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The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.

Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS.

Proc Natl Acad Sci U S A. 2020 Feb 3. pii: 201917914. doi: 10.1073/pnas.1917914117. [Epub ahead of print]


Inhibition of synucleinopathic seeding by rationally designed inhibitors.

Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS.

Elife. 2020 Jan 2;9. pii: e46775. doi: 10.7554/eLife.46775.


Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.

Basavalingappa V, Bera S, Xue B, Azuri I, Tang Y, Tao K, Shimon LJW, Sawaya MR, Kolusheva S, Eisenberg DS, Kronik L, Cao Y, Wei G, Gazit E.

Nat Commun. 2019 Nov 20;10(1):5256. doi: 10.1038/s41467-019-13250-x.


Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure.

Makam P, Yamijala SSRKC, Tao K, Shimon LJW, Eisenberg DS, Sawaya MR, Wong BM, Gazit E.

Nat Catal. 2019 Nov;2(11):977-985. doi: 10.1038/s41929-019-0348-x. Epub 2019 Sep 23.


Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.

Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS.

Nat Struct Mol Biol. 2019 Nov;26(11):1044-1052. doi: 10.1038/s41594-019-0322-y. Epub 2019 Nov 6.


Structure-based inhibitors of amyloid beta core suggest a common interface with tau.

Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS.

Elife. 2019 Oct 15;8. pii: e46924. doi: 10.7554/eLife.46924.


Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.

Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS.

J Biol Chem. 2019 Nov 1;294(44):16451-16464. doi: 10.1074/jbc.RA119.009688. Epub 2019 Sep 19.


Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2019 Oct;26(10):988. doi: 10.1038/s41594-019-0316-9.


Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.

Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG.

Nat Commun. 2019 Jul 26;10(1):3357. doi: 10.1038/s41467-019-11183-z.


Cryo-EM structures of four polymorphic TDP-43 amyloid cores.

Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS.

Nat Struct Mol Biol. 2019 Jul;26(7):619-627. doi: 10.1038/s41594-019-0248-4. Epub 2019 Jun 24.


A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils.

Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS.

J Biol Chem. 2019 Apr 12;294(15):6130-6141. doi: 10.1074/jbc.RA118.005257. Epub 2019 Feb 7.


Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.

Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, Sipe JD, Westermark P.

Amyloid. 2018 Dec;25(4):215-219. doi: 10.1080/13506129.2018.1549825. Epub 2019 Jan 7.


TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R.

Nature. 2018 Nov;563(7732):508-513. doi: 10.1038/s41586-018-0665-2. Epub 2018 Oct 31.


Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L.

Nat Chem. 2018 Dec;10(12):1267. doi: 10.1038/s41557-018-0182-9.


Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.

Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS.

J Biol Chem. 2018 Dec 21;293(51):19659-19671. doi: 10.1074/jbc.RA118.004142. Epub 2018 Oct 24.


Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L.

Nat Chem. 2018 Dec;10(12):1213-1221. doi: 10.1038/s41557-018-0147-z. Epub 2018 Oct 8. Erratum in: Nat Chem. 2018 Nov 12;:.


Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR.

Saelices L, Pokrzywa M, Pawelek K, Eisenberg DS.

Neurobiol Dis. 2018 Dec;120:118-125. doi: 10.1016/j.nbd.2018.09.007. Epub 2018 Sep 10. No abstract available.


Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.

Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L.

Nat Commun. 2018 Sep 6;9(1):3609. doi: 10.1038/s41467-018-05971-2.


Atomic insights into the genesis of cellular filaments by globular proteins.

McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR.

Nat Struct Mol Biol. 2018 Aug;25(8):705-714. doi: 10.1038/s41594-018-0096-7. Epub 2018 Aug 3.


Paul D. Boyer (1918-2018).

Eisenberg DS.

Science. 2018 Jul 27;361(6400):334. doi: 10.1126/science.aau6601. No abstract available.


How Hard It Is Seeing What Is in Front of Your Eyes.

Eisenberg DS.

Cell. 2018 Jun 28;174(1):8-11. doi: 10.1016/j.cell.2018.06.027. No abstract available.


Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.

Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6741-E6750. doi: 10.1073/pnas.1805131115. Epub 2018 Jun 28.


Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2018 Jun;25(6):463-471. doi: 10.1038/s41594-018-0064-2. Epub 2018 May 21. Erratum in: Nat Struct Mol Biol. 2019 Oct;26(10):988.


Crystal structures of amyloidogenic segments of human transthyretin.

Saelices L, Sievers SA, Sawaya MR, Eisenberg DS.

Protein Sci. 2018 Jul;27(7):1295-1303. doi: 10.1002/pro.3420. Epub 2018 Jun 13.


Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS.

Nat Struct Mol Biol. 2018 Apr;25(4):311-319. doi: 10.1038/s41594-018-0045-5. Epub 2018 Mar 12.


Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.

Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS.

Protein Sci. 2018 Jul;27(7):1231-1242. doi: 10.1002/pro.3391. Epub 2018 Mar 10.


Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS.

Science. 2018 Feb 9;359(6376):698-701. doi: 10.1126/science.aan6398.


Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS.

Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20.


Distal amyloid β-protein fragments template amyloid assembly.

Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT.

Protein Sci. 2018 Jul;27(7):1181-1190. doi: 10.1002/pro.3375. Epub 2018 Feb 16.


Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA.

Nat Struct Mol Biol. 2018 Feb;25(2):131-134. doi: 10.1038/s41594-017-0018-0. Epub 2018 Jan 15.


Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS.

J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27.


Asparagine and glutamine ladders promote cross-species prion conversion.

Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ.

J Biol Chem. 2017 Nov 17;292(46):19076-19086. doi: 10.1074/jbc.M117.794107. Epub 2017 Sep 20.


Propagation of Tau Aggregates and Neurodegeneration.

Goedert M, Eisenberg DS, Crowther RA.

Annu Rev Neurosci. 2017 Jul 25;40:189-210. doi: 10.1146/annurev-neuro-072116-031153. Review.


Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).

Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775. doi: 10.1073/pnas.1705091114. Epub 2017 Jul 31.


Neurodegeneration: Taming tangled tau.

Eisenberg DS, Sawaya MR.

Nature. 2017 Jul 13;547(7662):170-171. doi: 10.1038/nature23094. Epub 2017 Jul 5. No abstract available.


Taking the measure of MicroED.

Rodriguez JA, Eisenberg DS, Gonen T.

Curr Opin Struct Biol. 2017 Oct;46:79-86. doi: 10.1016/ Epub 2017 Jun 22. Review.


Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.

Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, Cascio D, Chavas LMG, Chen JPJ, Ding K, Fleckenstein H, Gumprecht L, Harimoorthy R, Mossou E, Sawaya MR, Brewster AS, Hattne J, Sauter NK, Seibert M, Seuring C, Stellato F, Tilp T, Eisenberg DS, Messerschmidt M, Williams GJ, Koglin JE, Makowski L, Millane RP, Forsyth T, Boutet S, White TA, Barty A, Chapman H, Chen SL, Liang M, Neutze R, Robinson RC.

Cytoskeleton (Hoboken). 2017 Dec;74(12):472-481. doi: 10.1002/cm.21378. Epub 2017 Jun 19.


Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis.

Sangwan S, Eisenberg DS.

Postepy Biochem. 2016;62(3):362-369. Review.


Structural Studies of Amyloid Proteins at the Molecular Level.

Eisenberg DS, Sawaya MR.

Annu Rev Biochem. 2017 Jun 20;86:69-95. doi: 10.1146/annurev-biochem-061516-045104. Epub 2017 Jan 3. Review.


Toward the Atomic Structure of PrPSc.

Rodriguez JA, Jiang L, Eisenberg DS.

Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9). pii: a031336. doi: 10.1101/cshperspect.a031336. Review.


Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.


The activities of amyloids from a structural perspective.

Riek R, Eisenberg DS.

Nature. 2016 Nov 10;539(7628):227-235. doi: 10.1038/nature20416. Review.


De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.

Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS.

Nature. 2016 Nov 3;539(7627):43-47. doi: 10.1038/nature19825. Epub 2016 Sep 28.


Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.

Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11232-11236. Epub 2016 Sep 19.


Implications for Alzheimer's disease of an atomic resolution structure of amyloid-β(1-42) fibrils.

Eisenberg DS, Sawaya MR.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9398-400. doi: 10.1073/pnas.1610806113. Epub 2016 Aug 9. No abstract available.


The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.


A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.

Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS.

Cancer Cell. 2016 Jan 11;29(1):90-103. doi: 10.1016/j.ccell.2015.12.002. Epub 2015 Dec 31.


Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.

Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS.

Elife. 2015 Nov 18;4:e10935. doi: 10.7554/eLife.10935.


Uncovering the Mechanism of Aggregation of Human Transthyretin.

Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS.

J Biol Chem. 2015 Nov 27;290(48):28932-43. doi: 10.1074/jbc.M115.659912. Epub 2015 Oct 12.


Structure of the toxic core of α-synuclein from invisible crystals.

Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS.

Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9.

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