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The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.

Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK.

Open Biol. 2019 Aug 30;9(8):190117. doi: 10.1098/rsob.190117. Epub 2019 Aug 14.


Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.

Thompson PS, Amidon KM, Mohni KN, Cortez D, Eichman BF.

Nat Struct Mol Biol. 2019 Jul;26(7):613-618. doi: 10.1038/s41594-019-0255-5. Epub 2019 Jun 24.


Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts.

Steenwyk JL, Opulente DA, Kominek J, Shen XX, Zhou X, Labella AL, Bradley NP, Eichman BF, Čadež N, Libkind D, DeVirgilio J, Hulfachor AB, Kurtzman CP, Hittinger CT, Rokas A.

PLoS Biol. 2019 May 21;17(5):e3000255. doi: 10.1371/journal.pbio.3000255. eCollection 2019 May.


Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.

Mullins EA, Rodriguez AA, Bradley NP, Eichman BF.

Trends Biochem Sci. 2019 Sep;44(9):765-781. doi: 10.1016/j.tibs.2019.04.006. Epub 2019 May 9. Review.


HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.

Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D.

Cell. 2019 Jan 10;176(1-2):144-153.e13. doi: 10.1016/j.cell.2018.10.055. Epub 2018 Dec 13.


Movement of the RecG Motor Domain upon DNA Binding Is Required for Efficient Fork Reversal.

Warren GM, Stein RA, Mchaourab HS, Eichman BF.

Int J Mol Sci. 2018 Oct 6;19(10). pii: E3049. doi: 10.3390/ijms19103049.


Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases.

Shi R, Shen XX, Rokas A, Eichman BF.

Bioessays. 2018 Nov;40(11):e1800133. doi: 10.1002/bies.201800133. Epub 2018 Sep 28. Review.


The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression.

Chavez DA, Greer BH, Eichman BF.

J Biol Chem. 2018 Jun 1;293(22):8484-8494. doi: 10.1074/jbc.RA118.002905. Epub 2018 Apr 11.


Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.

Shi R, Mullins EA, Shen XX, Lay KT, Yuen PK, David SS, Rokas A, Eichman BF.

EMBO J. 2018 Jan 4;37(1):63-74. doi: 10.15252/embj.201797833. Epub 2017 Oct 20.


Toxicity and repair of DNA adducts produced by the natural product yatakemycin.

Mullins EA, Shi R, Eichman BF.

Nat Chem Biol. 2017 Sep;13(9):1002-1008. doi: 10.1038/nchembio.2439. Epub 2017 Jul 24.



Eichman BF.

Methods Enzymol. 2017;592:xvii-xx. doi: 10.1016/S0076-6879(17)30213-6. No abstract available.



Eichman BF.

Methods Enzymol. 2017;591:xv-xviii. doi: 10.1016/S0076-6879(17)30200-8. No abstract available.


Structure of a DNA glycosylase that unhooks interstrand cross-links.

Mullins EA, Warren GM, Bradley NP, Eichman BF.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4400-4405. doi: 10.1073/pnas.1703066114. Epub 2017 Apr 10.


A Catalytic Role for C-H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD.

Parsons ZD, Bland JM, Mullins EA, Eichman BF.

J Am Chem Soc. 2016 Sep 14;138(36):11485-8. doi: 10.1021/jacs.6b07399. Epub 2016 Sep 1.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3).

Badu-Nkansah A, Mason AC, Eichman BF, Cortez D.

J Biol Chem. 2016 Apr 8;291(15):8251-7. doi: 10.1074/jbc.M115.709733. Epub 2016 Feb 16.


The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.

Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF.

Nature. 2015 Nov 12;527(7577):254-8. doi: 10.1038/nature15728. Epub 2015 Oct 28.


HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.

Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA.

Mol Cell. 2015 Jun 18;58(6):1090-100. doi: 10.1016/j.molcel.2015.05.013. Epub 2015 Jun 4.


A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases.

Mullins EA, Shi R, Kotsch LA, Eichman BF.

PLoS One. 2015 May 15;10(5):e0127733. doi: 10.1371/journal.pone.0127733. eCollection 2015.


Correction to differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.

Szulik MW, Pallan PS, Nocek B, Voehler M, Banerjee S, Brooks S, Joachimiak A, Egli M, Eichman BF, Stone MP.

Biochemistry. 2015 Apr 21;54(15):2550. doi: 10.1021/acs.biochem.5b00344. Epub 2015 Apr 10. No abstract available.


Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.

Szulik MW, Pallan PS, Nocek B, Voehler M, Banerjee S, Brooks S, Joachimiak A, Egli M, Eichman BF, Stone MP.

Biochemistry. 2015 Feb 10;54(5):1294-305. doi: 10.1021/bi501534x. Epub 2015 Jan 29. Erratum in: Biochemistry. 2015 Apr 21;54(15):2550.


A structure-specific nucleic acid-binding domain conserved among DNA repair proteins.

Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7618-23. doi: 10.1073/pnas.1324143111. Epub 2014 May 12.


Structural analysis of replication protein A recruitment of the DNA damage response protein SMARCAL1.

Feldkamp MD, Mason AC, Eichman BF, Chazin WJ.

Biochemistry. 2014 May 13;53(18):3052-61. doi: 10.1021/bi500252w. Epub 2014 Apr 30.


Interplay between base excision repair activity and toxicity of 3-methyladenine DNA glycosylases in an E. coli complementation system.

Troll CJ, Adhikary S, Cueff M, Mitra I, Eichman BF, Camps M.

Mutat Res. 2014 May-Jun;763-764:64-73. doi: 10.1016/j.mrfmmm.2014.03.007. Epub 2014 Apr 4.


5-methylcytosine recognition by Arabidopsis thaliana DNA glycosylases DEMETER and DML3.

Brooks SC, Fischer RL, Huh JH, Eichman BF.

Biochemistry. 2014 Apr 22;53(15):2525-32. doi: 10.1021/bi5002294. Epub 2014 Apr 9.


Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases.

Jang H, Shin H, Eichman BF, Huh JH.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1067-72. doi: 10.1016/j.bbrc.2014.03.060. Epub 2014 Mar 21.


The substrate binding interface of alkylpurine DNA glycosylase AlkD.

Mullins EA, Rubinson EH, Eichman BF.

DNA Repair (Amst). 2014 Jan;13:50-4. doi: 10.1016/j.dnarep.2013.10.009. Epub 2013 Nov 26.


Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.

Vaithiyalingam S, Arnett DR, Aggarwal A, Eichman BF, Fanning E, Chazin WJ.

J Mol Biol. 2014 Feb 6;426(3):558-69. doi: 10.1016/j.jmb.2013.11.007. Epub 2013 Nov 13.


Depurination of N7-methylguanine by DNA glycosylase AlkD is dependent on the DNA backbone.

Rubinson EH, Christov PP, Eichman BF.

Biochemistry. 2013 Oct 22;52(42):7363-5. doi: 10.1021/bi401195r. Epub 2013 Oct 7.


Mcm10 self-association is mediated by an N-terminal coiled-coil domain.

Du W, Josephrajan A, Adhikary S, Bowles T, Bielinsky AK, Eichman BF.

PLoS One. 2013 Jul 23;8(7):e70518. doi: 10.1371/journal.pone.0070518. Print 2013.


An HPLC-tandem mass spectrometry method for simultaneous detection of alkylated base excision repair products.

Mullins EA, Rubinson EH, Pereira KN, Calcutt MW, Christov PP, Eichman BF.

Methods. 2013 Nov;64(1):59-66. doi: 10.1016/j.ymeth.2013.07.020. Epub 2013 Jul 20.


Substrate-selective repair and restart of replication forks by DNA translocases.

Bétous R, Couch FB, Mason AC, Eichman BF, Manosas M, Cortez D.

Cell Rep. 2013 Jun 27;3(6):1958-69. doi: 10.1016/j.celrep.2013.05.002. Epub 2013 Jun 6.


Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe.

Adhikary S, Cato MC, McGary KL, Rokas A, Eichman BF.

DNA Repair (Amst). 2013 Mar 1;12(3):196-204. doi: 10.1016/j.dnarep.2012.12.001. Epub 2012 Dec 28.


Recent advances in the structural mechanisms of DNA glycosylases.

Brooks SC, Adhikary S, Rubinson EH, Eichman BF.

Biochim Biophys Acta. 2013 Jan;1834(1):247-71. doi: 10.1016/j.bbapap.2012.10.005. Epub 2012 Oct 14. Review.


Structural biology of replication initiation factor Mcm10.

Du W, Stauffer ME, Eichman BF.

Subcell Biochem. 2012;62:197-216. doi: 10.1007/978-94-007-4572-8_11. Review.


Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.

Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A.

J Biol Chem. 2012 Oct 12;287(42):35139-52. doi: 10.1074/jbc.M112.358648. Epub 2012 Aug 10.


SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.

Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D.

Genes Dev. 2012 Jan 15;26(2):151-62. doi: 10.1101/gad.178459.111.


Nucleic acid recognition by tandem helical repeats.

Rubinson EH, Eichman BF.

Curr Opin Struct Biol. 2012 Feb;22(1):101-9. doi: 10.1016/ Epub 2011 Dec 9. Review.


Unraveling a connection between DNA demethylation repair and cancer.

Camps M, Eichman BF.

Mol Cell. 2011 Nov 4;44(3):343-4. doi: 10.1016/j.molcel.2011.10.009.


Analysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylase.

Adhikary S, Eichman BF.

EMBO Rep. 2011 Dec 1;12(12):1286-92. doi: 10.1038/embor.2011.189.


Domain structure of the DEMETER 5-methylcytosine DNA glycosylase.

Mok YG, Uzawa R, Lee J, Weiner GM, Eichman BF, Fischer RL, Huh JH.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19225-30. doi: 10.1073/pnas.1014348107. Epub 2010 Oct 25.


An unprecedented nucleic acid capture mechanism for excision of DNA damage.

Rubinson EH, Gowda AS, Spratt TE, Gold B, Eichman BF.

Nature. 2010 Nov 18;468(7322):406-11. doi: 10.1038/nature09428. Epub 2010 Oct 3.


Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.

Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13684-9. doi: 10.1073/pnas.1002009107. Epub 2010 Jul 19.


Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif.

Robertson PD, Chagot B, Chazin WJ, Eichman BF.

J Biol Chem. 2010 Jul 23;285(30):22942-9. doi: 10.1074/jbc.M110.131276. Epub 2010 May 19.


Physical interactions between Mcm10, DNA, and DNA polymerase alpha.

Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF.

J Biol Chem. 2009 Sep 4;284(36):24662-72. doi: 10.1074/jbc.M109.020438. Epub 2009 Jul 16.


Structural basis for DNA binding by replication initiator Mcm10.

Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF.

Structure. 2008 Dec 10;16(12):1892-901. doi: 10.1016/j.str.2008.10.005.


Structure and DNA binding of alkylation response protein AidB.

Bowles T, Metz AH, O'Quin J, Wawrzak Z, Eichman BF.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15299-304. doi: 10.1073/pnas.0806521105. Epub 2008 Sep 30.


A new protein architecture for processing alkylation damaged DNA: the crystal structure of DNA glycosylase AlkD.

Rubinson EH, Metz AH, O'Quin J, Eichman BF.

J Mol Biol. 2008 Aug 1;381(1):13-23. doi: 10.1016/j.jmb.2008.05.078. Epub 2008 Jun 5.


Domain architecture and biochemical characterization of vertebrate Mcm10.

Robertson PD, Warren EM, Zhang H, Friedman DB, Lary JW, Cole JL, Tutter AV, Walter JC, Fanning E, Eichman BF.

J Biol Chem. 2008 Feb 8;283(6):3338-48. Epub 2007 Dec 6.


DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).

Metz AH, Hollis T, Eichman BF.

EMBO J. 2007 May 2;26(9):2411-20. Epub 2007 Apr 5.

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