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Items: 1 to 50 of 251

1.

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung.

Liao S, Eickelberg O, Schmidt EP, Yang Y.

J Vis Exp. 2019 May 20;(147). doi: 10.3791/59450.

PMID:
31157786
2.

The oncogene ECT2 contributes to a hyperplastic, proliferative lung epithelial cell phenotype in IPF.

Ulke HM, Mutze K, Lehmann M, Wagner DE, Heinzelmann K, Günther A, Eickelberg O, Königshoff M.

Am J Respir Cell Mol Biol. 2019 May 30. doi: 10.1165/rcmb.2019-0047OC. [Epub ahead of print]

PMID:
31145635
3.

The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.

Ballester-López C, Conlon TM, Ertüz Z, Greiffo FR, Irmler M, Verleden SE, Beckers J, Fernandez IE, Eickelberg O, Yildirim AÖ.

EBioMedicine. 2019 May;43:562-575. doi: 10.1016/j.ebiom.2019.03.054. Epub 2019 May 4.

4.

Altered relaxation times in MRI indicate bronchopulmonary dysplasia.

Förster K, Ertl-Wagner B, Ehrhardt H, Busen H, Sass S, Pomschar A, Naehrlich L, Schulze A, Flemmer AW, Hübener C, Eickelberg O, Theis F, Dietrich O, Hilgendorff A.

Thorax. 2019 May 2. pii: thoraxjnl-2018-212384. doi: 10.1136/thoraxjnl-2018-212384. [Epub ahead of print]

PMID:
31048507
5.

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, Cho MH, James JA, Guthridge JM, Cogan JD, Kropski JA, Swigris JJ, Bair C, Kim DS, Ji W, Kim H, Song JW, Maier LA, Pacheco KA, Hirani N, Poon AS, Li F, Jenkins RG, Braybrooke R, Saini G, Maher TM, Molyneaux PL, Saunders P, Zhang Y, Gibson KF, Kass DJ, Rojas M, Sembrat J, Wolters PJ, Collard HR, Sundy JS, O'Riordan T, Strek ME, Noth I, Ma SF, Porteous MK, Kreider ME, Patel NB, Inoue Y, Hirose M, Arai T, Akagawa S, Eickelberg O, Fernandez IE, Behr J, Mogulkoc N, Corte TJ, Glaspole I, Tomassetti S, Ravaglia C, Poletti V, Crestani B, Borie R, Kannengiesser C, Parfrey H, Fiddler C, Rassl D, Molina-Molina M, Machahua C, Worboys AM, Gudmundsson G, Isaksson HJ, Lederer DJ, Podolanczuk AJ, Montesi SB, Bendstrup E, Danchel V, Selman M, Pardo A, Henry MT, Keane MP, Doran P, Vašáková M, Sterclova M, Ryerson CJ, Wilcox PG, Okamoto T, Furusawa H, Miyazaki Y, Laurent G, Baltic S, Prele C, Moodley Y, Shea BS, Ohta K, Suzukawa M, Narumoto O, Nathan SD, Venuto DC, Woldehanna ML, Kokturk N, de Andrade JA, Luckhardt T, Kulkarni T, Bonella F, Donnelly SC, McElroy A, Armstong ME, Aranda A, Carbone RG, Puppo F, Beckman KB, Nickerson DA, Fingerlin TE, Schwartz DA.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):199-208. doi: 10.1164/rccm.201810-1891OC.

6.

Altered proteasome function in right ventricular hypertrophy.

Heitmeier T, Sydykov A, Lukas C, Vroom C, Korfei M, Petrovic A, Klingel K, Günther A, Eickelberg O, Weissmann N, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Meiners S, Kosanovic D.

Cardiovasc Res. 2019 Apr 24. pii: cvz103. doi: 10.1093/cvr/cvz103. [Epub ahead of print]

PMID:
31020333
7.

Three Is Better than One: An Improved Multiple-Hit Model of Primary Graft Dysfunction.

Smirnova NF, Eickelberg O.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):141-142. doi: 10.1165/rcmb.2019-0082ED. No abstract available.

8.

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics.

Angelidis I, Simon LM, Fernandez IE, Strunz M, Mayr CH, Greiffo FR, Tsitsiridis G, Ansari M, Graf E, Strom TM, Nagendran M, Desai T, Eickelberg O, Mann M, Theis FJ, Schiller HB.

Nat Commun. 2019 Feb 27;10(1):963. doi: 10.1038/s41467-019-08831-9.

9.

Inhibition of B cell-dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation.

Smirnova NF, Conlon TM, Morrone C, Dorfmuller P, Humbert M, Stathopoulos GT, Umkehrer S, Pfeiffer F, Yildirim AÖ, Eickelberg O.

JCI Insight. 2019 Feb 7;4(3). pii: 123971. doi: 10.1172/jci.insight.123971. [Epub ahead of print]

10.

Defining the Cell Types That Drive Idiopathic Pulmonary Fibrosis Using Single-Cell RNA Sequencing.

Poczobutt JM, Eickelberg O.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1454-1456. doi: 10.1164/rccm.201901-0197ED. No abstract available.

11.

Dissecting the molecular effects of cigarette smoke on proteasome function.

Kammerl IE, Caniard A, Merl-Pham J, Ben-Nissan G, Mayr CH, Mossina A, Geerlof A, Eickelberg O, Hauck SM, Sharon M, Meiners S.

J Proteomics. 2019 Feb 20;193:1-9. doi: 10.1016/j.jprot.2018.12.015. Epub 2018 Dec 14.

PMID:
30557664
12.

Ezrin in Asthma: A First Step to Early Biomarkers of Airway Epithelial Dysfunction.

Wu Q, Eickelberg O.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):408-410. doi: 10.1164/rccm.201810-1964ED. No abstract available.

PMID:
30383410
13.

Pharmacometabolic response to pirfenidone in pulmonary fibrosis detected by MALDI-FTICR-MSI.

Sun N, Fernandez IE, Wei M, Witting M, Aichler M, Feuchtinger A, Burgstaller G, Verleden SE, Schmitt-Kopplin P, Eickelberg O, Walch A.

Eur Respir J. 2018 Sep 15;52(3). pii: 1702314. doi: 10.1183/13993003.02314-2017. Print 2018 Sep.

PMID:
30072508
14.

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.

Heinzelmann K, Lehmann M, Gerckens M, Noskovičová N, Frankenberger M, Lindner M, Hatz R, Behr J, Hilgendorff A, Königshoff M, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L682-L696. doi: 10.1152/ajplung.00439.2017. Epub 2018 Jun 28.

PMID:
29952218
15.

Preservation with α1-antitrypsin improves primary graft function of murine lung transplants.

Götzfried J, Smirnova NF, Morrone C, Korkmaz B, Yildirim AÖ, Eickelberg O, Jenne DE.

J Heart Lung Transplant. 2018 Aug;37(8):1021-1028. doi: 10.1016/j.healun.2018.03.015. Epub 2018 Mar 30.

16.

Optimising experimental research in respiratory diseases: an ERS statement.

Bonniaud P, Fabre A, Frossard N, Guignabert C, Inman M, Kuebler WM, Maes T, Shi W, Stampfli M, Uhlig S, White E, Witzenrath M, Bellaye PS, Crestani B, Eickelberg O, Fehrenbach H, Guenther A, Jenkins G, Joos G, Magnan A, Maitre B, Maus UA, Reinhold P, Vernooy JHJ, Richeldi L, Kolb M.

Eur Respir J. 2018 May 17;51(5). pii: 1702133. doi: 10.1183/13993003.02133-2017. Print 2018 May.

PMID:
29773606
17.

Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.

Dehmel S, Nathan P, Bartel S, El-Merhie N, Scherb H, Milger K, John-Schuster G, Yildirim AO, Hylkema M, Irmler M, Beckers J, Schaub B, Eickelberg O, Krauss-Etschmann S.

Sci Rep. 2018 May 15;8(1):7547. doi: 10.1038/s41598-018-25762-5.

18.

Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.

Jia J, Conlon TM, Sarker RS, Taşdemir D, Smirnova NF, Srivastava B, Verleden SE, Güneş G, Wu X, Prehn C, Gao J, Heinzelmann K, Lintelmann J, Irmler M, Pfeiffer S, Schloter M, Zimmermann R, Hrabé de Angelis M, Beckers J, Adamski J, Bayram H, Eickelberg O, Yildirim AÖ.

EMBO Mol Med. 2018 May;10(5). pii: e8349. doi: 10.15252/emmm.201708349.

19.

FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis.

Knüppel L, Heinzelmann K, Lindner M, Hatz R, Behr J, Eickelberg O, Staab-Weijnitz CA.

Respir Res. 2018 Apr 19;19(1):67. doi: 10.1186/s12931-018-0768-1.

20.

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

Wolters PJ, Blackwell TS, Eickelberg O, Loyd JE, Kaminski N, Jenkins G, Maher TM, Molina-Molina M, Noble PW, Raghu G, Richeldi L, Schwarz MI, Selman M, Wuyts WA, Schwartz DA.

Lancet Respir Med. 2018 Feb;6(2):154-160. doi: 10.1016/S2213-2600(18)30007-9. Review.

21.

X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice.

Hellbach K, Meinel FG, Conlon TM, Willer K, Yaroshenko A, Velroyen A, Braunagel M, Auweter S, Reiser MF, Eickelberg O, Pfeiffer F, Yildirim AÖ.

Sci Rep. 2018 Feb 1;8(1):2096. doi: 10.1038/s41598-018-20193-8.

22.

Upregulation and Nuclear Location of MMP28 in Alveolar Epithelium of Idiopathic Pulmonary Fibrosis.

Maldonado M, Salgado-Aguayo A, Herrera I, Cabrera S, Ortíz-Quintero B, Staab-Weijnitz CA, Eickelberg O, Ramírez R, Manicone AM, Selman M, Pardo A.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):77-86. doi: 10.1165/rcmb.2017-0223OC.

PMID:
29373068
23.

Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.

Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L695-L707. doi: 10.1152/ajplung.00205.2017. Epub 2018 Jan 4.

24.

Epithelial Progenitor Cells Take Center Stage in Lung Transplantation.

Smirnova NF, Eickelberg O.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):981-983. doi: 10.1164/rccm.201712-2557ED. No abstract available.

PMID:
29350973
25.

Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures.

Burgstaller G, Sengupta A, Vierkotten S, Preissler G, Lindner M, Behr J, Königshoff M, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L708-L723. doi: 10.1152/ajplung.00408.2017. Epub 2018 Jan 18.

26.

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond.

Benam KH, Königshoff M, Eickelberg O.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):869-875. doi: 10.1164/rccm.201709-1795PP. No abstract available.

PMID:
29262260
27.

Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

Sasidhar MV, Chevooru SK, Eickelberg O, Hartung HP, Neuhaus O.

PLoS One. 2017 Dec 18;12(12):e0189701. doi: 10.1371/journal.pone.0189701. eCollection 2017.

28.

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.

Al-Tamari HM, Dabral S, Schmall A, Sarvari P, Ruppert C, Paik J, DePinho RA, Grimminger F, Eickelberg O, Guenther A, Seeger W, Savai R, Pullamsetti SS.

EMBO Mol Med. 2018 Feb;10(2):276-293. doi: 10.15252/emmm.201606261.

29.

Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung.

Wu Q, Jiang D, Schaefer NR, Harmacek L, O'Connor BP, Eling TE, Eickelberg O, Chu HW.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L514-L527. doi: 10.1152/ajplung.00324.2017. Epub 2017 Nov 30.

30.

Early Identification of Bronchopulmonary Dysplasia Using Novel Biomarkers by Proteomic Screening.

Förster K, Sass S, Ehrhardt H, Mous DS, Rottier RJ, Oak P, Schulze A, Flemmer AW, Gronbach J, Hübener C, Desai T, Eickelberg O, Theis FJ, Hilgendorff A.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1076-1080. doi: 10.1164/rccm.201706-1218LE. No abstract available.

PMID:
29053024
31.

Systems medicine advances in interstitial lung disease.

Greiffo FR, Eickelberg O, Fernandez IE.

Eur Respir Rev. 2017 Sep 27;26(145). pii: 170021. doi: 10.1183/16000617.0021-2017. Print 2017 Sep 30. Review.

32.

Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.

Oak P, Pritzke T, Thiel I, Koschlig M, Mous DS, Windhorst A, Jain N, Eickelberg O, Foerster K, Schulze A, Goepel W, Reicherzer T, Ehrhardt H, Rottier RJ, Ahnert P, Gortner L, Desai TJ, Hilgendorff A.

EMBO Mol Med. 2017 Nov;9(11):1504-1520. doi: 10.15252/emmm.201607308.

33.

Recovery from Critical Illness: Physical Rehabilitation in the Intensive Care Unit, Timing of Persistent Critical Illness, and Caregiver Outcomes.

Kelmenson DA, Neumeier A, Badlam JB, Eickelberg O.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1068-1070. doi: 10.1164/rccm.201704-0828RR. No abstract available.

PMID:
28841330
34.

Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.

Milger K, Yu Y, Brudy E, Irmler M, Skapenko A, Mayinger M, Lehmann M, Beckers J, Reichenberger F, Behr J, Eickelberg O, Königshoff M, Krauss-Etschmann S.

Thorax. 2017 Nov;72(11):1007-1020. doi: 10.1136/thoraxjnl-2016-208423. Epub 2017 Aug 5.

PMID:
28780502
35.

Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice.

Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, Fuchs H, Gailus-Durner V, Wurst W, Hrabě de Angelis M, Graw J, Hölter SM.

Mol Neurobiol. 2018 Jun;55(6):4580-4595. doi: 10.1007/s12035-017-0659-3. Epub 2017 Jul 10.

PMID:
28695538
36.

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease.

Burgstaller G, Oehrle B, Gerckens M, White ES, Schiller HB, Eickelberg O.

Eur Respir J. 2017 Jul 5;50(1). pii: 1601805. doi: 10.1183/13993003.01805-2016. Print 2017 Jul. Review.

37.

Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis.

Schiller HB, Mayr CH, Leuschner G, Strunz M, Staab-Weijnitz C, Preisendörfer S, Eckes B, Moinzadeh P, Krieg T, Schwartz DA, Hatz RA, Behr J, Mann M, Eickelberg O.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1298-1310. doi: 10.1164/rccm.201611-2263OC.

PMID:
28654764
38.

microRNA cluster 106a~363 is involved in T helper 17 cell differentiation.

Kästle M, Bartel S, Geillinger-Kästle K, Irmler M, Beckers J, Ryffel B, Eickelberg O, Krauss-Etschmann S.

Immunology. 2017 Nov;152(3):402-413. doi: 10.1111/imm.12775. Epub 2017 Jul 28.

39.

Mutant KRAS promotes malignant pleural effusion formation.

Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A, Stathopoulos GT.

Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.

40.

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

Budinger GRS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1492-1500. doi: 10.1093/gerona/glx090. Review.

41.

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology.

Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.

42.

Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma.

Bartel S, Schulz N, Alessandrini F, Schamberger AC, Pagel P, Theis FJ, Milger K, Noessner E, Stick SM, Kicic A, Eickelberg O, Freishtat RJ, Krauss-Etschmann S.

Sci Rep. 2017 Apr 6;7:46026. doi: 10.1038/srep46026.

43.

X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice.

Scherer K, Yaroshenko A, Bölükbas DA, Gromann LB, Hellbach K, Meinel FG, Braunagel M, Berg JV, Eickelberg O, Reiser MF, Pfeiffer F, Meiners S, Herzen J.

Sci Rep. 2017 Mar 24;7(1):402. doi: 10.1038/s41598-017-00489-x.

44.

X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model.

Hellbach K, Yaroshenko A, Willer K, Conlon TM, Braunagel MB, Auweter S, Yildirim AÖ, Eickelberg O, Pfeiffer F, Reiser MF, Meinel FG.

Sci Rep. 2017 Mar 23;7(1):340. doi: 10.1038/s41598-017-00475-3.

45.

A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone. Inhibition of Collagen Fibril Assembly.

Knüppel L, Ishikawa Y, Aichler M, Heinzelmann K, Hatz R, Behr J, Walch A, Bächinger HP, Eickelberg O, Staab-Weijnitz CA.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):77-90. doi: 10.1165/rcmb.2016-0217OC.

PMID:
28257580
46.

Detecting Swelling States of Red Blood Cells by "Cell-Fluid Coupling Spectroscopy".

Zensen C, Fernandez IE, Eickelberg O, Feldmann J, Lohmüller T.

Adv Sci (Weinh). 2016 Oct 13;4(2):1600238. doi: 10.1002/advs.201600238. eCollection 2017 Feb.

47.

Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Feb;214(2):565. doi: 10.1084/jem.2016067501052017c. Epub 2017 Jan 9. No abstract available.

48.

Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.

Sattler C, Moritz F, Chen S, Steer B, Kutschke D, Irmler M, Beckers J, Eickelberg O, Schmitt-Kopplin P, Adler H, Stoeger T.

Part Fibre Toxicol. 2017 Jan 10;14(1):2. doi: 10.1186/s12989-016-0181-1.

49.

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Jan;214(1):143-163. doi: 10.1084/jem.20160675. Epub 2016 Dec 15. Erratum in: J Exp Med. 2017 Feb;214(2):565.

50.

Cigarette smoke alters the secretome of lung epithelial cells.

Mossina A, Lukas C, Merl-Pham J, Uhl FE, Mutze K, Schamberger A, Staab-Weijnitz C, Jia J, Yildirim AÖ, Königshoff M, Hauck SM, Eickelberg O, Meiners S.

Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600243.

PMID:
27891773

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