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How Thermophilic Gram-Positive Organisms Perform Extracellular Electron Transfer: Characterization of the Cell Surface Terminal Reductase OcwA.

Costa NL, Hermann B, Fourmond V, Faustino MM, Teixeira M, Einsle O, Paquete CM, Louro RO.

MBio. 2019 Aug 20;10(4). pii: e01210-19. doi: 10.1128/mBio.01210-19.


Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism To Achieve N2 Reduction.

Harris DF, Lukoyanov DA, Kallas H, Trncik C, Yang ZY, Compton P, Kelleher N, Einsle O, Dean DR, Hoffman BM, Seefeldt LC.

Biochemistry. 2019 Jul 30;58(30):3293-3301. doi: 10.1021/acs.biochem.9b00468. Epub 2019 Jul 19.


Functional assembly of nitrous oxide reductase provides insights into copper site maturation.

Zhang L, Wüst A, Prasser B, Müller C, Einsle O.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12822-12827. doi: 10.1073/pnas.1903819116. Epub 2019 Jun 12.


A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.

Schulte M, Frick K, Gnandt E, Jurkovic S, Burschel S, Labatzke R, Aierstock K, Fiegen D, Wohlwend D, Gerhardt S, Einsle O, Friedrich T.

Nat Commun. 2019 Jun 11;10(1):2551. doi: 10.1038/s41467-019-10429-0.


X-ray Magnetic Circular Dichroism Spectroscopy Applied to Nitrogenase and Related Models: Experimental Evidence for a Spin-Coupled Molybdenum(III) Center.

Kowalska JK, Henthorn JT, Van Stappen C, Trncik C, Einsle O, Keavney D, DeBeer S.

Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9373-9377. doi: 10.1002/anie.201901899. Epub 2019 Jun 18.


KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.

Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R.

Nat Struct Mol Biol. 2019 May;26(5):361-371. doi: 10.1038/s41594-019-0219-9. Epub 2019 May 6.


Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol.

Li M, Müller C, Fröhlich K, Gorka O, Zhang L, Groß O, Schilling O, Einsle O, Jessen-Trefzer C.

Cell Chem Biol. 2019 Jun 20;26(6):852-862.e6. doi: 10.1016/j.chembiol.2019.03.002. Epub 2019 Apr 18.


Crystal structure of VnfH, the iron protein component of vanadium nitrogenase.

Rohde M, Trncik C, Sippel D, Gerhardt S, Einsle O.

J Biol Inorg Chem. 2018 Oct;23(7):1049-1056. doi: 10.1007/s00775-018-1602-4. Epub 2018 Aug 23.


The Critical E4 State of Nitrogenase Catalysis.

Rohde M, Sippel D, Trncik C, Andrade SLA, Einsle O.

Biochemistry. 2018 Sep 25;57(38):5497-5504. doi: 10.1021/acs.biochem.8b00509. Epub 2018 Jul 17.


A bound reaction intermediate sheds light on the mechanism of nitrogenase.

Sippel D, Rohde M, Netzer J, Trncik C, Gies J, Grunau K, Djurdjevic I, Decamps L, Andrade SLA, Einsle O.

Science. 2018 Mar 30;359(6383):1484-1489. doi: 10.1126/science.aar2765.


Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures.

Parnell AE, Mordhorst S, Kemper F, Giurrandino M, Prince JP, Schwarzer NJ, Hofer A, Wohlwend D, Jessen HJ, Gerhardt S, Einsle O, Oyston PCF, Andexer JN, Roach PL.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3350-3355. doi: 10.1073/pnas.1710741115. Epub 2018 Mar 12.


Another twist on nitrogenases.

Einsle O.

Nat Microbiol. 2018 Mar;3(3):263-264. doi: 10.1038/s41564-018-0116-8. No abstract available.


Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12476-12480. doi: 10.1002/anie.201705516. Epub 2017 Sep 7.


Structural and Functional Analysis of Latex Clearing Protein (Lcp) Provides Insight into the Enzymatic Cleavage of Rubber.

Ilcu L, Röther W, Birke J, Brausemann A, Einsle O, Jendrossek D.

Sci Rep. 2017 Jul 21;7(1):6179. doi: 10.1038/s41598-017-05268-2.


The structure of vanadium nitrogenase reveals an unusual bridging ligand.

Sippel D, Einsle O.

Nat Chem Biol. 2017 Sep;13(9):956-960. doi: 10.1038/nchembio.2428. Epub 2017 Jul 10.


Structure of Phytoene Desaturase Provides Insights into Herbicide Binding and Reaction Mechanisms Involved in Carotene Desaturation.

Brausemann A, Gemmecker S, Koschmieder J, Ghisla S, Beyer P, Einsle O.

Structure. 2017 Aug 1;25(8):1222-1232.e3. doi: 10.1016/j.str.2017.06.002. Epub 2017 Jun 29.


NMR studies of the interaction between inner membrane-associated and periplasmic cytochromes from Geobacter sulfurreducens.

Dantas JM, Brausemann A, Einsle O, Salgueiro CA.

FEBS Lett. 2017 Jun;591(12):1657-1666. doi: 10.1002/1873-3468.12695. Epub 2017 Jun 12.


Nitrogenase Cofactor: Inspiration for Model Chemistry.

Djurdjevic I, Einsle O, Decamps L.

Chem Asian J. 2017 Jul 4;12(13):1447-1455. doi: 10.1002/asia.201700478. Epub 2017 May 31. Review.


Epsilonproteobacterial hydroxylamine oxidoreductase (εHao): characterization of a 'missing link' in the multihaem cytochrome c family.

Haase D, Hermann B, Einsle O, Simon J.

Mol Microbiol. 2017 Jul;105(1):127-138. doi: 10.1111/mmi.13690. Epub 2017 May 9.


Comparative electronic structures of nitrogenase FeMoco and FeVco.

Rees JA, Bjornsson R, Kowalska JK, Lima FA, Schlesier J, Sippel D, Weyhermüller T, Einsle O, Kovacs JA, DeBeer S.

Dalton Trans. 2017 Feb 21;46(8):2445-2455. doi: 10.1039/c7dt00128b.


Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity.

Siegrist J, Netzer J, Mordhorst S, Karst L, Gerhardt S, Einsle O, Richter M, Andexer JN.

FEBS Lett. 2017 Jan;591(2):312-321. doi: 10.1002/1873-3468.12530. Epub 2017 Jan 8.


Production and isolation of vanadium nitrogenase from Azotobacter vinelandii by molybdenum depletion.

Sippel D, Schlesier J, Rohde M, Trncik C, Decamps L, Djurdjevic I, Spatzal T, Andrade SL, Einsle O.

J Biol Inorg Chem. 2017 Jan;22(1):161-168. doi: 10.1007/s00775-016-1423-2. Epub 2016 Dec 7.


Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases.

Conradt D, Hermann B, Gerhardt S, Einsle O, Müller M.

Angew Chem Int Ed Engl. 2016 Dec 12;55(50):15531-15534. doi: 10.1002/anie.201607494. Epub 2016 Nov 22.


The flavinyl transferase ApbE of Pseudomonas stutzeri matures the NosR protein required for nitrous oxide reduction.

Zhang L, Trncik C, Andrade SLA, Einsle O.

Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):95-102. doi: 10.1016/j.bbabio.2016.11.008. Epub 2016 Nov 15.


Chloroplast FBPase and SBPase are thioredoxin-linked enzymes with similar architecture but different evolutionary histories.

Gütle DD, Roret T, Müller SJ, Couturier J, Lemaire SD, Hecker A, Dhalleine T, Buchanan BB, Reski R, Einsle O, Jacquot JP.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6779-84. doi: 10.1073/pnas.1606241113. Epub 2016 May 25.


Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Schmidtkunz K, Jung M, Schüle R, Einsle O, Günther S, Wohlwend D.

Data Brief. 2016 Apr 11;7:1370-4. doi: 10.1016/j.dib.2016.04.009. eCollection 2016 Jun.


Nitrogenase FeMoco investigated by spatially resolved anomalous dispersion refinement.

Spatzal T, Schlesier J, Burger EM, Sippel D, Zhang L, Andrade SL, Rees DC, Einsle O.

Nat Commun. 2016 Mar 14;7:10902. doi: 10.1038/ncomms10902.


Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment.

Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PM, Krüger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H.

J Mol Microbiol Biotechnol. 2016;26(1-3):5-28. doi: 10.1159/000443997. Epub 2016 Mar 10. Review.


Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase.

Boll M, Einsle O, Ermler U, Kroneck PM, Ullmann GM.

J Mol Microbiol Biotechnol. 2016;26(1-3):119-37. doi: 10.1159/000440805. Epub 2016 Mar 10. Review.


Role of Calcium in Secondary Structure Stabilization during Maturation of Nitrous Oxide Reductase.

Schneider LK, Einsle O.

Biochemistry. 2016 Mar 15;55(10):1433-40. doi: 10.1021/acs.biochem.5b01278. Epub 2016 Feb 29.


Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae.

Brausemann A, Gerhardt S, Schott AK, Einsle O, Große-Berkenbusch A, Johnsson N, Gronemeyer T.

J Struct Biol. 2016 Mar;193(3):157-161. doi: 10.1016/j.jsb.2016.01.004. Epub 2016 Jan 9.


Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.

Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R.

Nat Struct Mol Biol. 2016 Feb;23(2):132-9. doi: 10.1038/nsmb.3153. Epub 2016 Jan 11.


Structure-Based Development of an Affinity Probe for Sirtuin 2.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. doi: 10.1002/anie.201509843. Epub 2016 Jan 8.


4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).

Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Einsle O, Günther S, Wohlwend D.

J Med Chem. 2016 Feb 25;59(4):1518-30. doi: 10.1021/acs.jmedchem.5b01267. Epub 2016 Jan 14.


Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M.

J Med Chem. 2016 Feb 25;59(4):1599-612. doi: 10.1021/acs.jmedchem.5b01517. Epub 2016 Jan 7.


Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition.

Newie J, Andreou A, Neumann P, Einsle O, Feussner I, Ficner R.

J Lipid Res. 2016 Feb;57(2):276-87. doi: 10.1194/jlr.M064980. Epub 2015 Dec 14.


A Conformational Switch Triggers Nitrogenase Protection from Oxygen Damage by Shethna Protein II (FeSII).

Schlesier J, Rohde M, Gerhardt S, Einsle O.

J Am Chem Soc. 2016 Jan 13;138(1):239-47. doi: 10.1021/jacs.5b10341. Epub 2015 Dec 24.


Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.

Rumpf T, Gerhardt S, Einsle O, Jung M.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1498-510. doi: 10.1107/S2053230X15019986. Epub 2015 Nov 18.


The Fe-V Cofactor of Vanadium Nitrogenase Contains an Interstitial Carbon Atom.

Rees JA, Bjornsson R, Schlesier J, Sippel D, Einsle O, DeBeer S.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13249-52. doi: 10.1002/anie.201505930. Epub 2015 Sep 17.


Active sites without restraints: high-resolution analysis of metal cofactors.

Burger EM, Andrade SL, Einsle O.

Curr Opin Struct Biol. 2015 Dec;35:32-40. doi: 10.1016/ Epub 2015 Sep 1. Review.


Molybdenum L-Edge XAS Spectra of MoFe Nitrogenase.

Bjornsson R, Delgado-Jaime MU, Lima FA, Sippel D, Schlesier J, Weyhermüller T, Einsle O, Neese F, DeBeer S.

Z Anorg Allg Chem. 2015 Jan;641(1):65-71. Epub 2014 Nov 27.


Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis.

Gemmecker S, Schaub P, Koschmieder J, Brausemann A, Drepper F, Rodriguez-Franco M, Ghisla S, Warscheid B, Einsle O, Beyer P.

PLoS One. 2015 Jul 6;10(7):e0131717. doi: 10.1371/journal.pone.0131717. eCollection 2015.


Structural and Functional Studies of NirC from Salmonella typhimurium.

Rycovska-Blume A, Lü W, Andrade S, Fendler K, Einsle O.

Methods Enzymol. 2015;556:475-97. doi: 10.1016/bs.mie.2014.12.034. Epub 2015 Mar 20.


Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases.

Cahn JK, Brinkmann-Chen S, Spatzal T, Wiig JA, Buller AR, Einsle O, Hu Y, Ribbe MW, Arnold FH.

Biochem J. 2015 Jun 15;468(3):475-84. doi: 10.1042/BJ20150183. Epub 2015 Apr 7.


Substrate pathways in the nitrogenase MoFe protein by experimental identification of small molecule binding sites.

Morrison CN, Hoy JA, Zhang L, Einsle O, Rees DC.

Biochemistry. 2015 Mar 24;54(11):2052-60. doi: 10.1021/bi501313k. Epub 2015 Mar 9.


Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.

Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263.


The octahaem MccA is a haem c-copper sulfite reductase.

Hermann B, Kern M, La Pietra L, Simon J, Einsle O.

Nature. 2015 Apr 30;520(7549):706-9. doi: 10.1038/nature14109. Epub 2015 Feb 2.


Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.

Tam HK, Härle J, Gerhardt S, Rohr J, Wang G, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O.

Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2811-5. doi: 10.1002/anie.201409792. Epub 2015 Jan 7.


The discovery of Mo(III) in FeMoco: reuniting enzyme and model chemistry.

Bjornsson R, Neese F, Schrock RR, Einsle O, DeBeer S.

J Biol Inorg Chem. 2015 Mar;20(2):447-60. doi: 10.1007/s00775-014-1230-6. Epub 2014 Dec 31. Review.


No laughing matter: the unmaking of the greenhouse gas dinitrogen monoxide by nitrous oxide reductase.

Schneider LK, Wüst A, Pomowski A, Zhang L, Einsle O.

Met Ions Life Sci. 2014;14:177-210. doi: 10.1007/978-94-017-9269-1_8. Review.


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