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Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2.

Kuo IY, Brill AL, Lemos FO, Jiang JY, Falcone JL, Kimmerling EP, Cai Y, Dong K, Kaplan DL, Wallace DP, Hofer AM, Ehrlich BE.

Sci Signal. 2019 May 7;12(580). pii: eaat7397. doi: 10.1126/scisignal.aat7397.


TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.

Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A.

Nat Commun. 2019 May 2;10(1):2024. doi: 10.1038/s41467-019-10045-y.


Neuronal calcium sensor 1 (NCS1) promotes motility and metastatic spread of breast cancer cells in vitro and in vivo.

Apasu JE, Schuette D, LaRanger R, Steinle JA, Nguyen LD, Grosshans HK, Zhang M, Cai WL, Yan Q, Robert ME, Mak M, Ehrlich BE.

FASEB J. 2019 Apr;33(4):4802-4813. doi: 10.1096/fj.201802004R. Epub 2018 Dec 28.


Hepatocellular Carcinoma Outcome Is Predicted by Expression of Neuronal Calcium Sensor 1.

Schuette D, Moore LM, Robert ME, Taddei TH, Ehrlich BE.

Cancer Epidemiol Biomarkers Prev. 2018 Sep;27(9):1091-1100. doi: 10.1158/1055-9965.EPI-18-0167. Epub 2018 May 22.


NCS-1 is a regulator of calcium signaling in health and disease.

Boeckel GR, Ehrlich BE.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1660-1667. doi: 10.1016/j.bbamcr.2018.05.005. Epub 2018 May 8. Review.


An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients.

Moore LM, Wilkinson R, Altan M, Toki M, Carvajal-Hausdorf DE, McGuire J, Ehrlich BE, Rimm DL.

NPJ Breast Cancer. 2018 Mar 12;4:6. doi: 10.1038/s41523-018-0057-7. eCollection 2018.


The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients.

Wadia RJ, Stolar M, Grens C, Ehrlich BE, Chao HH.

Oncotarget. 2017 Dec 19;9(7):7322-7331. doi: 10.18632/oncotarget.23467. eCollection 2018 Jan 26.


Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.

Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE.

Hepatol Commun. 2017 Feb;1(1):23-35. doi: 10.1002/hep4.1012. Epub 2016 Nov 11.


Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation.

Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X.

Genes Dev. 2017 Aug 15;31(16):1655-1665. doi: 10.1101/gad.305441.117. Epub 2017 Sep 13.


Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress.

Giehl E, Lemos FO, Huang Y, Giordano FJ, Kuo IY, Ehrlich BE.

Pflugers Arch. 2017 Nov;469(11):1507-1517. doi: 10.1007/s00424-017-2042-7. Epub 2017 Jul 31.


Polycystin and calcium signaling in cell death and survival.

Lemos FO, Ehrlich BE.

Cell Calcium. 2018 Jan;69:37-45. doi: 10.1016/j.ceca.2017.05.011. Epub 2017 May 24. Review.


Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival.

Moore LM, England A, Ehrlich BE, Rimm DL.

Mol Cancer Res. 2017 Jul;15(7):942-952. doi: 10.1158/1541-7786.MCR-16-0408. Epub 2017 Mar 8.


Low-dose dasatinib rescues cardiac function in Noonan syndrome.

Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM.

JCI Insight. 2016 Dec 8;1(20):e90220. doi: 10.1172/jci.insight.90220.


The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function.

Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ.

Mol Biol Cell. 2017 Jan 15;28(2):261-269. doi: 10.1091/mbc.E16-08-0597. Epub 2016 Nov 23.


Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics.

Wang B, Boeckel GR, Huynh L, Nguyen L, Cao W, De La Cruz EM, Kaftan EJ, Ehrlich BE.

PLoS One. 2016 Aug 30;11(8):e0161414. doi: 10.1371/journal.pone.0161414. eCollection 2016.


Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging.

Kuo IY, Duong SL, Nguyen L, Ehrlich BE.

PLoS One. 2016 Apr 15;11(4):e0153632. doi: 10.1371/journal.pone.0153632. eCollection 2016.


Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.

Yang Y, Ehrlich BE.

J Physiol. 2016 Aug 1;594(15):4141-9. doi: 10.1113/JP270933. Epub 2016 Apr 27. Review.


Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail.

Yang Y, Hodsdon ME, Lolis EJ, Ehrlich BE.

Biochem J. 2016 Feb 1;473(3):285-96. doi: 10.1042/BJ20151031. Epub 2015 Nov 16.


The effects of mycoplasma contamination upon the ability to form bioengineered 3D kidney cysts.

DesRochers TM, Kuo IY, Kimmerling EP, Ehrlich BE, Kaplan DL.

PLoS One. 2015 Mar 20;10(3):e0120097. doi: 10.1371/journal.pone.0120097. eCollection 2015.


Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties.

Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME.

J Biol Chem. 2015 Apr 17;290(16):10544-54. doi: 10.1074/jbc.M115.641803. Epub 2015 Feb 25.


Muscling in on the ryanodine receptor.

Kuo IY, Ehrlich BE.

Nat Struct Mol Biol. 2015 Feb;22(2):106-7. doi: 10.1038/nsmb.2960. No abstract available.


Signaling in muscle contraction.

Kuo IY, Ehrlich BE.

Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023. Review.


Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.

Kuo IY, Hu J, Ha Y, Ehrlich BE.

J Biol Chem. 2015 Mar 6;290(10):6419-27. doi: 10.1074/jbc.M114.629584. Epub 2015 Jan 21.


Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways.

Kuo IY, Kwaczala AT, Nguyen L, Russell KS, Campbell SG, Ehrlich BE.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16604-9. doi: 10.1073/pnas.1415933111. Epub 2014 Nov 3.


Altered trafficking and stability of polycystins underlie polycystic kidney disease.

Cai Y, Fedeles SV, Dong K, Anyatonwu G, Onoe T, Mitobe M, Gao JD, Okuhara D, Tian X, Gallagher AR, Tang Z, Xie X, Lalioti MD, Lee AH, Ehrlich BE, Somlo S.

J Clin Invest. 2014 Dec;124(12):5129-44. doi: 10.1172/JCI67273. Epub 2014 Nov 3.


Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.

Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE.

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1057-64. doi: 10.1152/ajpendo.00236.2014. Epub 2014 Oct 14.


Cyst formation following disruption of intracellular calcium signaling.

Kuo IY, DesRochers TM, Kimmerling EP, Nguyen L, Ehrlich BE, Kaplan DL.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14283-8. doi: 10.1073/pnas.1412323111. Epub 2014 Sep 16.


The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function.

Kuo IY, Keeler C, Corbin R, Ćelić A, Petri ET, Hodsdon ME, Ehrlich BE.

FASEB J. 2014 May;28(5):2332-46. doi: 10.1096/fj.13-247106. Epub 2014 Feb 20.


An explicit formulation approach for the analysis of calcium binding to EF-hand proteins using isothermal titration calorimetry.

Keeler C, Poon G, Kuo IY, Ehrlich BE, Hodsdon ME.

Biophys J. 2013 Dec 17;105(12):2843-53. doi: 10.1016/j.bpj.2013.11.017.


The role of chromogranin B in an animal model of multiple sclerosis.

Mo M, Hoang HT, Schmidt S, Clark RB, Ehrlich BE.

Mol Cell Neurosci. 2013 Sep;56:102-14. doi: 10.1016/j.mcn.2013.04.003. Epub 2013 Apr 24.


Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy.

Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris PC, Torres VE, Ehrlich BE.

J Mol Cell Cardiol. 2013 May;58:199-208. doi: 10.1016/j.yjmcc.2013.01.015. Epub 2013 Jan 30.


Inhibition of paclitaxel-induced decreases in calcium signaling.

Benbow JH, Mann T, Keeler C, Fan C, Hodsdon ME, Lolis E, DeGray B, Ehrlich BE.

J Biol Chem. 2012 Nov 2;287(45):37907-16. doi: 10.1074/jbc.M112.385070. Epub 2012 Sep 17.


Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.

Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H.

Science. 2012 Oct 12;338(6104):226-31. doi: 10.1126/science.1222538. Epub 2012 Sep 13.


Prevention of paclitaxel-induced peripheral neuropathy by lithium pretreatment.

Mo M, Erdelyi I, Szigeti-Buck K, Benbow JH, Ehrlich BE.

FASEB J. 2012 Nov;26(11):4696-709. doi: 10.1096/fj.12-214643. Epub 2012 Aug 13.


A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

Zhang HS, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, Su H, Jovin IS, Kunis M, Hinkley S, Liang Y, Hinh L, Spratt SK, Case CC, Rebar EJ, Ehrlich BE, Ehrlich B, Gregory PD, Giordano FJ.

Mol Ther. 2012 Aug;20(8):1508-15. doi: 10.1038/mt.2012.80. Epub 2012 Jul 24. Erratum in: Mol Ther. 2012 Dec;20(12):2370. Ehrlich, Barbara [corrected to Ehrlich, Barbara E].


Ion channels in renal disease.

Kuo IY, Ehrlich BE.

Chem Rev. 2012 Dec 12;112(12):6353-72. doi: 10.1021/cr3001077. Epub 2012 Jul 18. Review. No abstract available.


Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating.

Ćelić AS, Petri ET, Benbow J, Hodsdon ME, Ehrlich BE, Boggon TJ.

J Biol Chem. 2012 May 18;287(21):17232-40. doi: 10.1074/jbc.M112.354613. Epub 2012 Apr 3.


Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.

Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y.

Stem Cell Res. 2012 Jan;8(1):49-57. doi: 10.1016/j.scr.2011.08.004. Epub 2011 Aug 22.


High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells.

Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y.

Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):51-7. doi: 10.1016/j.bbrc.2011.10.140. Epub 2011 Nov 6.


C-terminal domain of chromogranin B regulates intracellular calcium signaling.

Schmidt S, Mo M, Heidrich FM, Ćelić A, Ehrlich BE.

J Biol Chem. 2011 Dec 30;286(52):44888-96. doi: 10.1074/jbc.M111.251330. Epub 2011 Oct 20.


Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy.

Schulze C, McGowan M, Jordt SE, Ehrlich BE.

Clin Colorectal Cancer. 2011 Jun;10(2):126-33. doi: 10.1016/j.clcc.2011.03.010. Epub 2011 Apr 22.


Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.

Benbow JH, DeGray B, Ehrlich BE.

J Biol Chem. 2011 Oct 7;286(40):34575-82. doi: 10.1074/jbc.M111.265751. Epub 2011 Aug 1.


Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.

Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y.

J Mol Cell Cardiol. 2011 Sep;51(3):280-7. doi: 10.1016/j.yjmcc.2011.04.012. Epub 2011 May 4.


Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation.

Bimboese P, Gibson CJ, Schmidt S, Xiang W, Ehrlich BE.

J Biol Chem. 2011 May 6;286(18):15688-97. doi: 10.1074/jbc.M110.206482. Epub 2011 Mar 7.


Unloading intracellular calcium stores reveals regionally specific functions.

Schmidt S, Ehrlich BE.

Neuron. 2010 Dec 9;68(5):806-8. doi: 10.1016/j.neuron.2010.11.039.


Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R.

Zhang K, Heidrich FM, DeGray B, Boehmerle W, Ehrlich BE.

J Mol Cell Cardiol. 2010 Nov;49(5):829-35. doi: 10.1016/j.yjmcc.2010.08.018. Epub 2010 Aug 27.


Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity.

Petri ET, Celic A, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9176-81. doi: 10.1073/pnas.0912295107. Epub 2010 May 3.


Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding.

Blachford C, Celić A, Petri ET, Ehrlich BE.

Cell Calcium. 2009 Oct;46(4):257-62. doi: 10.1016/j.ceca.2009.08.002. Epub 2009 Sep 3.


Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2.

Casuscelli J, Schmidt S, DeGray B, Petri ET, Celić A, Folta-Stogniew E, Ehrlich BE, Boggon TJ.

Am J Physiol Renal Physiol. 2009 Nov;297(5):F1310-5. doi: 10.1152/ajprenal.00412.2009. Epub 2009 Sep 2.


Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons.

Collin T, Franconville R, Ehrlich BE, Llano I.

J Neurosci. 2009 Jul 22;29(29):9281-91. doi: 10.1523/JNEUROSCI.1865-09.2009.

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