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Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers.

Kang M, Eisen TJ, Eisen EA, Chakraborty AK, Eisen HN.

PLoS One. 2015 Oct 7;10(10):e0139222. doi: 10.1371/journal.pone.0139222. eCollection 2015.


Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells.

Li Y, Shen C, Zhu B, Shi F, Eisen HN, Chen J.

J Immunol. 2015 Aug 15;195(4):1591-8. doi: 10.4049/jimmunol.1500451. Epub 2015 Jul 10.


Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.

Wang S, Mata-Fink J, Kriegsman B, Hanson M, Irvine DJ, Eisen HN, Burton DR, Wittrup KD, Kardar M, Chakraborty AK.

Cell. 2015 Feb 12;160(4):785-797. doi: 10.1016/j.cell.2015.01.027. Epub 2015 Feb 5.


Remembrance of immunology past: conversations with Herman Eisen.

Eisen HN, Schlesinger S.

Annu Rev Immunol. 2015;33:1-28. doi: 10.1146/annurev-immunol-111214-122349. Epub 2015 Jan 12.


Koch Institute Symposium on Cancer Immunology and Immunotherapy.

Drake A, Joshi NS, Szeto GL, Zhu E, Eisen HN, Irvine DJ.

Cancer Immunol Res. 2013 Oct;1:217-222.


Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virus.

Eisen HN, Chakraborty AK.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):7-8. doi: 10.1073/pnas.1219396110. No abstract available.


Promiscuous binding of extracellular peptides to cell surface class I MHC protein.

Eisen HN, Hou XH, Shen C, Wang K, Tanguturi VK, Smith C, Kozyrytska K, Nambiar L, McKinley CA, Chen J, Cohen RJ.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4580-5. doi: 10.1073/pnas.1201586109. Epub 2012 Mar 7.


Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs.

Stone JD, Artyomov MN, Chervin AS, Chakraborty AK, Eisen HN, Kranz DM.

J Immunol. 2011 Dec 15;187(12):6281-90. doi: 10.4049/jimmunol.1101734. Epub 2011 Nov 18.


Evolving concepts of specificity in immune reactions.

Eisen HN, Chakraborty AK.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22373-80. doi: 10.1073/pnas.1012051108. Epub 2010 Dec 20.


Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues.

Shen CH, Talay O, Mahajan VS, Leskov IB, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22587-92. doi: 10.1073/pnas.1016350108. Epub 2010 Dec 13.


Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.

Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC.

Nature. 2010 Sep 30;467(7315):591-5. doi: 10.1038/nature09385.


The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.

Chervin AS, Stone JD, Holler PD, Bai A, Chen J, Eisen HN, Kranz DM.

J Immunol. 2009 Jul 15;183(2):1166-78. doi: 10.4049/jimmunol.0900054. Epub 2009 Jun 24.


Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.

Bai A, Higham E, Eisen HN, Wittrup KD, Chen J.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13003-8. doi: 10.1073/pnas.0805599105. Epub 2008 Aug 22.


Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes.

Leng Q, Ge Q, Nguyen T, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5038-43. Epub 2007 Mar 14.


Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms.

Ge Q, Holler PD, Mahajan VS, Nuygen T, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1822-7. Epub 2006 Jan 27.


Multiple intracellular routes in the cross-presentation of a soluble protein by murine dendritic cells.

Palliser D, Guillen E, Ju M, Eisen HN.

J Immunol. 2005 Feb 15;174(4):1879-87.


Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines.

Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9534-9. Epub 2004 Jun 21.


Michael Heidelberger.

Eisen HN.

Biogr Mem Natl Acad Sci. 2001;80:122-40. No abstract available.


Inhibition of influenza virus production in virus-infected mice by RNA interference.

Ge Q, Filip L, Bai A, Nguyen T, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8676-81. Epub 2004 Jun 1.


Use of siRNAs to prevent and treat influenza virus infection.

Ge Q, Eisen HN, Chen J.

Virus Res. 2004 Jun 1;102(1):37-42. Review.


Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines.

Wang C, Ge Q, Ting D, Nguyen D, Shen HR, Chen J, Eisen HN, Heller J, Langer R, Putnam D.

Nat Mater. 2004 Mar;3(3):190-6. Epub 2004 Feb 15.


A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.

Rudolph MG, Shen LQ, Lamontagne SA, Luz JG, Delaney JR, Ge Q, Cho BK, Palliser D, McKinley CA, Chen J, Wilson IA, Eisen HN.

J Immunol. 2004 Mar 1;172(5):2994-3002.


A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein.

Palliser D, Huang Q, Hacohen N, Lamontagne SP, Guillen E, Young RA, Eisen HN.

J Immunol. 2004 Mar 1;172(5):2885-93.


Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors.

Ge Q, Bai A, Jones B, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3041-6. Epub 2004 Feb 19.


CD4+ T-cell responses to self-peptide--MHC.

Ge Q, Bai A, Shen CH, Eisen HN, Chen J.

Trends Immunol. 2003 Apr;24(4):186-9.


A model T-cell receptor system for studying memory T-cell development.

Chen J, Eisen HN, Kranz DM.

Microbes Infect. 2003 Mar;5(3):233-40. Review.


RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription.

Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2718-23. Epub 2003 Feb 19.


Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.

Ge Q, Stone JD, Thompson MT, Cochran JR, Rushe M, Eisen HN, Chen J, Stern LJ.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13729-34. Epub 2002 Oct 8.


Naïve to memory T-cell differentiation during homeostasis-driven proliferation.

Ge Q, Hu H, Eisen HN, Chen J.

Microbes Infect. 2002 Apr;4(5):555-8. Review.


Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.

Ge Q, Palliser D, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2983-8. Epub 2002 Feb 19.


How do cultured CD8(+) murine T cell clones survive repeated ligation of the TCR?

Sugawa S, Palliser D, Eisen HN, Chen J.

Int Immunol. 2002 Jan;14(1):23-30.


Potent cytolytic response by a CD8+ CTL clone to multiple peptides from the same protein in association with an allogeneic class I MHC molecule.

Kageyama S, Tsomides TJ, Fukusen N, Papayannopoulos IA, Eisen HN, Sykulev Y.

J Immunol. 2001 Mar 1;166(5):3028-34.


Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.

Cho BK, Lian KC, Lee P, Brunmark A, McKinley C, Chen J, Kranz DM, Eisen HN.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1723-7.


A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins.

Cho BK, Palliser D, Guillen E, Wisniewski J, Young RA, Chen J, Eisen HN.

Immunity. 2000 Mar;12(3):263-72.


Breaking the affinity ceiling for antibodies and T cell receptors.

Foote J, Eisen HN.

Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10679-81. No abstract available.


Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.

Cho BK, Rao VP, Ge Q, Eisen HN, Chen J.

J Exp Med. 2000 Aug 21;192(4):549-56.


Increased generation of CD8+ T cell clones in p53 mutant mice.

Zhou X, Wong S, Walter J, Jacks T, Eisen HN.

J Immunol. 1999 Apr 1;162(7):3957-60.


Functional differences between memory and naive CD8 T cells.

Cho BK, Wang C, Sugawa S, Eisen HN, Chen J.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2976-81.


Peptide antagonism and T cell receptor interactions with peptide-MHC complexes.

Sykulev Y, Vugmeyster Y, Brunmark A, Ploegh HL, Eisen HN.

Immunity. 1998 Oct;9(4):475-83.


A mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors.

Walter JB, Garboczi DN, Fan QR, Zhou X, Walker BD, Eisen HN.

J Immunol Methods. 1998 May 1;214(1-2):41-50.


Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.

Walter JB, Brander C, Mammen M, Garboczi DN, Kalams SA, Whitesides GM, Walker BD, Eisen HN.

Int Immunol. 1997 Mar;9(3):451-9.


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