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Items: 49


Self-organized formation of developing appendages from murine pluripotent stem cells.

Mori S, Sakakura E, Tsunekawa Y, Hagiwara M, Suzuki T, Eiraku M.

Nat Commun. 2019 Aug 23;10(1):3802. doi: 10.1038/s41467-019-11702-y.


Toward the formation of neural circuits in human brain organoids.

Seto Y, Eiraku M.

Curr Opin Cell Biol. 2019 Dec;61:86-91. doi: 10.1016/ Epub 2019 Aug 16. Review.


Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.

Tu HY, Watanabe T, Shirai H, Yamasaki S, Kinoshita M, Matsushita K, Hashiguchi T, Onoe H, Matsuyama T, Kuwahara A, Kishino A, Kimura T, Eiraku M, Suzuma K, Kitaoka T, Takahashi M, Mandai M.

EBioMedicine. 2019 Jan;39:562-574. doi: 10.1016/j.ebiom.2018.11.028. Epub 2018 Nov 28.


Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.

Okuda S, Takata N, Hasegawa Y, Kawada M, Inoue Y, Adachi T, Sasai Y, Eiraku M.

Sci Adv. 2018 Nov 21;4(11):eaau1354. doi: 10.1126/sciadv.aau1354. eCollection 2018 Nov.


Human brain development and its in vitro recapitulation.

Seto Y, Eiraku M.

Neurosci Res. 2019 Jan;138:33-42. doi: 10.1016/j.neures.2018.09.011. Epub 2018 Oct 13. Review.


Publisher Correction: Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching.

Okuda S, Miura T, Inoue Y, Adachi T, Eiraku M.

Sci Rep. 2018 Jun 4;8(1):8522. doi: 10.1038/s41598-018-24858-2.


Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.

Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M.

Stem Cell Reports. 2018 Mar 13;10(3):1059-1074. doi: 10.1016/j.stemcr.2018.01.032. Epub 2018 Mar 1.


Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching.

Okuda S, Miura T, Inoue Y, Adachi T, Eiraku M.

Sci Rep. 2018 Feb 5;8(1):2386. doi: 10.1038/s41598-018-20678-6. Erratum in: Sci Rep. 2018 Jun 4;8(1):8522.


Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine.

Takata N, Eiraku M.

J Hum Genet. 2018 Feb;63(2):165-178. doi: 10.1038/s10038-017-0348-0. Epub 2017 Oct 11. Review.


An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.

Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil HJ, Lavado A, Geng X, Interiano A, Neale G, Eiraku M, Sasai Y, Oliver G.

Cell Rep. 2017 Nov 7;21(6):1534-1549. doi: 10.1016/j.celrep.2017.10.041.


Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism.

Takata N, Sakakura E, Eiraku M, Kasukawa T, Sasai Y.

Nat Commun. 2017 Nov 7;8(1):1339. doi: 10.1038/s41467-017-01105-2.


Contractile actin belt and mesh structures provide the opposite dependence of epithelial stiffness on the spontaneous curvature of constituent cells.

Okuda S, Unoki K, Eiraku M, Tsubota KI.

Dev Growth Differ. 2017 Jun;59(5):455-464. doi: 10.1111/dgd.12373. Epub 2017 Jul 14.


A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells.

Ohgushi M, Minaguchi M, Eiraku M, Sasai Y.

Stem Cell Reports. 2017 Jul 11;9(1):58-66. doi: 10.1016/j.stemcr.2017.05.003. Epub 2017 Jun 1.


Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane.

Okuda S, Eiraku M.

Biomech Model Mechanobiol. 2017 Oct;16(5):1805-1818. doi: 10.1007/s10237-017-0920-8. Epub 2017 May 29.


Generation of a Three-Dimensional Retinal Tissue from Self-Organizing Human ESC Culture.

Kuwahara A, Nakano T, Eiraku M.

Methods Mol Biol. 2017;1597:17-29. doi: 10.1007/978-1-4939-6949-4_2.


Generation of Various Telencephalic Regions from Human Embryonic Stem Cells in Three-Dimensional Culture.

Kadoshima T, Sakaguchi H, Eiraku M.

Methods Mol Biol. 2017;1597:1-16. doi: 10.1007/978-1-4939-6949-4_1.


Emergence of dorsal-ventral polarity in ESC-derived retinal tissue.

Hasegawa Y, Takata N, Okuda S, Kawada M, Eiraku M, Sasai Y.

Development. 2016 Nov 1;143(21):3895-3906. Epub 2016 Sep 15.


Data describing Rax positive optic-vesicle generation from mouse embryonic stem cells in vitro.

Takata N, Eiraku M, Sakakura E.

Data Brief. 2016 Jun 3;8:465-9. doi: 10.1016/j.dib.2016.05.070. eCollection 2016 Sep.


Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture.

Sakakura E, Eiraku M, Takata N.

Mech Dev. 2016 Aug;141:90-99. doi: 10.1016/j.mod.2016.05.001. Epub 2016 May 3.


Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells.

Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y.

Nat Commun. 2016 Jan 14;7:10351. doi: 10.1038/ncomms10351.


Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.

Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E81-90. doi: 10.1073/pnas.1512590113. Epub 2015 Dec 22.


Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.

Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, Sasai Y.

Nat Commun. 2015 Nov 17;6:8896. doi: 10.1038/ncomms9896.


Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework.

Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y.

Biomech Model Mechanobiol. 2016 Aug;15(4):805-16. doi: 10.1007/s10237-015-0724-7. Epub 2015 Sep 11.


Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells.

Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M.

Curr Eye Res. 2016 Apr;41(4):558-68. doi: 10.3109/02713683.2015.1038359. Epub 2015 Apr 16.


Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue.

Kuwahara A, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y.

Nat Commun. 2015 Feb 19;6:6286. doi: 10.1038/ncomms7286.


Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis.

Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y.

Biomech Model Mechanobiol. 2015 Apr;14(2):413-25. doi: 10.1007/s10237-014-0613-5. Epub 2014 Sep 17.


Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.

Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M, Yonemura S, Sasai Y, Takahashi M.

Stem Cell Reports. 2014 Apr 24;2(5):662-74. doi: 10.1016/j.stemcr.2014.03.011. eCollection 2014 May 6.


Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos.

Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H.

Mech Dev. 2014 May;132:44-58. doi: 10.1016/j.mod.2014.01.004. Epub 2014 Feb 7.


Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.

Kadoshima T, Sakaguchi H, Nakano T, Soen M, Ando S, Eiraku M, Sasai Y.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20284-9. doi: 10.1073/pnas.1315710110. Epub 2013 Nov 25. Erratum in: Proc Natl Acad Sci U S A. 2014 May 20;111(20):7498.


Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance.

Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T.

J Biomech. 2013 Jun 21;46(10):1705-13. doi: 10.1016/j.jbiomech.2013.03.035. Epub 2013 May 12.


Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture.

Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai Y.

PLoS One. 2012;7(12):e53024. doi: 10.1371/journal.pone.0053024. Epub 2012 Dec 31.


Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework.

Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T.

Biomech Model Mechanobiol. 2013 Oct;12(5):987-96. doi: 10.1007/s10237-012-0458-8. Epub 2012 Nov 30.


In vitro organogenesis in three dimensions: self-organising stem cells.

Sasai Y, Eiraku M, Suga H.

Development. 2012 Nov;139(22):4111-21. doi: 10.1242/dev.079590. Review.


Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis.

Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T.

Biomech Model Mechanobiol. 2013 Aug;12(4):627-44. doi: 10.1007/s10237-012-0430-7. Epub 2012 Sep 2.


Self-formation of optic cups and storable stratified neural retina from human ESCs.

Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, Saito K, Yonemura S, Eiraku M, Sasai Y.

Cell Stem Cell. 2012 Jun 14;10(6):771-785. doi: 10.1016/j.stem.2012.05.009.


Self-formation of layered neural structures in three-dimensional culture of ES cells.

Eiraku M, Sasai Y.

Curr Opin Neurobiol. 2012 Oct;22(5):768-77. doi: 10.1016/j.conb.2012.02.005. Epub 2012 Mar 9. Review.


Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues.

Eiraku M, Sasai Y.

Nat Protoc. 2011 Dec 15;7(1):69-79. doi: 10.1038/nprot.2011.429.


Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level.

Eiraku M, Adachi T, Sasai Y.

Bioessays. 2012 Jan;34(1):17-25. doi: 10.1002/bies.201100070. Epub 2011 Nov 3.


Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.

Kaneko M, Yamaguchi K, Eiraku M, Sato M, Takata N, Kiyohara Y, Mishina M, Hirase H, Hashikawa T, Kengaku M.

PLoS One. 2011;6(5):e20108. doi: 10.1371/journal.pone.0020108. Epub 2011 May 31.


Self-organizing optic-cup morphogenesis in three-dimensional culture.

Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y.

Nature. 2011 Apr 7;472(7341):51-6. doi: 10.1038/nature09941.


Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.

Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y.

J Neurosci. 2011 Feb 2;31(5):1919-33. doi: 10.1523/JNEUROSCI.5128-10.2011.


Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.

Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y.

Cell Stem Cell. 2010 Aug 6;7(2):225-39. doi: 10.1016/j.stem.2010.06.018.


Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, Matsumura M, Wataya T, Nishiyama A, Muguruma K, Sasai Y.

Cell Stem Cell. 2008 Nov 6;3(5):519-32. doi: 10.1016/j.stem.2008.09.002.


Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.

Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11796-801. doi: 10.1073/pnas.0803078105. Epub 2008 Aug 12.


Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.

Fukazawa N, Yokoyama S, Eiraku M, Kengaku M, Maeda N.

Mol Cell Biol. 2008 Jul;28(14):4494-506. doi: 10.1128/MCB.00074-08. Epub 2008 May 12.


Impaired cerebellar functions in mutant mice lacking DNER.

Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi SY, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H.

Mol Cell Neurosci. 2006 Feb;31(2):326-33. Epub 2005 Nov 17.


DNER acts as a neuron-specific Notch ligand during Bergmann glial development.

Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, Kengaku M.

Nat Neurosci. 2005 Jul;8(7):873-80.


Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes.

Kawaji K, Umeshima H, Eiraku M, Hirano T, Kengaku M.

Mol Cell Neurosci. 2004 Feb;25(2):228-40.


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