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Items: 1 to 20 of 469

1.

Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation.

Eichler HG, Koenig F, Arlett P, Enzmann H, Humphreys A, Pétavy F, Schwarzer-Daum B, Sepodes B, Vamvakas S, Rasi G.

Clin Pharmacol Ther. 2019 Oct 1. doi: 10.1002/cpt.1638. [Epub ahead of print]

PMID:
31574163
2.

Added therapeutic benefit and drug licensing.

Eichler HG, Enzmann H, Rasi G.

Nat Rev Drug Discov. 2019 Sep;18(9):651-652. doi: 10.1038/d41573-019-00068-x. No abstract available.

PMID:
31477854
3.

Cross-reacting inhibitors against recombinant porcine factor VIII in acquired hemophilia A: Data from the GTH-AH 01/2010 Study.

Türkantoz H, Königs C, Knöbl P, Klamroth R, Holstein K, Huth-Kühne A, Heinz J, Eichler H, Tiede A.

J Thromb Haemost. 2019 Aug 26. doi: 10.1111/jth.14618. [Epub ahead of print]

PMID:
31448877
4.

Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results.

Shapiro AD, Angchaisuksiri P, Astermark J, Benson G, Castaman G, Chowdary P, Eichler H, Jiménez-Yuste V, Kavakli K, Matsushita T, Poulsen LH, Wheeler AP, Young G, Zupancic-Salek S, Oldenburg J.

Blood. 2019 Nov 28;134(22):1973-1982. doi: 10.1182/blood.2019001542.

PMID:
31444162
5.

[Leitlinie der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) zur Struktur- und Prozessqualität von Hämophilie-Zentren].

Eichler H, Pedroni MA, Halimeh S, Königs C, Langer F, Miesbach W, Oldenburg J, Scholz U, Streif W, Klamroth R.

Hamostaseologie. 2019 Nov;39(4):311-321. doi: 10.1055/s-0039-1688450. Epub 2019 Apr 24. German. No abstract available.

PMID:
31018219
6.

Factor VIII: Long-established role in haemophilia A and emerging evidence beyond haemostasis.

Samuelson Bannow B, Recht M, Négrier C, Hermans C, Berntorp E, Eichler H, Mancuso ME, Klamroth R, O'Hara J, Santagostino E, Matsushita T, Kessler C.

Blood Rev. 2019 May;35:43-50. doi: 10.1016/j.blre.2019.03.002. Epub 2019 Mar 3. Review.

7.

Macrophage Polarization is Deregulated in Haemophilia.

Knowles LM, Kagiri D, Bernard M, Schwarz EC, Eichler H, Pilch J.

Thromb Haemost. 2019 Feb;119(2):234-245. doi: 10.1055/s-0038-1676796. Epub 2019 Jan 16.

8.

Smart Medication ™, an Electronic Diary for Surveillance of Haemophilia Home Care and Optimization of Resource Distribution.

Mondorf W, Eichler H, Fischer R, Holstein K, Klamroth R, Nimtz-Talaska A, Wermes C, Richter H, Severin K.

Hamostaseologie. 2019 Nov;39(4):339-346. doi: 10.1055/s-0038-1675575. Epub 2019 Jan 8.

PMID:
30620988
9.

Efficacy and Effectiveness Too Trials: Clinical Trial Designs to Generate Evidence on Efficacy and on Effectiveness in Wide Practice.

Selker HP, Eichler HG, Stockbridge NL, McElwee NE, Dere WH, Cohen T, Erban JK, Seyfert-Margolis VL, Honig PK, Kaitin KI, Oye KA, D'Agostino RB Sr.

Clin Pharmacol Ther. 2019 Apr;105(4):857-866. doi: 10.1002/cpt.1347. Epub 2019 Feb 12.

10.

Recognizing that Evidence is Made, not Born.

Lim R, Lee DK, Sabourin P, Ferguson J, Metcalf M, Smith M, Corriol-Rohou S, Eichler HG, Lumpkin M, Hirsch G, Chen IM, O'Rourke B, Schiel A, Crabb N, Aronson N, Pezalla E, Boutin M, Binder L, Wilhelm L.

Clin Pharmacol Ther. 2019 Apr;105(4):844-856. doi: 10.1002/cpt.1317. Epub 2019 Jan 4.

11.

Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data.

Eichler H, Angchaisuksiri P, Kavakli K, Knoebl P, Windyga J, Jiménez-Yuste V, Harder Delff P, Chowdary P.

Haemophilia. 2019 Jan;25(1):60-66. doi: 10.1111/hae.13627. Epub 2018 Nov 8.

PMID:
30408848
12.

Data Rich, Information Poor: Can We Use Electronic Health Records to Create a Learning Healthcare System for Pharmaceuticals?

Eichler HG, Bloechl-Daum B, Broich K, Kyrle PA, Oderkirk J, Rasi G, Santos Ivo R, Schuurman A, Senderovitz T, Slawomirski L, Wenzl M, Paris V.

Clin Pharmacol Ther. 2019 Apr;105(4):912-922. doi: 10.1002/cpt.1226. Epub 2018 Oct 14.

13.

A randomized trial of safety, pharmacokinetics and pharmacodynamics of concizumab in people with hemophilia A.

Eichler H, Angchaisuksiri P, Kavakli K, Knoebl P, Windyga J, Jiménez-Yuste V, Hyseni A, Friedrich U, Chowdary P.

J Thromb Haemost. 2018 Nov;16(11):2184-2195. doi: 10.1111/jth.14272. Epub 2018 Sep 30.

PMID:
30137664
14.

Emerging technologies for food and drug safety.

Slikker W Jr, de Souza Lima TA, Archella D, de Silva JB Junior, Barton-Maclaren T, Bo L, Buvinich D, Chaudhry Q, Chuan P, Deluyker H, Domselaar G, Freitas M, Hardy B, Eichler HG, Hugas M, Lee K, Liao CD, Loo LH, Okuda H, Orisakwe OE, Patri A, Sactitono C, Shi L, Silva P, Sistare F, Thakkar S, Tong W, Valdez ML, Whelan M, Zhao-Wong A.

Regul Toxicol Pharmacol. 2018 Oct;98:115-128. doi: 10.1016/j.yrtph.2018.07.013. Epub 2018 Jul 23.

15.

Feasibility and Results of a Mobile Haemophilia Outpatient Care Pilot Project.

Eichler H, Schleicher C, Heine S, Graf N, von Mackensen S.

Hamostaseologie. 2018 Aug;38(3):129-140. doi: 10.1055/s-0038-1654721. Epub 2018 Jul 11.

PMID:
29996170
16.

The evolution of adaptiveness: balancing speed and evidence.

Eichler HG, Barker R, Bedlington N, Bouvy JC, Broekmans AW, Bucsics A, Cerreta F, Corriol-Rohou S, Granados A, Le Cam Y, Schuurman A.

Nat Rev Drug Discov. 2018 Dec;17(12):845-846. doi: 10.1038/nrd.2018.90. Epub 2018 Jul 6. No abstract available.

PMID:
29977052
17.

[The use of Idarucizumab in intracerebral bleeding - a case report].

Hummel BA, Senger S, Schleicher C, Eichler H.

Dtsch Med Wochenschr. 2018 Jul;113(13):961-964. doi: 10.1055/a-0620-7459. Epub 2018 Jul 4. German.

PMID:
29972840
18.

Medicines Adaptive Pathways to Patients: Why, When, and How to Engage?

Eichler HG, Bedlington N, Boudes M, Bouvy JC, Broekmans AW, Cerreta F, Faulkner SD, Forda SR, Joos A, Le Cam Y, Mayer MH, Pirard V, Corriol-Rohou S; ADAPT SMART Consortium.

Clin Pharmacol Ther. 2019 May;105(5):1148-1155. doi: 10.1002/cpt.1121. Epub 2018 Sep 11. Review.

19.

Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits.

Knörck A, Marx S, Friedmann KS, Zöphel S, Lieblang L, Hässig C, Müller I, Pilch J, Sester U, Hoth M, Eichler H, Sester M, Schwarz EC.

Transfusion. 2018 Jun;58(6):1516-1526. doi: 10.1111/trf.14616. Epub 2018 May 6.

PMID:
29732580
20.

The evolution of clinical trials: Can we address the challenges of the future?

Eichler HG, Sweeney F.

Clin Trials. 2018 Feb;15(1_suppl):27-32. doi: 10.1177/1740774518755058.

PMID:
29452522

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