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Items: 43

1.

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control.

Lang Lehrskov L, Lyngbaek MP, Soederlund L, Legaard GE, Ehses JA, Heywood SE, Wewer Albrechtsen NJ, Holst JJ, Karstoft K, Pedersen BK, Ellingsgaard H.

Cell Metab. 2018 Jun 5;27(6):1201-1211.e3. doi: 10.1016/j.cmet.2018.04.008. Epub 2018 May 3.

2.

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.

Westwell-Roper C, Denroche HC, Ehses JA, Verchere CB.

J Biol Chem. 2016 Apr 22;291(17):8908-17. doi: 10.1074/jbc.M115.712455. Epub 2016 Jan 19.

3.

Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.

Ngoh EN, Weisser SB, Lo Y, Kozicky LK, Jen R, Brugger HK, Menzies SC, McLarren KW, Nackiewicz D, van Rooijen N, Jacobson K, Ehses JA, Turvey SE, Sly LM.

Gastroenterology. 2016 Feb;150(2):465-76. doi: 10.1053/j.gastro.2015.09.049. Epub 2015 Oct 19.

PMID:
26481854
4.

Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes.

Ehses JA, Donath MY.

Diabetologia. 2015 Mar;58(3):425-8. doi: 10.1007/s00125-014-3482-7. Epub 2014 Dec 24.

PMID:
25537834
5.

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.

Westwell-Roper CY, Chehroudi CA, Denroche HC, Courtade JA, Ehses JA, Verchere CB.

Diabetologia. 2015 Mar;58(3):575-85. doi: 10.1007/s00125-014-3447-x. Epub 2014 Dec 10.

PMID:
25491100
6.

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6.

Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA.

Diabetologia. 2014 Aug;57(8):1645-54. doi: 10.1007/s00125-014-3249-1. Epub 2014 May 12.

PMID:
24816367
7.

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA.

Diabetes. 2014 Sep;63(9):2984-95. doi: 10.2337/db13-1121. Epub 2014 May 8.

8.

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.

Calderari S, Irminger JC, Giroix MH, Ehses JA, Gangnerau MN, Coulaud J, Rickenbach K, Gauguier D, Halban P, Serradas P, Homo-Delarche F.

PLoS One. 2014 Feb 26;9(2):e90045. doi: 10.1371/journal.pone.0090045. eCollection 2014.

9.

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.

Westwell-Roper C, Nackiewicz D, Dan M, Ehses JA.

Immunol Cell Biol. 2014 Apr;92(4):314-23. doi: 10.1038/icb.2014.4. Epub 2014 Feb 4. Review.

PMID:
24492799
10.

Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?

Westwell-Roper C, Ehses JA.

Diabetologia. 2014 Mar;57(3):447-50. doi: 10.1007/s00125-013-3151-2. Epub 2013 Dec 21.

PMID:
24362729
11.

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.

Han JM, Patterson SJ, Speck M, Ehses JA, Levings MK.

J Immunol. 2014 Jan 15;192(2):623-9. doi: 10.4049/jimmunol.1302181. Epub 2013 Dec 9.

12.

Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.

Westwell-Roper CY, Ehses JA, Verchere CB.

Diabetes. 2014 May;63(5):1698-711. doi: 10.2337/db13-0863. Epub 2013 Nov 12.

13.

Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation.

Tang C, Naassan AE, Chamson-Reig A, Koulajian K, Goh TT, Yoon F, Oprescu AI, Ghanim H, Lewis GF, Dandona P, Donath MY, Ehses JA, Arany E, Giacca A.

Endocrinology. 2013 Jan;154(1):89-101. doi: 10.1210/en.2012-1720. Epub 2012 Nov 13.

PMID:
23150493
14.

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, Eppler E, Bouzakri K, Wueest S, Muller YD, Hansen AM, Reinecke M, Konrad D, Gassmann M, Reimann F, Halban PA, Gromada J, Drucker DJ, Gribble FM, Ehses JA, Donath MY.

Nat Med. 2011 Oct 30;17(11):1481-9. doi: 10.1038/nm.2513.

15.

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.

Westwell-Roper C, Dai DL, Soukhatcheva G, Potter KJ, van Rooijen N, Ehses JA, Verchere CB.

J Immunol. 2011 Sep 1;187(5):2755-65. doi: 10.4049/jimmunol.1002854. Epub 2011 Aug 3.

16.

Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat.

Giroix MH, Irminger JC, Lacraz G, Noll C, Calderari S, Ehses JA, Coulaud J, Cornut M, Kassis N, Schmidlin F, Paul JL, Kergoat M, Janel N, Halban PA, Homo-Delarche F.

Diabetologia. 2011 Sep;54(9):2451-62. doi: 10.1007/s00125-011-2223-4. Epub 2011 Jul 10.

PMID:
21744291
17.

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, Wielinga PY, Schraenen A, Lemaire K, Debray S, Van Lommel L, Pospisilik JA, Tschopp O, Schultze SM, Malipiero U, Esterbauer H, Ellingsgaard H, Rütti S, Schuit FC, Lutz TA, Böni-Schnetzler M, Konrad D, Donath MY.

Diabetologia. 2010 Aug;53(8):1795-806. doi: 10.1007/s00125-010-1747-3. Epub 2010 Apr 21.

PMID:
20407745
18.

Cytokine production by islets in health and diabetes: cellular origin, regulation and function.

Donath MY, Böni-Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA.

Trends Endocrinol Metab. 2010 May;21(5):261-7. doi: 10.1016/j.tem.2009.12.010. Epub 2010 Jan 22. Review.

PMID:
20096598
19.

Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.

Donath MY, Böni-Schnetzler M, Ellingsgaard H, Ehses JA.

Physiology (Bethesda). 2009 Dec;24:325-31. doi: 10.1152/physiol.00032.2009. Review.

20.

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Dec;150(12):5218-29. doi: 10.1210/en.2009-0543. Epub 2009 Oct 9.

PMID:
19819943
21.

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, Irminger JC, Kergoat M, Portha B, Donath MY, Ehses JA, Homo-Delarche F.

PLoS One. 2009 Sep 9;4(9):e6963. doi: 10.1371/journal.pone.0006963.

22.

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.

Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N, Irminger JC, Kergoat M, Portha B, Homo-Delarche F, Donath MY.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13998-4003. doi: 10.1073/pnas.0810087106. Epub 2009 Jul 30.

23.

Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.

Ehses JA, Ellingsgaard H, Böni-Schnetzler M, Donath MY.

Arch Physiol Biochem. 2009 Oct;115(4):240-7. doi: 10.1080/13813450903025879. Review.

PMID:
19645635
24.

Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells.

Rütti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, Meier DT, Niclauss N, Berney T, Donath MY, von Eckardstein A.

Endocrinology. 2009 Oct;150(10):4521-30. doi: 10.1210/en.2009-0252. Epub 2009 Jul 23.

25.

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T.

Diabetes Care. 2009 Sep;32(9):1663-8. doi: 10.2337/dc09-0533. Epub 2009 Jun 19.

26.

Insulitis in type 2 diabetes.

Böni-Schnetzler M, Ehses JA, Faulenbach M, Donath MY.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:201-4. doi: 10.1111/j.1463-1326.2008.00950.x.

PMID:
18834448
27.

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. doi: 10.1073/pnas.0801059105. Epub 2008 Aug 21.

28.

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. doi: 10.1210/jc.2008-0396. Epub 2008 Jul 29.

29.

Macrophages, cytokines and beta-cell death in Type 2 diabetes.

Ehses JA, Böni-Schnetzler M, Faulenbach M, Donath MY.

Biochem Soc Trans. 2008 Jun;36(Pt 3):340-2. doi: 10.1042/BST0360340. Review.

30.

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

Donath MY, Schumann DM, Faulenbach M, Ellingsgaard H, Perren A, Ehses JA.

Diabetes Care. 2008 Feb;31 Suppl 2:S161-4. doi: 10.2337/dc08-s243. Review.

PMID:
18227479
31.

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Böni-Schnetzler M, Hammar E, Irminger JC, Donath MY, Halban PA.

Endocrinology. 2007 Nov;148(11):5582-90. Epub 2007 Aug 16.

PMID:
17702850
32.

Increased number of islet-associated macrophages in type 2 diabetes.

Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, Gueripel X, Ellingsgaard H, Schneider MK, Biollaz G, Fontana A, Reinecke M, Homo-Delarche F, Donath MY.

Diabetes. 2007 Sep;56(9):2356-70. Epub 2007 Jun 19.

33.

TNF-alpha -308G>A polymorphism modulates cytokine serum concentrations and macrovascular complications in diabetic patients on aspirin.

Krayenbuehl PA, Wiesli P, Schmid M, Schmid C, Ehses JA, Hersberger M, Vetter W, Schulthess G.

Exp Clin Endocrinol Diabetes. 2007 May;115(5):322-6.

PMID:
17516296
34.

Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY.

N Engl J Med. 2007 Apr 12;356(15):1517-26.

35.

Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was.

Donath MY, Ehses JA.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12217-8. Epub 2006 Aug 7. No abstract available.

36.

Mechanisms of beta-cell death in type 2 diabetes.

Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M.

Diabetes. 2005 Dec;54 Suppl 2:S108-13. Review.

37.

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.

38.

Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

Ehses JA, Casilla VR, Doty T, Pospisilik JA, Winter KD, Demuth HU, Pederson RA, McIntosh CH.

Endocrinology. 2003 Oct;144(10):4433-45. Epub 2003 Jun 19.

PMID:
12960055
39.

Dipeptidyl peptidase IV inhibition in animal models of diabetes.

Pospisilik JA, Ehses JA, Doty T, McIntosh CH, Demuth HU, Pederson RA.

Adv Exp Med Biol. 2003;524:281-91. No abstract available.

PMID:
12675250
40.

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.

41.

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.

PMID:
12475913
42.

Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.

Ehses JA, Pelech SL, Pederson RA, McIntosh CH.

J Biol Chem. 2002 Oct 4;277(40):37088-97. Epub 2002 Jul 22.

43.

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