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Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB.

Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19.


Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.

Lee JJ, Lee SK, Song N, Nathan TO, Swarts BM, Eum SY, Ehrt S, Cho SN, Eoh H.

Nat Commun. 2019 Jul 2;10(1):2928. doi: 10.1038/s41467-019-10975-7.


Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT.

Nature. 2019 Jul;571(7763):72-78. doi: 10.1038/s41586-019-1315-z. Epub 2019 Jun 19.


Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.

Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T.

Front Microbiol. 2018 Oct 26;9:2542. doi: 10.3389/fmicb.2018.02542. eCollection 2018.


Targeting protein biotinylation enhances tuberculosis chemotherapy.

Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D.

Sci Transl Med. 2018 Apr 25;10(438). pii: eaal1803. doi: 10.1126/scitranslmed.aal1803.


Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.

Ehrt S, Schnappinger D, Rhee KY.

Nat Rev Microbiol. 2018 Aug;16(8):496-507. doi: 10.1038/s41579-018-0013-4. Review.


Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.

Ngadjeua F, Braud E, Saidjalolov S, Iannazzo L, Schnappinger D, Ehrt S, Hugonnet JE, Mengin-Lecreulx D, Patin D, Ethève-Quelquejeu M, Fonvielle M, Arthur M.

Chemistry. 2018 Apr 17;24(22):5743-5747. doi: 10.1002/chem.201706082. Epub 2018 Feb 21.


Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.

Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J.

MBio. 2017 Sep 12;8(5). pii: e01183-17. doi: 10.1128/mBio.01183-17.


Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.

Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01334-17. doi: 10.1128/AAC.01334-17. Print 2017 Dec.


Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2225-E2232. doi: 10.1073/pnas.1617655114. Epub 2017 Mar 6.


Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.

Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt S.

Cell Chem Biol. 2017 Mar 16;24(3):306-315. doi: 10.1016/j.chembiol.2017.01.005. Epub 2017 Feb 16.


PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis.

Mitra A, Speer A, Lin K, Ehrt S, Niederweis M.

MBio. 2017 Jan 24;8(1). pii: e01720-16. doi: 10.1128/mBio.01720-16.


Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR.

MBio. 2017 Jan 17;8(1). pii: e02133-16. doi: 10.1128/mBio.02133-16.


Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.

Botella H, Vaubourgeix J, Lee MH, Song N, Xu W, Makinoshima H, Glickman MS, Ehrt S.

EMBO J. 2017 Feb 15;36(4):536-548. doi: 10.15252/embj.201695028. Epub 2017 Jan 5.


Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R.

PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec.


A broader spectrum of tuberculosis.

Schnappinger D, Ehrt S.

Nat Med. 2016 Oct 6;22(10):1076-1077. doi: 10.1038/nm.4186. No abstract available.


Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.

Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HI, Rhee KY, Barry CE 3rd, Mizrahi V.

ACS Infect Dis. 2016 Dec 9;2(12):958-968. Epub 2016 Oct 5.


Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.

Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S.

PLoS Pathog. 2016 Jun 1;12(6):e1005675. doi: 10.1371/journal.ppat.1005675. eCollection 2016 Jun.


Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis.

Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N.

PLoS Pathog. 2015 Dec 9;11(12):e1005336. doi: 10.1371/journal.ppat.1005336. eCollection 2015 Dec.


Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPS, Rhee K, Ehrt S.

Nat Commun. 2015 Aug 10;6:7912. doi: 10.1038/ncomms8912.


Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.

Speer A, Sun J, Danilchanka O, Meikle V, Rowland JL, Walter K, Buck BR, Pavlenok M, Hölscher C, Ehrt S, Niederweis M.

Mol Microbiol. 2015 Sep;97(5):881-97. doi: 10.1111/mmi.13073. Epub 2015 Jul 4.


Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.

Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C.

PLoS One. 2015 May 15;10(5):e0126211. doi: 10.1371/journal.pone.0126211. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0131145.


Construction of conditional knockdown mutants in mycobacteria.

Schnappinger D, O'Brien KM, Ehrt S.

Methods Mol Biol. 2015;1285:151-75. doi: 10.1007/978-1-4939-2450-9_9.


Mycobacterial genes essential for the pathogen's survival in the host.

Ehrt S, Rhee K, Schnappinger D.

Immunol Rev. 2015 Mar;264(1):319-26. doi: 10.1111/imr.12256. Review.


Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.

Goodsmith N, Guo XV, Vandal OH, Vaubourgeix J, Wang R, Botella H, Song S, Bhatt K, Liba A, Salgame P, Schnappinger D, Ehrt S.

PLoS Pathog. 2015 Feb 6;11(2):e1004645. doi: 10.1371/journal.ppat.1004645. eCollection 2015 Feb.


Regulated Expression Systems for Mycobacteria and Their Applications.

Schnappinger D, Ehrt S.

Microbiol Spectr. 2014;2(1). pii: 03.


Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.

Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, Rosen H, Spicer TP, Nathan CF.

ACS Chem Biol. 2015 Feb 20;10(2):364-71. doi: 10.1021/cb500746z. Epub 2014 Dec 5.


LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.

Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N.

PLoS Pathog. 2014 Sep 18;10(9):e1004376. doi: 10.1371/journal.ppat.1004376. eCollection 2014 Sep. Erratum in: PLoS Pathog. 2014 Oct;10(10):e1004489. PLoS Pathog. 2014 Oct;10(10):e1004494. Gibbs, Sara [corrected to González-Nilo, Fernando D]. PLoS Pathog. 2015 Dec 9;11(12):e1005336.


Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S.

PLoS Pathog. 2014 May 22;10(5):e1004144. doi: 10.1371/journal.ppat.1004144. eCollection 2014 May.


Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.

Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S.

MBio. 2014 Apr 22;5(2):e00085. doi: 10.1128/mBio.00085-14.


An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.

Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS, Muñoz LE, Herrmann M, Ehrt S, Berens C, Niederweis M.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6750-5. doi: 10.1073/pnas.1400136111. Epub 2014 Apr 21.


Regulated Expression Systems for Mycobacteria and Their Applications.

Schnappinger D, Ehrt S.

Microbiol Spectr. 2014 Feb;2(1):MGM2-0018-2013. doi: 10.1128/microbiolspec.MGM2-0018-2013. Review.


A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.

Kim JH, O'Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE 3rd, Rhee KY, Ehrt S, Schnappinger D.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19095-100. doi: 10.1073/pnas.1315860110. Epub 2013 Nov 4.


Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.

Small JL, Park SW, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S.

MBio. 2013 Sep 17;4(5):e00475-13. doi: 10.1128/mBio.00475-13.


Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.

Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Brickner SJ, Nathan C.

PLoS One. 2013 Jul 30;8(7):e68942. doi: 10.1371/journal.pone.0068942. Print 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/760b5b07-4922-42c4-b33a-162c1e9ae188. Anderson, Olaf S [corrected to Andersen, Olaf S].


Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.

Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S.

J Biol Chem. 2013 May 3;288(18):12489-99. doi: 10.1074/jbc.M113.456541. Epub 2013 Mar 15.


Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.

Marrero J, Trujillo C, Rhee KY, Ehrt S.

PLoS Pathog. 2013 Jan;9(1):e1003116. doi: 10.1371/journal.ppat.1003116. Epub 2013 Jan 10.


Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.

Sakamoto K, Kim MJ, Rhoades ER, Allavena RE, Ehrt S, Wainwright HC, Russell DG, Rohde KH.

Infect Immun. 2013 Mar;81(3):764-76. doi: 10.1128/IAI.00906-12. Epub 2012 Dec 21.


Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.

Ehrt S, Rhee K.

Curr Top Microbiol Immunol. 2013;374:163-88. doi: 10.1007/82_2012_299. Review.


Detection and treatment of subclinical tuberculosis.

Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, Kaplan G, Kaufmann SH, Kim P, Lienhardt C, Mizrahi V, Rubin E, Schnappinger D, Sherman D, Thole J, Vandal O, Walzl G, Warner D, Wilkinson R, Young D.

Tuberculosis (Edinb). 2012 Nov;92(6):447-52. doi: 10.1016/ Epub 2012 Jul 21.


M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.

Blumenthal A, Nagalingam G, Huch JH, Walker L, Guillemin GJ, Smythe GA, Ehrt S, Britton WJ, Saunders BM.

PLoS One. 2012;7(5):e37314. doi: 10.1371/journal.pone.0037314. Epub 2012 May 23.


Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE 3rd, Aldrich CC, Ehrt S, Schnappinger D.

PLoS Pathog. 2011 Sep;7(9):e1002264. doi: 10.1371/journal.ppat.1002264. Epub 2011 Sep 29.


Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.

de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M.

J Biol Chem. 2011 Nov 18;286(46):40219-31. doi: 10.1074/jbc.M111.259440. Epub 2011 Sep 23.


Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.

Darby CM, Venugopal A, Ehrt S, Nathan CF.

Tuberculosis (Edinb). 2011 Sep;91(5):343-7. doi: 10.1016/ Epub 2011 Jul 20.


Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.

Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C.

Trends Microbiol. 2011 Jul;19(7):307-14. doi: 10.1016/j.tim.2011.03.008. Epub 2011 May 10.


Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.

Koo MS, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S, Kaplan G.

PLoS One. 2011 Feb 25;6(2):e17091. doi: 10.1371/journal.pone.0017091.


Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.

Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C.

Cell Host Microbe. 2011 Jan 20;9(1):21-31. doi: 10.1016/j.chom.2010.12.004.


Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.

Blumenthal A, Trujillo C, Ehrt S, Schnappinger D.

PLoS One. 2010 Dec 22;5(12):e15667. doi: 10.1371/journal.pone.0015667.


Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses.

Tan MP, Sequeira P, Lin WW, Phong WY, Cliff P, Ng SH, Lee BH, Camacho L, Schnappinger D, Ehrt S, Dick T, Pethe K, Alonso S.

PLoS One. 2010 Oct 26;5(10):e13356. doi: 10.1371/journal.pone.0013356.


Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.

de Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY.

Chem Biol. 2010 Oct 29;17(10):1122-31. doi: 10.1016/j.chembiol.2010.08.009.

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