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Strong Signs for a Weak Wall in Tricuspid Aortic Valve Associated Aneurysms and a Role for Osteopontin in Bicuspid Aortic Valve Associated Aneurysms.

Stern C, Scharinger B, Tuerkcan A, Nebert C, Mimler T, Baranyi U, Doppler C, Aschacher T, Andreas M, Stelzmueller ME, Ehrlich M, Graf A, Laufer G, Bernhard D, Messner B.

Int J Mol Sci. 2019 Sep 26;20(19). pii: E4782. doi: 10.3390/ijms20194782.


Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling.

Cirnaru MD, Melis C, Fanutza T, Naphade S, Tshilenge KT, Muntean BS, Martemyanov KA, Plotkin JL, Ellerby LM, Ehrlich ME.

eNeuro. 2019 Oct 10;6(5). pii: ENEURO.0305-19.2019. doi: 10.1523/ENEURO.0305-19.2019. Print 2019 Sep/Oct.


Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models.

Creus-Muncunill J, Ehrlich ME.

Neurotherapeutics. 2019 Sep 16. doi: 10.1007/s13311-019-00782-9. [Epub ahead of print] Review.


NTRC plays a crucial role in starch metabolism, redox balance and tomato fruit growth.

Hou LY, Ehrlich M, Thormählen I, Lehmann M, Krahnert I, Obata T, Cejudo FJ, Fernie AR, Geigenberger P.

Plant Physiol. 2019 Sep 16. pii: pp.00911.2019. doi: 10.1104/pp.19.00911. [Epub ahead of print]


Bilateral or unilateral antegrade cerebral perfusion during surgery for acute type A dissection.

Angleitner P, Stelzmueller ME, Mahr S, Kaider A, Laufer G, Ehrlich M.

J Thorac Cardiovasc Surg. 2019 Jul 8. pii: S0022-5223(19)31353-4. doi: 10.1016/j.jtcvs.2019.06.057. [Epub ahead of print]


Data showing atherosclerosis-associated differentially methylated regions are often at enhancers.

Lacey M, Baribault C, Ehrlich KC, Ehrlich M.

Data Brief. 2019 Mar 7;23:103812. doi: 10.1016/j.dib.2019.103812. eCollection 2019 Apr.


Diverse Mechanisms Lead to Common Dysfunction of Striatal Cholinergic Interneurons in Distinct Genetic Mouse Models of Dystonia.

Eskow Jaunarajs KL, Scarduzio M, Ehrlich ME, McMahon LL, Standaert DG.

J Neurosci. 2019 Sep 4;39(36):7195-7205. doi: 10.1523/JNEUROSCI.0407-19.2019. Epub 2019 Jul 18.


Emergence of a Novel Reassortant Strain of Bluetongue Serotype 6 in Israel, 2017: Clinical Manifestations of the Disease and Molecular Characterization.

Golender N, Eldar A, Ehrlich M, Khinich Y, Kenigswald G, Varsano JS, Ertracht S, Abramovitz I, Assis I, Shlamovitz I, Tiomkin E, Yonay E, Sharir B, Bumbarov VY.

Viruses. 2019 Jul 10;11(7). pii: E633. doi: 10.3390/v11070633.


DNA hypermethylation in disease: mechanisms and clinical relevance.

Ehrlich M.

Epigenetics. 2019 Dec;14(12):1141-1163. doi: 10.1080/15592294.2019.1638701. Epub 2019 Jul 8.


Neurobehavioral effects of neonatal opioid exposure in mice: Influence of the OPRM1 SNP.

Robinson SA, Jones AD, Brynildsen JK, Ehrlich ME, Blendy JA.

Addict Biol. 2019 Jul 2:e12806. doi: 10.1111/adb.12806. [Epub ahead of print]


Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans.

Elder GA, Ehrlich ME, Gandy S.

Neurosci Lett. 2019 Aug 10;707:134294. doi: 10.1016/j.neulet.2019.134294. Epub 2019 May 26. Review.


Frozen elephant trunk does not increase incidence of paraplegia in patients with acute type A aortic dissection.

Poon SS, Tian DH, Yan T, Harrington D, Nawaytou O, Kuduvalli M, Haverich A, Ehrlich M, Ma WG, Sun LZ, Estrera AL, Field M; International Aortic Arch Surgery Study Group.

J Thorac Cardiovasc Surg. 2019 Apr 14. pii: S0022-5223(19)30800-1. doi: 10.1016/j.jtcvs.2019.03.097. [Epub ahead of print]


Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer.

Liubomirski Y, Lerrer S, Meshel T, Morein D, Rubinstein-Achiasaf L, Sprinzak D, Wiemann S, Körner C, Ehrlich M, Ben-Baruch A.

Front Immunol. 2019 Apr 24;10:804. doi: 10.3389/fimmu.2019.00804. eCollection 2019.


Communicating Uncertainty From Limitations in Quality of Evidence to the Public in Written Health Information: Protocol for a Web-Based Randomized Controlled Trial.

Büchter RB, Betsch C, Ehrlich M, Fechtelpeter D, Grouven U, Keller S, Meuer R, Rossmann C, Waltering A.

JMIR Res Protoc. 2019 May 13;8(5):e13425. doi: 10.2196/13425.


Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus.

Ehrlich ME, Liang L, Xu H, Kosinski AS, Hernandez AF, Schwamm LH, Smith EE, Fonarow GC, Bhatt DL, Peterson ED, Xian Y.

Stroke. 2019 Jun;50(6):1497-1503. doi: 10.1161/STROKEAHA.118.024172. Epub 2019 Apr 30.


Modeling Parkinson's disease in midbrain-like organoids.

Smits LM, Reinhardt L, Reinhardt P, Glatza M, Monzel AS, Stanslowsky N, Rosato-Siri MD, Zanon A, Antony PM, Bellmann J, Nicklas SM, Hemmer K, Qing X, Berger E, Kalmbach N, Ehrlich M, Bolognin S, Hicks AA, Wegner F, Sterneckert JL, Schwamborn JC.

NPJ Parkinsons Dis. 2019 Apr 5;5:5. doi: 10.1038/s41531-019-0078-4. eCollection 2019.


Tumor control and survival in patients with ten or more brain metastases treated with stereotactic radiosurgery: a retrospective analysis.

Ehrlich MI, Schiff E, Knisely JPS, Chang J, Qian X, Goenka A, Schulder M.

J Neurooncol. 2019 May;143(1):167-174. doi: 10.1007/s11060-019-03153-8. Epub 2019 Apr 3.


The in vivo timeline of differentiation of engrafted human neural progenitor cells.

Vogel S, Schäfer C, Hess S, Folz-Donahue K, Nelles M, Minassian A, Schwarz MK, Kukat C, Ehrlich M, Zaehres H, Kloppenburg P, Hoehn M, Aswendt M.

Stem Cell Res. 2019 May;37:101429. doi: 10.1016/j.scr.2019.101429. Epub 2019 Mar 25.


Extracellular matrix in ascending aortic aneurysms and dissections - What we learn from decellularization and scanning electron microscopy.

Mimler T, Nebert C, Eichmair E, Winter B, Aschacher T, Stelzmueller ME, Andreas M, Ehrlich M, Laufer G, Messner B.

PLoS One. 2019 Mar 18;14(3):e0213794. doi: 10.1371/journal.pone.0213794. eCollection 2019.


Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.

Ehrlich KC, Lacey M, Ehrlich M.

Epigenomics. 2019 Feb;11(2):169-186. doi: 10.2217/epi-2018-0150. Epub 2019 Jan 28.


PKR: A Kinase to Remember.

Gal-Ben-Ari S, Barrera I, Ehrlich M, Rosenblum K.

Front Mol Neurosci. 2019 Jan 9;11:480. doi: 10.3389/fnmol.2018.00480. eCollection 2018. Review.


Thoracic endovascular repair for acute complicated type B aortic dissections.

Stelzmueller ME, Nolz R, Mahr S, Beitzke D, Wolf F, Funovics M, Laufer G, Loewe C, Hutschala D, Ehrlich MP.

J Vasc Surg. 2019 Feb;69(2):318-326. doi: 10.1016/j.jvs.2018.05.234.


Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers.

Lacey M, Baribault C, Ehrlich KC, Ehrlich M.

Atherosclerosis. 2019 Jan;280:183-191. doi: 10.1016/j.atherosclerosis.2018.11.031. Epub 2018 Nov 27.


Noninvasive mapping before surgical ablation for persistent, long-standing atrial fibrillation.

Ehrlich MP, Laufer G, Coti I, Peter M, Andreas M, Stix G, Ad N.

J Thorac Cardiovasc Surg. 2019 Jan;157(1):248-256. doi: 10.1016/j.jtcvs.2018.07.104. Epub 2018 Sep 25.


SHP2 regulates intramembranous ossification by modifying the TGFβ and BMP2 signaling pathway.

Wang L, Huang J, Moore DC, Song Y, Ehrlich MG, Yang W.

Bone. 2019 Mar;120:327-335. doi: 10.1016/j.bone.2018.11.014. Epub 2018 Nov 22.


Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME.

Mol Psychiatry. 2019 Mar;24(3):472. doi: 10.1038/s41380-018-0301-4.


Acute aortic dissections with entry tear in the arch: A report from the International Registry of Acute Aortic Dissection.

Trimarchi S, de Beaufort HWL, Tolenaar JL, Bavaria JE, Desai ND, Di Eusanio M, Di Bartolomeo R, Peterson MD, Ehrlich M, Evangelista A, Montgomery DG, Myrmel T, Hughes GC, Appoo JJ, De Vincentiis C, Yan TD, Nienaber CA, Isselbacher EM, Deeb GM, Gleason TG, Patel HJ, Sundt TM, Eagle KA.

J Thorac Cardiovasc Surg. 2019 Jan;157(1):66-73. doi: 10.1016/j.jtcvs.2018.07.101. Epub 2018 Sep 21.


Right Heart Thrombi: Patient Outcomes by Treatment Modality and Predictors of Mortality: A Pooled Analysis.

Islam M, Nesheim D, Acquah S, Kory P, Kourouni I, Ramesh N, Ehrlich M, Bajpayee G, Steiger D, Filopei J.

J Intensive Care Med. 2018 Oct 29:885066618808193. doi: 10.1177/0885066618808193. [Epub ahead of print]


Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo.

Beauvais G, Watson JL, Aguirre JA, Tecedor L, Ehrlich ME, Gonzalez-Alegre P.

Brain Res. 2019 Mar 1;1706:24-31. doi: 10.1016/j.brainres.2018.10.025. Epub 2018 Oct 23.


Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.

Jayasuriya CT, Twomey-Kozak J, Newberry J, Desai S, Feltman P, Franco JR, Li N, Terek R, Ehrlich MG, Owens BD.

Stem Cells. 2019 Jan;37(1):102-114. doi: 10.1002/stem.2923. Epub 2018 Nov 2.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME.

Mol Psychiatry. 2019 Mar;24(3):431-446. doi: 10.1038/s41380-018-0255-6. Epub 2018 Oct 3. Erratum in: Mol Psychiatry. 2018 Nov 21;:.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S.

Mol Psychiatry. 2019 Sep;24(9):1383-1397. doi: 10.1038/s41380-018-0258-3. Epub 2018 Oct 3.


The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.

Wang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, Mahajan M, Mangravite LM, Dammer EB, Duong DM, Lah JJ, Seyfried NT, Levey AI, Buxbaum JD, Ehrlich M, Gandy S, Katsel P, Haroutunian V, Schadt E, Zhang B.

Sci Data. 2018 Sep 11;5:180185. doi: 10.1038/sdata.2018.185.


Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism.

Shapira KE, Ehrlich M, Henis YI.

Mol Biol Cell. 2018 Oct 1;29(20):2494-2507. doi: 10.1091/mbc.E18-03-0175. Epub 2018 Aug 9.


The metastatic microenvironment: Melanoma-microglia cross-talk promotes the malignant phenotype of melanoma cells.

Izraely S, Ben-Menachem S, Sagi-Assif O, Telerman A, Zubrilov I, Ashkenazi O, Meshel T, Maman S, Orozco JIJ, Salomon MP, Marzese DM, Pasmanik-Chor M, Pikarski E, Ehrlich M, Hoon DSB, Witz IP.

Int J Cancer. 2019 Feb 15;144(4):802-817. doi: 10.1002/ijc.31745. Epub 2018 Nov 1.


An atlas of chromatin accessibility in the adult human brain.

Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P.

Genome Res. 2018 Aug;28(8):1243-1252. doi: 10.1101/gr.232488.117. Epub 2018 Jun 26.


Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.

Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT.

Neuron. 2018 Jul 11;99(1):64-82.e7. doi: 10.1016/j.neuron.2018.05.023. Epub 2018 Jun 21.


The authors reply.

Filopei J, Acquah S, Bondarsky E, Steiger D, Ehrlich M, Patrawalla P.

Crit Care Med. 2018 Jun;46(6):e623-e624. doi: 10.1097/CCM.0000000000003065. No abstract available.


Molecular characterization of mesenchymal stem cells in human osteoarthritis cartilage reveals contribution to the OA phenotype.

Jayasuriya CT, Hu N, Li J, Lemme N, Terek R, Ehrlich MG, Chen Q.

Sci Rep. 2018 May 4;8(1):7044. doi: 10.1038/s41598-018-25395-8.


The Sequence of Two Bacteriophages with Hypermodified Bases Reveals Novel Phage-Host Interactions.

Kropinski AM, Turner D, Nash JHE, Ackermann HW, Lingohr EJ, Warren RA, Ehrlich KC, Ehrlich M.

Viruses. 2018 Apr 24;10(5). pii: E217. doi: 10.3390/v10050217.


Publisher Correction: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.

Weider M, Starost LJ, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M.

Nat Commun. 2018 Apr 23;9(1):1667. doi: 10.1038/s41467-018-03871-z.


Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.

Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators.

Circulation. 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. Review.


SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.

Zuo C, Wang L, Kamalesh RM, Bowen ME, Moore DC, Dooner MS, Reginato AM, Wu Q, Schorl C, Song Y, Warman ML, Neel BG, Ehrlich MG, Yang W.

Bone Res. 2018 Apr 6;6:12. doi: 10.1038/s41413-018-0013-z. eCollection 2018.


Presenting Systolic Blood Pressure and Outcomes in Patients With Acute Aortic Dissection.

Bossone E, Gorla R, LaBounty TM, Suzuki T, Gilon D, Strauss C, Ballotta A, Patel HJ, Evangelista A, Ehrlich MP, Hutchison S, Kline-Rogers E, Montgomery DG, Nienaber CA, Isselbacher EM, Eagle KA.

J Am Coll Cardiol. 2018 Apr 3;71(13):1432-1440. doi: 10.1016/j.jacc.2018.01.064.


Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM.

Genome Med. 2018 Mar 29;10(1):26. doi: 10.1186/s13073-018-0530-9.


Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm.

Islam M, Filopei J, Frank M, Ramesh N, Verzosa S, Ehrlich M, Bondarsky E, Miller A, Steiger D.

Respirology. 2018 Mar 25. doi: 10.1111/resp.13299. [Epub ahead of print]


The Pharmacokinetics and Pharmacodynamics of Buprenorphine in Neonatal Abstinence Syndrome.

Moore JN, Gastonguay MR, Ng CM, Adeniyi-Jones SC, Moody DE, Fang WB, Ehrlich ME, Kraft WK.

Clin Pharmacol Ther. 2018 Jun;103(6):1029-1037. doi: 10.1002/cpt.1064. Epub 2018 Apr 28.


Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.

Weider M, Starost LJ, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M.

Nat Commun. 2018 Mar 2;9(1):899. doi: 10.1038/s41467-018-03336-3. Erratum in: Nat Commun. 2018 Apr 23;9(1):1667.


Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription.

Baribault C, Ehrlich KC, Ponnaluri VKC, Pradhan S, Lacey M, Ehrlich M.

Epigenetics. 2018;13(3):275-289. doi: 10.1080/15592294.2018.1445900. Epub 2018 Apr 18.


Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States.

Danziger O, Pupko T, Bacharach E, Ehrlich M.

Front Immunol. 2018 Jan 30;9:94. doi: 10.3389/fimmu.2018.00094. eCollection 2018.

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