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Items: 1 to 50 of 127

1.

Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS.

Garbuzova-Davis S, Ehrhart J, Mustafa H, Llauget A, Boccio KJ, Sanberg PR, Appel SH, Borlongan CV.

Brain Res. 2019 Dec 1;1724:146428. doi: 10.1016/j.brainres.2019.146428. Epub 2019 Sep 4.

PMID:
31493389
2.

A Gutsy Move for Cell-Based Regenerative Medicine in Parkinson's Disease: Targeting the Gut Microbiome to Sequester Inflammation and Neurotoxicity.

Lee JY, Tuazon JP, Corey S, Bonsack B, Acosta S, Ehrhart J, Sanberg PR, Borlongan CV.

Stem Cell Rev Rep. 2019 Oct;15(5):690-702. doi: 10.1007/s12015-019-09906-2.

3.

A Hallmark Clinical Study of Cord Blood Therapy in Adults with Ischemic Stroke.

Sanberg PR, Ehrhart J.

Cell Transplant. 2019 Sep-Oct;28(9-10):1329-1332. doi: 10.1177/0963689719854354. Epub 2019 Jun 11.

4.

Gutting the brain of inflammation: A key role of gut microbiome in human umbilical cord blood plasma therapy in Parkinson's disease model.

Lee JY, Tuazon JP, Ehrhart J, Sanberg PR, Borlongan CV.

J Cell Mol Med. 2019 Aug;23(8):5466-5474. doi: 10.1111/jcmm.14429. Epub 2019 May 31.

5.

Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.

Pio B, Chobanian HR, Guo Y, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Ashley E, Orr R, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Samuel K, Chen Q, Shang J, Lamca J, Ehrhart J, Nargund R, Howard AD, Colletti SL.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1842-1848. doi: 10.1016/j.bmcl.2019.04.050. Epub 2019 May 2.

PMID:
31109791
6.

Plasma derived from human umbilical cord blood: Potential cell-additive or cell-substitute therapeutic for neurodegenerative diseases.

Ehrhart J, Sanberg PR, Garbuzova-Davis S.

J Cell Mol Med. 2018 Dec;22(12):6157-6166. doi: 10.1111/jcmm.13898. Epub 2018 Oct 18.

7.

Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.

Chen HY, Plummer CW, Xiao D, Chobanian HR, DeMong D, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Di Salvo J, Thomas-Fowlkes B, Souza S, Tatosian DA, Chen Q, Hafey MJ, Houle R, Nolting AF, Orr R, Ehrhart J, Weinglass AB, Tschirret-Guth R, Howard AD, Colletti SL.

ACS Med Chem Lett. 2018 Jun 14;9(7):685-690. doi: 10.1021/acsmedchemlett.8b00149. eCollection 2018 Jul 12.

8.

Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients.

Delic V, Kurien C, Cruz J, Zivkovic S, Barretta J, Thomson A, Hennessey D, Joseph J, Ehrhart J, Willing AE, Bradshaw P, Garbuzova-Davis S.

J Neurosci Res. 2018 Aug;96(8):1353-1366. doi: 10.1002/jnr.24249. Epub 2018 May 6.

PMID:
29732581
9.

Potential Role of Humoral IL-6 Cytokine in Mediating Pro-Inflammatory Endothelial Cell Response in Amyotrophic Lateral Sclerosis.

Garbuzova-Davis S, Ehrhart J, Sanberg PR, Borlongan CV.

Int J Mol Sci. 2018 Jan 31;19(2). pii: E423. doi: 10.3390/ijms19020423. Review.

10.

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.

Myers RW, Guan HP, Ehrhart J, Petrov A, Prahalada S, Tozzo E, Yang X, Kurtz MM, Trujillo M, Gonzalez Trotter D, Feng D, Xu S, Eiermann G, Holahan MA, Rubins D, Conarello S, Niu X, Souza SC, Miller C, Liu J, Lu K, Feng W, Li Y, Painter RE, Milligan JA, He H, Liu F, Ogawa A, Wisniewski D, Rohm RJ, Wang L, Bunzel M, Qian Y, Zhu W, Wang H, Bennet B, LaFranco Scheuch L, Fernandez GE, Li C, Klimas M, Zhou G, van Heek M, Biftu T, Weber A, Kelley DE, Thornberry N, Erion MD, Kemp DM, Sebhat IK.

Science. 2017 Aug 4;357(6350):507-511. doi: 10.1126/science.aah5582. Epub 2017 Jul 13.

PMID:
28705990
11.

Cord blood as a potential therapeutic for amyotrophic lateral sclerosis.

Garbuzova-Davis S, Ehrhart J, Sanberg PR.

Expert Opin Biol Ther. 2017 Jul;17(7):837-851. doi: 10.1080/14712598.2017.1323862. Epub 2017 May 8. Review.

PMID:
28443372
12.

Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

Dong S, VanGelder K, Shi ZC, Yu Y, Wu Z, Ferguson R, Guo ZZ, Tang H, Frie J, Fu Q, Gu X, Priest BT, Thomas-Fowlkes B, Weinglass A, Margulis M, Liu J, Pai LY, Hampton C, Haimbach RE, Owens K, Tong V, Xu S, Hu M, Zingaro GJ, Morissette P, Ehrhart J, Roy S, Sullivan K, Pasternak A.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566. doi: 10.1016/j.bmcl.2017.03.086. Epub 2017 Mar 30.

PMID:
28431879
13.

Drug Release by Direct Jump from Poly(ethylene-glycol-b-ε-caprolactone) Nano-Vector to Cell Membrane.

Till U, Gibot L, Mingotaud AF, Ehrhart J, Wasungu L, Mingotaud C, Souchard JP, Poinso A, Rols MP, Violleau F, Vicendo P.

Molecules. 2016 Nov 30;21(12). pii: E1643.

14.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

Zhu Y, de Jesus RK, Tang H, Walsh SP, Jiang J, Gu X, Teumelsan N, Shahripour A, Pio B, Ding FX, Ha S, Priest BT, Swensen AM, Alonso-Galicia M, Felix JP, Brochu RM, Bailey T, Thomas-Fowlkes B, Zhou X, Pai LY, Hampton C, Hernandez M, Owens K, Ehrhart J, Roy S, Kaczorowski GJ, Yang L, Parmee ER, Sullivan K, Garcia ML, Pasternak A.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702. doi: 10.1016/j.bmcl.2016.10.064. Epub 2016 Oct 24.

PMID:
27839686
15.

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.

Walsh SP, Shahripour A, Tang H, de Jesus RK, Teumelsan N, Zhu Y, Frie J, Priest BT, Swensen AM, Alonso-Galicia M, Felix JP, Brochu RM, Bailey T, Thomas-Fowlkes B, Zhou X, Pai LY, Hampton C, Hernandez M, Owens K, Ehrhart J, Roy S, Kaczorowski GJ, Yang L, Garcia ML, Pasternak A.

Bioorg Med Chem Lett. 2016 May 1;26(9):2339-43. doi: 10.1016/j.bmcl.2016.03.035. Epub 2016 Mar 12.

PMID:
27017115
16.

Biodistribution of Infused Human Umbilical Cord Blood Cells in Alzheimer's Disease-Like Murine Model.

Ehrhart J, Darlington D, Kuzmin-Nichols N, Sanberg CD, Sawmiller DR, Sanberg PR, Tan J.

Cell Transplant. 2016;25(1):195-9. doi: 10.3727/096368915X689604. Epub 2015 Sep 25.

17.

Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-β pathology in PSAPP mice.

Darlington D, Li S, Hou H, Habib A, Tian J, Gao Y, Ehrhart J, Sanberg PR, Sawmiller D, Giunta B, Mori T, Tan J.

Cell Transplant. 2015;24(11):2237-50. doi: 10.3727/096368915X688894. Epub 2015 Jul 30.

18.

Plasma Derived From Human Umbilical Cord Blood Modulates Mitogen-Induced Proliferation of Mononuclear Cells Isolated From the Peripheral Blood of ALS Patients.

Eve DJ, Ehrhart J, Zesiewicz T, Jahan I, Kuzmin-Nichols N, Sanberg CD, Gooch C, Sanberg PR, Garbuzova-Davis S.

Cell Transplant. 2016;25(5):963-71. doi: 10.3727/096368915X688579. Epub 2015 Jul 8.

PMID:
26159164
19.

Humoral factors in ALS patients during disease progression.

Ehrhart J, Smith AJ, Kuzmin-Nichols N, Zesiewicz TA, Jahan I, Shytle RD, Kim SH, Sanberg CD, Vu TH, Gooch CL, Sanberg PR, Garbuzova-Davis S.

J Neuroinflammation. 2015 Jun 28;12:127. doi: 10.1186/s12974-015-0350-4.

20.

Cytokine correlations in youth with tic disorders.

Parker-Athill EC, Ehrhart J, Tan J, Murphy TK.

J Child Adolesc Psychopharmacol. 2015 Feb;25(1):86-92. doi: 10.1089/cap.2014.0103. Epub 2015 Feb 6.

21.

Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response.

Tajiri N, Hernandez D, Acosta S, Shinozuka K, Ishikawa H, Ehrhart J, Diamandis T, Gonzales-Portillo C, Borlongan MC, Tan J, Kaneko Y, Borlongan CV.

Brain Res. 2014 Apr 22;1559:65-71. doi: 10.1016/j.brainres.2014.02.041. Epub 2014 Mar 3.

22.

Improving lithium therapeutics by crystal engineering of novel ionic cocrystals.

Smith AJ, Kim SH, Duggirala NK, Jin J, Wojtas L, Ehrhart J, Giunta B, Tan J, Zaworotko MJ, Shytle RD.

Mol Pharm. 2013 Dec 2;10(12):4728-38. doi: 10.1021/mp400571a. Epub 2013 Nov 18.

23.

Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model.

Zhang SQ, Obregon D, Ehrhart J, Deng J, Tian J, Hou H, Giunta B, Sawmiller D, Tan J.

J Neurosci Res. 2013 Sep;91(9):1239-46. doi: 10.1002/jnr.23244. Epub 2013 May 17.

24.

Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice.

Darlington D, Deng J, Giunta B, Hou H, Sanberg CD, Kuzmin-Nichols N, Zhou HD, Mori T, Ehrhart J, Sanberg PR, Tan J.

Stem Cells Dev. 2013 Feb 1;22(3):412-21. doi: 10.1089/scd.2012.0345. Epub 2012 Sep 5.

25.

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders.

Giunta B, Ehrhart J, Obregon DF, Lam L, Le L, Jin J, Fernandez F, Tan J, Shytle RD.

Mol Brain. 2011 Jun 7;4(1):23. doi: 10.1186/1756-6606-4-23. Review.

27.

CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.

Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J.

J Neurosci. 2011 Jan 26;31(4):1355-65. doi: 10.1523/JNEUROSCI.3268-10.2011.

28.

A mesofluidic multiplex immunosensor for detection of circulating cytokeratin-positive cells in the blood of breast cancer patients.

Breton F, Bennetau B, Lidereau R, Thomas L, Regnier G, Ehrhart JC, Tauc P, Tran PL.

Biomed Microdevices. 2011 Feb;13(1):1-9. doi: 10.1007/s10544-010-9465-7.

PMID:
20814745
29.

Molecular tectonics: formation and structural studies on a 2-D directional coordination network based on a non-centric metacyclophane based tecton and zinc cation.

Ehrhart J, Planeix JM, Kyritsakas-Gruber N, Hosseini MW.

Dalton Trans. 2010 Feb 28;39(8):2137-46. doi: 10.1039/b917089h. Epub 2010 Jan 15.

PMID:
20148234
30.

Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study.

Shytle DR, Tan J, Ehrhart J, Smith AJ, Sanberg CD, Sanberg PR, Anderson J, Bickford PC.

Med Sci Monit. 2010 Jan;16(1):BR1-5.

PMID:
20037479
31.

Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology.

Zhu Y, Obregon D, Hou H, Giunta B, Ehrhart J, Fernandez F, Mori T, Nikolic W, Zhao Y, Morgan D, Town T, Tan J.

J Cell Mol Med. 2011 Feb;15(2):327-38. doi: 10.1111/j.1582-4934.2009.00962.x.

32.

Molecular tectonics: generation and structural studies on 1- and 2D coordination networks based on a meta-cyclophane in 1,3-alternate conformation bearing four pyrazolyl units and cobalt, zinc and copper cations.

Ehrhart J, Planeix JM, Kyritsakas-Gruber N, Hosseini MW.

Dalton Trans. 2009 Aug 28;(32):6309-14. doi: 10.1039/b903674a. Epub 2009 Jun 29.

PMID:
19655064
33.

Synthesis and structural studies of metallamacrotricycles based on a metacyclophane in 1,3-alternate conformation bearing four imidazolyl units.

Ehrhart J, Planeix JM, Kyritsakas-Gruber N, Hosseini MW.

Dalton Trans. 2009 Apr 14;(14):2552-7. doi: 10.1039/b816053h. Epub 2009 Feb 12.

PMID:
19319400
34.

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression.

Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD.

J Neuroinflammation. 2008 Sep 25;5:41. doi: 10.1186/1742-2094-5-41.

35.

A new immunosensor for breast cancer cell detection using antibody-coated long alkylsilane self-assembled monolayers in a parallel plate flow chamber.

Ehrhart JC, Bennetau B, Renaud L, Madrange JP, Thomas L, Morisot J, Brosseau A, Allano S, Tauc P, Tran PL.

Biosens Bioelectron. 2008 Nov 15;24(3):467-74. doi: 10.1016/j.bios.2008.04.027. Epub 2008 May 8.

PMID:
18547800
36.

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone.

Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, Messina E, Peterson LB, Sharif-Rodriguez W, Siegl PK, Sinclair PJ, Sparrow CP, Stevenson AS, Sun SY, Tsai C, Vargas H, Walker M 3rd, West SH, White V, Woltmann RF.

Br J Pharmacol. 2008 Aug;154(7):1465-73. doi: 10.1038/bjp.2008.229. Epub 2008 Jun 9.

37.

CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation.

Zhu Y, Hou H, Nikolic WV, Ehrhart J, Rrapo E, Bickford P, Giunta B, Tan J.

PLoS One. 2008 May 14;3(5):e2135. doi: 10.1371/journal.pone.0002135.

38.

Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice.

Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J.

Stem Cells Dev. 2008 Jun;17(3):423-39. doi: 10.1089/scd.2008.0018.

39.

Modulation of neuronal differentiation by CD40 isoforms.

Hou H, Obregon D, Lou D, Ehrhart J, Fernandez F, Silver A, Tan J.

Biochem Biophys Res Commun. 2008 May 2;369(2):641-7. doi: 10.1016/j.bbrc.2008.02.094. Epub 2008 Feb 27.

40.

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J.

Neurobiol Dis. 2008 Feb;29(2):336-53. Epub 2007 Oct 16.

41.

Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds.

Shytle RD, Ehrhart J, Tan J, Vila J, Cole M, Sanberg CD, Sanberg PR, Bickford PC.

Rejuvenation Res. 2007 Jun;10(2):173-8.

PMID:
17518694
42.

Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage.

Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2507-12. Epub 2007 Jan 30.

43.

BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.

Gosselet FP, Magnaldo T, Culerrier RM, Sarasin A, Ehrhart JC.

Cell Signal. 2007 Apr;19(4):731-9. Epub 2006 Oct 4.

PMID:
17112701
44.

EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia.

Giunta B, Obregon D, Hou H, Zeng J, Sun N, Nikolic V, Ehrhart J, Shytle D, Fernandez F, Tan J.

Brain Res. 2006 Dec 6;1123(1):216-225. doi: 10.1016/j.brainres.2006.09.057. Epub 2006 Oct 31.

45.

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.

Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J.

J Biol Chem. 2006 Jun 16;281(24):16419-27. Epub 2006 Apr 19.

46.

Sleep stage 2: an electroencephalographic, autonomic, and hormonal duality.

Brandenberger G, Ehrhart J, Buchheit M.

Sleep. 2005 Dec;28(12):1535-40.

PMID:
16408412
47.

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.

Ehrhart J, Obregon D, Mori T, Hou H, Sun N, Bai Y, Klein T, Fernandez F, Tan J, Shytle RD.

J Neuroinflammation. 2005 Dec 12;2:29.

48.

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J.

J Neurosci. 2005 Sep 21;25(38):8807-14.

49.

Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration.

Zeevalk GD, Bernard LP, Song C, Gluck M, Ehrhart J.

Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1117-39. Review.

PMID:
16115016
50.

Is slow wave sleep an appropriate recording condition for heart rate variability analysis?

Brandenberger G, Buchheit M, Ehrhart J, Simon C, Piquard F.

Auton Neurosci. 2005 Aug 31;121(1-2):81-6.

PMID:
16005265

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