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Items: 1 to 50 of 464

1.

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.

Pugliese A, Boulware D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molina C, Harrison LC, Schatz D, Palmer JP, Greenbaum C, Eisenbarth GS, Sosenko JM; Type 1 Diabetes TrialNet Study Group.

Diabetes. 2016 Apr;65(4):1109-19. doi: 10.2337/db15-1105. Epub 2016 Jan 28.

2.

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.

Brorsson CA, Onengut S, Chen WM, Wenzlau J, Yu L, Baker P, Williams AJ, Bingley PJ, Hutton JC, Eisenbarth GS, Concannon P, Rich SS, Pociot F; Type 1 Diabetes Genetics Consortium.

Diabetes. 2015 Aug;64(8):3017-27. doi: 10.2337/db14-1730. Epub 2015 Mar 31.

3.

Risk of pediatric celiac disease according to HLA haplotype and country.

Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D; TEDDY Study Group.

N Engl J Med. 2014 Jul 3;371(1):42-9. doi: 10.1056/NEJMoa1313977. Erratum in: N Engl J Med. 2014 Jul 24;371(4):390.

4.

γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.

Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK.

Mol Immunol. 2014 Aug;60(2):116-28. doi: 10.1016/j.molimm.2014.04.007. Epub 2014 May 20.

5.

MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD mice.

Zhang L, Londono P, Yu L, Grimes S, Blackburn P, Gottlieb P, Eisenbarth GS.

Autoimmunity. 2014 Aug;47(5):341-50. doi: 10.3109/08916934.2014.910768. Epub 2014 May 1.

6.

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.

Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61. doi: 10.1073/pnas.1323436111. Epub 2014 Feb 3.

7.

GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes.

Miao D, Guyer KM, Dong F, Jiang L, Steck AK, Rewers M, Eisenbarth GS, Yu L.

Diabetes. 2013 Dec;62(12):4174-8. doi: 10.2337/db13-0534. Epub 2013 Aug 23.

8.

Type 1 diabetes.

Atkinson MA, Eisenbarth GS, Michels AW.

Lancet. 2014 Jan 4;383(9911):69-82. doi: 10.1016/S0140-6736(13)60591-7. Epub 2013 Jul 26. Review.

9.

Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY).

Frederiksen B, Kroehl M, Lamb MM, Seifert J, Barriga K, Eisenbarth GS, Rewers M, Norris JM.

JAMA Pediatr. 2013 Sep;167(9):808-15. doi: 10.1001/jamapediatrics.2013.317.

10.

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

Roep BO, Solvason N, Gottlieb PA, Abreu JRF, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, Garren H; BHT-3021 Investigators, Steinman L.

Sci Transl Med. 2013 Jun 26;5(191):191ra82. doi: 10.1126/scitranslmed.3006103.

11.

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.

Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, Winkler C, Ilonen J, Veijola R, Knip M, Bonifacio E, Eisenbarth GS.

JAMA. 2013 Jun 19;309(23):2473-9. doi: 10.1001/jama.2013.6285.

12.

Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes.

Pietropaolo M, Towns R, Eisenbarth GS.

Cold Spring Harb Perspect Med. 2012 Oct 1;2(10). pii: a012831. doi: 10.1101/cshperspect.a012831. Review.

13.

Juvenile diabetes.

Babu SR, Eisenbarth GS.

Indian J Med Res. 2012 Aug;136(2):179-81. No abstract available.

14.

Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).

Frederiksen B, Liu E, Romanos J, Steck AK, Yin X, Kroehl M, Fingerlin TE, Erlich H, Eisenbarth GS, Rewers M, Norris JM.

J Steroid Biochem Mol Biol. 2013 Jan;133:51-7. doi: 10.1016/j.jsbmb.2012.08.012. Epub 2012 Sep 7.

15.

Type 1 diabetes: primary antigen/peptide/register/trimolecular complex.

Sosinowski T, Eisenbarth GS.

Immunol Res. 2013 Mar;55(1-3):270-6. doi: 10.1007/s12026-012-8367-6. Review.

16.

Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes.

Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS; Type 1 Diabetes Genetics Consortium.

Diabetes. 2012 Nov;61(11):3012-7. doi: 10.2337/db11-1694. Epub 2012 Aug 13.

17.

Autoimmune diabetes inflames the heart.

Eckel RH, Eisenbarth GS.

Sci Transl Med. 2012 Jun 13;4(138):138fs18. doi: 10.1126/scitranslmed.3004219.

PMID:
22700952
18.

Prevention of type 1A diabetes mellitus.

Eisenbarth GS.

Endocr Pract. 2012 Sep-Oct;18(5):745-9. doi: 10.4158/EP12080.OR. Review.

19.

Paradigm shift or shifting paradigm for type 1 diabetes.

Nakayama M, Eisenbarth GS.

Diabetes. 2012 May;61(5):976-8. doi: 10.2337/db12-0057. No abstract available.

20.

Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.

Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2012 Jun;35(6):1213-8. doi: 10.2337/dc11-2081. Epub 2012 Mar 23.

21.

Congruence as a measurement of extended haplotype structure across the genome.

Baschal EE, Jasinski JM, Boyle TA, Fain PR, Eisenbarth GS, Siebert JC.

J Transl Med. 2012 Feb 27;10:32. doi: 10.1186/1479-5876-10-32.

22.

Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.

Steck AK, Wong R, Wagner B, Johnson K, Liu E, Romanos J, Wijmenga C, Norris JM, Eisenbarth GS, Rewers MJ.

Diabetes. 2012 Mar;61(3):753-8. doi: 10.2337/db11-1228. Epub 2012 Feb 7.

23.

Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.

Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS.

Diabetes. 2012 Apr;61(4):857-65. doi: 10.2337/db11-1113. Epub 2012 Feb 7.

24.

Confirmation of novel type 1 diabetes risk loci in families.

Cooper JD, Howson JM, Smyth D, Walker NM, Stevens H, Yang JH, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS; Type 1 Diabetes Genetics Consortium.

Diabetologia. 2012 Apr;55(4):996-1000. doi: 10.1007/s00125-012-2450-3. Epub 2012 Jan 26.

25.

Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay.

Yu L, Miao D, Scrimgeour L, Johnson K, Rewers M, Eisenbarth GS.

Diabetes. 2012 Jan;61(1):179-86. doi: 10.2337/db11-0670. Epub 2011 Nov 28.

26.

Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice.

Zhang L, Stadinski BD, Michels A, Kappler JW, Eisenbarth GS.

Diabetes Metab Res Rev. 2011 Nov;27(8):784-9. doi: 10.1002/dmrr.1252.

PMID:
22069260
27.

Predicting the onset of Addison's disease: ACTH, renin, cortisol and 21-hydroxylase autoantibodies.

Baker PR, Nanduri P, Gottlieb PA, Yu L, Klingensmith GJ, Eisenbarth GS, Barker JM.

Clin Endocrinol (Oxf). 2012 May;76(5):617-24. doi: 10.1111/j.1365-2265.2011.04276.x.

28.

Autoimmunity: Celiac disease in T1DM-the need to look long term.

Rewers M, Eisenbarth GS.

Nat Rev Endocrinol. 2011 Nov 8;8(1):7-8. doi: 10.1038/nrendo.2011.193.

29.

Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening.

Tiberti C, Yu L, Lucantoni F, Panimolle F, Spagnuolo I, Lenzi A, Eisenbarth GS, Dotta F.

Clin Exp Immunol. 2011 Dec;166(3):317-24. doi: 10.1111/j.1365-2249.2011.04479.x.

30.

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS.

J Immunol. 2011 Dec 1;187(11):5921-30. doi: 10.4049/jimmunol.1100746. Epub 2011 Oct 31.

31.

Immune intervention in type 1 diabetes.

Michels AW, Eisenbarth GS.

Semin Immunol. 2011 Jun;23(3):214-9. doi: 10.1016/j.smim.2011.07.003. Epub 2011 Aug 17. Review.

32.

Rituximab selectively suppresses specific islet antibodies.

Yu L, Herold K, Krause-Steinrauf H, McGee PL, Bundy B, Pugliese A, Krischer J, Eisenbarth GS; Type 1 Diabetes TrialNet Anti-CD20 Study Group.

Diabetes. 2011 Oct;60(10):2560-5. doi: 10.2337/db11-0674. Epub 2011 Aug 10.

33.

Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex.

Baschal EE, Sarkar SA, Boyle TA, Siebert JC, Jasinski JM, Grabek KR, Armstrong TK, Babu SR, Fain PR, Steck AK, Rewers MJ, Eisenbarth GS.

J Diabetes. 2011 Sep;3(3):238-47. doi: 10.1111/j.1753-0407.2011.00131.x.

34.

Measuring adrenal autoantibody response: interlaboratory concordance in the first international serum exchange for the determination of 21-hydroxylase autoantibodies.

Falorni A, Chen S, Zanchetta R, Yu L, Tiberti C, Bacosi ML, Furmaniak J, Bini V, Dotta F, Eisenbarth GS, Smith BR, Betterle C.

Clin Immunol. 2011 Sep;140(3):291-9. doi: 10.1016/j.clim.2011.04.012. Epub 2011 Apr 28.

PMID:
21570358
35.

Dominant suppression of Addison's disease associated with HLA-B15.

Baker PR, Baschal EE, Fain PR, Nanduri P, Triolo TM, Siebert JC, Armstrong TK, Babu SR, Rewers MJ, Gottlieb PA, Barker JM, Eisenbarth GS.

J Clin Endocrinol Metab. 2011 Jul;96(7):2154-62. doi: 10.1210/jc.2010-2964. Epub 2011 May 11.

36.

Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young.

Steck AK, Johnson K, Barriga KJ, Miao D, Yu L, Hutton JC, Eisenbarth GS, Rewers MJ.

Diabetes Care. 2011 Jun;34(6):1397-9. doi: 10.2337/dc10-2088. Epub 2011 May 11.

37.

The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes.

Baschal EE, Baker PR, Eyring KR, Siebert JC, Jasinski JM, Eisenbarth GS.

Diabetologia. 2011 Jul;54(7):1702-9. doi: 10.1007/s00125-011-2161-1. Epub 2011 May 1.

38.

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.

Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ.

Diabetes. 2011 May;60(5):1370-9. doi: 10.2337/db10-1797. No abstract available.

39.

Persistently autoantibody negative (PAN) type 1 diabetes mellitus in children.

Hameed S, Ellard S, Woodhead HJ, Neville KA, Walker JL, Craig ME, Armstrong T, Yu L, Eisenbarth GS, Hattersley AT, Verge CF.

Pediatr Diabetes. 2011 May;12(3 Pt 1):142-9. doi: 10.1111/j.1399-5448.2010.00681.x. Epub 2010 Sep 6.

PMID:
21518407
40.

Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY).

Miller MR, Yin X, Seifert J, Clare-Salzler M, Eisenbarth GS, Rewers M, Norris JM.

Pediatr Diabetes. 2011 Dec;12(8):669-75. doi: 10.1111/j.1399-5448.2011.00760.x. Epub 2011 Mar 24.

41.

Additional autoimmune disease found in 33% of patients at type 1 diabetes onset.

Triolo TM, Armstrong TK, McFann K, Yu L, Rewers MJ, Klingensmith GJ, Eisenbarth GS, Barker JM.

Diabetes Care. 2011 May;34(5):1211-3. doi: 10.2337/dc10-1756. Epub 2011 Mar 23.

42.

Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years.

Steck AK, Armstrong TK, Babu SR, Eisenbarth GS; Type 1 Diabetes Genetics Consortium.

Diabetes. 2011 Mar;60(3):1045-9. doi: 10.2337/db10-1419. Epub 2011 Feb 9.

43.

The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages.

Nakahara M, Nagayama Y, Ichikawa T, Yu L, Eisenbarth GS, Abiru N.

Autoimmunity. 2011 Sep;44(6):504-10. doi: 10.3109/08916934.2010.548839. Epub 2011 Feb 9.

PMID:
21306188
44.

CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse.

Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nakamura H, Nagayama Y, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Araki E, Mori M, Oyadomari S, Eguchi K.

Apoptosis. 2011 Apr;16(4):438-48. doi: 10.1007/s10495-011-0576-2.

PMID:
21274633
45.

Analysis of pathogenesis of juvenile new-onset diabetes.

Wang J, Miao D, Wang Y, Lu B, Babu S, Klingensmith G, Rewers M, Eisenbarth GS, Yu L.

J Diabetes. 2011 Jun;3(2):132-7. doi: 10.1111/j.1753-0407.2010.00105.x.

46.

Genome-wide analysis of copy number variation in type 1 diabetes.

Grayson BL, Smith ME, Thomas JW, Wang L, Dexheimer P, Jeffrey J, Fain PR, Nanduri P, Eisenbarth GS, Aune TM.

PLoS One. 2010 Nov 15;5(11):e15393. doi: 10.1371/journal.pone.0015393.

47.

Prediction and prevention of Type 1 diabetes mellitus.

Zhang L, Eisenbarth GS.

J Diabetes. 2011 Mar;3(1):48-57. doi: 10.1111/j.1753-0407.2010.00102.x. Review.

48.

Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY).

Stene LC, Oikarinen S, Hyöty H, Barriga KJ, Norris JM, Klingensmith G, Hutton JC, Erlich HA, Eisenbarth GS, Rewers M.

Diabetes. 2010 Dec;59(12):3174-80. doi: 10.2337/db10-0866. Epub 2010 Sep 21.

49.

Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's disease.

Baker PR, Baschal EE, Fain PR, Triolo TM, Nanduri P, Siebert JC, Armstrong TK, Babu SR, Rewers MJ, Gottlieb PA, Barker JM, Eisenbarth GS.

J Clin Endocrinol Metab. 2010 Oct;95(10):E263-70. doi: 10.1210/jc.2010-0508. Epub 2010 Jul 14.

50.

Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC.

J Clin Endocrinol Metab. 2010 Oct;95(10):4712-9. doi: 10.1210/jc.2010-0169. Epub 2010 Jul 7.

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