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A Novel Transgenic Mouse Model to Investigate the Cell-Autonomous Effects of torsinA(ΔE) Expression in Striatal Output Neurons.

Gonzalez-Alegre P, Beauvais G, Martin J, Koch RJ, Walker RH, Patel JC, Rice ME, Ehrlich ME.

Neuroscience. 2019 Dec 1;422:1-11. doi: 10.1016/j.neuroscience.2019.09.007. Epub 2019 Oct 26.


Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling.

Cirnaru MD, Melis C, Fanutza T, Naphade S, Tshilenge KT, Muntean BS, Martemyanov KA, Plotkin JL, Ellerby LM, Ehrlich ME.

eNeuro. 2019 Oct 10;6(5). pii: ENEURO.0305-19.2019. doi: 10.1523/ENEURO.0305-19.2019. Print 2019 Sep/Oct.


Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models.

Creus-Muncunill J, Ehrlich ME.

Neurotherapeutics. 2019 Sep 16. doi: 10.1007/s13311-019-00782-9. [Epub ahead of print] Review.


Diverse Mechanisms Lead to Common Dysfunction of Striatal Cholinergic Interneurons in Distinct Genetic Mouse Models of Dystonia.

Eskow Jaunarajs KL, Scarduzio M, Ehrlich ME, McMahon LL, Standaert DG.

J Neurosci. 2019 Sep 4;39(36):7195-7205. doi: 10.1523/JNEUROSCI.0407-19.2019. Epub 2019 Jul 18.


Neurobehavioral effects of neonatal opioid exposure in mice: Influence of the OPRM1 SNP.

Robinson SA, Jones AD, Brynildsen JK, Ehrlich ME, Blendy JA.

Addict Biol. 2019 Jul 2:e12806. doi: 10.1111/adb.12806. [Epub ahead of print]


Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans.

Elder GA, Ehrlich ME, Gandy S.

Neurosci Lett. 2019 Aug 10;707:134294. doi: 10.1016/j.neulet.2019.134294. Epub 2019 May 26. Review.


Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus.

Ehrlich ME, Liang L, Xu H, Kosinski AS, Hernandez AF, Schwamm LH, Smith EE, Fonarow GC, Bhatt DL, Peterson ED, Xian Y.

Stroke. 2019 Jun;50(6):1497-1503. doi: 10.1161/STROKEAHA.118.024172. Epub 2019 Apr 30.


Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME.

Mol Psychiatry. 2019 Mar;24(3):472. doi: 10.1038/s41380-018-0301-4.


Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo.

Beauvais G, Watson JL, Aguirre JA, Tecedor L, Ehrlich ME, Gonzalez-Alegre P.

Brain Res. 2019 Mar 1;1706:24-31. doi: 10.1016/j.brainres.2018.10.025. Epub 2018 Oct 23.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME.

Mol Psychiatry. 2019 Mar;24(3):431-446. doi: 10.1038/s41380-018-0255-6. Epub 2018 Oct 3. Erratum in: Mol Psychiatry. 2018 Nov 21;:.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S.

Mol Psychiatry. 2019 Sep;24(9):1383-1397. doi: 10.1038/s41380-018-0258-3. Epub 2018 Oct 3.


An atlas of chromatin accessibility in the adult human brain.

Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P.

Genome Res. 2018 Aug;28(8):1243-1252. doi: 10.1101/gr.232488.117. Epub 2018 Jun 26.


Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.

Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT.

Neuron. 2018 Jul 11;99(1):64-82.e7. doi: 10.1016/j.neuron.2018.05.023. Epub 2018 Jun 21.


Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM.

Genome Med. 2018 Mar 29;10(1):26. doi: 10.1186/s13073-018-0530-9.


The Pharmacokinetics and Pharmacodynamics of Buprenorphine in Neonatal Abstinence Syndrome.

Moore JN, Gastonguay MR, Ng CM, Adeniyi-Jones SC, Moody DE, Fang WB, Ehrlich ME, Kraft WK.

Clin Pharmacol Ther. 2018 Jun;103(6):1029-1037. doi: 10.1002/cpt.1064. Epub 2018 Apr 28.


Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.

Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P, Ehrlich ME.

PLoS Genet. 2018 Jan 24;14(1):e1007169. doi: 10.1371/journal.pgen.1007169. eCollection 2018 Jan.


Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.

Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P.

Neuroscience. 2018 Feb 10;371:455-468. doi: 10.1016/j.neuroscience.2017.12.033. Epub 2017 Dec 28.


CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.

Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S.

Acta Neuropathol Commun. 2017 Oct 27;5(1):77. doi: 10.1186/s40478-017-0475-z.


Buprenorphine for the Neonatal Abstinence Syndrome.

Kraft WK, Adeniyi-Jones SC, Ehrlich ME.

N Engl J Med. 2017 Sep 7;377(10):997-998. doi: 10.1056/NEJMc1709121. No abstract available.


Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME.

Acta Neuropathol. 2017 Nov;134(5):769-788. doi: 10.1007/s00401-017-1737-3. Epub 2017 Jun 13.


THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation.

Aguilo F, Zakirova Z, Nolan K, Wagner R, Sharma R, Hogan M, Wei C, Sun Y, Walsh MJ, Kelley K, Zhang W, Ozelius LJ, Gonzalez-Alegre P, Zwaka TP, Ehrlich ME.

Stem Cell Reports. 2017 Jul 11;9(1):92-107. doi: 10.1016/j.stemcr.2017.04.032. Epub 2017 Jun 1.


Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome.

Kraft WK, Adeniyi-Jones SC, Chervoneva I, Greenspan JS, Abatemarco D, Kaltenbach K, Ehrlich ME.

N Engl J Med. 2017 Jun 15;376(24):2341-2348. doi: 10.1056/NEJMoa1614835. Epub 2017 May 4.


Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.

Kaur G, Pawlik M, Gandy SE, Ehrlich ME, Smiley JF, Levy E.

Mol Psychiatry. 2017 Jul;22(7):981-989. doi: 10.1038/mp.2016.189. Epub 2016 Oct 25.


Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.

Beauvais G, Bode NM, Watson JL, Wen H, Glenn KA, Kawano H, Harata NC, Ehrlich ME, Gonzalez-Alegre P.

J Neurosci. 2016 Oct 5;36(40):10245-10256.


Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke: A Single-Center Experience.

Ehrlich ME, Turner HL, Currie LJ, Wintermark M, Worrall BB, Southerland AM.

Stroke. 2016 Aug;47(8):2045-50. doi: 10.1161/STROKEAHA.116.013973. Epub 2016 Jun 30.


Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S.

Acta Neuropathol Commun. 2016 Feb 25;4:16. doi: 10.1186/s40478-016-0282-y.


Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME.

Mol Psychiatry. 2016 Aug;21(8):1153-4. doi: 10.1038/mp.2015.215. Epub 2016 Jan 19. No abstract available.


Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling.

Xie K, Masuho I, Shih CC, Cao Y, Sasaki K, Lai CW, Han PL, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA.

Elife. 2015 Nov 27;4. pii: e10451. doi: 10.7554/eLife.10451.


Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.

Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME.

Sci Rep. 2015 Nov 26;5:17042. doi: 10.1038/srep17042.


Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME.

Mol Psychiatry. 2016 Aug;21(8):1099-111. doi: 10.1038/mp.2015.167. Epub 2015 Nov 10. Erratum in: Mol Psychiatry. 2016 Aug;21(8):1153-4.


Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.

Moreno CL, Ehrlich ME, Mobbs CV.

Neurobiol Dis. 2016 Jan;85:25-34. doi: 10.1016/j.nbd.2015.09.012. Epub 2015 Oct 17.


Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia.

Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Méneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME.

Hum Mol Genet. 2015 Dec 20;24(25):7159-70. doi: 10.1093/hmg/ddv384. Epub 2015 Sep 16.


Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells.

Jiang L, O'Leary C, Kim HA, Parish CL, Massalas J, Waddington JL, Ehrlich ME, Schütz G, Gantois I, Lawrence AJ, Drago J.

Neurobiol Dis. 2015 Apr;76:137-158. doi: 10.1016/j.nbd.2015.02.006. Epub 2015 Feb 12.


Teaching NeuroImages: Radiation-associated symptomatic carotid artery disease with ipsilateral radiodermatitis.

Ehrlich ME, Gulvezan T, Southerland AM.

Neurology. 2015 Feb 3;84(5):e31-2. doi: 10.1212/WNL.0000000000001210. No abstract available.


Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S.

Mol Psychiatry. 2015 Feb;20(1):109-17. doi: 10.1038/mp.2014.135. Epub 2014 Oct 28.


Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathology.

Price KA, Varghese M, Sowa A, Yuk F, Brautigam H, Ehrlich ME, Dickstein DL.

Mol Neurodegener. 2014 Oct 13;9:41. doi: 10.1186/1750-1326-9-41.


Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.

Ortiz-Virumbrales M, Ruiz M, Hone E, Dolios G, Wang R, Morant A, Kottwitz J, Ozelius LJ, Gandy S, Ehrlich ME.

Acta Neuropathol Commun. 2014 Sep 18;2:139. doi: 10.1186/s40478-014-0139-1.


Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse.

Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S.

Mol Psychiatry. 2014 Nov;19(11):1235-42. doi: 10.1038/mp.2014.87. Epub 2014 Aug 12.


Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons.

Unterwald EM, Page ME, Brown TB, Miller JS, Ruiz M, Pescatore KA, Xu B, Reichardt LF, Beverley J, Tang B, Steiner H, Thomas EA, Ehrlich ME.

Mol Neurodegener. 2013 Dec 26;8:47. doi: 10.1186/1750-1326-8-47.


Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2.

Chandwani S, Keilani S, Ortiz-Virumbrales M, Morant A, Bezdecny S, Ehrlich ME.

PLoS One. 2013 Oct 21;8(10):e76842. doi: 10.1371/journal.pone.0076842. eCollection 2013.


Resolving pathobiological mechanisms relating to Huntington disease: gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells.

Kim HA, Jiang L, Madsen H, Parish CL, Massalas J, Smardencas A, O'Leary C, Gantois I, O'Tuathaigh C, Waddington JL, Ehrlich ME, Lawrence AJ, Drago J.

Neurobiol Dis. 2014 Feb;62:323-37. doi: 10.1016/j.nbd.2013.09.015. Epub 2013 Oct 14.


Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases.

Smardencas A, Rizkalla K, Kim HA, Massalas J, O'Leary C, Ehrlich ME, Schütz G, Lawrence AJ, Drago J.

BMC Neurosci. 2013 Oct 3;14:111. doi: 10.1186/1471-2202-14-111.


Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D.

J Biol Chem. 2013 Nov 1;288(44):32050-63. doi: 10.1074/jbc.M113.504365. Epub 2013 Sep 19.


Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.

Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S.

J Neurosci. 2013 Apr 17;33(16):7099-107. doi: 10.1523/JNEUROSCI.5270-12.2013.


Mutations in GNAL cause primary torsion dystonia.

Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Hervé D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ.

Nat Genet. 2013 Jan;45(1):88-92. doi: 10.1038/ng.2496. Epub 2012 Dec 9.


Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.

Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC.

PLoS One. 2012;7(9):e44273. doi: 10.1371/journal.pone.0044273. Epub 2012 Sep 7.


Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, Martins RN.

J Alzheimers Dis. 2012;32(4):949-67. doi: 10.3233/JAD-2012-120178.


Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S.

Mol Psychiatry. 2013 Aug;18(8):882-8. doi: 10.1038/mp.2012.115. Epub 2012 Aug 7.


Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S.

Mol Psychiatry. 2013 Aug;18(8):889-97. doi: 10.1038/mp.2012.106. Epub 2012 Jul 31.

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