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Items: 35

1.

Molecular characterization of carbapenem-resistant Acinetobacter baumannii using WGS revealed missed transmission events in Germany from 2012-15.

Eigenbrod T, Reuter S, Gross A, Kocer K, Günther F, Zimmermann S, Heeg K, Mutters NT, Nurjadi D.

J Antimicrob Chemother. 2019 Aug 31. pii: dkz360. doi: 10.1093/jac/dkz360. [Epub ahead of print]

PMID:
31504593
2.

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T.

RNA. 2019 Jul;25(7):869-880. doi: 10.1261/rna.070243.118. Epub 2019 Apr 24.

PMID:
31019095
3.

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo.

Hafner A, Kolbe U, Freund I, Castiglia V, Kovarik P, Poth T, Herster F, Weigand MA, Weber ANR, Dalpke AH, Eigenbrod T.

Front Immunol. 2019 Feb 21;10:198. doi: 10.3389/fimmu.2019.00198. eCollection 2019.

4.

RNA Modifications Modulate Activation of Innate Toll-Like Receptors.

Freund I, Eigenbrod T, Helm M, Dalpke AH.

Genes (Basel). 2019 Jan 29;10(2). pii: E92. doi: 10.3390/genes10020092. Review.

5.

Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M.

Nucleic Acids Res. 2018 Oct 12;46(18):9764-9775. doi: 10.1093/nar/gky644.

6.

First isolation of Mycoplasma canis from human tissue samples after a dog bite.

Klein S, Klotz M, Eigenbrod T.

New Microbes New Infect. 2018 May 25;25:14-15. doi: 10.1016/j.nmni.2018.05.003. eCollection 2018 Sep.

7.

From macrophage to osteoclast - How metabolism determines function and activity.

Kubatzky KF, Uhle F, Eigenbrod T.

Cytokine. 2018 Dec;112:102-115. doi: 10.1016/j.cyto.2018.06.013. Epub 2018 Jun 18.

PMID:
29914791
8.

The SiLuDrain Trial: a prospective randomized controlled trial comparing standard versus silver-impregnated lumbar drains.

Jakobs M, Klein S, Eigenbrod T, Unterberg AW, Sakowitz OW.

J Neurosurg. 2018 Jun 1:1-8. doi: 10.3171/2018.1.JNS181522. [Epub ahead of print]

PMID:
29905509
9.

Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells.

Klöss V, Grünvogel O, Wabnitz G, Eigenbrod T, Ehrhardt S, Lasitschka F, Lohmann V, Dalpke AH.

Front Immunol. 2017 Sep 29;8:1238. doi: 10.3389/fimmu.2017.01238. eCollection 2017.

10.

Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts.

Chakraborty S, Kloos B, Roetz N, Schmidt S, Eigenbrod T, Kamitani S, Kubatzky KF.

Immunobiology. 2018 Jan;223(1):142-150. doi: 10.1016/j.imbio.2017.09.001. Epub 2017 Sep 12.

PMID:
29030011
11.

Identification of an optimized 2'-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8.

Schmitt FCF, Freund I, Weigand MA, Helm M, Dalpke AH, Eigenbrod T.

RNA. 2017 Sep;23(9):1344-1351. doi: 10.1261/rna.061952.117. Epub 2017 Jun 2.

12.

Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.

Hellmuth I, Freund I, Schlöder J, Seidu-Larry S, Thüring K, Slama K, Langhanki J, Kaloyanova S, Eigenbrod T, Krumb M, Röhm S, Peneva K, Opatz T, Jonuleit H, Dalpke AH, Helm M.

Front Immunol. 2017 Mar 24;8:312. doi: 10.3389/fimmu.2017.00312. eCollection 2017.

13.

Evaluation of antibiotic resistance to orally administrable antibiotics in staphylococcal bone and joint infections in one of the largest university hospitals in Germany: is there a role for fusidic acid?

Klein S, Nurjadi D, Eigenbrod T, Bode KA.

Int J Antimicrob Agents. 2016 Feb;47(2):155-7. doi: 10.1016/j.ijantimicag.2015.12.002. Epub 2015 Dec 21.

PMID:
26774158
14.

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

Stammler D, Eigenbrod T, Menz S, Frick JS, Sweet MJ, Shakespear MR, Jantsch J, Siegert I, Wölfle S, Langer JD, Oehme I, Schaefer L, Fischer A, Knievel J, Heeg K, Dalpke AH, Bode KA.

J Immunol. 2015 Dec 1;195(11):5421-31. doi: 10.4049/jimmunol.1501195. Epub 2015 Oct 30.

15.

Recognition of Specified RNA Modifications by the Innate Immune System.

Eigenbrod T, Keller P, Kaiser S, Rimbach K, Dalpke AH, Helm M.

Methods Enzymol. 2015;560:73-89. doi: 10.1016/bs.mie.2015.03.006. Epub 2015 Jul 22.

PMID:
26253966
16.

Cell-contact dependent inhibition of monocytes by airway epithelial cells and reversion by infection with Respiratory Syncytial Virus.

Oumouna M, Weitnauer M, Mijošek V, Schmidt LM, Eigenbrod T, Dalpke AH.

Immunobiology. 2015 Nov;220(11):1240-5. doi: 10.1016/j.imbio.2015.06.017. Epub 2015 Jun 27.

PMID:
26153873
17.

Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses.

Eigenbrod T, Dalpke AH.

J Immunol. 2015 Jul 15;195(2):411-8. doi: 10.4049/jimmunol.1500530. Review.

18.

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.

Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke AH.

J Immunol. 2015 Aug 1;195(3):1092-9. doi: 10.4049/jimmunol.1403173. Epub 2015 Jun 22.

19.

2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.

Rimbach K, Kaiser S, Helm M, Dalpke AH, Eigenbrod T.

J Innate Immun. 2015;7(5):482-93. doi: 10.1159/000375460. Epub 2015 Mar 20.

20.

DAMP signaling is a key pathway inducing immune modulation after brain injury.

Liesz A, Dalpke A, Mracsko E, Antoine DJ, Roth S, Zhou W, Yang H, Na SY, Akhisaroglu M, Fleming T, Eigenbrod T, Nawroth PP, Tracey KJ, Veltkamp R.

J Neurosci. 2015 Jan 14;35(2):583-98. doi: 10.1523/JNEUROSCI.2439-14.2015. Erratum in: J Neurosci. 2019 Jul 3;39(27):5419.

21.

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.

Franchi L, Eigenbrod T, Muñoz-Planillo R, Ozkurede U, Kim YG, Arindam C, Gale M Jr, Silverman RH, Colonna M, Akira S, Núñez G.

J Immunol. 2014 Oct 15;193(8):4214-4222. doi: 10.4049/jimmunol.1400582. Epub 2014 Sep 15.

22.

A modified dinucleotide motif specifies tRNA recognition by TLR7.

Kaiser S, Rimbach K, Eigenbrod T, Dalpke AH, Helm M.

RNA. 2014 Sep;20(9):1351-5. doi: 10.1261/rna.044024.113. Epub 2014 Jul 22.

23.

Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling.

Bretz NP, Ridinger J, Rupp AK, Rimbach K, Keller S, Rupp C, Marmé F, Umansky L, Umansky V, Eigenbrod T, Sammar M, Altevogt P.

J Biol Chem. 2013 Dec 20;288(51):36691-702. doi: 10.1074/jbc.M113.512806. Epub 2013 Nov 13.

24.

TLR7 inhibition: A novel strategy for pancreatic cancer treatment?

Eigenbrod T, Dalpke AH.

JAKSTAT. 2013 Jan 1;2(1):e23011. doi: 10.4161/jkst.23011.

25.

Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.

Eigenbrod T, Bode KA, Dalpke AH.

J Immunol. 2013 Jun 15;190(12):6533-41. doi: 10.4049/jimmunol.1300324. Epub 2013 May 10.

26.

Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.

Eigenbrod T, Franchi L, Muñoz-Planillo R, Kirschning CJ, Freudenberg MA, Núñez G, Dalpke A.

J Immunol. 2012 Jul 1;189(1):328-36. doi: 10.4049/jimmunol.1103258. Epub 2012 May 25.

27.

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity.

Gehrig S, Eberle ME, Botschen F, Rimbach K, Eberle F, Eigenbrod T, Kaiser S, Holmes WM, Erdmann VA, Sprinzl M, Bec G, Keith G, Dalpke AH, Helm M.

J Exp Med. 2012 Feb 13;209(2):225-33. doi: 10.1084/jem.20111044. Epub 2012 Feb 6.

28.

Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.

Hausding M, Tepe M, Ubel C, Lehr HA, Röhrig B, Höhn Y, Pautz A, Eigenbrod T, Anke T, Kleinert H, Erkel G, Finotto S.

Int Immunol. 2011 Jan;23(1):1-15. doi: 10.1093/intimm/dxq451. Epub 2010 Dec 6.

PMID:
21135031
29.

Inflammasomes as microbial sensors.

Franchi L, Muñoz-Planillo R, Reimer T, Eigenbrod T, Núñez G.

Eur J Immunol. 2010 Mar;40(3):611-5. doi: 10.1002/eji.200940180. Review.

30.

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.

Franchi L, Eigenbrod T, Núñez G.

J Immunol. 2009 Jul 15;183(2):792-6. doi: 10.4049/jimmunol.0900173. Epub 2009 Jun 19.

31.

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G.

Nat Immunol. 2009 Mar;10(3):241-7. doi: 10.1038/ni.1703. Review.

32.
34.

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.

Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF.

Int Immunol. 2007 Jun;19(6):685-93. Epub 2007 May 11.

PMID:
17496315
35.

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el-B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S.

J Clin Invest. 2005 Feb;115(2):313-25. Erratum in: J Clin Invest. 2005 May;115(5):1388. Lehr, Hans A [added].

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