2011;6(6):e20597. doi: 10.1371/journal.pone.0020597. Epub 2011 Jun 8.


Role of sulfatide in vaccinia virus infection.

Perino J, Foo CH, Spehner D, Cohen GH, Eisenberg RJ, Crance JM, Favier AL.

Biol Cell. 2011 Jul;103(7):319-31. doi: 10.1042/BC20110012.


Capturing the herpes simplex virus core fusion complex (gB-gH/gL) in an acidic environment.

Cairns TM, Whitbeck JC, Lou H, Heldwein EE, Chowdary TK, Eisenberg RJ, Cohen GH.

J Virol. 2011 Jul;85(13):6175-84. doi: 10.1128/JVI.00119-11. Epub 2011 Apr 20.


Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig.

Bernstein DI, Earwood JD, Bravo FJ, Cohen GH, Eisenberg RJ, Clark JR, Fairman J, Cardin RD.

Vaccine. 2011 Mar 3;29(11):2071-8. doi: 10.1016/j.vaccine.2011.01.005. Epub 2011 Jan 14.


Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1.

Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE.

J Virol. 2010 Dec;84(24):12924-33. doi: 10.1128/JVI.01750-10. Epub 2010 Oct 13.


Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB.

Atanasiu D, Saw WT, Cohen GH, Eisenberg RJ.

J Virol. 2010 Dec;84(23):12292-9. doi: 10.1128/JVI.01700-10. Epub 2010 Sep 22.


Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition.

Stiles KM, Whitbeck JC, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C.

J Virol. 2010 Nov;84(22):11646-60. doi: 10.1128/JVI.01550-10. Epub 2010 Sep 8.


A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge.

Buchman GW, Cohen ME, Xiao Y, Richardson-Harman N, Silvera P, DeTolla LJ, Davis HL, Eisenberg RJ, Cohen GH, Isaacs SN.

Vaccine. 2010 Sep 14;28(40):6627-36. doi: 10.1016/j.vaccine.2010.07.030. Epub 2010 Jul 24.


Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL.

Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE.

Nat Struct Mol Biol. 2010 Jul;17(7):882-8. doi: 10.1038/nsmb.1837. Epub 2010 Jul 4.


Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion.

Atanasiu D, Whitbeck JC, de Leon MP, Lou H, Hannah BP, Cohen GH, Eisenberg RJ.

J Virol. 2010 Apr;84(8):3825-34. doi: 10.1128/JVI.02687-09. Epub 2010 Feb 3.


Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB.

Wright CC, Wisner TW, Hannah BP, Eisenberg RJ, Cohen GH, Johnson DC.

J Virol. 2009 Nov;83(22):11847-56. doi: 10.1128/JVI.01397-09. Epub 2009 Sep 16.


Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops.

Hannah BP, Cairns TM, Bender FC, Whitbeck JC, Lou H, Eisenberg RJ, Cohen GH.

J Virol. 2009 Jul;83(13):6825-36. doi: 10.1128/JVI.00301-09. Epub 2009 Apr 15.


Vaccinia virus exhibits cell-type-dependent entry characteristics.

Whitbeck JC, Foo CH, Ponce de Leon M, Eisenberg RJ, Cohen GH.

Virology. 2009 Mar 15;385(2):383-91. doi: 10.1016/j.virol.2008.12.029. Epub 2009 Jan 21.


Vaccinia virus L1 binds to cell surfaces and blocks virus entry independently of glycosaminoglycans.

Foo CH, Lou H, Whitbeck JC, Ponce-de-León M, Atanasiu D, Eisenberg RJ, Cohen GH.

Virology. 2009 Mar 15;385(2):368-82. doi: 10.1016/j.virol.2008.12.019. Epub 2009 Jan 21.


Disparity between levels of in vitro neutralization of vaccinia virus by antibody to the A27 protein and protection of mice against intranasal challenge.

Fogg CN, Americo JL, Earl PL, Resch W, Aldaz-Carroll L, Eisenberg RJ, Cohen GH, Moss B.

J Virol. 2008 Aug;82(16):8022-9. doi: 10.1128/JVI.00568-08. Epub 2008 Jun 4.


The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination.

Xu RH, Cohen M, Tang Y, Lazear E, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ.

J Exp Med. 2008 Apr 14;205(4):981-92. doi: 10.1084/jem.20071854. Epub 2008 Apr 7.


An HSV-1 gD mutant virus as an entry-impaired live virus vaccine.

Awasthi S, Lubinski JM, Eisenberg RJ, Cohen GH, Friedman HM.

Vaccine. 2008 Feb 26;26(9):1195-203. doi: 10.1016/j.vaccine.2007.12.032. Epub 2008 Jan 14.


Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses.

Lasaro MO, Tatsis N, Hensley SE, Whitbeck JC, Lin SW, Rux JJ, Wherry EJ, Cohen GH, Eisenberg RJ, Ertl HC.

Nat Med. 2008 Feb;14(2):205-12. doi: 10.1038/nm1704. Epub 2008 Jan 13.


The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D.

Stiles KM, Milne RS, Cohen GH, Eisenberg RJ, Krummenacher C.

Virology. 2008 Mar 30;373(1):98-111. Epub 2008 Feb 20.


Engineered disulfide bonds in herpes simplex virus type 1 gD separate receptor binding from fusion initiation and viral entry.

Lazear E, Carfi A, Whitbeck JC, Cairns TM, Krummenacher C, Cohen GH, Eisenberg RJ.

J Virol. 2008 Jan;82(2):700-9. Epub 2007 Nov 21.


Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion.

Atanasiu D, Whitbeck JC, Cairns TM, Reilly B, Cohen GH, Eisenberg RJ.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18718-23. Epub 2007 Nov 14.


Characterization of chimpanzee/human monoclonal antibodies to vaccinia virus A33 glycoprotein and its variola virus homolog in vitro and in a vaccinia virus mouse protection model.

Chen Z, Earl P, Americo J, Damon I, Smith SK, Yu F, Sebrell A, Emerson S, Cohen G, Eisenberg RJ, Gorshkova I, Schuck P, Satterfield W, Moss B, Purcell R.

J Virol. 2007 Sep;81(17):8989-95. Epub 2007 Jun 20.

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