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Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box.

DuChane CM, Karpin GW, Ehrich M, Falkinham JO 3rd, Merola JS.

Medchemcomm. 2019 May 14;10(8):1391-1398. doi: 10.1039/c9md00140a. eCollection 2019 Aug 1.


Alum as an adjuvant for nanoparticle based vaccines: A case study with a hybrid nanoparticle-based nicotine vaccine.

Hu Y, Smith D, Zhao Z, Harmon T, Pentel PR, Ehrich M, Zhang C.

Nanomedicine. 2019 Aug;20:102023. doi: 10.1016/j.nano.2019.102023. Epub 2019 Jun 10.


The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.

Leber A, Hontecillas R, Zoccoli-Rodriguez V, Colombel JF, Chauhan J, Ehrich M, Farinola N, Bassaganya-Riera J.

Inflamm Bowel Dis. 2019 May 11. pii: izz094. doi: 10.1093/ibd/izz094. [Epub ahead of print]


Effect of Adjuvant Release Rate on the Immunogenicity of Nanoparticle-Based Vaccines: A Case Study with a Nanoparticle-Based Nicotine Vaccine.

Zhao Z, Hu Y, Harmon T, Pentel P, Ehrich M, Zhang C.

Mol Pharm. 2019 Jun 3;16(6):2766-2775. doi: 10.1021/acs.molpharmaceut.9b00279. Epub 2019 May 22.


Nonclinical Toxicology and Toxicokinetic Profile of an Oral Lanthionine Synthetase C-Like 2 (LANCL2) Agonist, BT-11.

Leber A, Hontecillas R, Zoccoli-Rodriguez V, Ehrich M, Davis J, Chauhan J, Bassaganya-Riera J.

Int J Toxicol. 2019 Mar/Apr;38(2):96-109. doi: 10.1177/1091581819827509. Epub 2019 Feb 21.


Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients.

Jensen TJ, Goodman AM, Kato S, Ellison CK, Daniels GA, Kim L, Nakashe P, McCarthy E, Mazloom AR, McLennan G, Grosu DS, Ehrich M, Kurzrock R.

Mol Cancer Ther. 2019 Feb;18(2):448-458. doi: 10.1158/1535-7163.MCT-18-0535. Epub 2018 Dec 6.


Paradox of PEGylation in fabricating hybrid nanoparticle-based nicotine vaccines.

Hu Y, Zhao Z, Harmon T, Pentel PR, Ehrich M, Zhang C.

Biomaterials. 2018 Nov;182:72-81. doi: 10.1016/j.biomaterials.2018.08.015. Epub 2018 Aug 7.


High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells.

Orbach SM, Ehrich MF, Rajagopalan P.

Toxicol In Vitro. 2018 Sep;51:83-94. doi: 10.1016/j.tiv.2018.05.006. Epub 2018 May 8.


Hybrid nanoparticle-based nicotine nanovaccines: Boosting the immunological efficacy by conjugation of potent carrier proteins.

Zhao Z, Hu Y, Harmon T, Pentel PR, Ehrich M, Zhang C.

Nanomedicine. 2018 Jul;14(5):1655-1665. doi: 10.1016/j.nano.2018.04.016. Epub 2018 Apr 30.


Synthesis and Evaluation of Doxorubicin-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.

Du Y, Xia L, Jo A, Davis RM, Bissel P, Ehrich MF, Kingston DGI.

Bioconjug Chem. 2018 Feb 21;29(2):420-430. doi: 10.1021/acs.bioconjchem.7b00756. Epub 2018 Jan 11.


Rational incorporation of molecular adjuvants into a hybrid nanoparticle-based nicotine vaccine for immunotherapy against nicotine addiction.

Zhao Z, Harris B, Hu Y, Harmon T, Pentel PR, Ehrich M, Zhang C.

Biomaterials. 2018 Feb;155:165-175. doi: 10.1016/j.biomaterials.2017.11.021. Epub 2017 Nov 20.


Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing.

Dharajiya NG, Grosu DS, Farkas DH, McCullough RM, Almasri E, Sun Y, Kim SK, Jensen TJ, Saldivar JS, Topol EJ, van den Boom D, Ehrich M.

Clin Chem. 2018 Feb;64(2):329-335. doi: 10.1373/clinchem.2017.277517. Epub 2017 Oct 5.


Genome-wide cfDNA screening: clinical laboratory experience with the first 10,000 cases.

Ehrich M, Tynan J, Mazloom A, Almasri E, McCullough R, Boomer T, Grosu D, Chibuk J.

Genet Med. 2017 Dec;19(12):1332-1337. doi: 10.1038/gim.2017.56. Epub 2017 Jun 15.


Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization.

Zhao Z, Hu Y, Harmon T, Pentel P, Ehrich M, Zhang C.

Biomaterials. 2017 Sep;138:46-56. doi: 10.1016/j.biomaterials.2017.05.031. Epub 2017 May 19.


Investigating acetaminophen hepatotoxicity in multi-cellular organotypic liver models.

Orbach SM, Cassin ME, Ehrich MF, Rajagopalan P.

Toxicol In Vitro. 2017 Aug;42:10-20. doi: 10.1016/j.tiv.2017.03.008. Epub 2017 Mar 19.


Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.

Rzigalinski BA, Carfagna CS, Ehrich M.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jul;9(4). doi: 10.1002/wnan.1444. Epub 2016 Nov 8. Review.


Using Targeted Sequencing of Paralogous Sequences for Noninvasive Detection of Selected Fetal Aneuploidies.

Ellison CK, Sun Y, Hogg G, Fox J, Tao H, McCarthy E, Sagoe B, Azab MA, Mazloom AR, Tynan J, Burcham T, Kim SK, van den Boom D, Ehrich M, Jensen TJ.

Clin Chem. 2016 Dec;62(12):1621-1629. Epub 2016 Sep 30.


The next-generation nicotine vaccine: a novel and potent hybrid nanoparticle-based nicotine vaccine.

Hu Y, Smith D, Frazier E, Hoerle R, Ehrich M, Zhang C.

Biomaterials. 2016 Nov;106:228-39. doi: 10.1016/j.biomaterials.2016.08.028. Epub 2016 Aug 18.



Ehrich M, Grosu D, van den Boom D, Tynan J.

Am J Obstet Gynecol. 2016 Oct;215(4):534-5. doi: 10.1016/j.ajog.2016.06.009. Epub 2016 Jun 15. No abstract available.


Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease.

Bissel P, Boes K, Hinckley J, Jortner BS, Magnin-Bissel G, Werre SR, Ehrich M, Carbo A, Philipson C, Hontecillas R, Philipson N, Gandour RD, Bassaganya-Riera J.

Int J Toxicol. 2016 Sep;35(5):521-9. doi: 10.1177/1091581816646356. Epub 2016 May 26.


Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants.

Lefkowitz RB, Tynan JA, Liu T, Wu Y, Mazloom AR, Almasri E, Hogg G, Angkachatchai V, Zhao C, Grosu DS, McLennan G, Ehrich M.

Am J Obstet Gynecol. 2016 Aug;215(2):227.e1-227.e16. doi: 10.1016/j.ajog.2016.02.030. Epub 2016 Feb 17.


Copy-Number Variation and False Positive Results of Prenatal Screening.

van den Boom D, Ehrich M, Kim SK.

N Engl J Med. 2015 Dec 24;373(26):2584. doi: 10.1056/NEJMc1507106. No abstract available.


Ultrasensitive Detection of Multiplexed Somatic Mutations Using MALDI-TOF Mass Spectrometry.

Mosko MJ, Nakorchevsky AA, Flores E, Metzler H, Ehrich M, van den Boom DJ, Sherwood JL, Nygren AO.

J Mol Diagn. 2016 Jan;18(1):23-31. doi: 10.1016/j.jmoldx.2015.08.001. Epub 2015 Nov 18.


Negatively Charged Carbon Nanohorn Supported Cationic Liposome Nanoparticles: A Novel Delivery Vehicle for Anti-Nicotine Vaccine.

Zheng H, Hu Y, Huang W, de Villiers S, Pentel P, Zhang J, Dorn H, Ehrich M, Zhang C.

J Biomed Nanotechnol. 2015 Dec;11(12):2197-210.


Application of risk score analysis to low-coverage whole genome sequencing data for the noninvasive detection of trisomy 21, trisomy 18, and trisomy 13.

Tynan JA, Kim SK, Mazloom AR, Zhao C, McLennan G, Tim R, Liu L, Hannum G, Hull A, Bombard AT, Oeth P, Burcham T, van den Boom D, Ehrich M.

Prenat Diagn. 2016 Jan;36(1):56-62. doi: 10.1002/pd.4712. Epub 2015 Dec 23.


Engineering the lipid layer of lipid-PLGA hybrid nanoparticles for enhanced in vitro cellular uptake and improved stability.

Hu Y, Hoerle R, Ehrich M, Zhang C.

Acta Biomater. 2015 Dec;28:149-159. doi: 10.1016/j.actbio.2015.09.032. Epub 2015 Sep 30.


Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts.

Kim SK, Hannum G, Geis J, Tynan J, Hogg G, Zhao C, Jensen TJ, Mazloom AR, Oeth P, Ehrich M, van den Boom D, Deciu C.

Prenat Diagn. 2015 Aug;35(8):810-5. doi: 10.1002/pd.4615. Epub 2015 Jun 3.


Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains.

Jensen TJ, Kim SK, Zhu Z, Chin C, Gebhard C, Lu T, Deciu C, van den Boom D, Ehrich M.

Genome Biol. 2015 Apr 15;16:78. doi: 10.1186/s13059-015-0645-x.


Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma.

Zhao C, Tynan J, Ehrich M, Hannum G, McCullough R, Saldivar JS, Oeth P, van den Boom D, Deciu C.

Clin Chem. 2015 Apr;61(4):608-16. doi: 10.1373/clinchem.2014.233312. Epub 2015 Feb 20.


Circulating cell free DNA testing: are some test failures informative?

Palomaki GE, Kloza EM, Lambert-Messerlian GM, van den Boom D, Ehrich M, Deciu C, Bombard AT, Haddow JE.

Prenat Diagn. 2015 Mar;35(3):289-93. doi: 10.1002/pd.4541. Epub 2015 Jan 8.


In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters.

Hu Y, Ehrich M, Fuhrman K, Zhang C.

Nanoscale Res Lett. 2014 Aug 27;9(1):434. doi: 10.1186/1556-276X-9-434. eCollection 2014.


Noninvasive detection of a balanced fetal translocation from maternal plasma.

Jensen TJ, Kim SK, van den Boom D, Deciu C, Ehrich M.

Clin Chem. 2014 Oct;60(10):1298-305. doi: 10.1373/clinchem.2014.223198. Epub 2014 Jul 16.


Cefazolin concentration in surgically created wounds treated with negative pressure wound therapy compared to surgically created wounds treated with nonadherent wound dressings.

Coutin JV, Lanz OI, Magnin-Bissel GC, Ehrich MF, Miller EI, Werre SR, Riegel TO.

Vet Surg. 2015 Jan;44(1):9-16. doi: 10.1111/j.1532-950X.2014.12218.x. Epub 2014 Jun 24.


Noninvasive prenatal screening for fetal trisomies 21, 18, 13 and the common sex chromosome aneuploidies from maternal blood using massively parallel genomic sequencing of DNA.

Porreco RP, Garite TJ, Maurel K, Marusiak B; Obstetrix Collaborative Research Network, Ehrich M, van den Boom D, Deciu C, Bombard A.

Am J Obstet Gynecol. 2014 Oct;211(4):365.e1-12. doi: 10.1016/j.ajog.2014.03.042. Epub 2014 Mar 19.


Fetal Aneuploidy Detection by Cell-Free DNA Sequencing for Multiple Pregnancies and Quality Issues with Vanishing Twins.

Grömminger S, Yagmur E, Erkan S, Nagy S, Schöck U, Bonnet J, Smerdka P, Ehrich M, Wegner RD, Hofmann W, Stumm M.

J Clin Med. 2014 Jun 25;3(3):679-92. doi: 10.3390/jcm3030679.


Maternal plasma DNA testing for aneuploidy in pregnancies achieved by assisted reproductive technologies.

Lambert-Messerlian G, Kloza EM, Williams J 3rd, Loucky J, O'Brien B, Wilkins-Haug L, Mahoney MJ, De Biasio P, Borrell A, Ehrich M, van den Boom D, Bombard AT, Deciu C, Palomaki GE.

Genet Med. 2014 May;16(5):419-22. doi: 10.1038/gim.2013.149. Epub 2013 Oct 3.


Optimizing blood collection, transport and storage conditions for cell free DNA increases access to prenatal testing.

Wong D, Moturi S, Angkachatchai V, Mueller R, DeSantis G, van den Boom D, Ehrich M.

Clin Biochem. 2013 Aug;46(12):1099-1104. doi: 10.1016/j.clinbiochem.2013.04.023. Epub 2013 Apr 30.


Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell-free DNA from maternal plasma.

Mazloom AR, Džakula Ž, Oeth P, Wang H, Jensen T, Tynan J, McCullough R, Saldivar JS, Ehrich M, van den Boom D, Bombard AT, Maeder M, McLennan G, Meschino W, Palomaki GE, Canick JA, Deciu C.

Prenat Diagn. 2013 Jun;33(6):591-7. doi: 10.1002/pd.4127.


High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma.

Jensen TJ, Zwiefelhofer T, Tim RC, Džakula Ž, Kim SK, Mazloom AR, Zhu Z, Tynan J, Lu T, McLennan G, Palomaki GE, Canick JA, Oeth P, Deciu C, van den Boom D, Ehrich M.

PLoS One. 2013;8(3):e57381. doi: 10.1371/journal.pone.0057381. Epub 2013 Mar 6.


Cell-type specific DNA methylation patterns define human breast cellular identity.

Novak P, Stampfer MR, Munoz-Rodriguez JL, Garbe JC, Ehrich M, Futscher BW, Jensen TJ.

PLoS One. 2012;7(12):e52299. doi: 10.1371/journal.pone.0052299. Epub 2012 Dec 20.


Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis.

Emerick GL, Ehrich M, Jortner BS, Oliveira RV, Deoliveira GH.

Toxicology. 2012 Dec 8;302(1):88-95. doi: 10.1016/j.tox.2012.08.002. Epub 2012 Aug 15.


Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy.

Emerick GL, DeOliveira GH, dos Santos AC, Ehrich M.

Chem Biol Interact. 2012 Sep 30;199(3):177-84. doi: 10.1016/j.cbi.2012.07.002. Epub 2012 Jul 20. Review.


Transient alterations of the blood-brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos.

Li W, Ehrich M.

J Appl Toxicol. 2013 Oct;33(10):1187-91. doi: 10.1002/jat.2762. Epub 2012 May 18.


DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations.

Canick JA, Kloza EM, Lambert-Messerlian GM, Haddow JE, Ehrich M, van den Boom D, Bombard AT, Deciu C, Palomaki GE.

Prenat Diagn. 2012 Aug;32(8):730-4. doi: 10.1002/pd.3892. Epub 2012 May 14.


Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers.

Waldhaus J, Cimerman J, Gohlke H, Ehrich M, Müller M, Löwenheim H.

PLoS One. 2012;7(5):e36066. doi: 10.1371/journal.pone.0036066. Epub 2012 May 3.


Detection of microdeletion 22q11.2 in a fetus by next-generation sequencing of maternal plasma.

Jensen TJ, Dzakula Z, Deciu C, van den Boom D, Ehrich M.

Clin Chem. 2012 Jul;58(7):1148-51. doi: 10.1373/clinchem.2011.180794. Epub 2012 May 4.


Organophosphorus compound effects on neurotrophin receptors and intracellular signaling.

Pomeroy-Black M, Ehrich M.

Toxicol In Vitro. 2012 Aug;26(5):759-65. doi: 10.1016/j.tiv.2012.03.008. Epub 2012 Mar 16.


DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study.

Palomaki GE, Deciu C, Kloza EM, Lambert-Messerlian GM, Haddow JE, Neveux LM, Ehrich M, van den Boom D, Bombard AT, Grody WW, Nelson SF, Canick JA.

Genet Med. 2012 Mar;14(3):296-305. doi: 10.1038/gim.2011.73. Epub 2012 Feb 2.

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