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Items: 1 to 50 of 64

1.

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.

Mueller M, Thorell A, Claudel T, Jha P, Koefeler H, Lackner C, Hoesel B, Fauler G, Stojakovic T, Einarsson C, Marschall HU, Trauner M.

J Hepatol. 2015 Jun;62(6):1398-404. doi: 10.1016/j.jhep.2014.12.034. Epub 2015 Jan 21.

2.

Gallstone disease in Swedish twins is associated with the Gilbert variant of UGT1A1.

Marschall HU, Krawczyk M, Grünhage F, Katsika D, Einarsson C, Lammert F.

Liver Int. 2013 Jul;33(6):904-8. doi: 10.1111/liv.12141. Epub 2013 Mar 20.

PMID:
23517300
3.

Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotype.

Katsika D, Magnusson P, Krawczyk M, Grünhage F, Lichtenstein P, Einarsson C, Lammert F, Marschall HU.

J Intern Med. 2010 Sep;268(3):279-85. doi: 10.1111/j.1365-2796.2010.02249.x. Epub 2010 Apr 28.

4.

The genetic background of gallstone formation: an update.

Marschall HU, Katsika D, Rudling M, Einarsson C.

Biochem Biophys Res Commun. 2010 May 21;396(1):58-62. doi: 10.1016/j.bbrc.2010.02.143. Review.

PMID:
20494111
5.

ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients.

Parini P, Jiang ZY, Einarsson C, Eggertsen G, Zhang SD, Rudel LL, Han TQ, Eriksson M.

Atherosclerosis. 2009 Nov;207(1):266-71. doi: 10.1016/j.atherosclerosis.2009.04.010. Epub 2009 Apr 17.

6.

Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.

Jiang ZY, Jiang CY, Wang L, Wang JC, Zhang SD, Einarsson C, Eriksson M, Han TQ, Parini P, Eggertsen G.

Biochem Biophys Res Commun. 2009 Jan 30;379(1):49-54. doi: 10.1016/j.bbrc.2008.11.131. Epub 2008 Dec 9.

PMID:
19071091
7.

Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2.

Parini P, Gustafsson U, Davis MA, Larsson L, Einarsson C, Wilson M, Rudling M, Tomoda H, Omura S, Sahlin S, Angelin B, Rudel LL, Eriksson M.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1200-6. doi: 10.1161/ATVBAHA.107.157172. Epub 2008 Mar 13.

8.

Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice.

Leikin-Frenkel A, Parini P, Konikoff FM, Benthin L, Leikin-Gobbi D, Goldiner I, Einarsson C, Gilat T.

Arch Biochem Biophys. 2008 Mar 1;471(1):63-71. doi: 10.1016/j.abb.2007.12.005. Epub 2007 Dec 23.

PMID:
18167305
9.

Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients.

Jiang ZY, Parini P, Eggertsen G, Davis MA, Hu H, Suo GJ, Zhang SD, Rudel LL, Han TQ, Einarsson C.

J Lipid Res. 2008 Feb;49(2):464-72. Epub 2007 Nov 15.

10.

Ethanol stimulates bile acid formation in primary human hepatocytes.

Nilsson LM, Sjövall J, Strom S, Bodin K, Nowak G, Einarsson C, Ellis E.

Biochem Biophys Res Commun. 2007 Dec 28;364(4):743-7. Epub 2007 Oct 15.

PMID:
17976534
11.

Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study.

Katsika D, Tuvblad C, Einarsson C, Lichtenstein P, Marschall HU.

J Intern Med. 2007 Nov;262(5):581-7. Epub 2007 Oct 1.

12.

Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.

Sanyal S, Båvner A, Haroniti A, Nilsson LM, Lundåsen T, Rehnmark S, Witt MR, Einarsson C, Talianidis I, Gustafsson JA, Treuter E.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15665-70. Epub 2007 Sep 25.

13.

Gallstone disease.

Marschall HU, Einarsson C.

J Intern Med. 2007 Jun;261(6):529-42. Review.

14.

Bile acids and lipoprotein metabolism: effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression.

Nilsson LM, Abrahamsson A, Sahlin S, Gustafsson U, Angelin B, Parini P, Einarsson C.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):707-11. Epub 2007 Apr 9.

PMID:
17448444
15.

Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse.

Wang J, Olin M, Rozell B, Björkhem I, Einarsson C, Eggertsen G, Gåfvels M.

Histochem Cell Biol. 2007 Mar;127(3):253-61. Epub 2007 Jan 20.

PMID:
17237956
16.

Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption.

Montagnani M, Abrahamsson A, Gälman C, Eggertsen G, Marschall HU, Ravaioli E, Einarsson C, Dawson PA.

World J Gastroenterol. 2006 Dec 21;12(47):7710-4.

17.

The micro-flora of the small bowel in health and disease.

Sullivan A, Törnblom H, Lindberg G, Hammarlund B, Palmgren AC, Einarsson C, Nord CE.

Anaerobe. 2003 Feb;9(1):11-4.

PMID:
16887682
18.

Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice.

Wang J, Gåfvels M, Rudling M, Murphy C, Björkhem I, Einarsson C, Eggertsen G.

Biochem Biophys Res Commun. 2006 Apr 21;342(4):1382-8. Epub 2006 Feb 28.

PMID:
16516849
19.

Gallbladder bile composition in patients with Crohn 's disease.

Lapidus A, Akerlund JE, Einarsson C.

World J Gastroenterol. 2006 Jan 7;12(1):70-4.

20.

Gastrointestinal absorption of metallic mercury.

Sandborgh-Englund G, Einarsson C, Sandström M, Ekstrand J.

Arch Environ Health. 2004 Sep;59(9):449-54.

PMID:
16381485
21.

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.

Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU.

J Hepatol. 2006 Jan;44(1):243-5. Epub 2005 Oct 27.

PMID:
16288819
22.

Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile.

Abrahamsson A, Gåfvels M, Reihnér E, Björkhem I, Einarsson C, Eggertsen G.

Scand J Clin Lab Invest. 2005;65(7):595-600.

PMID:
16271991
23.

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.

Wang J, Einarsson C, Murphy C, Parini P, Björkhem I, Gåfvels M, Eggertsen G.

J Lipid Res. 2006 Feb;47(2):421-30. Epub 2005 Nov 1.

24.

Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration.

Abrahamsson A, Krapivner S, Gustafsson U, Muhrbeck O, Eggertsen G, Johansson I, Persson I, Angelin B, Ingelman-Sundberg M, Björkhem I, Einarsson C, van't Hooft FM.

Atherosclerosis. 2005 Sep;182(1):37-45. Epub 2005 Mar 3.

PMID:
16115473
25.

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.

Marschall HU, Wagner M, Zollner G, Fickert P, Diczfalusy U, Gumhold J, Silbert D, Fuchsbichler A, Benthin L, Grundström R, Gustafsson U, Sahlin S, Einarsson C, Trauner M.

Gastroenterology. 2005 Aug;129(2):476-85.

PMID:
16083704
26.

Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern.

Wang J, Greene S, Eriksson LC, Rozell B, Reihnér E, Einarsson C, Eggertsen G, Gåfvels M.

Histochem Cell Biol. 2005 Jun;123(4-5):441-6. Epub 2005 May 13.

PMID:
15891895
27.

Changes in gallbladder bile composition and crystal detection time in morbidly obese subjects after bariatric surgery.

Gustafsson U, Benthin L, Granström L, Groen AK, Sahlin S, Einarsson C.

Hepatology. 2005 Jun;41(6):1322-8.

PMID:
15834935
28.

Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.

Abrahamsson A, Gustafsson U, Ellis E, Nilsson LM, Sahlin S, Björkhem I, Einarsson C.

Biochem Biophys Res Commun. 2005 May 6;330(2):395-9.

PMID:
15796896
29.

Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs.

Katsika D, Grjibovski A, Einarsson C, Lammert F, Lichtenstein P, Marschall HU.

Hepatology. 2005 May;41(5):1138-43.

PMID:
15747383
30.

Ursodeoxycholic acid treatment in IBD-patients with colorectal dysplasia and/or DNA-aneuploidy: a prospective, double-blind, randomized controlled pilot study.

Sjöqvist U, Tribukait B, Ost A, Einarsson C, Oxelmark L, Löfberg R.

Anticancer Res. 2004 Sep-Oct;24(5B):3121-7.

31.

ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.

Parini P, Davis M, Lada AT, Erickson SK, Wright TL, Gustafsson U, Sahlin S, Einarsson C, Eriksson M, Angelin B, Tomoda H, Omura S, Willingham MC, Rudel LL.

Circulation. 2004 Oct 5;110(14):2017-23. Epub 2004 Sep 27.

PMID:
15451793
32.

Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).

Yang Y, Eggertsen G, Gåfvels M, Andersson U, Einarsson C, Björkhem I, Chiang JY.

Biochem Biophys Res Commun. 2004 Aug 6;320(4):1204-10.

PMID:
15249218
33.

Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians.

Gälman C, Miquel JF, Pérez RM, Einarsson C, Ståhle L, Marshall G, Nervi F, Rudling M.

Gastroenterology. 2004 Mar;126(3):741-8.

PMID:
14988828
34.

Studies on the mechanism of accumulation of cholesterol in the gallbladder mucosa. Evidence that sterol 27-hydroxylase is not a pathogenetic factor.

Strömsten A, von Bahr S, Bringman S, Saeki M, Sahlin S, Björkhem I, Einarsson C.

J Hepatol. 2004 Jan;40(1):8-13.

PMID:
14672608
35.

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.

Ellis E, Axelson M, Abrahamsson A, Eggertsen G, Thörne A, Nowak G, Ericzon BG, Björkhem I, Einarsson C.

Hepatology. 2003 Oct;38(4):930-8.

PMID:
14512880
36.

High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation.

Gustafsson U, Sahlin S, Einarsson C.

World J Gastroenterol. 2003 Jul;9(7):1576-9.

37.

Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver.

Rudling M, Angelin B, Ståhle L, Reihnér E, Sahlin S, Olivecrona H, Björkhem I, Einarsson C.

J Clin Endocrinol Metab. 2002 Sep;87(9):4307-13.

PMID:
12213890
38.

Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism.

Hillebrant CG, Nyberg B, Gustafsson U, Sahlin S, Björkhem I, Rudling M, Einarsson C.

Eur J Clin Invest. 2002 Jul;32(7):528-34.

PMID:
12153554
39.

DNA ploidy and S-phase fraction in carcinoma of the gallbladder related to histopathology, number of gallstones and survival.

Gustafsson U, Einarsson C, Eriksson LC, Gadaleanu V, Sahlin S, Tribukait B.

Anal Cell Pathol. 2001;23(3-4):143-52.

40.

Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1.

Björkhem I, Araya Z, Rudling M, Angelin B, Einarsson C, Wikvall K.

J Biol Chem. 2002 Jul 26;277(30):26804-7. Epub 2002 May 13.

41.

GH is a regulator of IGF2 promoter-specific transcription in human liver.

von Horn H, Ekström C, Ellis E, Olivecrona H, Einarsson C, Tally M, Ekström TJ.

J Endocrinol. 2002 Mar;172(3):457-65.

PMID:
11874694
42.

Bile acid formation in primary human hepatocytes.

Einarsson C, Ellis E, Abrahamsson A, Ericzon BG, Bjorkhem I, Axelson M.

World J Gastroenterol. 2000 Aug;6(4):522-525.

43.

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

Taipalensuu J, Törnblom H, Lindberg G, Einarsson C, Sjöqvist F, Melhus H, Garberg P, Sjöström B, Lundgren B, Artursson P.

J Pharmacol Exp Ther. 2001 Oct;299(1):164-70.

PMID:
11561076
44.

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

Bodin K, Bretillon L, Aden Y, Bertilsson L, Broomé U, Einarsson C, Diczfalusy U.

J Biol Chem. 2001 Oct 19;276(42):38685-9. Epub 2001 Aug 20.

45.

From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans.

Bjorkhem I, Andersson U, Ellis E, Alvelius G, Ellegard L, Diczfalusy U, Sjovall J, Einarsson C.

J Biol Chem. 2001 Oct 5;276(40):37004-10. Epub 2001 Jul 19.

46.

Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans.

Diczfalusy MA, Björkhem I, Einarsson C, Hillebrant CG, Alexson SE.

J Lipid Res. 2001 Jul;42(7):1025-32.

47.

Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis.

Marschall HU, Broomé U, Einarsson C, Alvelius G, Thomas HG, Matern S.

J Lipid Res. 2001 May;42(5):735-42.

48.
50.

Effects of colectomy on bile composition, cholesterol saturation and cholesterol crystal formation in humans.

Akerlund JE, Einarsson C.

Int J Colorectal Dis. 2000 Aug;15(4):248-52.

PMID:
11008727

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