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Items: 1 to 50 of 140

1.

Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells.

Shah N, Decker TM, Eick D.

Biol Lett. 2019 May 31;15(5):20190068. doi: 10.1098/rsbl.2019.0068.

2.

Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner.

Nemec CM, Singh AK, Ali A, Tseng SC, Syal K, Ringelberg KJ, Ho YH, Hintermair C, Ahmad MF, Kar RK, Gasch AP, Akhtar MS, Eick D, Ansari AZ.

Nat Chem Biol. 2019 Feb;15(2):123-131. doi: 10.1038/s41589-018-0194-1. Epub 2018 Dec 31.

3.

MIR sequences recruit zinc finger protein ZNF768 to expressed genes.

Rohrmoser M, Kluge M, Yahia Y, Gruber-Eber A, Maqbool MA, Forné I, Krebs S, Blum H, Greifenberg AK, Geyer M, Descostes N, Imhof A, Andrau JC, Friedel CC, Eick D.

Nucleic Acids Res. 2019 Jan 25;47(2):700-715. doi: 10.1093/nar/gky1148.

4.

Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.

Sharma P, Lioutas A, Fernandez-Fuentes N, Quilez J, Carbonell-Caballero J, Wright RHG, Di Vona C, Le Dily F, Schüller R, Eick D, Oliva B, Beato M.

Mol Cell. 2019 Jan 3;73(1):84-96.e7. doi: 10.1016/j.molcel.2018.10.016. Epub 2018 Nov 21.

PMID:
30472187
5.

Getting to grips with c-Myc.

Eick D.

Elife. 2018 Jan 9;7. pii: e32010. doi: 10.7554/eLife.32010.

6.

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.

Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forné I, Decker TM, Martin D, Schüller R, Krebs S, Blum H, Imhof A, Eick D, Andrau JC.

Mol Cell. 2018 Jan 4;69(1):48-61.e6. doi: 10.1016/j.molcel.2017.12.009.

7.

CDK9-dependent RNA polymerase II pausing controls transcription initiation.

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P.

Elife. 2017 Oct 10;6. pii: e29736. doi: 10.7554/eLife.29736.

8.

Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1.

Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D.

Sci Rep. 2017 May 10;7(1):1684. doi: 10.1038/s41598-017-01943-6.

9.

Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner.

Nemec CM, Yang F, Gilmore JM, Hintermair C, Ho YH, Tseng SC, Heidemann M, Zhang Y, Florens L, Gasch AP, Eick D, Washburn MP, Varani G, Ansari AZ.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3944-E3953. doi: 10.1073/pnas.1700128114. Epub 2017 May 2.

10.

Getting Access to Low-Complexity Domain Modifications.

Schüller R, Eick D.

Trends Biochem Sci. 2016 Nov;41(11):894-897. doi: 10.1016/j.tibs.2016.05.010. Epub 2016 Jun 6.

PMID:
27283512
11.

A Nonradioactive Assay to Measure Production and Processing of Ribosomal RNA by 4sU-Tagging.

Burger K, Eick D.

Methods Mol Biol. 2016;1455:121-31. doi: 10.1007/978-1-4939-3792-9_10.

PMID:
27576715
12.

Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression.

Hintermair C, Voß K, Forné I, Heidemann M, Flatley A, Kremmer E, Imhof A, Eick D.

Sci Rep. 2016 Jun 6;6:27401. doi: 10.1038/srep27401.

13.

Heptad-Specific Phosphorylation of RNA Polymerase II CTD.

Schüller R, Forné I, Straub T, Schreieck A, Texier Y, Shah N, Decker TM, Cramer P, Imhof A, Eick D.

Mol Cell. 2016 Jan 21;61(2):305-14. doi: 10.1016/j.molcel.2015.12.003.

14.

Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.

Voss K, Forné I, Descostes N, Hintermair C, Schüller R, Maqbool MA, Heidemann M, Flatley A, Imhof A, Gut M, Gut I, Kremmer E, Andrau JC, Eick D.

Transcription. 2015;6(5):91-101. doi: 10.1080/21541264.2015.1114983.

15.

DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.

Kellner M, Rohrmoser M, Forné I, Voss K, Burger K, Mühl B, Gruber-Eber A, Kremmer E, Imhof A, Eick D.

Exp Cell Res. 2015 May 15;334(1):146-59. doi: 10.1016/j.yexcr.2015.03.017. Epub 2015 Mar 28.

PMID:
25825154
16.

Transcription-dependent generation of a specialized chromatin structure at the TCRβ locus.

Zacarías-Cabeza J, Belhocine M, Vanhille L, Cauchy P, Koch F, Pekowska A, Fenouil R, Bergon A, Gut M, Gut I, Eick D, Imbert J, Ferrier P, Andrau JC, Spicuglia S.

J Immunol. 2015 Apr 1;194(7):3432-43. doi: 10.4049/jimmunol.1400789. Epub 2015 Mar 2.

17.

Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae.

Coordes B, Brünger KM, Burger K, Soufi B, Horenk J, Eick D, Olsen JV, Sträßer K.

Eukaryot Cell. 2015 Jan;14(1):86-95. doi: 10.1128/EC.00106-14. Epub 2014 Nov 21.

18.

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells.

Descostes N, Heidemann M, Spinelli L, Schüller R, Maqbool MA, Fenouil R, Koch F, Innocenti C, Gut M, Gut I, Eick D, Andrau JC.

Elife. 2014 May 9;3:e02105. doi: 10.7554/eLife.02105.

19.

The structure and substrate specificity of human Cdk12/Cyclin K.

Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blazek D, Anand K, Fisher RP, Eick D, Geyer M.

Nat Commun. 2014 Mar 24;5:3505. doi: 10.1038/ncomms4505.

20.

4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response.

Burger K, Mühl B, Kellner M, Rohrmoser M, Gruber-Eber A, Windhager L, Friedel CC, Dölken L, Eick D.

RNA Biol. 2013 Oct;10(10):1623-30. doi: 10.4161/rna.26214. Epub 2013 Sep 4.

21.

Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels.

Schuhmacher M, Eick D.

Transcription. 2013 Jul-Aug;4(4):192-7. Epub 2013 Aug 2.

22.

The RNA polymerase II carboxy-terminal domain (CTD) code.

Eick D, Geyer M.

Chem Rev. 2013 Nov 13;113(11):8456-90. doi: 10.1021/cr400071f. Epub 2013 Aug 16. Review. No abstract available.

23.

Emerging roles for RNA polymerase II CTD in Arabidopsis.

Hajheidari M, Koncz C, Eick D.

Trends Plant Sci. 2013 Nov;18(11):633-43. doi: 10.1016/j.tplants.2013.07.001. Epub 2013 Jul 30. Review.

PMID:
23910452
24.

Cyclin-dependent kinase 9 links RNA polymerase II transcription to processing of ribosomal RNA.

Burger K, Mühl B, Rohrmoser M, Coordes B, Heidemann M, Kellner M, Gruber-Eber A, Heissmeyer V, Strässer K, Eick D.

J Biol Chem. 2013 Jul 19;288(29):21173-83. doi: 10.1074/jbc.M113.483719. Epub 2013 Jun 6.

25.

Functional ribosome biogenesis is a prerequisite for p53 destabilization: impact of chemotherapy on nucleolar functions and RNA metabolism.

Burger K, Eick D.

Biol Chem. 2013 Sep;394(9):1133-43. doi: 10.1515/hsz-2013-0153. Review.

PMID:
23640940
26.

In vivo live imaging of RNA polymerase II transcription factories in primary cells.

Ghamari A, van de Corput MP, Thongjuea S, van Cappellen WA, van Ijcken W, van Haren J, Soler E, Eick D, Lenhard B, Grosveld FG.

Genes Dev. 2013 Apr 1;27(7):767-77. doi: 10.1101/gad.216200.113. Erratum in: Genes Dev. 2013 Jun 15;27(12):1434. Genes Dev. 2013 May 15;27(10):1216.

27.

CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo.

Gu B, Eick D, Bensaude O.

Nucleic Acids Res. 2013 Feb 1;41(3):1591-603. doi: 10.1093/nar/gks1327. Epub 2012 Dec 28.

28.

Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription.

Heidemann M, Hintermair C, Voß K, Eick D.

Biochim Biophys Acta. 2013 Jan;1829(1):55-62. doi: 10.1016/j.bbagrm.2012.08.013. Epub 2012 Sep 7. Review.

PMID:
22982363
29.

Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code.

Heidemann M, Eick D.

RNA Biol. 2012 Sep;9(9):1144-6. doi: 10.4161/rna.21726. Epub 2012 Sep 1. Review.

30.

CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II.

Mayer A, Heidemann M, Lidschreiber M, Schreieck A, Sun M, Hintermair C, Kremmer E, Eick D, Cramer P.

Science. 2012 Jun 29;336(6089):1723-5. doi: 10.1126/science.1219651.

31.

Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical-sized rat calvarial defects implanted with bioactive glass scaffolds.

Bi L, Jung S, Day D, Neidig K, Dusevich V, Eick D, Bonewald L.

J Biomed Mater Res A. 2012 Dec;100(12):3267-75. doi: 10.1002/jbm.a.34272. Epub 2012 Jun 26.

PMID:
22733586
32.

Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.

Hochstatter J, Hölzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Längst G, Németh A.

J Biol Chem. 2012 Jul 13;287(29):24365-77. doi: 10.1074/jbc.M111.303719. Epub 2012 May 29.

33.

Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function.

Shchebet A, Karpiuk O, Kremmer E, Eick D, Johnsen SA.

Cell Cycle. 2012 Jun 1;11(11):2122-7. doi: 10.4161/cc.20548. Epub 2012 Jun 1.

PMID:
22592529
34.

Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.

Hintermair C, Heidemann M, Koch F, Descostes N, Gut M, Gut I, Fenouil R, Ferrier P, Flatley A, Kremmer E, Chapman RD, Andrau JC, Eick D.

EMBO J. 2012 Jun 13;31(12):2784-97. doi: 10.1038/emboj.2012.123. Epub 2012 May 1.

35.

Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution.

Windhager L, Bonfert T, Burger K, Ruzsics Z, Krebs S, Kaufmann S, Malterer G, L'Hernault A, Schilhabel M, Schreiber S, Rosenstiel P, Zimmer R, Eick D, Friedel CC, Dölken L.

Genome Res. 2012 Oct;22(10):2031-42. doi: 10.1101/gr.131847.111. Epub 2012 Apr 26.

36.

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.

Brookes E, de Santiago I, Hebenstreit D, Morris KJ, Carroll T, Xie SQ, Stock JK, Heidemann M, Eick D, Nozaki N, Kimura H, Ragoussis J, Teichmann SA, Pombo A.

Cell Stem Cell. 2012 Feb 3;10(2):157-70. doi: 10.1016/j.stem.2011.12.017.

37.

Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development.

Stadhouders R, Thongjuea S, Andrieu-Soler C, Palstra RJ, Bryne JC, van den Heuvel A, Stevens M, de Boer E, Kockx C, van der Sloot A, van den Hout M, van Ijcken W, Eick D, Lenhard B, Grosveld F, Soler E.

EMBO J. 2012 Feb 15;31(4):986-99. doi: 10.1038/emboj.2011.450. Epub 2011 Dec 13.

38.

Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription.

Clemente-Blanco A, Sen N, Mayan-Santos M, Sacristán MP, Graham B, Jarmuz A, Giess A, Webb E, Game L, Eick D, Bueno A, Merkenschlager M, Aragón L.

Nat Cell Biol. 2011 Oct 23;13(12):1450-6. doi: 10.1038/ncb2365.

39.

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M, Hsu C, Gorsler T, Hintermair C, Eick D, Kremmer E, Simons M, Beissbarth T, Johnsen SA.

Cancer Res. 2011 Sep 1;71(17):5739-53. doi: 10.1158/0008-5472.CAN-11-1896. Epub 2011 Aug 23.

40.

Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.

de Almeida SF, Grosso AR, Koch F, Fenouil R, Carvalho S, Andrade J, Levezinho H, Gut M, Eick D, Gut I, Andrau JC, Ferrier P, Carmo-Fonseca M.

Nat Struct Mol Biol. 2011 Jul 26;18(9):977-83. doi: 10.1038/nsmb.2123.

PMID:
21792193
41.

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

Polier G, Ding J, Konkimalla BV, Eick D, Ribeiro N, Köhler R, Giaisi M, Efferth T, Desaubry L, Krammer PH, Li-Weber M.

Cell Death Dis. 2011 Jul 21;2:e182. doi: 10.1038/cddis.2011.66.

42.

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

Koch F, Fenouil R, Gut M, Cauchy P, Albert TK, Zacarias-Cabeza J, Spicuglia S, de la Chapelle AL, Heidemann M, Hintermair C, Eick D, Gut I, Ferrier P, Andrau JC.

Nat Struct Mol Biol. 2011 Jul 17;18(8):956-63. doi: 10.1038/nsmb.2085.

PMID:
21765417
43.

Synthetic lethality-based targets for discovery of new cancer therapeutics.

Weidle UH, Maisel D, Eick D.

Cancer Genomics Proteomics. 2011 Jul-Aug;8(4):159-71. Review.

PMID:
21737609
44.

Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment.

Markaki Y, Gunkel M, Schermelleh L, Beichmanis S, Neumann J, Heidemann M, Leonhardt H, Eick D, Cremer C, Cremer T.

Cold Spring Harb Symp Quant Biol. 2010;75:475-92. doi: 10.1101/sqb.2010.75.042. Epub 2011 Apr 5.

PMID:
21467142
45.

The C-terminal domain of RNA polymerase II is modified by site-specific methylation.

Sims RJ 3rd, Rojas LA, Beck DB, Bonasio R, Schüller R, Drury WJ 3rd, Eick D, Reinberg D.

Science. 2011 Apr 1;332(6025):99-103. doi: 10.1126/science.1202663.

46.

The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword.

Hölzel M, Burger K, Mühl B, Orban M, Kellner M, Eick D.

Oncotarget. 2010 May;1(1):43-7.

47.

Nuclei of chicken neurons in tissues and three-dimensional cell cultures are organized into distinct radial zones.

Berchtold D, Fesser S, Bachmann G, Kaiser A, Eilert JC, Frohns F, Sadoni N, Muck J, Kremmer E, Eick D, Layer PG, Zink D.

Chromosome Res. 2011 Feb;19(2):165-82. doi: 10.1007/s10577-010-9182-3. Epub 2011 Jan 20.

PMID:
21249442
48.

Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II.

Verbruggen P, Ruf M, Blakqori G, Överby AK, Heidemann M, Eick D, Weber F.

J Biol Chem. 2011 Feb 4;286(5):3681-92. doi: 10.1074/jbc.M110.154799. Epub 2010 Nov 30.

49.

Chemical-genomic dissection of the CTD code.

Tietjen JR, Zhang DW, Rodríguez-Molina JB, White BE, Akhtar MS, Heidemann M, Li X, Chapman RD, Shokat K, Keles S, Eick D, Ansari AZ.

Nat Struct Mol Biol. 2010 Sep;17(9):1154-61. doi: 10.1038/nsmb.1900. Epub 2010 Aug 29.

50.

Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.

Burger K, Mühl B, Harasim T, Rohrmoser M, Malamoussi A, Orban M, Kellner M, Gruber-Eber A, Kremmer E, Hölzel M, Eick D.

J Biol Chem. 2010 Apr 16;285(16):12416-25. doi: 10.1074/jbc.M109.074211. Epub 2010 Feb 16.

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