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Items: 1 to 50 of 237

1.

The Expanding World of N-MYC-Driven Tumors.

Rickman DS, Schulte JH, Eilers M.

Cancer Discov. 2018 Feb;8(2):150-163. doi: 10.1158/2159-8290.CD-17-0273. Epub 2018 Jan 22. Review.

PMID:
29358508
2.

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.

Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M.

Cell Rep. 2017 Dec 19;21(12):3483-3497. doi: 10.1016/j.celrep.2017.11.090.

3.

MYC and tumor metabolism: chicken and egg.

Dejure FR, Eilers M.

EMBO J. 2017 Dec 1;36(23):3409-3420. doi: 10.15252/embj.201796438. Epub 2017 Nov 10. Review.

PMID:
29127156
4.

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project.

Moreno L, Caron H, Geoerger B, Eggert A, Schleiermacher G, Brock P, Valteau-Couanet D, Chesler L, Schulte JH, De Preter K, Molenaar J, Schramm A, Eilers M, Van Maerken T, Johnsen JI, Garrett M, George SL, Tweddle DA, Kogner P, Berthold F, Koster J, Barone G, Tucker ER, Marshall L, Herold R, Sterba J, Norga K, Vassal G, Pearson AD.

Expert Opin Drug Discov. 2017 Aug;12(8):801-811. doi: 10.1080/17460441.2017.1340269. Epub 2017 Jun 26. Review.

PMID:
28604107
5.

G Protein-Coupled Receptors Contain Two Conserved Packing Clusters.

Sanchez-Reyes OB, Cooke ALG, Tranter DB, Rashid D, Eilers M, Reeves PJ, Smith SO.

Biophys J. 2017 Jun 6;112(11):2315-2326. doi: 10.1016/j.bpj.2017.04.051.

6.

The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.

Dejure FR, Royla N, Herold S, Kalb J, Walz S, Ade CP, Mastrobuoni G, Vanselow JT, Schlosser A, Wolf E, Kempa S, Eilers M.

EMBO J. 2017 Jul 3;36(13):1854-1868. doi: 10.15252/embj.201796662. Epub 2017 Apr 13.

7.

A conformational switch regulates the ubiquitin ligase HUWE1.

Sander B, Xu W, Eilers M, Popov N, Lorenz S.

Elife. 2017 Feb 14;6. pii: e21036. doi: 10.7554/eLife.21036.

8.

The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4.

Sandbothe M, Buurman R, Reich N, Greiwe L, Vajen B, Gürlevik E, Schäffer V, Eilers M, Kühnel F, Vaquero A, Longerich T, Roessler S, Schirmacher P, Manns MP, Illig T, Schlegelberger B, Skawran B.

J Hepatol. 2017 May;66(5):1012-1021. doi: 10.1016/j.jhep.2017.01.004. Epub 2017 Jan 11.

PMID:
28088579
9.

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.

Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731. Epub 2016 Nov 11.

10.

Dietary Interventions in Multiple Sclerosis: Development and Pilot-Testing of an Evidence Based Patient Education Program.

Riemann-Lorenz K, Eilers M, von Geldern G, Schulz KH, Köpke S, Heesen C.

PLoS One. 2016 Oct 20;11(10):e0165246. doi: 10.1371/journal.pone.0165246. eCollection 2016.

11.

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.

Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M.

Oncogene. 2017 Apr 6;36(14):1911-1924. doi: 10.1038/onc.2016.354. Epub 2016 Oct 17.

PMID:
27748763
12.

TEAD activity is restrained by MYC and stratifies human breast cancer subtypes.

Elster D, Jaenicke LA, Eilers M, von Eyss B.

Cell Cycle. 2016 Oct;15(19):2551-2556. Epub 2016 Jul 19.

13.

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.

Dardenne E, Beltran H, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Yuen KS, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Demichelis F, Rickman DS.

Cancer Cell. 2016 Oct 10;30(4):563-577. doi: 10.1016/j.ccell.2016.09.005.

14.

Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.

Kimata N, Pope A, Eilers M, Opefi CA, Ziliox M, Hirshfeld A, Zaitseva E, Vogel R, Sheves M, Reeves PJ, Smith SO.

Nat Commun. 2016 Sep 2;7:12683. doi: 10.1038/ncomms12683.

15.

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma.

Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, Jamin Y, Thway K, Robinson SP, Roels F, Witt O, Fischer M, Chesler L, Eilers M.

Cancer Cell. 2016 Aug 8;30(2):357-358. doi: 10.1016/j.ccell.2016.07.002. Epub 2016 Aug 8. No abstract available.

16.

Different promoter affinities account for specificity in MYC-dependent gene regulation.

Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E.

Elife. 2016 Jul 27;5. pii: e15161. doi: 10.7554/eLife.15161.

17.

Free backbone carbonyls mediate rhodopsin activation.

Kimata N, Pope A, Sanchez-Reyes OB, Eilers M, Opefi CA, Ziliox M, Reeves PJ, Smith SO.

Nat Struct Mol Biol. 2016 Aug;23(8):738-43. doi: 10.1038/nsmb.3257. Epub 2016 Jul 4.

18.

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L.

Nat Med. 2016 Jul;22(7):744-53. doi: 10.1038/nm.4107. Epub 2016 May 23.

PMID:
27213815
19.

MYC regulates the antitumor immune response through CD47 and PD-L1.

Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gütgemann I, Eilers M, Felsher DW.

Science. 2016 Apr 8;352(6282):227-31. doi: 10.1126/science.aac9935. Epub 2016 Mar 10. Erratum in: Science. 2016 Apr 8;352(6282). pii: aaf7984. doi: 10.1126/science.aaf7984.

20.

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.

Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, Nikolaev SI.

Nat Genet. 2016 Apr;48(4):398-406. doi: 10.1038/ng.3525. Epub 2016 Mar 7.

PMID:
26950094
21.

MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures.

Haikala HM, Klefström J, Eilers M, Wiese KE.

Cell Cycle. 2016;15(3):316-23. doi: 10.1080/15384101.2015.1121351.

22.

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

Vo BT, Wolf E, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF.

Cancer Cell. 2016 Jan 11;29(1):5-16. doi: 10.1016/j.ccell.2015.12.003.

23.

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N.

Mol Cell. 2016 Jan 7;61(1):54-67. doi: 10.1016/j.molcel.2015.11.007. Epub 2015 Dec 10.

24.

A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.

von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M.

Cancer Cell. 2015 Dec 14;28(6):743-757. doi: 10.1016/j.ccell.2015.10.013.

25.

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R.

EMBO Rep. 2015 Dec;16(12):1723-36. doi: 10.15252/embr.201540717. Epub 2015 Nov 4.

26.

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas.

Meder L, König K, Ozretić L, Schultheis AM, Ueckeroth F, Ade CP, Albus K, Boehm D, Rommerscheidt-Fuss U, Florin A, Buhl T, Hartmann W, Wolf J, Merkelbach-Bruse S, Eilers M, Perner S, Heukamp LC, Buettner R.

Int J Cancer. 2016 Feb 15;138(4):927-38. doi: 10.1002/ijc.29835. Epub 2015 Sep 25.

27.

[Fritz Kahn's The Life of Man: Production and Transcription of a Bestseller].

Eilers M.

NTM. 2015;23(1-2):1-31. doi: 10.1007/s00048-015-0126-z. German.

PMID:
26253361
28.

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.

Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knöll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, López-Olañeta MM, Gómez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schäfer S, Hübner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knöll R.

Circ Cardiovasc Genet. 2015 Oct;8(5):643-52. doi: 10.1161/CIRCGENETICS.113.000690. Epub 2015 Jul 14.

29.

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.

Wiegering A, Uthe FW, Jamieson T, Ruoss Y, Hüttenrauch M, Küspert M, Pfann C, Nixon C, Herold S, Walz S, Taranets L, Germer CT, Rosenwald A, Sansom OJ, Eilers M.

Cancer Discov. 2015 Jul;5(7):768-781. doi: 10.1158/2159-8290.CD-14-1040. Epub 2015 May 1.

30.

Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.

Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.

EMBO J. 2015 Jun 3;34(11):1554-71. doi: 10.15252/embj.201490467. Epub 2015 Apr 20.

31.

Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.

Diefenbacher ME, Chakraborty A, Blake SM, Mitter R, Popov N, Eilers M, Behrens A.

Cancer Res. 2015 Apr 1;75(7):1181-6. doi: 10.1158/0008-5472.CAN-14-1726. Epub 2015 Feb 25.

32.

Adolescent pregnancy, birth, and abortion rates across countries: levels and recent trends.

Sedgh G, Finer LB, Bankole A, Eilers MA, Singh S.

J Adolesc Health. 2015 Feb;56(2):223-30. doi: 10.1016/j.jadohealth.2014.09.007.

33.

Taming of the beast: shaping Myc-dependent amplification.

Wolf E, Lin CY, Eilers M, Levens DL.

Trends Cell Biol. 2015 Apr;25(4):241-8. doi: 10.1016/j.tcb.2014.10.006. Epub 2014 Dec 1. Review.

34.

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.

Weber D, Heisig J, Kneitz S, Wolf E, Eilers M, Gessler M.

J Mol Cell Cardiol. 2015 Feb;79:79-88. doi: 10.1016/j.yjmcc.2014.11.004. Epub 2014 Nov 13.

PMID:
25446183
35.

Dual regulation of Fbw7 function and oncogenic transformation by Usp28.

Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Jänicke LA, Diefenbacher ME, Behrens A, Eilers M, Popov N.

Cell Rep. 2014 Nov 6;9(3):1099-109. doi: 10.1016/j.celrep.2014.09.057. Epub 2014 Oct 30.

36.

Secondhand tobacco smoke exposure among hospitalized nonsmokers with coronary heart disease.

Japuntich SJ, Eilers MA, Shenhav S, Park ER, Winickoff JP, Benowitz NL, Rigotti NA.

JAMA Intern Med. 2015 Jan;175(1):133-6. doi: 10.1001/jamainternmed.2014.5476. No abstract available.

37.

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M.

EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927.

38.

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L.

Nat Med. 2014 Oct;20(10):1138-46. doi: 10.1038/nm.3679. Epub 2014 Sep 14.

39.

BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.

Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ.

Cell Rep. 2014 Sep 11;8(5):1347-53. doi: 10.1016/j.celrep.2014.07.057. Epub 2014 Aug 28.

40.

Drugging MYCN through an allosteric transition in Aurora kinase A.

Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA.

Cancer Cell. 2014 Sep 8;26(3):414-427. doi: 10.1016/j.ccr.2014.07.015. Epub 2014 Aug 28.

41.

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M.

Nature. 2014 Jul 24;511(7510):483-7. doi: 10.1038/nature13473. Epub 2014 Jul 9. Erratum in: Nature. 2014 Dec 18;516(7531):440.

PMID:
25043018
42.

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.

Diefenbacher ME, Popov N, Blake SM, Schülein-Völk C, Nye E, Spencer-Dene B, Jaenicke LA, Eilers M, Behrens A.

J Clin Invest. 2014 Aug;124(8):3407-18. doi: 10.1172/JCI73733. Epub 2014 Jun 24.

43.

Advances in acetabular reconstruction in revision total hip arthroplasty: maximizing function and outcomes after treatment of periacetabular osteolysis around the well-fixed shell.

Hall A, Eilers M, Hansen R, Robinson BS, Maloney WJ, Paprosky WG, Ries MD, Saleh KJ.

Instr Course Lect. 2014;63:209-18. Review.

PMID:
24720307
44.

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V.

Cancer Discov. 2014 Jun;4(6):688-701. doi: 10.1158/2159-8290.CD-13-0593. Epub 2014 Apr 2.

45.

Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.

Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP.

PLoS One. 2014 Feb 19;9(2):e89187. doi: 10.1371/journal.pone.0089187. eCollection 2014.

46.

The role of MIZ-1 in MYC-dependent tumorigenesis.

Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M.

Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a014290. doi: 10.1101/cshperspect.a014290. Review.

47.

Amino acid conservation and interactions in rhodopsin: probing receptor activation by NMR spectroscopy.

Pope A, Eilers M, Reeves PJ, Smith SO.

Biochim Biophys Acta. 2014 May;1837(5):683-93. doi: 10.1016/j.bbabio.2013.10.007. Epub 2013 Oct 29. Review.

48.

CIP2A influences survival in colon cancer and is critical for maintaining Myc expression.

Wiegering A, Pfann C, Uthe FW, Otto C, Rycak L, Mäder U, Gasser M, Waaga-Gasser AM, Eilers M, Germer CT.

PLoS One. 2013 Oct 1;8(10):e75292. doi: 10.1371/journal.pone.0075292. eCollection 2013.

49.

Miz1 is required to maintain autophagic flux.

Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M.

Nat Commun. 2013;4:2535. doi: 10.1038/ncomms3535.

50.

High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant.

Xu B, Chakraborty R, Eilers M, Dakshinamurti S, O'Neil JD, Smith SO, Bhullar RP, Chelikani P.

PLoS One. 2013 Sep 23;8(9):e76481. doi: 10.1371/journal.pone.0076481. eCollection 2013.

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