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What's New in Musculoskeletal Basic Science.

Leucht P, Einhorn TA.

J Bone Joint Surg Am. 2019 Oct 10. doi: 10.2106/JBJS.19.00922. [Epub ahead of print] No abstract available.


Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.

HEALTH Investigators, Bhandari M, Einhorn TA, Guyatt G, Schemitsch EH, Zura RD, Sprague S, Frihagen F, Guerra-Farfán E, Kleinlugtenbelt YV, Poolman RW, Rangan A, Bzovsky S, Heels-Ansdell D, Thabane L, Walter SD, Devereaux PJ.

N Engl J Med. 2019 Sep 26. doi: 10.1056/NEJMoa1906190. [Epub ahead of print]


Orthobiologics A Comprehensive Review of the Current Evidence and Use in Orthopedic Subspecialties.

Bravo D, Jazrawi L, Cardone DA, Virk M, Passias PG, Einhorn TA, Leucht P.

Bull Hosp Jt Dis (2013). 2018 Dec;76(4):223-231.


Progranulin promotes diabetic fracture healing in mice with type 1 diabetes.

Wei J, Zhang L, Ding Y, Liu R, Guo Y, Hettinghouse A, Buza J, De La Croix J, Li X, Einhorn TA, Liu CJ.

Ann N Y Acad Sci. 2019 Aug 18. doi: 10.1111/nyas.14208. [Epub ahead of print]


A Comparison of Treatment Effects for Nonsurgical Therapies and the Minimum Clinically Important Difference in Knee Osteoarthritis: A Systematic Review.

Concoff A, Rosen J, Fu F, Bhandari M, Boyer K, Karlsson J, Einhorn TA, Schemitsch E.

JBJS Rev. 2019 Aug;7(8):e5. doi: 10.2106/JBJS.RVW.18.00150.


Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts' consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation.

Hiligsmann M, Reginster JY, Tosteson ANA, Bukata SV, Saag KG, Gold DT, Halbout P, Jiwa F, Lewiecki EM, Pinto D, Adachi JD, Al-Daghri N, Bruyère O, Chandran M, Cooper C, Harvey NC, Einhorn TA, Kanis JA, Kendler DL, Messina OD, Rizzoli R, Si L, Silverman S.

Osteoporos Int. 2019 Jan;30(1):45-57. doi: 10.1007/s00198-018-4744-x. Epub 2018 Oct 31.


The Role of Patient Education in Arthritis Management: The Utility of Technology.

Einhorn TA, Osmani FA, Sayeed Y, Karia R, Band P, Iorio R.

Orthop Clin North Am. 2018 Oct;49(4):389-396. doi: 10.1016/j.ocl.2018.06.004. Epub 2018 Aug 14. Review.


Osteoarthritis and stem cell therapy in humans: a systematic review.

Jevotovsky DS, Alfonso AR, Einhorn TA, Chiu ES.

Osteoarthritis Cartilage. 2018 Jun;26(6):711-729. doi: 10.1016/j.joca.2018.02.906. Epub 2018 Mar 13. Review.


A Comprehensive Review of Stem-Cell Therapy.

Elbuluk A, Einhorn TA, Iorio R.

JBJS Rev. 2017 Aug;5(8):e15. doi: 10.2106/JBJS.RVW.17.00002. Review. No abstract available.


TNFα contributes to diabetes impaired angiogenesis in fracture healing.

Lim JC, Ko KI, Mattos M, Fang M, Zhang C, Feinberg D, Sindi H, Li S, Alblowi J, Kayal RA, Einhorn TA, Gerstenfeld LC, Graves DT.

Bone. 2017 Jun;99:26-38. doi: 10.1016/j.bone.2017.02.014. Epub 2017 Mar 8.


Letter to the Editor in response to Drs. Safiri and Ayubi.

Zura R, Braid-Forbes MJ, Jeray K, Mehta S, Einhorn TA, Watson JT, Della Rocca GJ, Forbes K, Steen RG.

Bone. 2017 Dec;105:309. doi: 10.1016/j.bone.2016.12.010. Epub 2016 Dec 23. No abstract available.


Bone fracture nonunion rate decreases with increasing age: A prospective inception cohort study.

Zura R, Braid-Forbes MJ, Jeray K, Mehta S, Einhorn TA, Watson JT, Della Rocca GJ, Forbes K, Steen RG.

Bone. 2017 Feb;95:26-32. doi: 10.1016/j.bone.2016.11.006. Epub 2016 Nov 9.


Re-evaluation of low intensity pulsed ultrasound in treatment of tibial fractures (TRUST): randomized clinical trial.

TRUST Investigators writing group, Busse JW, Bhandari M, Einhorn TA, Schemitsch E, Heckman JD, Tornetta P 3rd, Leung KS, Heels-Ansdell D, Makosso-Kallyth S, Della Rocca GJ, Jones CB, Guyatt GH.

BMJ. 2016 Oct 25;355:i5351. doi: 10.1136/bmj.i5351.


New Article Type for JBJS Reviews.

Einhorn TA, Swiontkowski MF.

JBJS Rev. 2016 Mar 1;4(3). pii: 01874474-201603000-00004. doi: 10.2106/JBJS.RVW.15.00100. No abstract available.


Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling.

Zhao YP, Wei JL, Tian QY, Liu AT, Yi YS, Einhorn TA, Liu CJ.

Sci Rep. 2016 Feb 11;6:20909. doi: 10.1038/srep20909.


Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

Cooper C, Bardin T, Brandi ML, Cacoub P, Caminis J, Civitelli R, Cutolo M, Dere W, Devogelaer JP, Diez-Perez A, Einhorn TA, Emonts P, Ethgen O, Kanis JA, Kaufman JM, Kvien TK, Lems WF, McCloskey E, Miossec P, Reiter S, Ringe J, Rizzoli R, Saag K, Reginster JY.

Aging Clin Exp Res. 2016 Feb;28(1):1-16. doi: 10.1007/s40520-015-0522-1. Epub 2016 Jan 8. Review.


Healing Time and Complications in Operatively Treated Atypical Femur Fractures Associated With Bisphosphonate Use: A Multicenter Retrospective Cohort.

Bogdan Y, Tornetta P 3rd, Einhorn TA, Guy P, Leveille L, Robinson J, Bosse MJ, Haines N, Horwitz D, Jones C, Schemitsch E, Sagi C, Thomas B, Stahl D, Ricci W, Brady M, Sanders D, Kain M, Higgins TF, Collinge C, Kottmeier S, Friess D.

J Orthop Trauma. 2016 Apr;30(4):177-81. doi: 10.1097/BOT.0000000000000516.


Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial.

Bhandari M, Devereaux PJ, Einhorn TA, Thabane L, Schemitsch EH, Koval KJ, Frihagen F, Poolman RW, Tetsworth K, Guerra-Farfán E, Madden K, Sprague S, Guyatt G; HEALTH Investigators.

BMJ Open. 2015 Feb 13;5(2):e006263. doi: 10.1136/bmjopen-2014-006263.


Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism.

Ko KI, Coimbra LS, Tian C, Alblowi J, Kayal RA, Einhorn TA, Gerstenfeld LC, Pignolo RJ, Graves DT.

Diabetologia. 2015 Mar;58(3):633-642. doi: 10.1007/s00125-014-3470-y. Epub 2015 Jan 7.


Fracture healing: mechanisms and interventions.

Einhorn TA, Gerstenfeld LC.

Nat Rev Rheumatol. 2015 Jan;11(1):45-54. doi: 10.1038/nrrheum.2014.164. Epub 2014 Sep 30. Review.


Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study.

Busse JW, Bhandari M, Einhorn TA, Heckman JD, Leung KS, Schemitsch E, Tornetta P 3rd, Walter SD, Guyatt GH.

Trials. 2014 Jun 4;15:206. doi: 10.1186/1745-6215-15-206.


Has the Promise Been Kept?

Einhorn TA.

JBJS Rev. 2014 Jun 3;2(6). pii: 01874474-201402060-00003. doi: 10.2106/JBJS.RVW.N.00058. No abstract available.


Welcome to JBJS Reviews!

Einhorn TA, Tolo VT.

JBJS Rev. 2013 Nov 19;1(1). pii: 01874474-201311000-00001. doi: 10.2106/JBJS.RVW.M.00079. No abstract available.


Bisphosphonate-associated fractures of the femur: pathophysiology and treatment.

Einhorn TA, Bogdan Y, Tornetta P 3rd.

J Orthop Trauma. 2014 Jul;28(7):433-8. doi: 10.1097/BOT.0000000000000023. Review. No abstract available.


Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells.

Marsell R, Steen B, Bais MV, Mortlock DP, Einhorn TA, Gerstenfeld LC.

J Orthop Res. 2014 Jan;32(1):17-23. doi: 10.1002/jor.22487. Epub 2013 Sep 9.


2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues.

Rodeo SA, Boden SD, Murray MM, Einhorn TA.

J Bone Joint Surg Am. 2013 Aug 7;95(15):e109. doi: 10.2106/JBJS.K.01505. No abstract available.


Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research.

Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Ebeling PR, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Howe TS, van der Meulen MC, Weinstein RS, Whyte MP.

J Bone Miner Res. 2014 Jan;29(1):1-23. doi: 10.1002/jbmr.1998. Epub 2013 Oct 1. Review.


Functional role of Runx3 in the regulation of aggrecan expression during cartilage development.

Wigner NA, Soung do Y, Einhorn TA, Drissi H, Gerstenfeld LC.

J Cell Physiol. 2013 Nov;228(11):2232-42. doi: 10.1002/jcp.24396.


Invited commentary.

Einhorn TA.

J Orthop Trauma. 2014 Jan;28(1):62; discussion 62. doi: 10.1097/BOT.0b013e31828e15f1. No abstract available.


Chemokine expression is upregulated in chondrocytes in diabetic fracture healing.

Alblowi J, Tian C, Siqueira MF, Kayal RA, McKenzie E, Behl Y, Gerstenfeld L, Einhorn TA, Graves DT.

Bone. 2013 Mar;53(1):294-300. doi: 10.1016/j.bone.2012.12.006. Epub 2012 Dec 20.


Qualitative and quantitative differences between bone graft obtained from the medullary canal (with a Reamer/Irrigator/Aspirator) and the iliac crest of the same patient.

Sagi HC, Young ML, Gerstenfeld L, Einhorn TA, Tornetta P.

J Bone Joint Surg Am. 2012 Dec 5;94(23):2128-35. doi: 10.2106/JBJS.L.00159.


Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis.

Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, Gerstenfeld LC.

Bone. 2012 Jul;51(1):168-80. doi: 10.1016/j.bone.2012.02.017. Epub 2012 Feb 25.


Beyond a reasonable doubt? Bisphosphonates and atypical femur fractures.

Abrahamsen B, Einhorn TA.

Bone. 2012 May;50(5):1196-200. doi: 10.1016/j.bone.2012.02.009. Epub 2012 Feb 16. Review.


Poor citation of prior evidence in hip fracture trials.

Sheth U, Simunovic N, Tornetta P 3rd, Einhorn TA, Bhandari M.

J Bone Joint Surg Am. 2011 Nov 16;93(22):2079-86. doi: 10.2106/JBJS.J.01274. Review.


Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis.

Sheth U, Simunovic N, Klein G, Fu F, Einhorn TA, Schemitsch E, Ayeni OR, Bhandari M.

J Bone Joint Surg Am. 2012 Feb 15;94(4):298-307. doi: 10.2106/JBJS.K.00154. Review.


New technologies for the enhancement of skeletal repair: Challenges and opportunities.

Einhorn TA.

Indian J Orthop. 2011 Nov;45(6):489-91. doi: 10.4103/0019-5413.87113. No abstract available.


Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.

Bais MV, Shabin ZM, Young M, Einhorn TA, Kotton DN, Gerstnefeld LC.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):211-6. doi: 10.1016/j.bbrc.2011.11.087. Epub 2011 Nov 28.


Variability in the approach to total hip arthroplasty in patients with displaced femoral neck fractures.

Chaudhry H, Mundi R, Einhorn TA, Russell TA, Parvizi J, Bhandari M.

J Arthroplasty. 2012 Apr;27(4):569-74. doi: 10.1016/j.arth.2011.06.025. Epub 2011 Aug 19. Review.


The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation.

Grimes R, Jepsen KJ, Fitch JL, Einhorn TA, Gerstenfeld LC.

J Bone Miner Res. 2011 Nov;26(11):2597-609. doi: 10.1002/jbmr.486.


Managing bone defects.

Nauth A, McKee MD, Einhorn TA, Watson JT, Li R, Schemitsch EH.

J Orthop Trauma. 2011 Aug;25(8):462-6. doi: 10.1097/BOT.0b013e318224caf0.


Urine matrix metalloproteinases (MMPs) as biomarkers for the progression of fracture healing.

Wigner NA, Kulkarni N, Yakavonis M, Young M, Tinsley B, Meeks B, Einhorn TA, Gerstenfeld LC.

Injury. 2012 Mar;43(3):274-8. doi: 10.1016/j.injury.2011.05.038.


The biology of fracture healing.

Marsell R, Einhorn TA.

Injury. 2011 Jun;42(6):551-5. doi: 10.1016/j.injury.2011.03.031. Epub 2011 Apr 13.


Fracture healing and bone repair.

Giannoudis PV, Jones E, Einhorn TA.

Injury. 2011 Jun;42(6):549-50. doi: 10.1016/j.injury.2011.03.037. Epub 2011 Apr 7. No abstract available.


Bone healing: little secrets.

Einhorn TA.

Clin Cases Miner Bone Metab. 2011 Jan;8(1):17-20.


Use of clinical assessment tools in the evaluation of fracture healing.

Axelrad TW, Einhorn TA.

Injury. 2011 Mar;42(3):301-5. doi: 10.1016/j.injury.2010.11.043. Epub 2010 Dec 9. Review.


Anabolic agents and bone quality.

Sibai T, Morgan EF, Einhorn TA.

Clin Orthop Relat Res. 2011 Aug;469(8):2215-24. doi: 10.1007/s11999-010-1722-9. Review.


Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research.

Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M; American Society for Bone and Mineral Research.

J Bone Miner Res. 2010 Nov;25(11):2267-94. doi: 10.1002/jbmr.253. Erratum in: J Bone Miner Res. 2011 Aug;26(8):1987.


Growth factors: beyond bone morphogenetic proteins.

Nauth A, Giannoudis PV, Einhorn TA, Hankenson KD, Friedlaender GE, Li R, Schemitsch EH.

J Orthop Trauma. 2010 Sep;24(9):543-6. doi: 10.1097/BOT.0b013e3181ec4833. Review.


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