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Antimicrob Agents Chemother. 2011 Jun;55(6):3058-62. doi: 10.1128/AAC.01667-10. Epub 2011 Apr 4.

Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis.

Author information

1
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.

Abstract

Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics can make treatments less effective in some cases. We tested selected oligopeptoids--previously reported as mimics of natural host defense peptides--for activity against Mycobacterium tuberculosis and assessed their cytotoxicity. A tetrameric, alkylated, cationic peptoid (1-C13(4mer)) was most potent against M. tuberculosis and least cytotoxic, whereas an unalkylated analogue, peptoid 1(4mer), was inactive. Peptoid 1-C13(4mer) thus merits further study as a potential antituberculosis drug.

PMID:
21464254
PMCID:
PMC3101442
DOI:
10.1128/AAC.01667-10
[Indexed for MEDLINE]
Free PMC Article

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