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The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.

Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, Trimbuch T, Gimber N, Schmoranzer J, Lieberam I, Rosenmund C, Spahn C, Scheerer P, Szczepek M, Leondaritis G, Eickholt BJ.

Cell Rep. 2019 Nov 12;29(7):2028-2040.e8. doi: 10.1016/j.celrep.2019.10.039.


PTEN in Autism and Neurodevelopmental Disorders.

Rademacher S, Eickholt BJ.

Cold Spring Harb Perspect Med. 2019 Nov 1;9(11). pii: a036780. doi: 10.1101/cshperspect.a036780. Review.


Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.

Ebner C, Ledderose J, Zolnik TA, Dominiak SE, Turko P, Papoutsi A, Poirazi P, Eickholt BJ, Vida I, Larkum ME, Sachdev RNS.

Front Synaptic Neurosci. 2019 May 24;11:16. doi: 10.3389/fnsyn.2019.00016. eCollection 2019.


Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.

Jochner MCE, An J, Lättig-Tünnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C.

Sci Rep. 2019 Feb 28;9(1):3183. doi: 10.1038/s41598-019-39438-1.


ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.

Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ.

Nat Commun. 2019 Jan 30;10(1):486. doi: 10.1038/s41467-019-08420-w.


Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.

Panayotis N, Sheinin A, Dagan SY, Tsoory MM, Rother F, Vadhvani M, Meshcheriakova A, Koley S, Marvaldi L, Song DA, Reuveny E, Eickholt BJ, Hartmann E, Bader M, Michaelevski I, Fainzilber M.

Cell Rep. 2018 Dec 11;25(11):3169-3179.e7. doi: 10.1016/j.celrep.2018.11.066.


Improved methods for marking active neuron populations.

Moeyaert B, Holt G, Madangopal R, Perez-Alvarez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eickholt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, Schreiter ER.

Nat Commun. 2018 Oct 25;9(1):4440. doi: 10.1038/s41467-018-06935-2.


Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease.

Schiweck J, Eickholt BJ, Murk K.

Front Cell Neurosci. 2018 Aug 21;12:261. doi: 10.3389/fncel.2018.00261. eCollection 2018.


Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin.

Willmes CG, Mack TG, Ledderose J, Schmitz D, Wozny C, Eickholt BJ.

Sci Rep. 2017 Feb 15;7:42652. doi: 10.1038/srep42652.


RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620. Epub 2016 Sep 26.


The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme.

Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M.

J Neurochem. 2016 Oct;139(2):234-244. doi: 10.1111/jnc.13739. Epub 2016 Aug 9.


Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue.

Schrötter S, Leondaritis G, Eickholt BJ.

J Biol Chem. 2016 May 6;291(19):10239-51. doi: 10.1074/jbc.M115.700138. Epub 2016 Mar 4.


Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.

An W, Jackson RE, Hunter P, Gögel S, van Diepen M, Liu K, Meyer MP, Eickholt BJ.

PLoS One. 2015 Dec 30;10(12):e0145783. doi: 10.1371/journal.pone.0145783. eCollection 2015.


Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?

Mack TG, Kreis P, Eickholt BJ.

Biol Chem. 2016 Mar;397(3):223-9. doi: 10.1515/hsz-2015-0185. Review.


Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis.

Leondaritis G, Eickholt BJ.

PLoS Biol. 2015 Sep 3;13(9):e1002241. doi: 10.1371/journal.pbio.1002241. eCollection 2015.


Drebrin regulates neuroblast migration in the postnatal mammalian brain.

Sonego M, Oberoi M, Stoddart J, Gajendra S, Hendricusdottir R, Oozeer F, Worth DC, Hobbs C, Eickholt BJ, Gordon-Weeks PR, Doherty P, Lalli G.

PLoS One. 2015 May 6;10(5):e0126478. doi: 10.1371/journal.pone.0126478. eCollection 2015.


Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness.

Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, Ninnemann O, Schindler D, Damatova N, Eirich K, Sifringer M, Schrötter S, Eickholt BJ, van den Heuvel L, Casamina C, Stoltenburg-Didinger G, Ropers HH, Wienker TF, Hübner C, Kaindl AM.

Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35. doi: 10.1002/acn3.149. Epub 2014 Dec 3.


Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes.

Spinelli L, Black FM, Berg JN, Eickholt BJ, Leslie NR.

J Med Genet. 2015 Feb;52(2):128-34. doi: 10.1136/jmedgenet-2014-102803. Epub 2014 Dec 19.


Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10. doi: 10.1073/pnas.1400737111. Epub 2014 Aug 25.


A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15. doi: 10.1126/scisignal.2005560.


Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.

Kreis P, Leondaritis G, Lieberam I, Eickholt BJ.

Front Mol Neurosci. 2014 Apr 1;7:23. doi: 10.3389/fnmol.2014.00023. eCollection 2014. Review.


Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.

Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ.

PLoS One. 2013 Aug 5;8(8):e71957. doi: 10.1371/journal.pone.0071957. Print 2013.


Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.

Berglund FM, Weerasinghe NR, Davidson L, Lim JC, Eickholt BJ, Leslie NR.

Oncogene. 2013 Sep 12;32(37):4417-26. doi: 10.1038/onc.2012.459. Epub 2012 Oct 22.


New WAVEs in neuronal PI3K signalling.

Mack TG, Eickholt BJ.

EMBO J. 2011 Nov 30;30(23):4693-5. doi: 10.1038/emboj.2011.405. No abstract available.


Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation.

Kay L, Humphreys L, Eickholt BJ, Burrone J.

Nat Neurosci. 2011 Jun;14(6):688-90. doi: 10.1038/nn.2826. Epub 2011 May 1.


Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.

Hernández-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD.

J Neurosci. 2011 Apr 20;31(16):6174-87. doi: 10.1523/JNEUROSCI.5464-10.2011.


The neurodevelopmental implications of PI3K signaling.

Waite K, Eickholt BJ.

Curr Top Microbiol Immunol. 2010;346:245-65. doi: 10.1007/82_2010_82. Review.


Regulation of PTEN in neurons by myosin-based transport mechanisms.

Kreis P, van Diepen MT, Eickholt BJ.

Adv Enzyme Regul. 2010;50(1):119-24. doi: 10.1016/j.advenzreg.2009.10.014. Epub 2009 Nov 4. Review. No abstract available.


MyosinV controls PTEN function and neuronal cell size.

van Diepen MT, Parsons M, Downes CP, Leslie NR, Hindges R, Eickholt BJ.

Nat Cell Biol. 2009 Oct;11(10):1191-6. doi: 10.1038/ncb1961. Epub 2009 Sep 20. Erratum in: Nat Cell Biol. 2009 Nov;11(11):1387.


Semaphorin signalling.

Jackson RE, Eickholt BJ.

Curr Biol. 2009 Jul 14;19(13):R504-7. doi: 10.1016/j.cub.2009.04.055. No abstract available.


Functional diversity and mechanisms of action of the semaphorins.

Eickholt BJ.

Development. 2008 Aug;135(16):2689-94. doi: 10.1242/dev.019968.


Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells.

Schwarz Q, Vieira JM, Howard B, Eickholt BJ, Ruhrberg C.

Development. 2008 May;135(9):1605-13. doi: 10.1242/dev.015412. Epub 2008 Mar 20. Erratum in: Development. 2009 Jan;136(2):347.


Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neurons.

Cosker KE, Shadan S, van Diepen M, Morgan C, Li M, Allen-Baume V, Hobbs C, Doherty P, Cockcroft S, Eickholt BJ.

J Cell Sci. 2008 Mar 15;121(Pt 6):796-803. doi: 10.1242/jcs.019166. Epub 2008 Feb 19.


Function of PTEN during the formation and maintenance of neuronal circuits in the brain.

van Diepen MT, Eickholt BJ.

Dev Neurosci. 2008;30(1-3):59-64. Review.


Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.

Eickholt BJ, Ahmed AI, Davies M, Papakonstanti EA, Pearce W, Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM, Hamers FP, Giese KP, Bradbury EJ, Vanhaesebroeck B.

PLoS One. 2007 Sep 11;2(9):e869.


Intracellular kinases in semaphorin signaling.

Ahmed A, Eickholt BJ.

Adv Exp Med Biol. 2007;600:24-37. Review.


Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.

Fazzari P, Penachioni J, Gianola S, Rossi F, Eickholt BJ, Maina F, Alexopoulou L, Sottile A, Comoglio PM, Flavell RA, Tamagnone L.

BMC Dev Biol. 2007 May 22;7:55.


Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis.

Cosker KE, Eickholt BJ.

Biochem Soc Trans. 2007 Apr;35(Pt 2):207-10. Review.


Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.

Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, Hernández F, Eickholt BJ, Nikolic M, Sutherland C.

J Biol Chem. 2006 Jun 16;281(24):16591-8. Epub 2006 Apr 12.


PTEN couples Sema3A signalling to growth cone collapse.

Chadborn NH, Ahmed AI, Holt MR, Prinjha R, Dunn GA, Jones GE, Eickholt BJ.

J Cell Sci. 2006 Mar 1;119(Pt 5):951-7.


A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists.

Williams G, Eickholt BJ, Maison P, Prinjha R, Walsh FS, Doherty P.

J Neurochem. 2005 Mar;92(5):1180-90.


Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.

Bachelder RE, Lipscomb EA, Lin X, Wendt MA, Chadborn NH, Eickholt BJ, Mercurio AM.

Cancer Res. 2003 Sep 1;63(17):5230-3.


An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.

Eickholt BJ, Walsh FS, Doherty P.

J Cell Biol. 2002 Apr 15;157(2):211-7. Epub 2002 Apr 15.


Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling.

van Horck FP, Lavazais E, Eickholt BJ, Moolenaar WH, Divecha N.

Curr Biol. 2002 Feb 5;12(3):241-5.


Rhombomere interactions control the segmental differentiation of hindbrain neurons.

Eickholt BJ, Graham A, Lumsden A, Wizenmann A.

Mol Cell Neurosci. 2001 Aug;18(2):141-8.


Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.

Västrik I, Eickholt BJ, Walsh FS, Ridley A, Doherty P.

Curr Biol. 1999 Sep 23;9(18):991-8.


Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions.

Eickholt BJ, Mackenzie SL, Graham A, Walsh FS, Doherty P.

Development. 1999 May;126(10):2181-9.

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